PE20141265A1 - FREEZE-DRIED FORMULATIONS OF FGF-18 - Google Patents
FREEZE-DRIED FORMULATIONS OF FGF-18Info
- Publication number
- PE20141265A1 PE20141265A1 PE2013002832A PE2013002832A PE20141265A1 PE 20141265 A1 PE20141265 A1 PE 20141265A1 PE 2013002832 A PE2013002832 A PE 2013002832A PE 2013002832 A PE2013002832 A PE 2013002832A PE 20141265 A1 PE20141265 A1 PE 20141265A1
- Authority
- PE
- Peru
- Prior art keywords
- concentration
- fgf
- vial
- seq
- freeze
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
REFERIDO A UNA FORMULACION LIOFILIZADA ESTABLE QUE COMPRENDE: A) FACTOR DE CRECIMIENTO DE FIBROBLASTOS 18 (FGF-18), CON UNA CONCENTRACION DE 20 A 300 mcg/VIAL, EL CUAL SE SELECCIONA DE: a) UN POLIPEPTIDO QUE COMPRENDE LOS RESIDUOS DE AMINOACIDO 28-207 DE SEQ ID NO:1, b) UN POLIPETIDO QUE COMPRENDE LOS RESIDUOS DE AMINOACIDOS 28-196 DE SEQ ID NO:1 Y c) UN POLIPEPTIDO QUE COMPRENDE LA SEQ ID NO:2; B) UN TAMPON QUE MANTIENE UN pH ENTRE 6 Y 8, TAL COMO FOSFATO, CON UNA CONCENTRACION DE 5 A 100 mM; C) UN TENSIOACTIVO DE POLOXAMERO, TAL COMO POLOXAMERO 188, CON UNA CONCENTRACION DE 0,1 A 0,4 mg/VIAL; Y D) UN AZUCAR COMO AGENTE ESTABILIZANTE, TAL COMO SACAROSA, CON UNA CONCENTRACION DE 10 A 60 mg/ VIAL. REFERIDO ADEMAS A UN METODO PARA PRODUCIR LA FORMULACION LIOFILIZADA. DICHA FORMULACION ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS DE LOS CARTILAGOS TALES COMO OSTEOARTRITIS O LESION DE LOS CARTILAGOSREFERRED TO A STABLE LYOPHILIZED FORMULATION THAT INCLUDES: A) FIBROBLAST GROWTH FACTOR 18 (FGF-18), WITH A CONCENTRATION OF 20 TO 300 mcg / VIAL, WHICH IS SELECTED FROM: a) A POLYPEPTIDE THAT INCLUDES AMMODIUM RESIDUES 28-207 OF SEQ ID NO: 1, b) A POLYPEPTIDE INCLUDING THE RESIDUES OF AMINO ACIDS 28-196 OF SEQ ID NO: 1 AND c) A POLYPEPTIDE INCLUDING SEQ ID NO: 2; B) A BUFFER THAT MAINTAINS A pH BETWEEN 6 AND 8, SUCH AS PHOSPHATE, WITH A CONCENTRATION OF 5 TO 100 mM; C) A POLOXAMER SURFACTANT, SUCH AS POLOXAMER 188, WITH A CONCENTRATION OF 0.1 TO 0.4 mg / VIAL; AND D) A SUGAR AS A STABILIZING AGENT, SUCH AS SACROSE, WITH A CONCENTRATION OF 10 TO 60 mg / VIAL. ALSO REFERRED TO A METHOD TO PRODUCE THE LYOPHILIZED FORMULATION. SUCH FORMULATION IS USEFUL FOR THE TREATMENT OF DISORDERS OF THE CARTILAGES SUCH AS OSTEOARTHRITIS OR INJURY OF THE CARTILAGES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11170437 | 2011-06-17 | ||
US201161499216P | 2011-06-21 | 2011-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20141265A1 true PE20141265A1 (en) | 2014-09-29 |
Family
ID=47356563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002832A PE20141265A1 (en) | 2011-06-17 | 2012-06-15 | FREEZE-DRIED FORMULATIONS OF FGF-18 |
Country Status (31)
Country | Link |
---|---|
US (2) | US9326944B2 (en) |
EP (2) | EP3056211A1 (en) |
JP (1) | JP5981538B2 (en) |
KR (1) | KR102019520B1 (en) |
CN (2) | CN103619347A (en) |
AR (1) | AR086956A1 (en) |
AU (1) | AU2012268987B2 (en) |
BR (1) | BR112013032400B1 (en) |
CA (1) | CA2836667C (en) |
CL (1) | CL2013003618A1 (en) |
CO (1) | CO6940377A2 (en) |
CY (1) | CY1117933T1 (en) |
DK (1) | DK2720710T3 (en) |
EA (1) | EA024937B1 (en) |
EC (1) | ECSP14013157A (en) |
ES (1) | ES2575732T3 (en) |
HR (1) | HRP20160566T1 (en) |
HU (1) | HUE028355T2 (en) |
IL (1) | IL229977A (en) |
MX (1) | MX338017B (en) |
MY (1) | MY170630A (en) |
PE (1) | PE20141265A1 (en) |
PL (1) | PL2720710T3 (en) |
PT (1) | PT2720710E (en) |
RS (1) | RS54875B1 (en) |
