PE25491A1 - Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales - Google Patents
Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionalesInfo
- Publication number
- PE25491A1 PE25491A1 PE1990177644A PE17764490A PE25491A1 PE 25491 A1 PE25491 A1 PE 25491A1 PE 1990177644 A PE1990177644 A PE 1990177644A PE 17764490 A PE17764490 A PE 17764490A PE 25491 A1 PE25491 A1 PE 25491A1
- Authority
- PE
- Peru
- Prior art keywords
- raw material
- contamination
- purification
- preparation
- solublized
- Prior art date
Links
- 150000002270 gangliosides Chemical class 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000011109 contamination Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- 239000002994 raw material Substances 0.000 abstract 4
- 241000283690 Bos taurus Species 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 210000005013 brain tissue Anatomy 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
CARACTERIZADO PORQUE COMPRENDE: a) SOMETER UN TEJIDO DE CEREBRO DE BOVINO CONTENIENDO GANGLIOSIDOS A ELIMINACION LIPIDA CON ACETONA PARA PRODUCIR UN PRECIPITADO DE ACETONA QUE SE SUSPENDE EN UNA PRIMERA MEZCLA SOLVENTE CAPAZ DE SEPARAR A LAS SUSTANCIAS HIDROFOBICAS DE LAS SUSTANCIAS HIDROFILICAS, QUE ES FILTRADA OBTENIENDOSE UNA PRIMERA FASE LIQUIDA QUE SE PRECIPITA PARA FORMAR UNA PRIMERA MATERIA PRIMA QUE ES SOLUBILIZADA Y CALENTADA A UN PH DE 12; b) SOMETER DICHA MATERIA PRIMA A UN SEGUNDO PROCESO DE SEPARACION EN UNA SEGUNDA MEZCLA SOLVENTE PARA SEPARAR LAS SUSTANCIAS HIDROFOBICAS DE LAS HIDROFILICAS, SUPRIMIENDOSE LA FASE ORGANICA Y RETENIENDOSE LA FASE ACUOSA PARA PRODUCIR UNA SEGUNDA MATERIA PRIMA; c) SOLUBILIZAR DICHA SEGUNDA MATERIA PRIMA PREVIAMENTE ENFRIADA PARA FORMAR UNA TERCERA MATERIA PRIMA, QUE ES SOLUBILIZADA, NEUTRALIZADA Y SOMETIDA A DIALISIS A TRAVES DE UNA MEMBRANA CON UN CIERRE DE PM DE 10 KD PARA PRODUCIR UNA MEZCLA DE GANGLIOSIDOS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4174789A IT1236594B (it) | 1989-11-17 | 1989-11-17 | Metodo per la preparazione e purificazione di una miscela di glicosfingolipidi |
IT04171690A IT1243295B (it) | 1990-10-18 | 1990-10-18 | Metodo per la preparazione e purificazione di una miscela di glicosfingolipidi priva di contaminanti da virus non convenzionali |
Publications (1)
Publication Number | Publication Date |
---|---|
PE25491A1 true PE25491A1 (es) | 1991-09-12 |
Family
ID=26329145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1990177644A PE25491A1 (es) | 1989-11-17 | 1990-11-15 | Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales |
Country Status (22)
Country | Link |
---|---|
US (1) | US5521164A (es) |
EP (1) | EP0454818B1 (es) |
JP (1) | JP3140458B2 (es) |
KR (1) | KR0177820B1 (es) |
CN (1) | CN1027895C (es) |
AT (1) | ATE169926T1 (es) |
AU (1) | AU649635B2 (es) |
CA (1) | CA2045142C (es) |
DE (1) | DE69032578T2 (es) |
ES (1) | ES2119747T3 (es) |
FI (1) | FI97138C (es) |
HK (1) | HK1013294A1 (es) |
HU (2) | HUT58754A (es) |
IE (1) | IE904135A1 (es) |
IL (1) | IL96346A (es) |
IN (1) | IN171530B (es) |
NO (1) | NO175311C (es) |
NZ (1) | NZ236059A (es) |
PE (1) | PE25491A1 (es) |
PT (1) | PT95917B (es) |
WO (1) | WO1991007417A1 (es) |
YU (1) | YU218790A (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1235161B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisogangliosidi |
WO1992020695A1 (en) * | 1991-05-16 | 1992-11-26 | Fidia S.P.A. | Method for the preparation and purification of a mixture of glycosphingolipids free from contamination by non-conventional viruses |
IT1260149B (it) * | 1992-04-17 | 1996-03-28 | Fidia Spa | Metodo per la preparazione e purificazione di miscele di fosfolipidi prive di contaminanti da virus non convenzionali |
US6458761B2 (en) * | 1999-11-24 | 2002-10-01 | Lore Maria Klett-Loch | Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect |
DE60032262T2 (de) * | 2000-02-24 | 2007-06-14 | Menicon Co., Ltd., Nagoya | Verwendung einer behandlunglösung zur inaktivierung von prionen |
NZ531139A (en) | 2001-08-29 | 2007-09-28 | Neose Technologies Inc | Synthetic ganglioside derivatives and compositions thereof |
AU2004220087A1 (en) | 2003-03-06 | 2004-09-23 | Seneb Biosciences, Inc. | Methods and compositions for the enzymatic synthesis of gangliosides |
US7066261B2 (en) * | 2004-01-08 | 2006-06-27 | Halliburton Energy Services, Inc. | Perforating system and method |
WO2010062197A1 (en) * | 2008-11-25 | 2010-06-03 | Eduard Nekrasov | Dairy product and process |
WO2010111530A1 (en) | 2009-03-25 | 2010-09-30 | Seneb Biosciences, Inc. | Glycolipids as treatment for disease |
CN101838295B (zh) * | 2010-04-14 | 2015-02-25 | 李桂凤 | 一种利用具有特异识别功能色谱介质快速分离纯化神经节苷脂的工业化生产工艺 |
US8710385B2 (en) | 2012-05-07 | 2014-04-29 | Robert Butch Sickels | Reliability fire pressure switch |
CN105111253B (zh) * | 2015-09-18 | 2018-01-12 | 重庆寰瑞生物技术有限公司 | 一种提取分离神经节苷脂的方法 |
CN109320566B (zh) * | 2018-08-14 | 2022-03-15 | 四川兴杰象药业有限公司 | 一种从猪脑髓中提取神经节苷脂的分离纯化制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3346413A (en) * | 1964-10-12 | 1967-10-10 | Hooker Chemical Corp | Method and apparatus for coating wire and solvent recovery |
ES528692A0 (es) * | 1984-01-04 | 1985-07-01 | Bioiberica | Procedimiento para la obtencion de un complejo glicoesfingolipidico |
JPS60181019A (ja) * | 1984-02-28 | 1985-09-14 | Mitsui Toatsu Chem Inc | ガングリオシドの抽出方法 |
IT1177863B (it) * | 1984-07-03 | 1987-08-26 | Fidia Farmaceutici | Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche |
JPS61180719A (ja) * | 1985-02-06 | 1986-08-13 | Mitsui Toatsu Chem Inc | ガングリオシドの取得方法 |
US4710490A (en) * | 1985-10-01 | 1987-12-01 | Angio Medical Corporation | Compositions containing ganglioside molecules with enhanced angiogenic activity |
IT1223408B (it) * | 1987-12-09 | 1990-09-19 | Crinos Industria Farmaco | Procedimento per la preparazione di monosialoganglioside |
-
1990
- 1990-11-13 IN IN952/CAL/90A patent/IN171530B/en unknown
- 1990-11-13 NZ NZ236059A patent/NZ236059A/xx unknown
- 1990-11-14 IL IL96346A patent/IL96346A/xx active IP Right Grant
- 1990-11-15 PE PE1990177644A patent/PE25491A1/es not_active Application Discontinuation
- 1990-11-16 AU AU67275/90A patent/AU649635B2/en not_active Ceased
- 1990-11-16 YU YU218790A patent/YU218790A/sh unknown
- 1990-11-16 ES ES90916737T patent/ES2119747T3/es not_active Expired - Lifetime
- 1990-11-16 AT AT90916737T patent/ATE169926T1/de not_active IP Right Cessation
- 1990-11-16 HU HU912391A patent/HUT58754A/hu unknown
- 1990-11-16 WO PCT/EP1990/001960 patent/WO1991007417A1/en active IP Right Grant
- 1990-11-16 KR KR1019910700744A patent/KR0177820B1/ko not_active IP Right Cessation
- 1990-11-16 IE IE413590A patent/IE904135A1/en not_active IP Right Cessation
