PE20181952A1 - Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos - Google Patents

Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos

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Publication number
PE20181952A1
PE20181952A1 PE2018002029A PE2018002029A PE20181952A1 PE 20181952 A1 PE20181952 A1 PE 20181952A1 PE 2018002029 A PE2018002029 A PE 2018002029A PE 2018002029 A PE2018002029 A PE 2018002029A PE 20181952 A1 PE20181952 A1 PE 20181952A1
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PE
Peru
Prior art keywords
cdr
seq
group
kabat numbering
antibody
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Application number
PE2018002029A
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English (en)
Inventor
Laird Bloom
Karl Henry Nocka
James Reasoner Apgar
Mark A Farmer
Matthew Allister Lambert
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Pfizer
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Publication of PE20181952A1 publication Critical patent/PE20181952A1/es

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Referido a un anticuerpo o fragmento de union al antigeno del mismo, que se une especificamente a interleucina 33 (IL-33) humana, caracterizado porque comprende cualquiera de: (i) una CDR-L1 seleccionada del grupo que consiste de SEQ ID NO: 20, 37, 190, 193, 257, 258, 259 y 260 de acuerdo con la numeracion Kabat; (ii) una CDR-L2 seleccionada del grupo que consiste de SEQ ID NO: 21, 196, 199, 261, 262, 263, y 264 de acuerdo con la numeracion Kabat; (iii) una CDR-L3 seleccionada del grupo que consiste de SEQ ID NO: 22, 38, 208, 265, 26, 267 y 268 de acuerdo con la numeracion Kabat; (iv) una CDR-H1 seleccionada del grupo que consiste de SEQ ID NO: 16, 33, 269, 270 y 271 de acuerdo con la numeracion Kabat; (v) una CDR-H2 seleccionada del grupo que consiste de SEQ ID NO: 17, 34, 168, 171 ,174, 180, 202, 205, 211, 214, 217, 220, 223, 226, 229, 232, 235, 272, 273, 274, y 275 de acuerdo con la numeracion Kabat, y (vi) una CDR-H3 seleccionada del grupo que consiste de SEQ ID NO: 18, 35, 114, 119, 122, 127, 130, 133, 136, 139, 142, 145, 148, 153, 156, 159, 177, 187, 276, 277, 278, y 279 de acuerdo con la numeracion Kabat. En donde, este anticuerpo o fragmento de union al antigeno del mismo, comprende una o ambas secuencias de marco VL y VH es al menos 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% o 99% identica a la secuencia de la linea germinal de humano a partir de la cual se deriva. Tambien se refiere a una molecula aislada de acidos nucleicos, un vector, una celula huesped y un metodo para elaborar un anticuerpo. Una composicion farmaceutica que comprende un anticuerpo y metodos para tratar enfermedades inflamatorias, alergias, entre otras.
PE2018002029A 2016-04-27 2017-04-20 Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos PE20181952A1 (es)

Applications Claiming Priority (2)

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US201662328294P 2016-04-27 2016-04-27
US201762483781P 2017-04-10 2017-04-10

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PE20181952A1 true PE20181952A1 (es) 2018-12-17

