PE20091038A1 - Bisfosfonatos de alquilo de 2 a 5 atomos de carbono-imidazol - Google Patents
Bisfosfonatos de alquilo de 2 a 5 atomos de carbono-imidazolInfo
- Publication number
- PE20091038A1 PE20091038A1 PE2008001990A PE2008001990A PE20091038A1 PE 20091038 A1 PE20091038 A1 PE 20091038A1 PE 2008001990 A PE2008001990 A PE 2008001990A PE 2008001990 A PE2008001990 A PE 2008001990A PE 20091038 A1 PE20091038 A1 PE 20091038A1
- Authority
- PE
- Peru
- Prior art keywords
- phosphone
- imidazol
- hydroxy
- ethyl
- carbon atoms
- Prior art date
Links
- 229940122361 Bisphosphonate Drugs 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title 1
- 150000004663 bisphosphonates Chemical class 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 206010049088 Osteopenia Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ACIDOS [(IMIDAZOL-1-IL)-1-HIDROXI-1-FOSFONO-ETIL]-FOSFONICOS SUSTITUIDOS POR ALQUILO(C2-C5) DE FORMULA (I) DONDE UNO DE R1 Y R2 ES H, Y EL OTRO ES ALQUILO(C2-C5). SON COMPUESTOS PREFERIDOS: ACIDO [2-(4-PROPIL-IMIDAZOL-1-IL)-1-HIDROXI-1-FOSFONO-ETIL]-FOSFONICO, ACIDO [2-(4-BUTIL-IMIDAZOL-1-IL)-1-HIDROXI-1-FOSFONO-ETIL]-FOSFONICO, ACIDO [1-HIDROXI-2-(4-ISOPROPIL-IMIDAZOL-1-IL)-1-FOSFONO-ETIL]-FOSFONICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA RESORCION OSEA EXCESIVA O INAPROPIADA SIENDO UTILES EN EL TRATAMIENTO DE OSTEOPOROSIS, OSTEOPENIA, OSTEOARTRITIS, ARTRITIS REUMATOIDE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07122016 | 2007-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091038A1 true PE20091038A1 (es) | 2009-08-19 |
Family
ID=39154111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001990A PE20091038A1 (es) | 2007-11-30 | 2008-11-27 | Bisfosfonatos de alquilo de 2 a 5 atomos de carbono-imidazol |
Country Status (24)
Country | Link |
---|---|
US (2) | US7977323B2 (es) |
EP (1) | EP2225252B1 (es) |
JP (1) | JP5244917B2 (es) |
KR (1) | KR20100092035A (es) |
CN (1) | CN101835787A (es) |
AR (1) | AR069437A1 (es) |
AU (1) | AU2008328797B2 (es) |
BR (1) | BRPI0819902A2 (es) |
CA (1) | CA2701516A1 (es) |
CL (1) | CL2008003545A1 (es) |
CO (1) | CO6280421A2 (es) |
CR (1) | CR11362A (es) |
EA (1) | EA201000860A1 (es) |
EC (1) | ECSP10010321A (es) |
ES (1) | ES2386851T3 (es) |
IL (1) | IL204657A0 (es) |
MA (1) | MA31895B1 (es) |
MX (1) | MX2010005786A (es) |
NZ (1) | NZ584219A (es) |
PE (1) | PE20091038A1 (es) |
TN (1) | TN2010000138A1 (es) |
TW (1) | TW200932248A (es) |
WO (1) | WO2009068567A1 (es) |
ZA (1) | ZA201001992B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110034418A1 (en) * | 2008-04-04 | 2011-02-10 | Karen Beltz | Pharmaceutical composition with bisphosphonate |
US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
CA2769633C (en) | 2009-07-31 | 2017-06-06 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
US9290526B2 (en) | 2010-05-28 | 2016-03-22 | The Royal Institution For The Advancement Of Learning/Mcgill University | Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof |
US8816082B2 (en) | 2010-05-28 | 2014-08-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof |
US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
CN102659840B (zh) * | 2012-05-10 | 2013-08-14 | 苏州普瑞诺药物技术有限公司 | 咪唑双膦酸类化合物及其可药用盐及药物用途 |
US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
CN111225672B (zh) | 2017-10-16 | 2023-09-29 | 清华大学 | 甲羟戊酸通路抑制剂及其药物组合物 |
CN112980809B (zh) * | 2021-03-17 | 2023-04-11 | 云南中烟工业有限责任公司 | 一种烟草法尼基焦磷酸合酶基因及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL84497A (en) | 1986-11-21 | 1994-10-21 | Ciba Geigy Ag | History 2-) Imidazol-1-yl (ethane-1,1-diphosphonic acid, their preparation and pharmaceutical preparations containing them |
