PH12019502063A1 - Nucleic acid derivative having immunostimulatory activity - Google Patents

Nucleic acid derivative having immunostimulatory activity

Info

Publication number
PH12019502063A1
PH12019502063A1 PH12019502063A PH12019502063A PH12019502063A1 PH 12019502063 A1 PH12019502063 A1 PH 12019502063A1 PH 12019502063 A PH12019502063 A PH 12019502063A PH 12019502063 A PH12019502063 A PH 12019502063A PH 12019502063 A1 PH12019502063 A1 PH 12019502063A1
Authority
PH
Philippines
Prior art keywords
nucleic acid
acid derivative
strand
immunostimulatory activity
oligonucleotide
Prior art date
Application number
PH12019502063A
Inventor
Akira Kugimiya
Tetsuya Tanino
Mitsuaki Sekiguchi
Yasunori Mitsuoka
Norikazu Kuroda
Jun Nakamura
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of PH12019502063A1 publication Critical patent/PH12019502063A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The purpose of the present invention is to provide, as a nucleic acid derivative having an immunostimulatory activity, a double-stranded oligonucleotide containing a CpG oligonucleotide as mentioned below. An adjuvant comprising a double-stranded oligonucleotide in which a first strand is a CpG oligonucleotide composed of 8 to 50 nucleotides and a second strand is an oligonucleotide composed of 8 to 60 nucleotides and containing a sequence capable of hybridizing with the first strand, wherein a lipid is bonded to the second strand with a linker interposed therebetween.
PH12019502063A 2017-03-29 2019-09-11 Nucleic acid derivative having immunostimulatory activity PH12019502063A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2017/013025 WO2018179172A1 (en) 2017-03-29 2017-03-29 Nucleic acid derivative having immunostimulatory activity

Publications (1)

Publication Number Publication Date
PH12019502063A1 true PH12019502063A1 (en) 2020-09-28

Family

ID=63674710

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12019502063A PH12019502063A1 (en) 2017-03-29 2019-09-11 Nucleic acid derivative having immunostimulatory activity

Country Status (7)

Country Link
JP (1) JP6611298B2 (en)
BR (1) BR112019019177B8 (en)
IL (1) IL268983B1 (en)
MY (1) MY186779A (en)
PH (1) PH12019502063A1 (en)
SG (1) SG11201908059YA (en)
WO (1) WO2018179172A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018362008A1 (en) * 2017-11-02 2020-04-23 Alios Biopharma, Inc. Oligonucleotide constructs and uses thereof
JPWO2020246443A1 (en) 2019-06-03 2020-12-10

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100651294B1 (en) * 1999-08-13 2006-11-28 이데라 파마슈티칼즈, 인코포레이티드 MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES
AU2003203079B9 (en) * 2002-02-04 2009-01-15 Oncothyreon Inc. Immunostimulatory, covalently lipidated oligonucleotides
GB0605247D0 (en) * 2006-03-15 2006-04-26 Chiron Srl Compositions and methods for immunisation
US8846080B2 (en) * 2008-08-28 2014-09-30 Glaxosmithkline Biologicals S.A. Vaccine
MX337723B (en) * 2008-12-09 2016-03-15 Pfizer Vaccines Llc IgE CH3 PEPTIDE VACCINE.
EP2833918B1 (en) * 2012-04-05 2019-05-08 Massachusetts Institute of Technology Immunostimulatory compositions and methods of use thereof
WO2015105083A1 (en) * 2014-01-07 2015-07-16 塩野義製薬株式会社 Double-stranded oligonucleotide containing antisense oligonucleotide and sugar derivative

Also Published As

Publication number Publication date
BR112019019177A2 (en) 2020-04-14
JP6611298B2 (en) 2019-11-27
JPWO2018179172A1 (en) 2020-02-06
SG11201908059YA (en) 2019-10-30
BR112019019177B1 (en) 2021-05-11
IL268983A (en) 2019-10-31
IL268983B1 (en) 2024-03-01
MY186779A (en) 2021-08-19
WO2018179172A1 (en) 2018-10-04
BR112019019177B8 (en) 2022-09-13

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