PL2167492T3 - Novel amide derivative for inhibiting the growth of cancer cells - Google Patents

Novel amide derivative for inhibiting the growth of cancer cells

Info

Publication number
PL2167492T3
PL2167492T3 PL08766124T PL08766124T PL2167492T3 PL 2167492 T3 PL2167492 T3 PL 2167492T3 PL 08766124 T PL08766124 T PL 08766124T PL 08766124 T PL08766124 T PL 08766124T PL 2167492 T3 PL2167492 T3 PL 2167492T3
Authority
PL
Poland
Prior art keywords
inhibiting
growth
cancer cells
amide derivative
novel amide
Prior art date
Application number
PL08766124T
Other languages
Polish (pl)
Inventor
Kwang-Ok Lee
Mi Young Cha
Mi Ra Kim
Young Hee Jung
Chang Gon Lee
Se Young Kim
Keukchan Bang
Bum Woo Park
Bo Im Choi
Yun Jung Chae
Mi Young Ko
Han Kyong Kim
Young-Gil Ahn
Maeng Sup Kim
Gwan Sun Lee
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of PL2167492T3 publication Critical patent/PL2167492T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL08766124T 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells PL2167492T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20070054997 2007-06-05
PCT/KR2008/003162 WO2008150118A2 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells
EP08766124.5A EP2167492B1 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells

Publications (1)

Publication Number Publication Date
PL2167492T3 true PL2167492T3 (en) 2016-03-31

Family

ID=40094307

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08766124T PL2167492T3 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells

Country Status (25)