DK0573604T3 (da) * | 1991-02-26 | 1995-05-29 | Procter & Gamble Pharma | Fremgangsmåde til behandling af osteoporosis |
GB9324143D0 (en) | 1993-11-24 | 1994-01-12 | Schering Agrochemicals Ltd | Triazole phosphonate pesticides |
GB0029018D0 (en) * | 2000-11-28 | 2001-01-10 | Strakan Group Plc | Dermatological formulations |
GB0029111D0 (en) | 2000-11-29 | 2001-01-10 | Novartis Ag | Organic compounds |
WO2008128056A1 (en) | 2004-10-08 | 2008-10-23 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps |
US7358361B2 (en) | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
AR063121A1 (es) | 2006-10-05 | 2008-12-30 | Novartis Ag | Composicion farmaceutica |
CA2682231A1 (en) | 2007-03-28 | 2008-10-09 | Array Biopharma Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
-
2008
- 2008-11-26 MX MX2010005786A patent/MX2010005786A/es active IP Right Grant
- 2008-11-26 CA CA2701516A patent/CA2701516A1/en not_active Abandoned
- 2008-11-26 US US12/323,696 patent/US7977323B2/en not_active Expired - Fee Related
- 2008-11-26 KR KR1020107014395A patent/KR20100092035A/ko not_active Application Discontinuation
- 2008-11-26 ES ES08854485T patent/ES2386851T3/es active Active
- 2008-11-26 CN CN200880112351A patent/CN101835787A/zh active Pending
- 2008-11-26 JP JP2010535369A patent/JP5244917B2/ja active Active
- 2008-11-26 EA EA201000860A patent/EA201000860A1/ru unknown
- 2008-11-26 EP EP08854485A patent/EP2225252B1/en active Active
- 2008-11-26 BR BRPI0819902-7A patent/BRPI0819902A2/pt not_active IP Right Cessation
- 2008-11-26 WO PCT/EP2008/066245 patent/WO2009068567A1/en active Application Filing
- 2008-11-26 AU AU2008328797A patent/AU2008328797B2/en not_active Ceased
- 2008-11-26 NZ NZ584219A patent/NZ584219A/en not_active IP Right Cessation
- 2008-11-27 PE PE2008001990A patent/PE20091038A1/es not_active Application Discontinuation
- 2008-11-27 AR ARP080105163A patent/AR069437A1/es active IP Right Grant
- 2008-11-28 TW TW097146484A patent/TW200932248A/zh unknown
- 2008-11-28 CL CL2008003545A patent/CL2008003545A1/es unknown
-
2010
- 2010-03-19 ZA ZA2010/01992A patent/ZA201001992B/en unknown
- 2010-03-22 IL IL204657A patent/IL204657A0/en unknown
- 2010-03-26 TN TNP2010000138A patent/TN2010000138A1/fr unknown
- 2010-04-09 CR CR11362A patent/CR11362A/es unknown
- 2010-05-26 CO CO10063351A patent/CO6280421A2/es not_active Application Discontinuation
- 2010-05-31 MA MA32880A patent/MA31895B1/fr unknown
- 2010-06-30 EC EC2010010321A patent/ECSP10010321A/es unknown
-
2011
- 2011-05-26 US US13/116,671 patent/US20110224173A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2386851T3 (es) | 2012-09-03 |
EP2225252A1 (en) | 2010-09-08 |
WO2009068567A1 (en) | 2009-06-04 |
MX2010005786A (es) | 2010-06-09 |
US7977323B2 (en) | 2011-07-12 |
AR069437A1 (es) | 2010-01-20 |
CL2008003545A1 (es) | 2009-06-05 |
MA31895B1 (fr) | 2010-12-01 |
CO6280421A2 (es) | 2011-05-20 |
JP5244917B2 (ja) | 2013-07-24 |
CR11362A (es) | 2010-06-14 |
EA201000860A1 (ru) | 2010-12-30 |
US20090143337A1 (en) | 2009-06-04 |
TN2010000138A1 (en) | 2011-09-26 |
TW200932248A (en) | 2009-08-01 |
CA2701516A1 (en) | 2009-06-04 |
KR20100092035A (ko) | 2010-08-19 |
IL204657A0 (en) | 2010-11-30 |
JP2011504908A (ja) | 2011-02-17 |
CN101835787A (zh) | 2010-09-15 |
AU2008328797B2 (en) | 2011-11-03 |
EP2225252B1 (en) | 2012-06-27 |
ZA201001992B (en) | 2010-12-29 |
BRPI0819902A2 (pt) | 2015-05-19 |
US20110224173A1 (en) | 2011-09-15 |
AU2008328797A1 (en) | 2009-06-04 |
ECSP10010321A (es) | 2010-08-31 |
NZ584219A (en) | 2012-03-30 |
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Legal Events
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FC | Refusal |