SG (1) | SG195021A1 (en) |
SI (1) | SI2720710T1 (en) |
TW (1) | TWI527590B (en) |
UA (1) | UA113174C2 (en) |
WO (1) | WO2012172072A1 (en) |
ZA (1) | ZA201308698B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI527590B (en) * | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Freeze-dried formulations of fgf-18 |
SG11201604972TA (en) * | 2013-12-24 | 2016-07-28 | Ares Trading Sa | Fgf-18 formulation in alginate/collagen hydrogels |
US20180236032A1 (en) * | 2015-08-13 | 2018-08-23 | Merck Patent Gmbh | Combination composition comprising fgf-18 compound |
WO2019092637A1 (en) * | 2017-11-10 | 2019-05-16 | Novartis Ag | Extended release formulations for intra-articular applications |
CN109836487B (en) * | 2019-03-01 | 2022-06-17 | 重庆派金生物科技有限公司 | Human fibroblast growth factor 18, and soluble recombinant expression method, preparation and application thereof |
CN112121150A (en) * | 2019-06-24 | 2020-12-25 | 杭州生物医药创新研究中心 | Fibroblast growth factor 10 freeze-dried powder |
CN113304063A (en) * | 2021-04-23 | 2021-08-27 | 四川省恩乐生物工程有限公司 | Composition for skin beautifying and anti-aging and preparation method thereof |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
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US5217954A (en) * | 1990-04-04 | 1993-06-08 | Scios Nova Inc. | Formulations for stabilizing fibroblast growth factor |
GB9015824D0 (en) | 1990-07-18 | 1990-09-05 | Erba Carlo Spa | Stable pharmaceutical compositions containing a fibroblast growth factor |
CN1151842C (en) * | 1995-07-27 | 2004-06-02 | 基因技术股份有限公司 | Stable isotonic lyophilized protein formulation |
US20010056066A1 (en) * | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
PT931148E (en) | 1996-10-16 | 2006-06-30 | Zymogenetics Inc | HOMOLOGES OF THE FIBROBLASTIC GROWTH FACTOR |
CN1184673A (en) * | 1996-12-13 | 1998-06-17 | 中国医科大学 | FGF raw extraction polypeptide growth factor mixture, and extraction process therefor |
US6451303B1 (en) | 1998-10-13 | 2002-09-17 | Chiron Corporation | Method of treating coronary artery disease by administering a recombinant FGF |
AU1804201A (en) | 1999-12-02 | 2001-06-12 | Zymogenetics Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or-2 |
CN1303714A (en) * | 2000-01-13 | 2001-07-18 | 重庆多泰制药有限公司 | II type collagen oral gastric solubility preparation |
US7754686B2 (en) * | 2000-08-31 | 2010-07-13 | Novartis Vaccines And Diagnostics, Inc. | Stabilized FGF formulations containing reducing agents |
JP4317010B2 (en) * | 2001-07-25 | 2009-08-19 | ピーディーエル バイオファーマ,インコーポレイティド | Stable lyophilized pharmaceutical formulation of IgG antibody |
DE10204792A1 (en) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilized preparation containing immunocytokines |
AU2003279835B2 (en) * | 2002-10-07 | 2009-09-10 | Zymogenetics, Inc. | Methods of administering FGF18 |
CA2517310C (en) * | 2003-02-28 | 2015-11-24 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations comprising a poloxamer |
BRPI0510527A (en) * | 2004-06-01 | 2007-10-30 | Ares Trading Sa | protein stabilization method |
JP5948627B2 (en) * | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | Fibroblast growth factor (FGF) remodeling and carbohydrate pegylation |
PT1828239E (en) | 2004-12-10 | 2011-10-27 | Zymogenetics Inc | Fgf18 production in prokaryotic hosts |
KR101378194B1 (en) * | 2005-12-20 | 2014-03-27 | 브리스톨-마이어스 스큅 컴퍼니 | Stable protein formulations |
