PL2450437T3 - Defekty genu i zmutowana kinaza ALK w ludzkich guzach litych - Google Patents
Defekty genu i zmutowana kinaza ALK w ludzkich guzach litychInfo
- Publication number
- PL2450437T3 PL2450437T3 PL12150524T PL12150524T PL2450437T3 PL 2450437 T3 PL2450437 T3 PL 2450437T3 PL 12150524 T PL12150524 T PL 12150524T PL 12150524 T PL12150524 T PL 12150524T PL 2450437 T3 PL2450437 T3 PL 2450437T3
- Authority
- PL
- Poland
- Prior art keywords
- solid tumors
- human solid
- alk kinase
- gene defects
- mutant alk
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79236406P | 2006-04-14 | 2006-04-14 | |
EP12150524.2A EP2450437B1 (en) | 2006-04-14 | 2007-04-13 | Gene defects and mutant ALK kinase in human solid tumors |
EP07775495.0A EP2016089B1 (en) | 2006-04-14 | 2007-04-13 | Gene defects and mutant alk kinase in human solid tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2450437T3 true PL2450437T3 (pl) | 2017-12-29 |
Family
ID=40754049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12150524T PL2450437T3 (pl) | 2006-04-14 | 2007-04-13 | Defekty genu i zmutowana kinaza ALK w ludzkich guzach litych |
Country Status (9)
Country | Link |
---|---|
US (9) | US7700339B2 (pl) |
EP (4) | EP2447360A1 (pl) |
DK (2) | DK2447359T3 (pl) |
ES (2) | ES2637592T3 (pl) |
HK (2) | HK1170266A1 (pl) |
HU (1) | HUE035732T2 (pl) |
PL (1) | PL2450437T3 (pl) |
PT (1) | PT2450437T (pl) |
SI (1) | SI2450437T1 (pl) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
EP2447360A1 (en) | 2006-04-14 | 2012-05-02 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二(芳胺基)芳基化合物 |
WO2009054939A2 (en) * | 2007-10-19 | 2009-04-30 | Cell Signaling Technology, Inc. | Cancer classification and methods of use |
US20110110923A1 (en) * | 2008-02-12 | 2011-05-12 | The Brigham And Women's Hospital, Inc. | Fish assay for eml4 and alk fusion in lung cancer |
US20120202214A1 (en) * | 2009-10-06 | 2012-08-09 | Kazuya Omi | Method for detecting fusion gene |
TWI518325B (zh) * | 2010-02-04 | 2016-01-21 | 自治醫科大學 | 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療 |
TW201202703A (en) * | 2010-04-16 | 2012-01-16 | Response Genetics Inc | Primers, probes, methods, and kits for the detection of EML4-ALK variants |
WO2011146945A2 (en) * | 2010-05-21 | 2011-11-24 | Cell Signaling Technology, Inc. | Alk and ros kinase in cancer |
US20120101108A1 (en) | 2010-08-06 | 2012-04-26 | Cell Signaling Technology, Inc. | Anaplastic Lymphoma Kinase In Kidney Cancer |
WO2012075318A2 (en) * | 2010-12-01 | 2012-06-07 | Cell Signaling Technology, Inc. | Fn1 and alk gene translocations in cancer and alk kinase expression in ovarian cancer |
CA2823337C (en) * | 2010-12-29 | 2019-09-10 | Expression Pathology, Inc. | Her3 protein srm/mrm assay |
EP2670866A4 (en) * | 2011-04-05 | 2015-09-02 | Translational Genomics Res Inst | BIOMARKERS AND METHODS OF USE |
US9150929B2 (en) | 2011-05-17 | 2015-10-06 | The Johns Hopkins University | Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene |
EP2714038A1 (en) | 2011-05-24 | 2014-04-09 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/pi3k inhibitors |
AU2012280931A1 (en) | 2011-07-07 | 2014-02-27 | Synta Pharmaceuticals Corp. | Treating cancer with HSP90 inhibitory compounds |
WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
US9439899B2 (en) | 2011-11-02 | 2016-09-13 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of HSP90 inhibitors with topoisomerase I inhibitors |
CA2853806C (en) | 2011-11-02 | 2020-07-14 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with platinum-containing agents |
EP2780010A1 (en) | 2011-11-14 | 2014-09-24 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
DK2838998T3 (en) | 2012-04-18 | 2018-01-15 | Cell Signaling Technology Inc | EGFR AND ROS1 IN CANCER |
WO2013170182A1 (en) | 2012-05-11 | 2013-11-14 | Synta Pharmaceuticals Corp. | Treating cancer with an hsp90 inhibitory compound |
CA2882759C (en) * | 2012-08-31 | 2018-11-20 | The Regents Of The University Of Colorado | Detection of the ntrk1-mprip gene fusion for cancer diagnosis |
