PE25491A1 - Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales - Google Patents

Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales

Info

Publication number
PE25491A1
PE25491A1 PE1990177644A PE17764490A PE25491A1 PE 25491 A1 PE25491 A1 PE 25491A1 PE 1990177644 A PE1990177644 A PE 1990177644A PE 17764490 A PE17764490 A PE 17764490A PE 25491 A1 PE25491 A1 PE 25491A1
Authority
PE
Peru
Prior art keywords
raw material
contamination
purification
preparation
solublized
Prior art date
Application number
PE1990177644A
Other languages
English (en)
Inventor
Valle Francesco Della
Silvana Lorenzi
Lanfranco Callegaro
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT4174789A external-priority patent/IT1236594B/it
Priority claimed from IT04171690A external-priority patent/IT1243295B/it
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of PE25491A1 publication Critical patent/PE25491A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

CARACTERIZADO PORQUE COMPRENDE: a) SOMETER UN TEJIDO DE CEREBRO DE BOVINO CONTENIENDO GANGLIOSIDOS A ELIMINACION LIPIDA CON ACETONA PARA PRODUCIR UN PRECIPITADO DE ACETONA QUE SE SUSPENDE EN UNA PRIMERA MEZCLA SOLVENTE CAPAZ DE SEPARAR A LAS SUSTANCIAS HIDROFOBICAS DE LAS SUSTANCIAS HIDROFILICAS, QUE ES FILTRADA OBTENIENDOSE UNA PRIMERA FASE LIQUIDA QUE SE PRECIPITA PARA FORMAR UNA PRIMERA MATERIA PRIMA QUE ES SOLUBILIZADA Y CALENTADA A UN PH DE 12; b) SOMETER DICHA MATERIA PRIMA A UN SEGUNDO PROCESO DE SEPARACION EN UNA SEGUNDA MEZCLA SOLVENTE PARA SEPARAR LAS SUSTANCIAS HIDROFOBICAS DE LAS HIDROFILICAS, SUPRIMIENDOSE LA FASE ORGANICA Y RETENIENDOSE LA FASE ACUOSA PARA PRODUCIR UNA SEGUNDA MATERIA PRIMA; c) SOLUBILIZAR DICHA SEGUNDA MATERIA PRIMA PREVIAMENTE ENFRIADA PARA FORMAR UNA TERCERA MATERIA PRIMA, QUE ES SOLUBILIZADA, NEUTRALIZADA Y SOMETIDA A DIALISIS A TRAVES DE UNA MEMBRANA CON UN CIERRE DE PM DE 10 KD PARA PRODUCIR UNA MEZCLA DE GANGLIOSIDOS
PE1990177644A 1989-11-17 1990-11-15 Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales PE25491A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT4174789A IT1236594B (it) 1989-11-17 1989-11-17 Metodo per la preparazione e purificazione di una miscela di glicosfingolipidi
IT04171690A IT1243295B (it) 1990-10-18 1990-10-18 Metodo per la preparazione e purificazione di una miscela di glicosfingolipidi priva di contaminanti da virus non convenzionali

Publications (1)

Publication Number Publication Date
PE25491A1 true PE25491A1 (es) 1991-09-12

Family

ID=26329145

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1990177644A PE25491A1 (es) 1989-11-17 1990-11-15 Metodo para la preparacion y purificacion de una mezcla de gangliosidos libre de contaminacion por virus no convencionales

Country Status (22)

