PL123449B1 - Process for preparing novel derivatives of 2-iminothiazoline - Google Patents
Process for preparing novel derivatives of 2-iminothiazoline Download PDFInfo
- Publication number
- PL123449B1 PL123449B1 PL1977223798A PL22379877A PL123449B1 PL 123449 B1 PL123449 B1 PL 123449B1 PL 1977223798 A PL1977223798 A PL 1977223798A PL 22379877 A PL22379877 A PL 22379877A PL 123449 B1 PL123449 B1 PL 123449B1
- Authority
- PL
- Poland
- Prior art keywords
- formula
- compound
- optionally
- alkyl
- iminothiazoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (2)
1. Zastrzezenia patentowe 1. Sposób wytwarzania nowych pochodnych 2-iminoUazolilny o wzorze 1, ewentualnie w postaci jego farmaceutycznie dopuszczalnej soli, znamienny tym, ze zwiazek o wzorze 2 poddaje sie reakcji ze zwiazkiem o wzorze 3, w którym Y' oznacza grupe 10 wodorotlenowa, po czym otrzymany produkt ewen¬ tualnie przeprowadza sie w sól. 2. Sposób otrzymywania nowych pochodnych 2-imi-notiazoliny o wzorze 1, ewentualnie w postaci jego farmaceutycznie dopuszczalnej soli, znamienny tym, ze zwiazek o wzorze 2 poddaje sie reakcja ze zwiazkiem o wzorze Y-CO-CH2-CH2-CO-Y, w któ¬ rym Y oznacza atom chloru, grupe o wzorze 4, -N3, (alkil Ci_4)-0-COO-, -OCH2CN, podstawnik o wzorze 5, 6, 7, 8, 9 lub o wzorze -0-(alkil Ci_4), po czym otrzymany produkt ewentualnie przepro¬ wadza sie w sól. o o f =N-CCH2CI-UC-N=($1 I I CH3 CH3 WZÓR \ r~S CN=NH ^ CK 3 WZÓR 2 a 0 o ri_ » if l L 2 CH3 WZÓR 3123 449 N02^0^~ ° " WZÓR 4 F F F F W20R 5 H OH oV4n OPh WZÓR S O-C \ NH N(GK alkil)2 WZÓR 8 O-C \ CH: 0[CHalkil)2 WZÓR 9 L 632594 O 100 200300 400 500600700800 pg. proteiny enzymu 2 ™ 80.000 60.000 2: ¦o o c ? » ^c o o c N O » O a o. tn * c 'a "o o. u» c h- Zt. o "o* a *^ i ^r A0.0C0 h 20.000 2 godz. &% 3godz 7 godz. 52% 51% 85% BW 36% 54% 53% 55% 8,1 8,1 12,5 25 25 25 68 68 63 Dawka doustna (mg/kg) * 1 królik /grupe Fig.l Fig.
2. PL PL PL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68287676A | 1976-05-03 | 1976-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL123449B1 true PL123449B1 (en) | 1982-10-30 |
Family
ID=24741558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1977223798A PL123449B1 (en) | 1976-05-03 | 1977-04-30 | Process for preparing novel derivatives of 2-iminothiazoline |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS52133981A (pl) |
| AU (1) | AU508889B2 (pl) |
| BE (1) | BE854172A (pl) |
| CA (1) | CA1078846A (pl) |
| CH (1) | CH629490A5 (pl) |
| DE (1) | DE2719577A1 (pl) |
| DK (1) | DK173777A (pl) |
| ES (2) | ES458237A1 (pl) |
| FI (1) | FI771285A (pl) |
| FR (1) | FR2350351A1 (pl) |
| GB (1) | GB1534242A (pl) |
| HU (1) | HU180504B (pl) |
| IE (1) | IE46011B1 (pl) |
| IL (1) | IL51935A (pl) |
| IT (1) | IT1082657B (pl) |
| LU (1) | LU77243A1 (pl) |
| NL (1) | NL7704322A (pl) |
| NO (1) | NO146061C (pl) |
| NZ (1) | NZ183941A (pl) |
| PH (1) | PH14030A (pl) |
| PL (1) | PL123449B1 (pl) |
| SE (1) | SE7704594L (pl) |
| YU (1) | YU111677A (pl) |
| ZA (1) | ZA772614B (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU188852B (en) * | 1983-03-16 | 1986-05-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for producing thiazolidine derivatives active against gastric ulcer and intestinal ulcer |
