PL2276346T3 - Skondensowane bicykliczne związki pirymidynowe jako inhibitory kinazy aurora - Google Patents

Skondensowane bicykliczne związki pirymidynowe jako inhibitory kinazy aurora

Info

Publication number
PL2276346T3
PL2276346T3 PL09739460T PL09739460T PL2276346T3 PL 2276346 T3 PL2276346 T3 PL 2276346T3 PL 09739460 T PL09739460 T PL 09739460T PL 09739460 T PL09739460 T PL 09739460T PL 2276346 T3 PL2276346 T3 PL 2276346T3
Authority
PL
Poland
Prior art keywords
kinase inhibitors
fused bicyclic
aurora kinase
pyrimidine compounds
bicyclic pyrimidine
Prior art date
Application number
PL09739460T
Other languages
English (en)
Inventor
Hsing-Pang Hsieh
Mohane Selvaraj Coumar
Tsu-An Hsu
Su-Ying Wu
Yu-Sheng Chao
Original Assignee
National Health Research Institutes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Health Research Institutes filed Critical National Health Research Institutes
Publication of PL2276346T3 publication Critical patent/PL2276346T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL09739460T 2008-04-30 2009-04-22 Skondensowane bicykliczne związki pirymidynowe jako inhibitory kinazy aurora PL2276346T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4906308P 2008-04-30 2008-04-30
EP09739460.5A EP2276346B1 (en) 2008-04-30 2009-04-22 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors

Publications (1)

Publication Number Publication Date
PL2276346T3 true PL2276346T3 (pl) 2017-07-31

Family

ID=41255689

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09739460T PL2276346T3 (pl) 2008-04-30 2009-04-22 Skondensowane bicykliczne związki pirymidynowe jako inhibitory kinazy aurora

Country Status (13)

Country Link
US (1) US8138194B2 (pl)
EP (1) EP2276346B1 (pl)
JP (1) JP5502072B2 (pl)
KR (1) KR101667822B1 (pl)
CN (1) CN102014627B (pl)
AU (1) AU2009241469B2 (pl)
CA (1) CA2722220C (pl)
DK (1) DK2276346T3 (pl)
ES (1) ES2616255T3 (pl)
HK (1) HK1151694A1 (pl)
PL (1) PL2276346T3 (pl)
TW (1) TWI363627B (pl)
WO (1) WO2009134658A2 (pl)

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WO2013174744A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Thienopyrimidines
WO2013174743A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyrimidines
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EP2867236B1 (en) 2012-06-29 2017-06-14 Pfizer Inc Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
CN103664993B (zh) * 2012-09-25 2016-05-25 韩冰 一类治疗缺血性脑损伤的化合物及其用途
CN103012428A (zh) * 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
EP2951187A1 (en) 2013-02-01 2015-12-09 Bayer Pharma Aktiengesellschaft Substituted thienopyrimidines and pharmaceutical use thereof
US9675612B2 (en) 2013-03-06 2017-06-13 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
US9695171B2 (en) 2013-12-17 2017-07-04 Pfizer Inc. 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors
TN2016000452A1 (en) 2014-04-25 2018-04-04 Pfizer Heteroaromatic compounds and their use as dopamine d1 ligands.
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105061461B (zh) * 2015-08-18 2017-06-30 沈阳药科大学 含有苄胺结构的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用
CN105061460B (zh) * 2015-08-18 2017-06-30 沈阳药科大学 含有硫醚结构的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用
WO2017046675A1 (en) 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106243124B (zh) * 2016-07-29 2018-03-09 湖北民族学院 一种噻吩并嘧啶脲类化合物及其制备方法和应用
TW201811795A (zh) 2016-08-24 2018-04-01 美商亞闊股份有限公司 胺基－吡咯并嘧啶酮化合物及其用途
CN106810512B (zh) * 2017-01-18 2019-09-10 江苏省中医药研究院 Idh2突变体抑制剂及其用途
EP3988555A1 (en) 2017-08-15 2022-04-27 AbbVie Inc. Macrocyclic mcl-1 inhibitors and methods of use
EP3668502A4 (en) * 2017-08-15 2021-01-13 AbbVie Inc. MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
WO2019035899A1 (en) * 2017-08-15 2019-02-21 Abbvie Inc. MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
WO2021041392A1 (en) * 2019-08-26 2021-03-04 Chemwerth, Inc. Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors
CN112500421B (zh) * 2020-12-15 2021-08-24 河南科技大学第一附属医院 一种可用于杀菌消毒的苯并吡喃脲类化合物的制备方法及应用
WO2024039842A2 (en) * 2022-08-19 2024-02-22 National Health Research Institutes Inhibitors of tam receptors

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WO2006003440A1 (en) 2004-07-05 2006-01-12 Astex Therapeutics Limited 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
CN101160316A (zh) * 2004-07-16 2008-04-09 苏内西斯医药公司 适合用作aurora激酶抑制剂的噻吩并嘧啶
AU2005290226A1 (en) * 2004-07-16 2006-04-06 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as Aurora kinase inhibitors
CA2615946A1 (en) * 2005-07-22 2007-02-01 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
DE102005037499A1 (de) * 2005-08-09 2007-02-15 Merck Patent Gmbh Pyrazolderivate
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Also Published As

Publication number Publication date
CN102014627A (zh) 2011-04-13
KR101667822B1 (ko) 2016-10-19
EP2276346A2 (en) 2011-01-26
JP5502072B2 (ja) 2014-05-28
AU2009241469B2 (en) 2015-05-07
JP2011522789A (ja) 2011-08-04
HK1151694A1 (en) 2012-02-10
ES2616255T3 (es) 2017-06-12
TW200948365A (en) 2009-12-01
EP2276346B1 (en) 2016-11-23
KR20100132067A (ko) 2010-12-16
CA2722220A1 (en) 2009-11-05
WO2009134658A3 (en) 2009-12-30
CA2722220C (en) 2016-06-07
CN102014627B (zh) 2014-10-29
DK2276346T3 (en) 2017-02-27
EP2276346A4 (en) 2011-08-24
US20090275533A1 (en) 2009-11-05
TWI363627B (en) 2012-05-11
AU2009241469A1 (en) 2009-11-05
WO2009134658A2 (en) 2009-11-05
US8138194B2 (en) 2012-03-20

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