PL1991522T3 - Deuterated catecholamine derivatives and medicaments comprising said compounds - Google Patents

Deuterated catecholamine derivatives and medicaments comprising said compounds

Info

Publication number
PL1991522T3
PL1991522T3 PL07703542T PL07703542T PL1991522T3 PL 1991522 T3 PL1991522 T3 PL 1991522T3 PL 07703542 T PL07703542 T PL 07703542T PL 07703542 T PL07703542 T PL 07703542T PL 1991522 T3 PL1991522 T3 PL 1991522T3
Authority
PL
Poland
Prior art keywords
medicaments
compounds
catecholamine derivatives
deuterated catecholamine
deuterated
Prior art date
Application number
PL07703542T
Other languages
Polish (pl)
Inventor
Rudolf-Giesbert Alken
Frank Schneider
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of PL1991522T3 publication Critical patent/PL1991522T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
PL07703542T 2006-02-17 2007-02-16 Deuterated catecholamine derivatives and medicaments comprising said compounds PL1991522T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006008316 2006-02-17
EP07703542.6A EP1991522B1 (en) 2006-02-17 2007-02-16 Deuterated catecholamine derivatives and medicaments comprising said compounds

Publications (1)

Publication Number Publication Date
PL1991522T3 true PL1991522T3 (en) 2017-07-31

Family

ID=38236462

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07703542T PL1991522T3 (en) 2006-02-17 2007-02-16 Deuterated catecholamine derivatives and medicaments comprising said compounds

Country Status (24)

Country Link
US (2) US8247603B2 (en)
EP (2) EP3101001B1 (en)
JP (1) JP5248331B2 (en)
KR (1) KR101411422B1 (en)
CN (1) CN101384545B (en)
AU (1) AU2007214622B2 (en)
BR (1) BRPI0708071A8 (en)
CA (1) CA2642593C (en)
CY (1) CY1117995T1 (en)
DK (1) DK1991522T3 (en)
EA (1) EA017983B1 (en)
ES (1) ES2587368T3 (en)
HR (1) HRP20161039T1 (en)
HU (1) HUE028777T2 (en)
IL (1) IL193102A (en)
LT (1) LT1991522T (en)
ME (1) ME02508B (en)
PL (1) PL1991522T3 (en)
PT (1) PT1991522T (en)
RS (1) RS55142B1 (en)
SI (1) SI1991522T1 (en)
UA (1) UA97795C2 (en)
WO (1) WO2007093450A2 (en)
ZA (1) ZA200806568B (en)

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* Cited by examiner, † Cited by third party
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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
NO2303330T3 (en) 2008-06-06 2018-04-14
EP2312944B1 (en) 2008-07-15 2018-09-05 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use
EP2819656A1 (en) 2012-02-28 2015-01-07 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
IN2015DN01662A (en) 2012-09-18 2015-07-03 Auspex Pharmaceuticals Inc
US9763904B2 (en) 2013-02-05 2017-09-19 Teva Pharmaceuticals International Gmbh Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
KR20150115807A (en) 2013-02-05 2015-10-14 임파 악치엔게젤샤프트 Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
WO2014174425A2 (en) * 2013-04-24 2014-10-30 Mahesh Kandula Compositions and methods for the treatment of orthostasis and neurological diseases
EP3019467A4 (en) * 2013-07-08 2017-03-15 Auspex Pharmaceuticals, Inc. Dihydroxyphenyl neurotransmitter compounds, compositions and methods
MX2016006622A (en) * 2013-11-22 2016-12-09 Auspex Pharmaceuticals Inc Methods of treating abnormal muscular activity.
KR102391134B1 (en) 2013-12-03 2022-04-28 오스펙스 파마슈티칼스, 인코포레이티드 Methods of manufacturing benzoquinoline compounds
MX2016010213A (en) 2014-02-07 2017-04-13 Auspex Pharmaceuticals Inc Novel pharmaceutical formulations.
EP2918266A1 (en) 2014-03-11 2015-09-16 CDRD Berolina AB Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease
GB201420341D0 (en) * 2014-11-17 2014-12-31 Evolution Valves Ltd Valve arrangement
IL288712B2 (en) 2015-03-06 2024-01-01 Auspex Pharmaceuticals Inc Methods for the treatment of abnormal involuntary movement disorders
CN106343013A (en) * 2015-07-19 2017-01-25 中国科学院上海有机化学研究所 Grain storage method
CN105360267B (en) * 2015-10-09 2017-11-10 青岛振坤食品机械有限公司 A kind of automatic skewering machine
BR112018007118A2 (en) 2015-10-09 2018-12-11 Teva Pharmaceuticals Int Gmbh method for treating a dopamine deficiency disorder, method for improving active motor time without dyskinesia in a patient with parkinson's disease, method for reducing dyskinesia in an individual with a dopamine deficiency disorder, method for reducing inactive motor time in an individual with a dopamine deficiency disorder, method for reducing striatal dopamine level fluctuations in an individual with a dopamine deficiency disorder, method for reducing dyskinesia in an individual with a dopamine deficiency disorder after long-term treatment, pharmaceutical composition and packaging
CN105862897B (en) * 2016-04-11 2018-01-16 江苏省华建建设股份有限公司 Sandy Silt ground shallow foundation original groove pouring construction engineering method
JP2022510424A (en) * 2018-12-06 2022-01-26 センダ バイオサイエンシーズ， インコーポレイテッド Quaternary ammonium salt as an inhibitor of trimethylamine production

