PE20171133A1 - Particulas tipo virus modificadas de cmv - Google Patents
Particulas tipo virus modificadas de cmvInfo
- Publication number
- PE20171133A1 PE20171133A1 PE2017000737A PE2017000737A PE20171133A1 PE 20171133 A1 PE20171133 A1 PE 20171133A1 PE 2017000737 A PE2017000737 A PE 2017000737A PE 2017000737 A PE2017000737 A PE 2017000737A PE 20171133 A1 PE20171133 A1 PE 20171133A1
- Authority
- PE
- Peru
- Prior art keywords
- cmv
- polypeptide
- virus particles
- modified virus
- refers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/08—RNA viruses
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- C—CHEMISTRY; METALLURGY
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C12N2760/00011—Details
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- C12N2760/00011—Details
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- Cell Biology (AREA)
Abstract
Se refiere a una particula tipo virus (VLP) modificada del virus del mosaico del pepino (CMV) que consiste, por lo menos, en un polipeptido de CMV modificado, donde dicho polipeptido comprende: a) un polipeptido de CMV que a su vez comprende una secuencia de aminoacidos de una proteina de recubrimiento CMV o una secuencia de aminoacidos de una proteina de recubrimiento de CMV mutado; y b) un epitopo de celula T ayudante. Tambien se refiere a una composicion farmaceutica y a una vacuna. Dicha modificacion induce una buena respuesta de celulas T ayudantes en todos los sujetos
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MA40824A (fr) * | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
WO2017179025A1 (en) | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
WO2017186808A1 (en) * | 2016-04-27 | 2017-11-02 | Allergy Therapeutics (Uk) Limited | Treatment of peanut allergy |
CN109562156B (zh) * | 2016-04-27 | 2023-03-10 | 标杆动物健康有限公司 | 犬特应性皮炎的治疗 |
JP7365240B2 (ja) | 2017-03-07 | 2023-10-19 | ウニヴェルズィテート チューリッヒ | 馬の掻痒の治療 |
TWI741241B (zh) * | 2017-12-11 | 2021-10-01 | 美商聯合生物醫學公司 | 用於治療及/或預防異位性皮膚炎之il-31胜肽免疫原及其劑型 |
MA52011A (fr) * | 2018-03-16 | 2021-01-20 | Zoetis Services Llc | Vaccins peptidiques contre l'interleukine-31 |
MX2020010621A (es) | 2018-04-10 | 2020-10-20 | Ac Immune Sa | Vacunas terapeuticas anti-abeta. |
JP2021525754A (ja) | 2018-05-28 | 2021-09-27 | エヴァックス アーゲー | じんましんの治療 |
BR112021012055A2 (pt) * | 2018-12-20 | 2021-11-16 | Saiba AG | Partículas semelhantes a vírus do cmv modificado por fusão |
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WO2021260131A1 (en) | 2020-06-25 | 2021-12-30 | Saiba AG | Virus-like particles of cmv modified by fusion |
AU2021383841A1 (en) * | 2020-11-23 | 2023-06-22 | Scout Bio, Inc. | Antigen-binding molecules and uses thereof |
CN112724204B (zh) * | 2020-12-15 | 2023-12-19 | 深圳赫兹生命科学技术有限公司 | 一种用于生产vlp重组疫苗的cmv病毒样颗粒及其制备方法 |
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WO2023161527A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN |
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