| US5555162A (en) * | 1994-04-26 | 1996-09-10 | Sylvan R. Shemitz Designs, Inc. | Compact fluorescent luminaire |
| USRE37310E1 (en) | 1994-12-06 | 2001-08-07 | Sylvan R. Shemitz Designs, Inc. | Compact fluorescent luminaire |
| FR2748023B1 (fr) | 1996-04-30 | 1998-07-24 | Rhone Poulenc Chimie | Hydrogenofluorosulfonates de base organique, leur utilisation pour liberer les bases organiques de leur fluorhydrate, leur procede de preparation, compositions les comportant |
-
1977
- 1977-04-20 DK DK173777A patent/DK173777A/da active IP Right Grant
- 1977-04-20 NL NL7704322A patent/NL7704322A/xx not_active Application Discontinuation
- 1977-04-21 SE SE7704594A patent/SE7704594L/xx not_active Application Discontinuation
- 1977-04-21 NO NO77771375A patent/NO146061C/no unknown
- 1977-04-22 FI FI771285A patent/FI771285A/fi not_active Application Discontinuation
- 1977-04-25 IL IL51935A patent/IL51935A/xx unknown
- 1977-04-26 CH CH518177A patent/CH629490A5/de not_active IP Right Cessation
- 1977-04-26 NZ NZ183941A patent/NZ183941A/xx unknown
- 1977-04-27 AU AU24630/77A patent/AU508889B2/en not_active Expired
- 1977-04-27 CA CA277,184A patent/CA1078846A/en not_active Expired
- 1977-04-27 ES ES458237A patent/ES458237A1/es not_active Expired
- 1977-04-28 IT IT49173/77A patent/IT1082657B/it active
- 1977-04-29 PH PH19725A patent/PH14030A/en unknown
- 1977-04-29 FR FR7713017A patent/FR2350351A1/fr active Granted
- 1977-04-29 IE IE867/77A patent/IE46011B1/en unknown
- 1977-04-29 HU HU77ME2062A patent/HU180504B/hu unknown
- 1977-04-30 PL PL1977223798A patent/PL123449B1/pl unknown
- 1977-05-02 JP JP5003977A patent/JPS52133981A/ja active Pending
- 1977-05-02 GB GB18273/77A patent/GB1534242A/en not_active Expired
- 1977-05-02 ZA ZA00772614A patent/ZA772614B/xx unknown
- 1977-05-02 DE DE19772719577 patent/DE2719577A1/de not_active Withdrawn
- 1977-05-02 BE BE177189A patent/BE854172A/xx not_active IP Right Cessation
- 1977-05-03 LU LU77243A patent/LU77243A1/xx unknown
- 1977-12-28 YU YU01116/77A patent/YU111677A/xx unknown
-
1978
- 1978-03-30 ES ES468377A patent/ES468377A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI771285A (pl) | 1977-11-04 |
| BE854172A (fr) | 1977-11-03 |
| YU111677A (en) | 1983-01-21 |
| AU508889B2 (en) | 1980-04-03 |
| PH14030A (en) | 1980-12-12 |
| ES458237A1 (es) | 1978-07-01 |
| FR2350351A1 (fr) | 1977-12-02 |
| DE2719577A1 (de) | 1977-11-24 |
| IE46011B1 (en) | 1983-01-26 |
| IE46011L (en) | 1977-11-03 |
| IL51935A0 (en) | 1977-06-30 |
| NO146061B (no) | 1982-04-13 |
| NO771375L (no) | 1977-11-04 |
| LU77243A1 (pl) | 1977-12-13 |
| SE7704594L (sv) | 1977-11-04 |
| DK173777A (da) | 1977-11-04 |
| NL7704322A (nl) | 1977-11-07 |
| IL51935A (en) | 1981-07-31 |
| IT1082657B (it) | 1985-05-21 |
| JPS52133981A (en) | 1977-11-09 |
| AU2463077A (en) | 1978-11-02 |
| NO146061C (no) | 1982-07-28 |
| ZA772614B (en) | 1978-12-27 |
| HU180504B (en) | 1983-03-28 |
| NZ183941A (en) | 1980-12-19 |
| ES468377A1 (es) | 1978-12-16 |
| CH629490A5 (en) | 1982-04-30 |
| CA1078846A (en) | 1980-06-03 |
| FR2350351B1 (pl) | 1979-03-02 |
| GB1534242A (en) | 1978-11-29 |
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