PL2125697T3 - Dodatnio naładowane, rozpuszczalne w wodzie proleki retinoidów i związków podobnych do retinoidów o bardzo wysokich współczynnikach przenikania przez skórę - Google Patents
Dodatnio naładowane, rozpuszczalne w wodzie proleki retinoidów i związków podobnych do retinoidów o bardzo wysokich współczynnikach przenikania przez skóręInfo
- Publication number
- PL2125697T3 PL2125697T3 PL07700593T PL07700593T PL2125697T3 PL 2125697 T3 PL2125697 T3 PL 2125697T3 PL 07700593 T PL07700593 T PL 07700593T PL 07700593 T PL07700593 T PL 07700593T PL 2125697 T3 PL2125697 T3 PL 2125697T3
- Authority
- PL
- Poland
- Prior art keywords
- retinoid
- retinoids
- compounds
- positively charged
- skin penetration
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07700593.2A EP2125697B1 (en) | 2007-01-15 | 2007-01-15 | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
PCT/IB2007/050122 WO2008087493A1 (en) | 2007-01-15 | 2007-01-15 | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2125697T3 true PL2125697T3 (pl) | 2017-01-31 |
Family
ID=39635694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL07700593T PL2125697T3 (pl) | 2007-01-15 | 2007-01-15 | Dodatnio naładowane, rozpuszczalne w wodzie proleki retinoidów i związków podobnych do retinoidów o bardzo wysokich współczynnikach przenikania przez skórę |
Country Status (12)
Country | Link |
---|---|
US (5) | US9193672B2 (pl) |
EP (2) | EP3181132A1 (pl) |
JP (1) | JP5826459B2 (pl) |
CN (4) | CN101605754B (pl) |
CA (2) | CA2972344C (pl) |
DK (1) | DK2125697T3 (pl) |
ES (1) | ES2596857T3 (pl) |
HK (2) | HK1137413A1 (pl) |
HU (1) | HUE031712T2 (pl) |
PL (1) | PL2125697T3 (pl) |
PT (1) | PT2125697T (pl) |
WO (1) | WO2008087493A1 (pl) |
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US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
JP5424887B2 (ja) | 2006-11-08 | 2014-02-26 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
KR101853971B1 (ko) | 2007-06-04 | 2018-05-02 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
KR20210123406A (ko) * | 2008-12-04 | 2021-10-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
ES2845612T3 (es) | 2009-05-08 | 2021-07-27 | Techfields Biochem Co Ltd | Composiciones de profármaco de alta penetración de péptidos y compuestos relacionados con péptidos |
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CN103702967A (zh) * | 2011-03-14 | 2014-04-02 | 貝丝以色列女执事医疗中心 | 用于治疗增殖性病症的方法和组合物 |
EP2910549A1 (en) | 2011-09-15 | 2015-08-26 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene derivatives useful as rxr modulators for treating alzheimer's disease and cancer |
CN102503908B (zh) * | 2011-11-22 | 2013-09-04 | 江苏省原子医学研究所 | 维a酸衍生物、其制备方法、其药物组合物及其在制备抗肿瘤药物中的应用 |
MX370928B (es) | 2012-03-01 | 2020-01-08 | Retinagenix LLC | El uso de 9-cis-retinil acetato para mejorar la función visual de un sujeto que padece de pérdida de la función visual originada por una deficiencia retinoide endógena de 11-cis retinal. |
AU2013271378A1 (en) | 2012-06-07 | 2014-12-18 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the inhibition of Pin1 |
WO2014011676A1 (en) * | 2012-07-09 | 2014-01-16 | Tolleth Robert J | Prevention of alcohol reaction with dietary supplements |
EP2979162A1 (en) * | 2013-03-26 | 2016-02-03 | RealityGate (Pty) Ltd | Distortion viewing with improved focus targeting |
US10372204B2 (en) * | 2013-10-30 | 2019-08-06 | Technology Against Als | Communication and control system and method |
WO2015109318A2 (en) | 2014-01-17 | 2015-07-23 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Therapeutic methods |
US10351914B2 (en) | 2014-07-17 | 2019-07-16 | Beth Israel Deaconess Medical Center, Inc. | Biomarkers for Pin1-associated disorders |
US9968579B2 (en) | 2014-07-17 | 2018-05-15 | Beth Isreal Deaconess Medical Center, Inc. | ATRA for modulating Pin1 activity and stability |
WO2016145186A1 (en) | 2015-03-12 | 2016-09-15 | Beth Israel Deaconess Medical Center, Inc. | Enhanced atra-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions |
US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
AU2019278985A1 (en) * | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Vitamin cationic lipids |
WO2020257064A1 (en) * | 2019-06-20 | 2020-12-24 | Butzloff Peter Robert | Fullerenol xanthophyll adducts and methods |
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2007
- 2007-01-15 CN CN200780049882.9A patent/CN101605754B/zh active Active
- 2007-01-15 PT PT77005932T patent/PT2125697T/pt unknown
- 2007-01-15 CN CN201710903106.6A patent/CN107652212B/zh active Active
- 2007-01-15 CN CN202110941855.4A patent/CN113636966B/zh active Active
- 2007-01-15 CN CN201811258640.7A patent/CN109503446B/zh active Active
- 2007-01-15 EP EP16190916.3A patent/EP3181132A1/en active Pending
- 2007-01-15 WO PCT/IB2007/050122 patent/WO2008087493A1/en active Application Filing
- 2007-01-15 HU HUE07700593A patent/HUE031712T2/en unknown
- 2007-01-15 EP EP07700593.2A patent/EP2125697B1/en not_active Not-in-force
- 2007-01-15 CA CA2972344A patent/CA2972344C/en active Active
- 2007-01-15 JP JP2009545245A patent/JP5826459B2/ja not_active Expired - Fee Related
- 2007-01-15 ES ES07700593.2T patent/ES2596857T3/es active Active
- 2007-01-15 CA CA2674822A patent/CA2674822C/en active Active
- 2007-01-15 DK DK07700593.2T patent/DK2125697T3/en active
- 2007-01-15 PL PL07700593T patent/PL2125697T3/pl unknown
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2009
- 2009-07-15 US US12/503,739 patent/US9193672B2/en active Active
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2010
- 2010-01-28 HK HK10100926.7A patent/HK1137413A1/xx unknown
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2015
- 2015-10-07 US US14/877,788 patent/US20160184253A1/en not_active Abandoned
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2016
- 2016-09-22 HK HK16111137.3A patent/HK1222842A1/zh unknown
- 2016-11-21 US US15/356,988 patent/US20170072060A1/en not_active Abandoned
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2019
- 2019-03-12 US US16/299,560 patent/US11786497B2/en active Active
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Also Published As
Publication number | Publication date |
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CN109503446B (zh) | 2021-08-20 |
HUE031712T2 (en) | 2017-08-28 |
JP2010515716A (ja) | 2010-05-13 |
CN113636966B (zh) | 2024-01-12 |
EP3181132A1 (en) | 2017-06-21 |
HK1222842A1 (zh) | 2017-07-14 |
US20100010084A1 (en) | 2010-01-14 |
PT2125697T (pt) | 2016-10-18 |
EP2125697A4 (en) | 2010-10-27 |
JP5826459B2 (ja) | 2015-12-02 |
CN109503446A (zh) | 2019-03-22 |
HK1137413A1 (en) | 2010-07-30 |
WO2008087493A1 (en) | 2008-07-24 |
US20160184253A1 (en) | 2016-06-30 |
US20240156770A1 (en) | 2024-05-16 |
CA2674822C (en) | 2017-08-01 |
CN113636966A (zh) | 2021-11-12 |
US9193672B2 (en) | 2015-11-24 |
CN101605754A (zh) | 2009-12-16 |
CN107652212B (zh) | 2019-11-15 |
EP2125697B1 (en) | 2016-09-28 |
US11786497B2 (en) | 2023-10-17 |
EP2125697A1 (en) | 2009-12-02 |
US20170072060A1 (en) | 2017-03-16 |
DK2125697T3 (en) | 2016-11-14 |
ES2596857T3 (es) | 2017-01-12 |
CA2972344C (en) | 2021-10-26 |
CN107652212A (zh) | 2018-02-02 |
CA2972344A1 (en) | 2008-07-24 |
CN101605754B (zh) | 2015-09-16 |
US20210196664A1 (en) | 2021-07-01 |
CA2674822A1 (en) | 2008-07-24 |
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