PE20091567A1 - Derivados de metastina en el tratamiento del cancer - Google Patents
Derivados de metastina en el tratamiento del cancerInfo
- Publication number
- PE20091567A1 PE20091567A1 PE2009000637A PE2009000637A PE20091567A1 PE 20091567 A1 PE20091567 A1 PE 20091567A1 PE 2009000637 A PE2009000637 A PE 2009000637A PE 2009000637 A PE2009000637 A PE 2009000637A PE 20091567 A1 PE20091567 A1 PE 20091567A1
- Authority
- PE
- Peru
- Prior art keywords
- asn
- trp
- alkyl
- arg
- azagly
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000006332 Choriocarcinoma Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 206010033647 Pancreatitis acute Diseases 0.000 abstract 1
- 201000003229 acute pancreatitis Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE METASTINA DE FORMULA (I) DONDE V ES UN COMPUESTO DE FORMULA (a) O (b), EN DONDE W1 ES N, CH U O; W2 ES N O CH; Q1 ES ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON UN CICLICO AROMATICO FUSIONADO (C8-C14), HETEROCICLICO NO AROMATICO, ENTRE OTROS; P Y P' SON CADA UNO H, UN RESIDUO DE AMINOACIDO TALES COMO Asn-, Trp Asn-, Asn Trp Asn-, ENTRE OTROS; n ES 0 O 1; Z1, Z3, Z5 Y Z7 SON CADA UNO H O ALQUILO(C1-C3); Z4, Z6 Y Z8 SON CADA UNO H, O U S; R2 ES H, ALQUILO(C1-C10) CICLICO O LINEAL, ENTRE OTROS; R3 ES ALQUILO(C1-C8), ARALQUILO, ENTRE OTROS; R4 ES ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON UN HIDROCARBURO AROMATICO(C6-C12), UN HETEROCICLICO AROMATICO DE 5 A 14 MIEMBROS, ENTRE OTROS; Q2 ES CH2, NH U O; Y ES -CONH-, -CSNH-, -CH2NH-, ENTRE OTROS; Z9 ES H, O U S. SON COMPUESTOS PREFERIDOS: BENZOIL-Asn-Ser-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2, D-Arg-Acp-D-Tyr-D-Trp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2, BENZOIL-Asn-Ser-Phe(4F)-AzaGly-Leu-Arg(Me)-Trp-NH2, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SUPRIMEN LA METASTASIS DEL CANCER SIENDO UTILES PARA EL TRATAMIENTO DE CARCINOMA PULMONAR, PANCREATITIS AGUDA, CARCINOMA CORIONICO
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004187671 | 2004-06-25 | ||
JP2004363311 | 2004-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091567A1 true PE20091567A1 (es) | 2009-11-03 |
Family
ID=34971534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000728A PE20060371A1 (es) | 2004-06-25 | 2005-06-23 | Derivados de metastina en el tratamiento del cancer |
PE2009000637A PE20091567A1 (es) | 2004-06-25 | 2005-06-23 | Derivados de metastina en el tratamiento del cancer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000728A PE20060371A1 (es) | 2004-06-25 | 2005-06-23 | Derivados de metastina en el tratamiento del cancer |
Country Status (20)
Country | Link |
---|---|
US (2) | US7625869B2 (es) |
EP (2) | EP1758932A2 (es) |
JP (3) | JP4346650B2 (es) |
CN (2) | CN101845091A (es) |
AR (1) | AR049938A1 (es) |
AU (1) | AU2005257484A1 (es) |
BR (1) | BRPI0512397A (es) |
CA (1) | CA2571420A1 (es) |
CL (1) | CL2008003730A1 (es) |
CR (1) | CR8828A (es) |
IL (1) | IL179640A0 (es) |
MA (1) | MA28903B1 (es) |
MX (1) | MXPA06014206A (es) |
NO (1) | NO20065957L (es) |
NZ (1) | NZ552029A (es) |
PE (2) | PE20060371A1 (es) |
RU (1) | RU2006145886A (es) |
SG (1) | SG153865A1 (es) |
TW (1) | TW200607816A (es) |
WO (1) | WO2006001499A2 (es) |
Families Citing this family (45)
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EP1494732B1 (en) | 2002-03-20 | 2008-01-30 | MannKind Corporation | Inhalation apparatus |
CA2511858A1 (en) | 2002-12-26 | 2004-07-29 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
CA2518541C (en) | 2003-03-12 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Gonadal function improving agents |
WO2005113147A2 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
NZ552029A (en) | 2004-06-25 | 2009-01-31 | Takeda Pharmaceutical | Metastin derivatives and use thereof |
KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
IN2014DN09128A (es) | 2005-09-14 | 2015-07-10 | Mannkind Corp | |
US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
AR058584A1 (es) * | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