AU2013337264B2 (en) | 2012-11-05 | 2018-03-08 | Foundation Medicine, Inc. | Novel fusion molecules and uses thereof |
CA2890207A1 (en) | 2012-11-05 | 2014-05-08 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
CA3150658A1 (en) | 2013-01-18 | 2014-07-24 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
US10597725B2 (en) | 2014-09-01 | 2020-03-24 | Arkray, Inc. | Primer reagent for amplifying ALK fusion gene, ALK fusion gene amplification reagent kit including the same, and ALK fusion gene amplification method and ALK fusion gene analysis method using the same |
CA2976072A1 (en) | 2015-02-09 | 2016-08-18 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors and pd-1 inhibitors for treating cancer |
CN109312406A (zh) | 2016-06-01 | 2019-02-05 | 豪夫迈·罗氏有限公司 | 预测肺癌患者中对alk抑制剂疗法的响应的间变性淋巴瘤激酶中的新型突变 |
JP2020521440A (ja) * | 2017-05-31 | 2020-07-27 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Alk、ret、およびros融合の多重pcr検出 |
JP7385191B2 (ja) | 2019-08-30 | 2023-11-22 | 学校法人同志社 | Eml4-alk阻害ペプチドおよびこれを含む肺がん治療薬 |
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-
2007
- 2007-04-13 EP EP12150526A patent/EP2447360A1/en not_active Withdrawn
- 2007-04-13 EP EP12150524.2A patent/EP2450437B1/en not_active Revoked
- 2007-04-13 DK DK12150525.9T patent/DK2447359T3/en active
- 2007-04-13 HU HUE12150524A patent/HUE035732T2/en unknown
- 2007-04-13 DK DK12150524.2T patent/DK2450437T3/en active
- 2007-04-13 SI SI200731954T patent/SI2450437T1/sl unknown
- 2007-04-13 ES ES12150524.2T patent/ES2637592T3/es active Active
- 2007-04-13 US US11/787,132 patent/US7700339B2/en active Active
- 2007-04-13 ES ES12150525.9T patent/ES2561406T3/es active Active
- 2007-04-13 PL PL12150524T patent/PL2450437T3/pl unknown
- 2007-04-13 PT PT121505242T patent/PT2450437T/pt unknown
- 2007-04-13 EP EP17164972.6A patent/EP3266867A1/en not_active Withdrawn
- 2007-04-13 EP EP12150525.9A patent/EP2447359B1/en active Active
-
2009
- 2009-09-03 US US12/584,353 patent/US8232060B2/en active Active
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2010
- 2010-02-27 US US12/714,457 patent/US8288102B2/en active Active
- 2010-09-28 US US12/891,987 patent/US8377642B2/en active Active
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2012
- 2012-09-14 US US13/618,400 patent/US20130209452A1/en not_active Abandoned
- 2012-11-01 HK HK12111020.7A patent/HK1170266A1/zh unknown
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2015
- 2015-09-30 US US14/870,154 patent/US9988688B2/en active Active
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2016
- 2016-08-02 US US15/225,998 patent/US9523130B2/en active Active
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2018
- 2018-05-08 US US15/973,718 patent/US10870892B2/en active Active
- 2018-06-15 HK HK18107824.7A patent/HK1248280A1/zh unknown
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US20100304382A1 (en) | 2010-12-02 |
SI2450437T1 (sl) | 2017-12-29 |
EP2450437A3 (en) | 2012-08-01 |
US20090156475A1 (en) | 2009-06-18 |
EP2447360A1 (en) | 2012-05-02 |
PT2450437T (pt) | 2017-08-25 |
US20110021546A1 (en) | 2011-01-27 |
HUE035732T2 (en) | 2018-05-28 |
US8232060B2 (en) | 2012-07-31 |
US20130209452A1 (en) | 2013-08-15 |
EP2447359A1 (en) | 2012-05-02 |
US20160186268A1 (en) | 2016-06-30 |
HK1170266A1 (zh) | 2013-02-22 |
EP2447359B1 (en) | 2015-11-04 |
US10870892B2 (en) | 2020-12-22 |
HK1248280A1 (zh) | 2018-10-12 |
US7700339B2 (en) | 2010-04-20 |
ES2561406T3 (es) | 2016-02-26 |
US20190127804A1 (en) | 2019-05-02 |
EP3266867A1 (en) | 2018-01-10 |
EP2450437B1 (en) | 2017-05-17 |
US11505833B2 (en) | 2022-11-22 |
US8288102B2 (en) | 2012-10-16 |
EP2450437A2 (en) | 2012-05-09 |
US20160333425A1 (en) | 2016-11-17 |
DK2450437T3 (en) | 2017-09-11 |
ES2637592T3 (es) | 2017-10-13 |
US20210371933A1 (en) | 2021-12-02 |
US9523130B2 (en) | 2016-12-20 |
US8377642B2 (en) | 2013-02-19 |
US9988688B2 (en) | 2018-06-05 |
US20110223609A1 (en) | 2011-09-15 |
DK2447359T3 (en) | 2016-02-08 |
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