PL2049529T3 - Podstawione związki diazepanowe - antagoniści receptora oreksyny - Google Patents

Podstawione związki diazepanowe - antagoniści receptora oreksyny

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Publication number
PL2049529T3
PL2049529T3 PL07796852T PL07796852T PL2049529T3 PL 2049529 T3 PL2049529 T3 PL 2049529T3 PL 07796852 T PL07796852 T PL 07796852T PL 07796852 T PL07796852 T PL 07796852T PL 2049529 T3 PL2049529 T3 PL 2049529T3
Authority
PL
Poland
Prior art keywords
receptor antagonists
orexin receptor
substituted diazepan
substituted
compounds
Prior art date
Application number
PL07796852T
Other languages
English (en)
Inventor
Christopher D Cox
Michael J Breslin
Paul J Coleman
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PL2049529T3 publication Critical patent/PL2049529T3/pl

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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
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  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Tropical Medicine & Parasitology (AREA)
PL07796852T 2006-07-14 2007-07-13 Podstawione związki diazepanowe - antagoniści receptora oreksyny PL2049529T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83098306P 2006-07-14 2006-07-14
PCT/US2007/016038 WO2008008518A1 (en) 2006-07-14 2007-07-13 Substituted diazepan orexin receptor antagonists
EP07796852A EP2049529B1 (en) 2006-07-14 2007-07-13 Substituted diazepan orexin receptor antagonists

Publications (1)

Publication Number Publication Date
PL2049529T3 true PL2049529T3 (pl) 2011-01-31

Family

ID=38654759

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07796852T PL2049529T3 (pl) 2006-07-14 2007-07-13 Podstawione związki diazepanowe - antagoniści receptora oreksyny

Country Status (14)

Country Link
US (1) US20090192143A1 (pl)
EP (1) EP2049529B1 (pl)
JP (1) JP5479893B2 (pl)
AT (1) ATE477252T1 (pl)
AU (1) AU2007272855B2 (pl)
CA (1) CA2657552A1 (pl)
CY (1) CY1110882T1 (pl)
DE (1) DE602007008434D1 (pl)
DK (1) DK2049529T3 (pl)
ES (1) ES2348685T3 (pl)
PL (1) PL2049529T3 (pl)
PT (1) PT2049529E (pl)
SI (1) SI2049529T1 (pl)
WO (1) WO2008008518A1 (pl)

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PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
AU2008255005B2 (en) 2007-05-18 2013-05-02 Merck Sharp & Dohme Corp. OXO bridged diazepan orexin receptor antagonists
MY148544A (en) 2007-05-23 2013-04-30 Merck Sharp & Dohme Pyridyl piperidine orexin receptor antagonists
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2214676B1 (en) * 2007-10-29 2012-11-21 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists
EP2348846B1 (en) * 2008-10-21 2013-08-28 Merck Sharp & Dohme Corp. Disubstituted azepan orexin receptor antagonists
WO2010048514A1 (en) 2008-10-23 2010-04-29 Albany Molecular Research, Inc. Synthesis of 2-aminobenzoxazole compounds
EP2349273B1 (en) 2008-11-04 2015-04-08 ChemoCentryx, Inc. Modulators of cxcr7
US8853202B2 (en) 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
JP5847087B2 (ja) 2009-10-23 2016-01-20 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての縮合複素環式化合物
EP2491031B1 (en) 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as orexin receptor modulators
AU2010310595B2 (en) 2009-10-23 2015-07-16 Janssen Pharmaceutica Nv Disubstituted octahy - dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
CN102985425A (zh) 2010-07-09 2013-03-20 利奥制药有限公司 作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
BR112014019426A8 (pt) 2012-02-07 2017-07-11 Eolas Therapeutics Inc Prolinas/ piperidinas substituídas como antagonistas do receptor de orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
BR112015012366A8 (pt) 2012-11-29 2019-10-01 Chemocentryx Inc antagonistas de cxcr7, uso dos mesmos, composição farmacêutica, bem como métodos para detectar níveis elevados de cxcr7 em uma amostra e para imagear um tumor, órgão, ou tecido
WO2015095111A1 (en) 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2016020404A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Process for the resolution of (r,s)-diazepane and diazepanone derivatives
TW201613902A (en) 2014-08-13 2016-04-16 Eolas Therapeutics Inc Difluoropyrrolidines as orexin receptor modulators
CN105461699B (zh) * 2014-09-25 2019-07-09 广东东阳光药业有限公司 取代的杂环化合物及其使用方法和用途
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CA2657552A1 (en) 2008-01-17
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SI2049529T1 (sl) 2010-11-30
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