PE20210465A1 - Derivados de tiadiazina - Google Patents
Derivados de tiadiazinaInfo
- Publication number
- PE20210465A1 PE20210465A1 PE2021000052A PE2021000052A PE20210465A1 PE 20210465 A1 PE20210465 A1 PE 20210465A1 PE 2021000052 A PE2021000052 A PE 2021000052A PE 2021000052 A PE2021000052 A PE 2021000052A PE 20210465 A1 PE20210465 A1 PE 20210465A1
- Authority
- PE
- Peru
- Prior art keywords
- unsaturated
- saturated
- bicyclic
- monocyclic
- tiadiazine
- Prior art date
Links
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000047725 alpha7 Nicotinic Acetylcholine Receptor Human genes 0.000 abstract 1
- 108700006085 alpha7 Nicotinic Acetylcholine Receptor Proteins 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen los compuestos de la Formula (I) donde A es un carbociclilo saturado, insaturado o aromatico, monociclico o biciclico, o un heterociclico saturado, insaturado o aromatico, entre otros. B es un carbociclilo saturado, insaturado o aromatico, monociclico o biciclico, opcionalmente sustituido con uno o mas atomos de halogeno, entre otros; R 1 es C1-C6 alquilo, C1-C6 alquenilo, entre otros; o sales farmaceuticamente aceptables, metabolitos biologicamente activos, profarmacos, racematos, enantiomeros, diastereomeros, solvatos e hidratos de los mismos, asi como composiciones farmaceuticas que los contienen y su uso como moduladores de la actividad del receptor nicotinico de acetilcolina alfa7 en un sujeto mamifero.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1800249A HU231414B1 (hu) | 2018-07-13 | 2018-07-13 | Tiadiazin származékok |
| PCT/IB2019/055949 WO2020012423A1 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20210465A1 true PE20210465A1 (es) | 2021-03-08 |
Family
ID=89992726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021000052A PE20210465A1 (es) | 2018-07-13 | 2019-07-12 | Derivados de tiadiazina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20210267993A1 (es) |
| EP (1) | EP3820865A1 (es) |
| JP (2) | JP7440486B2 (es) |
| KR (1) | KR20210033003A (es) |
| CN (1) | CN112424198A (es) |
| AR (1) | AR115783A1 (es) |
| AU (1) | AU2019300515A1 (es) |
| BR (1) | BR112020027016A2 (es) |
| CA (1) | CA3104264A1 (es) |
| CL (1) | CL2021000081A1 (es) |
| CO (1) | CO2021001224A2 (es) |
| CU (1) | CU24622B1 (es) |
| EA (1) | EA202190246A1 (es) |
| GE (1) | GEP20237459B (es) |
| HU (1) | HU231414B1 (es) |
| IL (1) | IL279939A (es) |
| MX (1) | MX2021000461A (es) |
| PE (1) | PE20210465A1 (es) |
| PH (1) | PH12021550007A1 (es) |
| SG (1) | SG11202012769QA (es) |
| TW (1) | TWI827628B (es) |
| WO (1) | WO2020012423A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021163513A1 (en) * | 2020-02-14 | 2021-08-19 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Heat shock protein modulators and anti-huntington disease therapeutic agents |
| TW202202495A (zh) | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物 |
| CN111454232B (zh) * | 2020-05-30 | 2021-11-23 | 南方医科大学 | 一种1,3,4-噻二嗪类化合物及其应用 |
| HUP2100338A1 (hu) | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2617394C (en) | 2005-09-13 | 2014-06-03 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
| CN101815512B (zh) | 2007-10-04 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 环丙基芳基酰胺衍生物和其用途 |
| CA2701214C (en) | 2007-10-04 | 2016-08-02 | F. Hoffmann-La Roche Ag | Tetrazole-substituted aryl amide derivatives and uses thereof |