Family Cites Families (11)

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US3699158A (en) 1969-08-25 1972-10-17 Merck & Co Inc Selective deuteration of tyrosine, aspartic and glutamic acids
DE2049807A1 (en) 1970-10-10 1972-04-13 Hartmeyer H Conversion of closed cell plastics foam to - open cell structure
DE2049115C3 (en) 1970-10-06 1981-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Use of calcium 5-butyl picolinate and / or calcium 5-pentyl picolinate in the fight against Parkinsonism with 3- (3,4-dihydroxyphenyl) -L-alanine (L-Dopa)
ATE76747T1 (en) * 1986-06-10 1992-06-15 Chiesi Farma Spa PHARMACEUTICAL COMPOSITIONS CONTAINING LEVODOPA METHYL ESTER, THEIR PREPARATION AND THERAPEUTIC USES.
IT1226902B (en) 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog LEVODOPA SYNTHESIS PROCESS
US5354885A (en) * 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
EP1104760B1 (en) * 1999-12-03 2003-03-12 Pfizer Products Inc. Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
DE10261807A1 (en) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterated catecholamine derivatives and medicinal products containing these compounds
DE10261808A1 (en) * 2002-12-19 2004-07-08 Turicum Drug Development Ag Use of L-DOPA, its derivatives and medicaments containing these compounds for the prophylaxis of psychotic diseases

Also Published As

Publication number Publication date
AU2007214622A1 (en) 2007-08-23
EP3101001A1 (en) 2016-12-07
USRE46555E1 (en) 2017-09-19
ME02508B (en) 2017-06-20
EA017983B1 (en) 2013-04-30
IL193102A (en) 2015-01-29
CA2642593A1 (en) 2007-08-23
RS55142B1 (en) 2016-12-30
PT1991522T (en) 2016-08-23
UA97795C2 (en) 2012-03-26
CY1117995T1 (en) 2017-05-17
KR20080106539A (en) 2008-12-08
JP5248331B2 (en) 2013-07-31
WO2007093450A3 (en) 2007-09-27
BRPI0708071A2 (en) 2011-05-17
CN101384545A (en) 2009-03-11
US8247603B2 (en) 2012-08-21
EA200801826A1 (en) 2009-02-27
SI1991522T1 (en) 2016-10-28
AU2007214622B2 (en) 2012-02-23
WO2007093450A2 (en) 2007-08-23
EP1991522B1 (en) 2016-05-18
KR101411422B1 (en) 2014-07-03
US20090018191A1 (en) 2009-01-15
EP1991522A2 (en) 2008-11-19
ZA200806568B (en) 2009-07-29
CN101384545B (en) 2014-09-03
ES2587368T3 (en) 2016-10-24
HRP20161039T1 (en) 2016-11-04
IL193102A0 (en) 2009-02-11
LT1991522T (en) 2016-09-26
JP2009526799A (en) 2009-07-23
BRPI0708071A8 (en) 2017-12-26
HUE028777T2 (en) 2017-01-30
CA2642593C (en) 2014-11-04
DK1991522T3 (en) 2016-08-29
EP3101001B1 (en) 2020-04-01

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