Country Link
US (1) US8188102B2 (en)
EP (1) EP2167492B1 (en)
JP (1) JP5155391B2 (en)
KR (1) KR101013319B1 (en)
CN (1) CN101679384B (en)
AR (2) AR066876A1 (en)
AU (1) AU2008260772B2 (en)
BR (1) BRPI0811069B1 (en)
CA (1) CA2687180C (en)
DK (1) DK2167492T3 (en)
ES (1) ES2558623T3 (en)
HK (1) HK1142591A1 (en)
HR (1) HRP20160007T1 (en)
HU (1) HUE028243T2 (en)
IL (1) IL202154A (en)
MX (1) MX2009012772A (en)
MY (1) MY144972A (en)
NZ (1) NZ582412A (en)
PL (1) PL2167492T3 (en)
PT (1) PT2167492E (en)
RU (1) RU2434010C2 (en)
TW (1) TWI377944B (en)
UA (1) UA96045C2 (en)
WO (1) WO2008150118A2 (en)
ZA (1) ZA201000022B (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
BRPI0715016A2 (en) 2006-09-11 2013-05-28 Curis Inc composition, pharmaceutical composition, method for treating an egfr tyrosine kinase-related disease or disorder in an individual in need thereof, method for treating an hdac-mediated disease and method for treating both egfr and hdac tyrosine kinase diseases
US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
WO2010129053A2 (en) 2009-05-05 2010-11-11 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
KR101217526B1 (en) 2010-06-11 2013-01-02 한미사이언스 주식회사 Pharmaceutical composition comprising amide derivative or pharmaceutically acceptable salt thereof
US8828391B2 (en) 2011-05-17 2014-09-09 Boehringer Ingelheim International Gmbh Method for EGFR directed combination treatment of non-small cell lung cancer
KR101317809B1 (en) * 2011-06-07 2013-10-16 한미약품 주식회사 Pharmaceutical composition comprising amide derivative inhibiting the growth of cancer cell and non-metalic salt lubricant
KR101272613B1 (en) * 2011-10-05 2013-06-10 한미사이언스 주식회사 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxy quinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one hydrochloride and intermediates used therein
US9034885B2 (en) 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
US9586965B2 (en) 2012-01-13 2017-03-07 Acea Biosciences Inc. Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
CN110194748A (en) 2012-01-13 2019-09-03 艾森生物科学公司 Heterocyclic compound and its purposes as anticarcinogen
US9085540B2 (en) 2012-01-17 2015-07-21 Astellas Pharma Inc. Pyrazinecarboxamide compound
CN102659764A (en) * 2012-04-16 2012-09-12 中国科学院广州生物医药与健康研究院 Tyrosine kinase inreversible inhibitor, its preparation method and application
KR20140096571A (en) * 2013-01-28 2014-08-06 한미약품 주식회사 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one
ES2761572T3 (en) 2013-07-11 2020-05-20 Acea Therapeutics Inc Pyrimidine derivatives as kinase inhibitors
CN104513229A (en) 2013-09-28 2015-04-15 正大天晴药业集团股份有限公司 Quinazoline derivatives and preparation method thereof
WO2015154725A1 (en) * 2014-04-11 2015-10-15 四川海思科制药有限公司 Quinazoline derivative and preparation method and use in medicine thereof
WO2016090174A1 (en) * 2014-12-03 2016-06-09 Auckland Uniservices, Ltd. Kinase inhibitor prodrug for the treatment of cancer
EP3272746B1 (en) * 2015-03-20 2019-12-25 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Salts of quinazoline derivative and method for preparing same
RU2018115334A (en) 2015-10-09 2019-11-11 Ацея Терапьютикс, Инк. PHARMACEUTICAL SALTS, PHYSICAL FORMS AND COMPOSITIONS OF KYNASE, Pyrrolopyrimidine Inhibitors, and METHODS FOR PRODUCING THEM
WO2018036539A1 (en) * 2016-08-25 2018-03-01 正大天晴药业集团股份有限公司 Crystal of salt of quinazoline derivative
CN108069946B (en) * 2016-11-08 2020-06-05 威尚（上海）生物医药有限公司 Substituted quinazoline compounds having the ability to cross the blood brain barrier
EP3558979B1 (en) 2016-12-22 2021-02-17 Boehringer Ingelheim International GmbH Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
TWI808958B (en) 2017-01-25 2023-07-21 美商特普醫葯公司 Combination therapy involving diaryl macrocyclic compounds
EP3590929B1 (en) 2017-02-28 2021-09-15 Medshine Discovery Inc. Spiro compound and use thereof
EP3606925A1 (en) 2017-04-07 2020-02-12 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
AU2018259078B2 (en) * 2017-04-27 2021-10-07 Astrazeneca Ab C5-anilinoquinazoline compounds and their use in treating cancer
UY37935A (en) * 2017-10-18 2020-03-31 Spectrum Pharmaceuticals Inc INHIBITORS OF TYROSINE KINASES FROM THE FAMILY OF EGFR MUTANTS
JP7296641B2 (en) * 2017-12-19 2023-06-23 チェンドゥ・ジンルイ・ファウンデーション・バイオテック・カンパニー・リミテッド Quinazoline derivatives and uses thereof
EA202091491A1 (en) 2017-12-21 2020-11-13 Бёрингер Ингельхайм Интернациональ Гмбх NEW BENZYLAMINE SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS
MX2020010121A (en) 2018-03-27 2021-01-08 Univ Texas Compounds with anti-tumor activity against cancer cells bearing her2 exon 19 mutations.
CN110054613B (en) * 2018-05-24 2020-11-27 深圳市塔吉瑞生物医药有限公司 Substituted aminoquinazoline compound, pharmaceutical composition and application thereof
CN110577514B (en) * 2018-06-08 2022-07-05 江苏威凯尔医药科技有限公司 Human epidermal growth factor receptor inhibitor and preparation method and application thereof
WO2019233459A1 (en) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 Human epidermal growth factor receptor inhibitor, preparation method therefor and use thereof