| RU2010137114A (ru) | 2008-02-07 | 2012-03-20 | Эбботт Лэборетриз (Us) | Амидные производные как позитивные аллостерические модуляторы и способы их применения |
| ES2442932T3 (es) | 2008-03-19 | 2014-02-14 | Janssen Pharmaceutica N.V. | 1,2,4-Triazoles trisustituidos como moduladores de receptores nicotínicos de acetilcolina |
| JP2011516599A (ja) | 2008-04-17 | 2011-05-26 | グラクソ グループ リミテッド | ニコチン性アセチルコリン受容体サブタイプα７のモジュレーターとしてのインドール類 |
| EA018187B1 (ru) | 2008-05-09 | 2013-06-28 | Янссен Фармацевтика Нв | Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина |
| CA2776835A1 (en) * | 2009-10-13 | 2011-04-21 | Msd Oss B.V. | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
| JP5865397B2 (ja) * | 2011-02-03 | 2016-02-17 | ルピン・リミテッドＬｕｐｉｎ Ｌｉｍｉｔｅｄ | α７ｎＡＣｈＲのモジュレータとして使用されるピロール誘導体 |
| EP2970180A1 (en) * | 2013-03-13 | 2016-01-20 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
| DK3433234T3 (da) * | 2016-03-22 | 2022-01-03 | Merck Sharp & Dohme | Allosteriske modulatorer af nicotinacetylcholinreceptorer |
| JP7041141B2 (ja) | 2016-11-01 | 2022-03-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 置換された二環式ヘテロアリール系ニコチン性アセチルコリン受容体アロステリック調節剤 |
| WO2018160878A1 (en) * | 2017-03-02 | 2018-09-07 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
-
2018
- 2018-07-13 HU HUP1800249A patent/HU231414B1/hu unknown
-
2019
- 2019-06-27 TW TW108122604A patent/TWI827628B/zh active
- 2019-07-12 AU AU2019300515A patent/AU2019300515A1/en active Pending
- 2019-07-12 CU CU2020000109A patent/CU24622B1/es unknown
- 2019-07-12 EP EP19744869.9A patent/EP3820865A1/en active Pending
- 2019-07-12 SG SG11202012769QA patent/SG11202012769QA/en unknown
- 2019-07-12 CA CA3104264A patent/CA3104264A1/en active Pending
- 2019-07-12 JP JP2021500540A patent/JP7440486B2/ja active Active
- 2019-07-12 PE PE2021000052A patent/PE20210465A1/es unknown
- 2019-07-12 AR ARP190101992A patent/AR115783A1/es unknown
- 2019-07-12 WO PCT/IB2019/055949 patent/WO2020012423A1/en unknown
- 2019-07-12 GE GEAP201915558A patent/GEP20237459B/en unknown
- 2019-07-12 US US17/259,975 patent/US20210267993A1/en active Pending
- 2019-07-12 EA EA202190246A patent/EA202190246A1/ru unknown
- 2019-07-12 BR BR112020027016-4A patent/BR112020027016A2/pt unknown
- 2019-07-12 KR KR1020217004286A patent/KR20210033003A/ko unknown
- 2019-07-12 MX MX2021000461A patent/MX2021000461A/es unknown
- 2019-07-12 CN CN201980046660.4A patent/CN112424198A/zh active Pending
-
2021
- 2021-01-04 PH PH12021550007A patent/PH12021550007A1/en unknown
- 2021-01-04 IL IL279939A patent/IL279939A/en unknown
- 2021-01-12 CL CL2021000081A patent/CL2021000081A1/es unknown
- 2021-02-03 CO CONC2021/0001224A patent/CO2021001224A2/es unknown
-
2024
- 2024-02-14 JP JP2024020524A patent/JP2024056879A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CU20200109A7 (es) | 2021-08-06 |
| AU2019300515A1 (en) | 2021-02-11 |
| PH12021550007A1 (en) | 2021-09-20 |
| JP7440486B2 (ja) | 2024-02-28 |
| CA3104264A1 (en) | 2020-01-16 |
| JP2024056879A (ja) | 2024-04-23 |
| IL279939A (en) | 2021-03-01 |
| MX2021000461A (es) | 2021-06-23 |
| TWI827628B (zh) | 2024-01-01 |
| EP3820865A1 (en) | 2021-05-19 |
| TW202019431A (zh) | 2020-06-01 |
| BR112020027016A2 (pt) | 2021-04-06 |
| GEP20237459B (en) | 2023-01-25 |
| JP2021529813A (ja) | 2021-11-04 |
| EA202190246A1 (ru) | 2021-04-20 |
