PE20131096A1 - Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico - Google Patents

Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico

Info

Publication number
PE20131096A1
PE20131096A1 PE2013000186A PE2013000186A PE20131096A1 PE 20131096 A1 PE20131096 A1 PE 20131096A1 PE 2013000186 A PE2013000186 A PE 2013000186A PE 2013000186 A PE2013000186 A PE 2013000186A PE 20131096 A1 PE20131096 A1 PE 20131096A1
Authority
PE
Peru
Prior art keywords
pyrane
indol
dihydro
fluoro
amine
Prior art date
Application number
PE2013000186A
Other languages
English (en)
Inventor
Nadja Gruning
Marc Schiller
Ingo Friedrich
Chris Kirby
Ashish Hemani
John Bothmer
Andreas Scholz
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45556332&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131096(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20131096A1 publication Critical patent/PE20131096A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UNA FORMA DE DOSIFICACION FARMACEUTICA QUE CONTIENE UN COMPUESTO DE FORMULA (I), DONDE R ES H O CH3. SON COMPUESTOS FAVORITOS: (1r,4r)-6'-FLUORO-N,N-DIMETIL-4-FENIL-4',9'-DIHIDRO-3'H-ESPIRO[CICLOHEXAN-1,1'-PIRANO[3,4,b]INDOL]-4-AMINA, (1r,4r)-6'-FLUORO-N-METIL-4-FENIL-4',9'-DIHIDRO-3'H-ESPIRO[CICLOHEXAN-1,1'-PIRANO[3,4,b]INDOL]-4-AMINA O UNA SAL DE LOS MISMOS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DEL DOLOR NOCICEPTIVO AGUDO O CRONICO
PE2013000186A 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico PE20131096A1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US37064310P 2010-08-04 2010-08-04
US37064810P 2010-08-04 2010-08-04
US37063410P 2010-08-04 2010-08-04
EP10008116 2010-08-04
EP10008115 2010-08-04
EP10008117 2010-08-04

Publications (1)

Publication Number Publication Date
PE20131096A1 true PE20131096A1 (es) 2013-10-10

Family

ID=45556332

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013000187A PE20131084A1 (es) 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor nociceptivo
PE2013000186A PE20131096A1 (es) 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2013000187A PE20131084A1 (es) 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor nociceptivo

Country Status (28)

Country Link
US (3) US20120034297A1 (es)
EP (3) EP2600851B1 (es)
JP (2) JP5792298B2 (es)
KR (2) KR20130097173A (es)
CN (2) CN103260610A (es)
AU (2) AU2011287955B2 (es)
BR (2) BR112013002734A2 (es)
CA (2) CA2805523C (es)
CL (2) CL2013000218A1 (es)
CO (2) CO6670579A2 (es)
DK (2) DK2600850T3 (es)
EC (2) ECSP13012423A (es)
ES (1) ES2675316T3 (es)
HR (2) HRP20180904T1 (es)
HU (1) HUE039328T2 (es)
IL (2) IL224155A (es)
LT (2) LT2600851T (es)
MX (2) MX354686B (es)
NZ (2) NZ605888A (es)
PE (2) PE20131084A1 (es)
PL (2) PL2600850T3 (es)
PT (1) PT2600851T (es)
RS (2) RS57344B1 (es)
RU (2) RU2638818C2 (es)
SI (2) SI2600851T1 (es)
TR (1) TR201808244T4 (es)
WO (2) WO2012016698A2 (es)
ZA (1) ZA201300655B (es)

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Also Published As

Publication number Publication date
ECSP13012422A (es) 2013-03-28
DK2600851T3 (en) 2018-06-25
CA2805525A1 (en) 2012-02-09
JP5792299B2 (ja) 2015-10-07
PE20131084A1 (es) 2013-10-10
AU2011287954B2 (en) 2015-07-09
EP2600851A2 (en) 2013-06-12
HRP20180904T1 (hr) 2018-08-24
CA2805523C (en) 2018-06-12
CN103237545A (zh) 2013-08-07
SI2600850T1 (sl) 2018-12-31
LT2600850T (lt) 2018-12-10
EP2600851B1 (en) 2018-05-02
RU2631481C2 (ru) 2017-09-22
CL2013000225A1 (es) 2013-04-01
US9289416B2 (en) 2016-03-22
WO2012016697A2 (en) 2012-02-09
RS58017B1 (sr) 2019-02-28
US20160361294A1 (en) 2016-12-15
CN103260610A (zh) 2013-08-21
CO6680626A2 (es) 2013-05-31
SI2600851T1 (en) 2018-07-31
MX2013001345A (es) 2013-03-22
KR20130097173A (ko) 2013-09-02
WO2012016698A2 (en) 2012-02-09
US20150111939A1 (en) 2015-04-23
PL2600851T3 (pl) 2018-08-31
AU2011287954A1 (en) 2013-01-31
HRP20181856T1 (hr) 2018-12-28
KR20130137600A (ko) 2013-12-17
RU2638818C2 (ru) 2017-12-15
EP3459533A1 (en) 2019-03-27
WO2012016698A3 (en) 2012-08-16
IL224155A (en) 2017-05-29
WO2012016697A3 (en) 2012-08-16
JP2013532696A (ja) 2013-08-19
TR201808244T4 (tr) 2018-07-23
ES2675316T3 (es) 2018-07-10
CL2013000218A1 (es) 2013-03-15
ZA201300655B (en) 2013-09-25
CA2805523A1 (en) 2012-02-09
NZ605887A (en) 2014-08-29
ECSP13012423A (es) 2013-03-28
PT2600851T (pt) 2018-06-19
AU2011287955A1 (en) 2013-02-07
RS57344B1 (sr) 2018-08-31
CO6670579A2 (es) 2013-05-15
RU2013109135A (ru) 2014-09-10
JP2013532697A (ja) 2013-08-19
CA2805525C (en) 2018-10-09
BR112013003677A2 (pt) 2016-09-06
JP5792298B2 (ja) 2015-10-07
AU2011287955B2 (en) 2015-07-09
EP2600850B1 (en) 2018-10-17
DK2600850T3 (en) 2018-12-03
NZ605888A (en) 2014-08-29
LT2600851T (lt) 2018-06-25
BR112013002734A2 (pt) 2016-06-07
MX2013001289A (es) 2013-03-22
MX354686B (es) 2018-03-15
MX350154B (es) 2017-08-29
US20120034297A1 (en) 2012-02-09
IL224154B (en) 2018-10-31
RU2013109137A (ru) 2014-09-10
HUE039328T2 (hu) 2018-12-28
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US10912763B2 (en) 2021-02-09

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