JP4729740B2 (en) * | 2006-01-11 | 2011-07-20 | 独立行政法人産業技術総合研究所 | Mutant growth factor with altered receptor specificity and pharmaceutical composition containing the same |
EP1986612B1 (en) | 2006-02-07 | 2012-09-12 | Shire Human Genetic Therapies, Inc. | Stabilized composition of glucocerebrosidase |
JP5815206B2 (en) | 2006-08-25 | 2015-11-17 | アレス トレーディング ソシエテ アノニム | Treatment of cartilage disorders using FGF-18 |
CN101663046B (en) * | 2007-03-30 | 2017-07-28 | Ambrx公司 | Through modifying the polypeptides of FGF 21 and its purposes |
BRPI0809583B1 (en) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Modified fgf-21 polypeptide, composition comprising the same, method for producing said fgf-21 polypeptide, and cell comprising a polynucleotide |
CN101181280B (en) * | 2007-11-23 | 2010-07-14 | 深圳万乐药业有限公司 | Pirarubicin freeze-dry preparations and preparation method thereof |
AU2008340429C1 (en) * | 2007-12-21 | 2016-09-08 | F. Hoffmann-La Roche Ag | Antibody formulation |
TWI527590B (en) * | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Freeze-dried formulations of fgf-18 |
-
2012
- 2012-06-11 TW TW101120864A patent/TWI527590B/en active
- 2012-06-15 BR BR112013032400-7A patent/BR112013032400B1/en active IP Right Grant
- 2012-06-15 KR KR1020137034615A patent/KR102019520B1/en active IP Right Grant
- 2012-06-15 EA EA201490032A patent/EA024937B1/en not_active IP Right Cessation
- 2012-06-15 MX MX2013014894A patent/MX338017B/en active IP Right Grant
- 2012-06-15 AU AU2012268987A patent/AU2012268987B2/en active Active
- 2012-06-15 JP JP2014515216A patent/JP5981538B2/en active Active
- 2012-06-15 SI SI201230600A patent/SI2720710T1/en unknown
- 2012-06-15 DK DK12728509.6T patent/DK2720710T3/en active
- 2012-06-15 MY MYPI2013702439A patent/MY170630A/en unknown
- 2012-06-15 PT PT127285096T patent/PT2720710E/en unknown
- 2012-06-15 PL PL12728509.6T patent/PL2720710T3/en unknown
- 2012-06-15 PE PE2013002832A patent/PE20141265A1/en not_active Application Discontinuation
- 2012-06-15 EP EP16161448.2A patent/EP3056211A1/en not_active Withdrawn
- 2012-06-15 ES ES12728509.6T patent/ES2575732T3/en active Active
- 2012-06-15 CN CN201280029683.2A patent/CN103619347A/en active Pending
- 2012-06-15 EP EP12728509.6A patent/EP2720710B1/en active Active
- 2012-06-15 WO PCT/EP2012/061495 patent/WO2012172072A1/en active Application Filing
- 2012-06-15 CA CA2836667A patent/CA2836667C/en active Active
- 2012-06-15 HU HUE12728509A patent/HUE028355T2/en unknown
- 2012-06-15 AR ARP120102140A patent/AR086956A1/en not_active Application Discontinuation
- 2012-06-15 US US14/126,937 patent/US9326944B2/en active Active
- 2012-06-15 RS RS20160453A patent/RS54875B1/en unknown
- 2012-06-15 CN CN201710984784.XA patent/CN107715104A/en active Pending
- 2012-06-15 SG SG2013085162A patent/SG195021A1/en unknown
- 2012-06-15 UA UAA201314452A patent/UA113174C2/en unknown
-
2013
- 2013-11-20 ZA ZA2013/08698A patent/ZA201308698B/en unknown
- 2013-12-17 CL CL2013003618A patent/CL2013003618A1/en unknown
- 2013-12-17 IL IL229977A patent/IL229977A/en active IP Right Grant
-
2014
- 2014-01-15 CO CO14006968A patent/CO6940377A2/en unknown
- 2014-01-17 EC EC2014013157A patent/ECSP14013157A/en unknown
-
2016
- 2016-04-26 US US15/138,240 patent/US20160228374A1/en not_active Abandoned
- 2016-05-27 HR HRP20160566TT patent/HRP20160566T1/en unknown
- 2016-06-22 CY CY20161100564T patent/CY1117933T1/en unknown
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