| AR115783A1 (es) | 2021-02-24 |
| HUP1800249A2 (en) | 2020-01-28 |
| US20210267993A1 (en) | 2021-09-02 |
| CL2021000081A1 (es) | 2021-10-29 |
| CN112424198A (zh) | 2021-02-26 |
| CO2021001224A2 (es) | 2021-02-17 |
| KR20210033003A (ko) | 2021-03-25 |
| WO2020012423A1 (en) | 2020-01-16 |
| SG11202012769QA (en) | 2021-02-25 |
| HU231414B1 (hu) | 2023-08-28 |
| CU24622B1 (es) | 2022-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20210465A1 (es) | Derivados de tiadiazina | |
| DOP2023000016A (es) | Macrociclos como moduladores del regulador de conductancia transmembrana de la fibrosis quística, composiciones farmacéuticas de estos, su uso en el tratamiento de la fibrosis quística y procesos para elaborarlos | |
| ECSP22052564A (es) | Tetrahidrofuranos sustituidos como moduladores de canales de sodio | |
| PE20231206A1 (es) | Compuestos como agonistas de glp-1r | |
| CO2021001216A2 (es) | Derivados de espirocromano | |
| GT200500379A (es) | Derivados fusionados de pirazol y metodos de tratamiento de trastornos metabolicos con estos | |
| UY27322A1 (es) | Nuevos derivados de indol con afinidad por el receptor 5-ht6 | |
| AR069735A1 (es) | Derivados de 4-(2-amino-1- hidoxietil) fenol como agonistas del receptor adrenergico beta 2 | |
| GT199900008A (es) | Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1 | |
| UY27736A1 (es) | Miméticos de glucocorticoides, procedimientos para su preparación, composiciones farmacéuticas y su uso de los mismos. | |
| UY36673A (es) | Sulfonas tricíclicas como moduladores de ror y composiciones farmacéuticas que las contienen | |
| PE20190502A1 (es) | Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos | |
| AR121296A1 (es) | Moduladores de monoacilglicerol lipasa | |
| PE20091241A1 (es) | Derivados de n-bencil, n'-arilcarbonilpiperazina como moduladores del receptor lxr | |
| CL2020001564A1 (es) | Triazolobenzazepinas como antagonistas del receptor v1a de la vasopresina. | |
| CL2020001817A1 (es) | Moduladores del receptor c5a | |
| AR079467A1 (es) | Derivados heterociclicos nitrogenados de etinilo, composiciones farmaceuticas que los contienen, proceso para prepararlos y uso de los mismos para tratar y/o prevenir enfermedades cognitivas o esquizofrenia. | |
| ECSP19072975A (es) | Derivados pirazol[1,5-a]pirimidina sustituidos con alicíclicos farmacológicamente activos | |
| CO2019004164A2 (es) | Compuestos de piridina bicíclicos fusionados y su uso como moduladores de receptores ampa | |
| UY38809A (es) | Derivados de 3,6-diamino-piridazin-3ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos | |
| AR106137A1 (es) | Compuestos trifluoroalquenilo heterocíclicos con actividad nematicida, sus composiciones agronómicas y el uso de las mismas | |
| AR115228A1 (es) | DERIVADOS DE (AZA)INDOL SUSTITUIDOS, UN MÉTODO PARA SU PREPARACIÓN, INTERMEDIARIOS PARA SU SÍNTESIS, COMPOSICIÓN Y COMBINACIÓN FARMACÉUTICA QUE LOS COMPRENDEN Y EL USO DE LOS MISMOS EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS AL RECEPTOR NICOTÍNICO DE ACETILCOLINA a7 | |
| AR044275A1 (es) | Uso de derivados de sulfonamidas para la fabricacion de un medicamento para la profilaxis y/o tratamiento de las disfunciones alimentarias | |
| ES2152682T3 (es) | Derivados de indolina utiles como antagonistas del receptor 5ht-2c. | |
| AR125299A1 (es) | Nuevos (homo)piperidinil heterociclos como ligandos sigma |