Country Link
US (1) US5521164A (es)
EP (1) EP0454818B1 (es)
JP (1) JP3140458B2 (es)
KR (1) KR0177820B1 (es)
CN (1) CN1027895C (es)
AT (1) ATE169926T1 (es)
AU (1) AU649635B2 (es)
CA (1) CA2045142C (es)
DE (1) DE69032578T2 (es)
ES (1) ES2119747T3 (es)
FI (1) FI97138C (es)
HK (1) HK1013294A1 (es)
HU (2) HUT58754A (es)
IE (1) IE904135A1 (es)
IL (1) IL96346A (es)
IN (1) IN171530B (es)
NO (1) NO175311C (es)
NZ (1) NZ236059A (es)
PE (1) PE25491A1 (es)
PT (1) PT95917B (es)
WO (1) WO1991007417A1 (es)
YU (1) YU218790A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1235161B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisogangliosidi
WO1992020695A1 (en) * 1991-05-16 1992-11-26 Fidia S.P.A. Method for the preparation and purification of a mixture of glycosphingolipids free from contamination by non-conventional viruses
IT1260149B (it) * 1992-04-17 1996-03-28 Fidia Spa Metodo per la preparazione e purificazione di miscele di fosfolipidi prive di contaminanti da virus non convenzionali
US6458761B2 (en) * 1999-11-24 2002-10-01 Lore Maria Klett-Loch Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect
DE60032262T2 (de) * 2000-02-24 2007-06-14 Menicon Co., Ltd., Nagoya Verwendung einer behandlunglösung zur inaktivierung von prionen
NZ531139A (en) 2001-08-29 2007-09-28 Neose Technologies Inc Synthetic ganglioside derivatives and compositions thereof
AU2004220087A1 (en) 2003-03-06 2004-09-23 Seneb Biosciences, Inc. Methods and compositions for the enzymatic synthesis of gangliosides
US7066261B2 (en) * 2004-01-08 2006-06-27 Halliburton Energy Services, Inc. Perforating system and method
WO2010062197A1 (en) * 2008-11-25 2010-06-03 Eduard Nekrasov Dairy product and process
WO2010111530A1 (en) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease
CN101838295B (zh) * 2010-04-14 2015-02-25 李桂凤 一种利用具有特异识别功能色谱介质快速分离纯化神经节苷脂的工业化生产工艺
US8710385B2 (en) 2012-05-07 2014-04-29 Robert Butch Sickels Reliability fire pressure switch
CN105111253B (zh) * 2015-09-18 2018-01-12 重庆寰瑞生物技术有限公司 一种提取分离神经节苷脂的方法
CN109320566B (zh) * 2018-08-14 2022-03-15 四川兴杰象药业有限公司 一种从猪脑髓中提取神经节苷脂的分离纯化制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3346413A (en) * 1964-10-12 1967-10-10 Hooker Chemical Corp Method and apparatus for coating wire and solvent recovery
ES528692A0 (es) * 1984-01-04 1985-07-01 Bioiberica Procedimiento para la obtencion de un complejo glicoesfingolipidico
JPS60181019A (ja) * 1984-02-28 1985-09-14 Mitsui Toatsu Chem Inc ガングリオシドの抽出方法
IT1177863B (it) * 1984-07-03 1987-08-26 Fidia Farmaceutici Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche
JPS61180719A (ja) * 1985-02-06 1986-08-13 Mitsui Toatsu Chem Inc ガングリオシドの取得方法
US4710490A (en) * 1985-10-01 1987-12-01 Angio Medical Corporation Compositions containing ganglioside molecules with enhanced angiogenic activity
IT1223408B (it) * 1987-12-09 1990-09-19 Crinos Industria Farmaco Procedimento per la preparazione di monosialoganglioside

Also Published As

Publication number Publication date
CN1053067A (zh) 1991-07-17
IL96346A (en) 1997-06-10
IN171530B (es) 1992-11-07
AU649635B2 (en) 1994-06-02
FI97138C (fi) 1996-10-25
IE904135A1 (en) 1991-05-22
NO912780D0 (no) 1991-07-16
KR920701225A (ko) 1992-08-11
HK1013294A1 (en) 1999-08-20
EP0454818B1 (en) 1998-08-19
FI913454A0 (fi) 1991-07-17
KR0177820B1 (ko) 1999-04-01
IL96346A0 (en) 1991-08-16
HU912391D0 (en) 1991-12-30
NO912780L (no) 1991-07-16
HU210145B (en) 1995-02-28
ES2119747T3 (es) 1998-10-16
PT95917A (pt) 1991-09-13
US5521164A (en) 1996-05-28
ATE169926T1 (de) 1998-09-15
FI97138B (fi) 1996-07-15
NO175311C (no) 1994-09-28
YU218790A (sh) 1993-10-20
CN1027895C (zh) 1995-03-15
PT95917B (pt) 1998-04-30
HUT58754A (en) 1992-03-30
NZ236059A (en) 1993-03-26
CA2045142C (en) 2000-07-18
DE69032578T2 (de) 1999-04-29
JPH04503076A (ja) 1992-06-04
WO1991007417A1 (en) 1991-05-30
CA2045142A1 (en) 1991-05-18
AU6727590A (en) 1991-06-13
NO175311B (no) 1994-06-20
DE69032578D1 (de) 1998-09-24
JP3140458B2 (ja) 2001-03-05
EP0454818A1 (en) 1991-11-06

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