CN108623490A (en) * 2018-06-22 2018-10-09 苏州市贝克生物科技有限公司 The synthetic method of (2Z) -4- (dimethylamino) -2- butenoate hydrochlorates
TW202019412A (en) 2018-06-25 2020-06-01 美商光譜製藥公司 Combination of poziotinib with cytotoxic agent and/or other molecularly targeted agent and use thereof
TW202012391A (en) * 2018-07-04 2020-04-01 日商第一三共股份有限公司 Biaryl ether type quinazoline derivatives
US20220040180A1 (en) * 2018-09-14 2022-02-10 Spectrum Pharmaceuticals, Inc. Kits and methods for treating cancers
KR20210066841A (en) * 2018-09-21 2021-06-07 스펙트럼 파마슈티컬즈 인크 Novel Quinazoline EGFR Inhibitors
MX2021003517A (en) 2018-09-25 2021-08-16 Black Diamond Therapeutics Inc Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use.
KR101950942B1 (en) 2019-01-28 2019-02-22 한미약품 주식회사 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one
JP7109013B2 (en) 2019-03-19 2022-07-29 ボロノイ インコーポレイテッド Heteroaryl Derivatives, Methods for Producing Heteroaryl Derivatives, and Pharmaceutical Compositions Containing Heteroaryl Derivatives as Active Ingredients
CA3137901A1 (en) * 2019-04-25 2020-10-29 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of tyrosine kinase
WO2020227711A1 (en) 2019-05-09 2020-11-12 FUJIFILM Cellular Dynamics, Inc. Methods for the production of hepatocytes
JP7350374B2 (en) * 2019-06-19 2023-09-26 チェンドゥ・ジンルイ・ファウンデーション・バイオテック・カンパニー・リミテッド Crystals and salts of quinazoline compounds and their preparation method
WO2020262998A1 (en) * 2019-06-26 2020-12-30 한미약품 주식회사 Novel quinazoline derivative having anti-tumor activity and pharmaceutical composition comprising same
KR20210049004A (en) 2019-10-24 2021-05-04 한미약품 주식회사 A pharmaceutical preparation comprising an amide derivative inhibiting the growth of cancer cell and a pharmaceutical product containing the same
WO2021127397A1 (en) * 2019-12-19 2021-06-24 Black Diamond Therapeutics, Inc. Nitrogen heterocyclic compounds and methods of use
CA3166298A1 (en) * 2020-01-29 2021-08-05 John Heymach Use of quinazoline-based tyrosine kinase inhibitors for the treatment of cancers with nrg1 fusions
WO2021231400A1 (en) * 2020-05-12 2021-11-18 Accutar Biotechnology, Inc. Bis-aryl ethers containing n-acyl azetidine as egfr/her2 inhibitors
CN111763215B (en) * 2020-07-21 2021-05-18 成都海博为药业有限公司 Compound with nitrogen-containing heterocyclic structure and preparation method and application thereof
WO2022105908A1 (en) * 2020-11-23 2022-05-27 上海和誉生物医药科技有限公司 Egfr inhibitor, preparation method therefor, and pharmaceutical application thereof
WO2022170043A1 (en) * 2021-02-05 2022-08-11 Accutar Biotechnology, Inc. Quinazoline derived compounds as egfr inhibitors and their uses thereof
TW202317126A (en) 2021-06-15 2023-05-01 美商建南德克公司 Egfr inhibitor and perk activator in combination therapy
WO2022266426A1 (en) * 2021-06-17 2022-12-22 Black Diamond Therapeutics, Inc. 6-(heterocycloalkyl-oxy)-quinazoline derivatives and uses thereof
WO2022266427A1 (en) * 2021-06-17 2022-12-22 Black Diamond Therapeutics, Inc. 4-(aryl-methyl-amino)-quinazoline derivatives and uses thereof
AR126849A1 (en) * 2021-08-24 2023-11-22 Arthrosi Therapeutics Inc QUINAZOLINE COMPOUNDS FOR DISEASE TREATMENT
CN115894486B (en) * 2021-09-30 2024-02-09 北京赛特明强医药科技有限公司 Hydrogenated pyridoquinazoline compound, composition and application thereof
WO2023128350A1 (en) * 2021-12-30 2023-07-06 주식회사 비투에스바이오 Heteroaryl derivative and pharmaceutical composition for preventing or treating cancer comprising same as active ingredient
WO2024083120A1 (en) * 2022-10-18 2024-04-25 南京明德新药研发有限公司 Benzylaminoquinoline compound and preparation method therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
EA009300B1 (en) 2002-03-30 2007-12-28 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг 4-(n-phenylamino)-quinazolines/quinolines as tyrosine kinase inhibitors
GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
BRPI0413066A (en) * 2003-07-29 2006-10-17 Astrazeneca Ab quinazoline derivative, or a pharmaceutically acceptable salt, or a pharmaceutically acceptable ester thereof, of formula I, use and process for the preparation thereof, compound, pharmaceutical composition, and methods for producing an antiproliferative effect in an animal of warm blood, for the prevention or treatment of a tumor, to provide a selective egfr tyrosine kinase inhibitory effect, and to treat cancer in a warm-blooded animal
WO2005026151A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
BRPI0414735A (en) * 2003-09-25 2006-11-21 Astrazeneca Ab quinazoline derivative, compound, pharmaceutical composition, use of quinazoline derivative, method for producing an antiproliferative effect on a warm-blooded animal, and process for the preparation of a quinazoline derivative
US7687502B2 (en) 2004-03-23 2010-03-30 Banyu Pharmaceutical Co., Ltd. Substituted quinazoline or pyridopyrimidine derivative
CA2619037A1 (en) 2005-08-22 2007-03-01 Boehringer Ingelheim International Gmbh Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof
WO2007055513A1 (en) * 2005-11-08 2007-05-18 Hanmi Pharm. Co., Ltd. Quinazoline derivatives as a signal transduction inhibitor and method for the preparation thereof