- 1990-11-16 PT PT95917A patent/PT95917B/pt not_active IP Right Cessation
- 1990-11-16 CA CA002045142A patent/CA2045142C/en not_active Expired - Fee Related
- 1990-11-16 JP JP02515353A patent/JP3140458B2/ja not_active Expired - Fee Related
- 1990-11-16 HU HU912391A patent/HU210145B/hu not_active IP Right Cessation
- 1990-11-16 DE DE69032578T patent/DE69032578T2/de not_active Expired - Fee Related
- 1990-11-16 EP EP90916737A patent/EP0454818B1/en not_active Expired - Lifetime
- 1990-11-17 CN CN90109855A patent/CN1027895C/zh not_active Expired - Fee Related
-
1991
- 1991-07-16 NO NO912780A patent/NO175311C/no not_active IP Right Cessation
- 1991-07-17 FI FI913454A patent/FI97138C/fi active
-
1993
- 1993-09-03 US US08/116,268 patent/US5521164A/en not_active Expired - Fee Related
-
1998
- 1998-12-22 HK HK98114612A patent/HK1013294A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE25491A1 (es) | Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales | |
Zimmermann et al. | Electric field-induced cell-to-cell fusion | |
DE69329461T2 (de) | Verfahren zur extraktion und reinigung von hamoglobin | |
FR2601959B1 (fr) | Procede d'elimination du cholesterol contenu dans une matiere grasse d'origine animale et matiere grasse appauvrie en cholesterol obtenue | |
DE3775783D1 (de) | Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung. | |
Hosaka et al. | Electron microscopic study of cell fusion by HVJ virions | |
PT1214129E (pt) | Processo para a preparacao de substancias medicinais finas | |
Brunschwig et al. | Ultrastructural observations of isolated intact and fragmented junctions of skeletal muscle by use of tannic acid mordanting. | |
Colten et al. | Ultracentrifugation of the first component of complement: effects of ionic strength | |
Polson et al. | Electron microscopy of neurotropic African horse-sickness virus | |
FI101128B (fi) | Menetelmä infektioita aiheuttamattoman veriplasman valmistamiseksi | |
CA1293941C (en) | Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product | |
Högman | The Principle of Mixed Agglutination Applied to Tissue Culture Systems: A Method for Study of Cell‐Bound Blood‐Group Antigens | |
Herrmann et al. | The requirements for antigen multivalency in class I antigen recognition and triggering of primed precursor cytolytic T lymphocytes. | |
JPH0214736A (ja) | 標的構造との脂質交換のための作用物質系 | |
Raynaud et al. | Metachromatic Leukodystrophy: Ultrastructural and Enzymatic Study of a Case of Variant 0 Form | |
Oku et al. | Electron microscopic study on the interaction of Sendai virus with liposomes containing glycophorin | |
US4541953A (en) | Preparation of anti-T-lymphocyte globulin | |
Donath et al. | Electric-field-induced fusion of enzyme-treated human red cells: Kinetics of intermembrane protein exchange | |
Boursnell et al. | Boar seminal plasma proteins | |
JPH05310799A (ja) | ムチンの精製方法 | |
RU2089204C1 (ru) | Способ получения пептидов, восстанавливающих функцию предстательной железы | |
Zampighi et al. | One-dimensional crystals of (Na++ K+)-ATPase dimers | |
ES2061731T3 (es) | Procedimiento de extraccion de antigenos de membrana con propiedades inmunogenicas de celulas neoplasicas humanas y los productos asi obtenidos. | |
KR930701463A (ko) | 미지 비루스에 오염되지 않는 글리코스핀고리피드 혼합물의 제조 및 정제방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |