PL2121636T3 - Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu - Google Patents

Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu

Info

Publication number
PL2121636T3
PL2121636T3 PL07855037T PL07855037T PL2121636T3 PL 2121636 T3 PL2121636 T3 PL 2121636T3 PL 07855037 T PL07855037 T PL 07855037T PL 07855037 T PL07855037 T PL 07855037T PL 2121636 T3 PL2121636 T3 PL 2121636T3
Authority
PL
Poland
Prior art keywords
piperazinyl
preparation
benzamide derivatives
diazepanyl benzamide
diazepanyl
Prior art date
Application number
PL07855037T
Other languages
English (en)
Inventor
Anusuya Choudhury
Jeffrey S. Grimm
Kirk L. Sorgi
David Palmer
Jing Liu
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of PL2121636T3 publication Critical patent/PL2121636T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PL07855037T 2006-12-14 2007-12-10 Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu PL2121636T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87000306P 2006-12-14 2006-12-14

Publications (1)

Publication Number Publication Date
PL2121636T3 true PL2121636T3 (pl) 2017-09-29

Family

ID=39387172

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07855037T PL2121636T3 (pl) 2006-12-14 2007-12-10 Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu

Country Status (33)

Country Link
US (2) US7893257B2 (pl)
EP (1) EP2121636B1 (pl)
JP (2) JP5385150B2 (pl)
KR (1) KR101462891B1 (pl)
CN (1) CN101605767A (pl)
AR (1) AR064358A1 (pl)
BR (1) BRPI0721088B8 (pl)
CA (2) CA2880932A1 (pl)
CL (1) CL2007003637A1 (pl)
CO (1) CO6210827A2 (pl)
CR (1) CR10928A (pl)
CY (1) CY1118814T1 (pl)
DK (1) DK2121636T3 (pl)
EA (1) EA200970583A1 (pl)
EC (1) ECSP099405A (pl)
ES (1) ES2620818T3 (pl)
HR (1) HRP20170621T1 (pl)
HU (1) HUE032761T2 (pl)
IL (2) IL199309A0 (pl)
LT (1) LT2121636T (pl)
MX (1) MX2009006472A (pl)
MY (1) MY147320A (pl)
NO (1) NO344305B1 (pl)
NZ (1) NZ577603A (pl)
PH (1) PH12012502236B1 (pl)
PL (1) PL2121636T3 (pl)
PT (1) PT2121636T (pl)
RS (1) RS55866B1 (pl)
SG (1) SG177207A1 (pl)
SI (1) SI2121636T1 (pl)
TW (1) TW200846004A (pl)
WO (1) WO2008076685A2 (pl)
ZA (1) ZA200904894B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
HUE031972T2 (en) 2005-12-29 2017-08-28 Celtaxsys Inc Diamin derivatives as leukotriene A4 hydrolase inhibitors
BRPI0721088B8 (pt) * 2006-12-14 2021-05-25 Janssen Pharmaceutica Nv processo para a preparação de derivados de piperazinil e diazepanil benzamida
CL2008002622A1 (es) 2007-09-06 2009-11-27 Glaxo Group Ltd 1-(1-metiletil)-4-{[4-(tetrahidro-2h-piran-4-iloxi)fenil]carbonil}piperazina y su sal hidrocloruro; formas cristalinas de la sal; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento o profilaxis de deterioro cognitivo, fatiga o trastorno del sueno.
TWI439462B (zh) 2007-12-10 2014-06-01 Novartis Ag 作為ｅｎａｃ阻抑劑之螺環胍化合物
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
MX2015011676A (es) 2013-03-14 2016-04-25 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
RU2678196C2 (ru) 2013-03-14 2019-01-24 Селтакссис, Инк. Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы
WO2014152229A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
CN108341792B (zh) * 2018-04-28 2021-09-17 苏州莱克施德药业有限公司 一种Volasertib中间体1-环丙基甲基哌嗪的制备方法
CA3102077A1 (en) 2018-05-31 2019-12-05 Sanjeev AHUJA Method of reducing pulmonary exacerbations in respiratory disease patients
CN113372245B (zh) * 2021-06-17 2023-01-13 仪征市海帆化工有限公司 一种n-苯甲酰基-o,o-对甲苯磺酰基-二乙醇胺的合成方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2525223A (en) * 1948-05-25 1950-10-10 American Cyanamid Co Preparation of n-substituted piperazines
DE818805C (de) 1948-08-02 1951-10-29 Rhone Poulenc Sa Verfahren zur Herstellung von am Stickstoff durch eine Alkylgruppe monosubstituierten Piperazinen
US3342816A (en) * 1965-06-01 1967-09-19 Lilly Co Eli Cyclopropylpiperazinoalkyl-phenothiazines
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3605005A1 (de) * 1986-02-18 1987-08-20 Basf Ag Verfahren zur herstellung von n-methylpiperazin
US6011029A (en) 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
CA2235642C (en) * 1998-05-15 2007-11-13 Torcan Chemical Ltd. Processes for preparing sildenafil
EP1351946A2 (en) 2000-09-01 2003-10-15 Icos Corporation Materials and methods to potentiate cancer treatment
US6642226B2 (en) 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
DE10201240A1 (de) 2002-01-15 2003-07-24 Bayer Ag Substituierte Alkyluracile und ihre Verwendung
NZ576432A (en) 2002-10-23 2010-06-25 Janssen Pharmaceutica Nv Piperazinyl and diazapanyl benzamides and benzthioamides
WO2005035534A1 (ja) * 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
GB0324159D0 (en) * 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
WO2006042103A2 (en) 2004-10-05 2006-04-20 Axys Pharmaceuticals, Inc. Reversible inhibitors of cathepsin b
WO2006067401A1 (en) 2004-12-24 2006-06-29 Astrazeneca Ab Heterocyclic compounds as ccr2b antagonists
FR2885616B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE602006013501D1 (de) * 2005-09-16 2010-05-20 Janssen Pharmaceutica Nv Cyclopropylamine als modulatoren des histamin-h3-rezeptors
US7795426B2 (en) * 2005-10-31 2010-09-14 Janssen Pharmaceutica Nv Processes for the preparation of cyclopropyl-amide derivatives
EP1951700A2 (en) * 2005-10-31 2008-08-06 Janssen Pharmaceutica N.V. Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
BRPI0721088B8 (pt) * 2006-12-14 2021-05-25 Janssen Pharmaceutica Nv processo para a preparação de derivados de piperazinil e diazepanil benzamida