Also Published As

Publication number Publication date
KR20080107294A (en) 2008-12-10
EP2167492B1 (en) 2015-10-14
WO2008150118A2 (en) 2008-12-11
ZA201000022B (en) 2011-04-28
AU2008260772A1 (en) 2008-12-11
CA2687180A1 (en) 2008-12-11
WO2008150118A3 (en) 2009-01-29
US20100179120A1 (en) 2010-07-15
NZ582412A (en) 2011-12-22
EP2167492A4 (en) 2010-12-15
PT2167492E (en) 2016-02-04
KR101013319B1 (en) 2011-02-09
JP5155391B2 (en) 2013-03-06
MY144972A (en) 2011-11-30
ES2558623T3 (en) 2016-02-05
HRP20160007T1 (en) 2016-02-12
RU2434010C2 (en) 2011-11-20
AR110003A2 (en) 2019-02-13
HUE028243T2 (en) 2016-12-28
RU2009149307A (en) 2011-07-20
IL202154A (en) 2014-05-28
JP2010529115A (en) 2010-08-26
AR066876A1 (en) 2009-09-16
CN101679384A (en) 2010-03-24
CA2687180C (en) 2012-07-24
CN101679384B (en) 2013-10-16
BRPI0811069B1 (en) 2022-08-30
AU2008260772B2 (en) 2011-06-02
BRPI0811069A2 (en) 2014-12-09
MX2009012772A (en) 2009-12-15
EP2167492A2 (en) 2010-03-31
TW200906414A (en) 2009-02-16
DK2167492T3 (en) 2016-01-11
UA96045C2 (en) 2011-09-26
IL202154A0 (en) 2010-06-16
US8188102B2 (en) 2012-05-29
TWI377944B (en) 2012-12-01
HK1142591A1 (en) 2010-12-10

Similar Documents

Publication Publication Date Title
IL202154A0 (en) Novel amide derivative for inhibiting the growth of cancer cells
IL200596A0 (en) Tetrahydroisoquinolines as tumour growth inhibitors
HK1143367A1 (en) Quinazolin-oxime derivatives as hsp90 inhibitors hsp90 -
EP2194817A4 (en) Arrangement for adjusting the width of the carrier means
EP2172447A4 (en) Amide compound
IL204970A0 (en) Amide compound
EP2202223A4 (en) Heterocyclic compound
HK1151291A1 (en) 2-benzylpyridazinone derivatives as met kinase inhibitors
GB0702854D0 (en) Method for the synthesis of sucrose-6-esters
HRP20140047T1 (en) Cycloptopyl amide derivatives
GB0718255D0 (en) Nucleobase characterisation
EP2210876A4 (en) Heterocyclic compound
IL201921A0 (en) 1,3-dihydroimidazol-2-thione derivative as inhibitors of dopamine-beta-hydroxylase
EP2119702A4 (en) Amide derivative
HK1137482A1 (en) Improvement of cell growth
GB0605685D0 (en) Inhibition of tumour growth
EP2117591A4 (en) Reducing tumor growth
GB2453005B (en) Macrocyclic tricothecene compounds for inhibiting the growth of cancer cells
GB2459413B (en) Methods for the synthesis of perfluoroparacyclophane
EP2134365A4 (en) Compositions and methods for inhibiting tumor cell growth
IL195092A0 (en) Crystalline form of (s)-1-phenylethylammonium (r)-diphenyl-methanesulphinyl-acetate
EP2176303A4 (en) Modification of polyolefins
GB0808076D0 (en) Cell growth inhibition composition
GB0702818D0 (en) Growth factor
GB0710032D0 (en) Growth factor