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US (2) US10544212B2 (es)
EP (1) EP3448888A1 (es)
JP (1) JP2019516362A (es)
KR (1) KR20180128028A (es)
CN (1) CN109415436A (es)
AU (1) AU2017257330A1 (es)
BR (1) BR112018071276A2 (es)
CA (1) CA2965089A1 (es)
CO (1) CO2018011364A2 (es)
IL (1) IL262497A (es)
MX (1) MX2018013038A (es)
PE (1) PE20181952A1 (es)
PH (1) PH12018502225A1 (es)
RU (1) RU2740309C2 (es)
SG (1) SG11201808693WA (es)
TW (2) TW201943729A (es)
WO (1) WO2017187307A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160168640A1 (en) 2014-11-10 2016-06-16 Genentech, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
EP3218403B1 (en) 2014-11-10 2020-05-13 F.Hoffmann-La Roche Ag Anti-interleukin-33 antibodies and uses thereof
US11248054B2 (en) 2017-06-12 2022-02-15 Bluefin Biomedicine, Inc. Anti-IL1RAP antibodies and antibody drug conjugates
EA202091871A1 (ru) * 2018-03-30 2021-06-22 Мерус Н.В. Поливалентное антитело
IL307286A (en) 2018-04-11 2023-11-01 Regeneron Pharma Methods and preparations for quantification of IL-33
WO2020123664A1 (en) * 2018-12-11 2020-06-18 Pionyr Immunotherapeutics, Inc. Methods of using anti-trem2 antibodies
CN112480252B (zh) * 2019-09-12 2023-02-07 上海麦济生物技术有限公司 抗白细胞介素-33抗体及其制备方法和应用
CN114901361A (zh) 2019-11-04 2022-08-12 免疫医疗有限公司 使用il-33拮抗剂的方法
WO2021089559A1 (en) * 2019-11-04 2021-05-14 Medimmune Limited Anti il-33 therapeutic agent fpr treating renal disorders
WO2021180858A1 (en) 2020-03-13 2021-09-16 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
AU2021236306A1 (en) 2020-03-13 2022-09-15 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
AU2021253117A1 (en) * 2020-04-06 2022-12-01 Medimmune Limited Treating acute respiratory distress syndrome with IL-33 axis binding antagonists
KR20230010239A (ko) 2020-05-11 2023-01-18 메디뮨 리미티드 항-il-33 항체의 제형물
CN111620948B (zh) * 2020-06-10 2022-04-08 南京赛新生物科技有限公司 针对il-33的抗体
KR20220022226A (ko) * 2020-08-18 2022-02-25 성균관대학교산학협력단 Il-33 항체 또는 이의 항원 결합 단편
CN113603775B (zh) * 2021-09-03 2022-05-20 江苏荃信生物医药股份有限公司 抗人白介素-33单克隆抗体及其应用
WO2023108101A1 (en) * 2021-12-09 2023-06-15 Emory University Antibodies that inhibit glycoprotein ib-ix mediated platelet signaling and uses in managing bleeding conditions
CN114397289A (zh) * 2022-01-14 2022-04-26 长春工业大学 一种土壤中重金属元素定量分析方法及相关设备
WO2023160610A1 (en) * 2022-02-24 2023-08-31 Sinomab Bioscience Limited Bispecific binding proteins against alarmins and uses thereof
TW202402790A (zh) 2022-03-25 2024-01-16 英商梅迪繆思有限公司 減少呼吸系統感染之方法
WO2024038185A1 (en) 2022-08-19 2024-02-22 Medimmune Limited Method of selecting patients for treatment with an il-33 axis antagonist
CN115947844A (zh) * 2022-12-09 2023-04-11 江苏荃信生物医药股份有限公司 一种新的抗人il-33单克隆抗体、包含其的试剂盒及其检测方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754065A (en) 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
ATE395413T1 (de) 2001-12-03 2008-05-15 Amgen Fremont Inc Antikörperkategorisierung auf der grundlage von bindungseigenschaften
NZ540730A (en) 2002-12-24 2010-09-30 Rinat Neuroscience Corp Anti-NGF antibodies and methods using same
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
WO2008144610A1 (en) 2007-05-18 2008-11-27 Medimmune, Llc Il-33 in inflammatory disease
AU2009231733B2 (en) 2008-03-31 2015-12-24 Genentech, Inc. Compositions and methods for treating and diagnosing asthma
WO2011031600A1 (en) 2009-09-10 2011-03-17 Schering Corporation Use of il-33 antagonists to treat fibrotic disease
BR112013013460A8 (pt) 2010-12-16 2019-02-12 Genentech Inc métodos de identificação de um paciente com asma, método de monitoramento de um paciente com asma, uso de um kit de detecção de periostina total, kit de medição da periostina total, uso de um anticorpo anti-il-13, uso de uma quantidade terapeuticamente eficaz de lebrikizumab, uso de um inibidor da via de th2, método de avaliação de eventos adversos, anticorpo anti-periostina e teste de periostina total
WO2012113813A1 (en) 2011-02-23 2012-08-30 F. Hoffmann-La Roche Ag Antibodies against human il33r and uses thereof
FR2972006B1 (fr) 2011-02-24 2016-03-25 Centre Nat Rech Scient Nouveaux fragments d'il-33 superactifs et leurs utilisations
EP2817417B1 (en) 2012-02-24 2017-10-25 Children's Hospital Medical Center Esophageal microrna expression profiles in eosinophilic esophagitis
AR091069A1 (es) 2012-05-18 2014-12-30 Amgen Inc Proteinas de union a antigeno dirigidas contra el receptor st2
AU2013320355B2 (en) 2012-09-19 2018-06-14 Innate Pharma KIR3DL2 binding agents
US20150250808A1 (en) 2012-10-15 2015-09-10 Vojo P. Deretic Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits
JO3532B1 (ar) * 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
WO2014152195A1 (en) 2013-03-15 2014-09-25 Regeneron Pharmaceuticals, Inc. Il-33 antagonists and uses thereof
WO2015099175A1 (ja) * 2013-12-26 2015-07-02 田辺三菱製薬株式会社 ヒト抗ｉｌ－３３中和モノクローナル抗体
RU2019118984A (ru) * 2014-01-10 2019-08-06 Анаптисбайо, Инк. Антитела, направленные против интерлейкина-33 (il-33)
US10040859B2 (en) 2014-04-21 2018-08-07 The Children's Hospital Of Philadelphia Methods of treating hemophagocytic lymphohistiocytosis with an IL-33 receptor antibody
EP3218403B1 (en) 2014-11-10 2020-05-13 F.Hoffmann-La Roche Ag Anti-interleukin-33 antibodies and uses thereof
US20160168640A1 (en) 2014-11-10 2016-06-16 Genentech, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
EP3733701A1 (en) 2015-03-31 2020-11-04 MedImmune Limited A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same
US10005834B2 (en) 2015-10-06 2018-06-26 Regeneron Pharmaceuticals, Inc. Biomarkers related to interleukin-33 (IL-33)-mediated diseases and uses thereof
BR112018014247A2 (pt) 2016-01-14 2018-12-18 Anaptysbio Inc inibição de reação alérgica usando um inibidor il-33

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