Also Published As

Publication number Publication date
EA200970583A1 (ru) 2009-12-30
PH12012502236A1 (en) 2015-02-23
PH12012502236B1 (en) 2015-02-23
ZA200904894B (en) 2010-09-29
EP2121636B1 (en) 2017-01-25
BRPI0721088B8 (pt) 2021-05-25
CA2672661C (en) 2015-04-28
RS55866B1 (sr) 2017-08-31
CA2672661A1 (en) 2008-06-26
CO6210827A2 (es) 2010-10-20
JP2010513295A (ja) 2010-04-30
ECSP099405A (es) 2009-07-31
ES2620818T3 (es) 2017-06-29
US7893257B2 (en) 2011-02-22
LT2121636T (lt) 2017-05-10
EP2121636A2 (en) 2009-11-25
TW200846004A (en) 2008-12-01
MX2009006472A (es) 2009-06-26
WO2008076685A2 (en) 2008-06-26
IL199309A0 (en) 2010-03-28
CN101605767A (zh) 2009-12-16
KR101462891B1 (ko) 2014-11-19
HUE032761T2 (en) 2017-10-30
NZ577603A (en) 2012-04-27
MY147320A (en) 2012-11-30
HRP20170621T1 (hr) 2017-07-28
US20080171870A1 (en) 2008-07-17
CA2880932A1 (en) 2008-06-26
CR10928A (es) 2009-11-17
DK2121636T3 (en) 2017-04-24
JP2013241453A (ja) 2013-12-05
US20110105752A1 (en) 2011-05-05
NO344305B1 (no) 2019-10-28
JP5385150B2 (ja) 2014-01-08
AU2007334111A1 (en) 2008-06-26
NO20092634L (no) 2009-09-08
BRPI0721088B1 (pt) 2020-11-10
CY1118814T1 (el) 2018-01-10
BRPI0721088A2 (pt) 2014-02-25
CL2007003637A1 (es) 2008-07-18
AR064358A1 (es) 2009-04-01
SI2121636T1 (sl) 2017-06-30
PT2121636T (pt) 2017-04-26
SG177207A1 (en) 2012-01-30
IL234893A (en) 2015-09-24
US8680273B2 (en) 2014-03-25
KR20090092319A (ko) 2009-08-31
WO2008076685A3 (en) 2008-12-24

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