BRPI0707991B8 (pt) | 2006-02-22 | 2021-05-25 | Mannkind Corp | métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco |
WO2007125619A1 (ja) * | 2006-04-26 | 2007-11-08 | Kyoto University | Gpr54アゴニスト活性を有する新規化合物 |
ITMI20061607A1 (it) | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
TWI404726B (zh) * | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
CN101528772B (zh) * | 2006-10-25 | 2013-03-13 | 武田药品工业株式会社 | Metastin衍生物及其用途 |
JPWO2009131191A1 (ja) * | 2008-04-24 | 2011-08-25 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
US8592379B2 (en) | 2008-04-30 | 2013-11-26 | Kyoto University | Metastin derivative and use thereof |
CN109568740B (zh) | 2008-06-13 | 2022-05-27 | 曼金德公司 | 干粉吸入器和用于药物输送的*** |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
ES2904623T3 (es) | 2008-06-20 | 2022-04-05 | Mannkind Corp | Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación |
EP2314609B1 (en) | 2008-07-30 | 2016-11-30 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
EA019738B1 (ru) * | 2008-12-29 | 2014-05-30 | Такеда Фармасьютикал Компани Лимитед | Профилактическое/терапевтическое средство против рака |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US8716228B2 (en) | 2009-05-27 | 2014-05-06 | Yeda Research And Development Co. Ltd. | GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
SG181436A1 (en) | 2009-12-22 | 2012-07-30 | Takeda Pharmaceutical | Sustained-release formulation |
KR20130117755A (ko) | 2010-06-21 | 2013-10-28 | 맨카인드 코포레이션 | 건조 분말 약물 운반 시스템 및 방법 |
US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
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BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
WO2013136338A1 (en) | 2012-03-14 | 2013-09-19 | Yeda Research And Development Co. Ltd At The Weizmann Institute Of Science | Modified kisspeptin peptides and uses thereof |
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JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
US10220069B2 (en) * | 2014-01-22 | 2019-03-05 | The Johns Hopkins University | Compositions and methods for treating diabetes |
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- 2005-06-23 CN CN200910225195A patent/CN101845091A/zh active Pending
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- 2005-06-23 AU AU2005257484A patent/AU2005257484A1/en not_active Abandoned
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- 2005-06-23 CN CN200910225194A patent/CN101863971A/zh active Pending
- 2005-06-23 WO PCT/JP2005/012021 patent/WO2006001499A2/en active Application Filing
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- 2005-06-23 EP EP09075257.7A patent/EP2113513B1/en active Active
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- 2006-12-22 CR CR8828A patent/CR8828A/es not_active Application Discontinuation
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- 2008-09-25 JP JP2008245073A patent/JP4654284B2/ja active Active
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Also Published As
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US20090298765A1 (en) | 2009-12-03 |
EP2113513A3 (en) | 2010-11-03 |
RU2006145886A (ru) | 2008-06-27 |
US20080312155A1 (en) | 2008-12-18 |
TW200607816A (en) | 2006-03-01 |
CN101845091A (zh) | 2010-09-29 |
NO20065957L (no) | 2007-01-25 |
CL2008003730A1 (es) | 2009-05-04 |
US8778871B2 (en) | 2014-07-15 |
SG153865A1 (en) | 2009-07-29 |
JP2009227687A (ja) | 2009-10-08 |
MXPA06014206A (es) | 2007-02-14 |
CR8828A (es) | 2007-07-19 |
BRPI0512397A (pt) | 2008-03-04 |
JP2009024028A (ja) | 2009-02-05 |
CA2571420A1 (en) | 2006-01-05 |
WO2006001499A3 (en) | 2006-03-02 |
AU2005257484A1 (en) | 2006-01-05 |
PE20060371A1 (es) | 2006-06-15 |
EP2113513B1 (en) | 2016-05-18 |
EP2113513A2 (en) | 2009-11-04 |
EP1758932A2 (en) | 2007-03-07 |
JP4654284B2 (ja) | 2011-03-16 |
MA28903B1 (fr) | 2007-10-01 |
CN101863971A (zh) | 2010-10-20 |
WO2006001499A2 (en) | 2006-01-05 |
US7625869B2 (en) | 2009-12-01 |
AR049938A1 (es) | 2006-09-13 |
JP4346650B2 (ja) | 2009-10-21 |
NZ552029A (en) | 2009-01-31 |
JP2008506632A (ja) | 2008-03-06 |
IL179640A0 (en) | 2007-05-15 |
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