PE20090447A1 - Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores relacionados de la gamma secretasa - Google Patents
Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores relacionados de la gamma secretasaInfo
- Publication number
- PE20090447A1 PE20090447A1 PE2008001184A PE2008001184A PE20090447A1 PE 20090447 A1 PE20090447 A1 PE 20090447A1 PE 2008001184 A PE2008001184 A PE 2008001184A PE 2008001184 A PE2008001184 A PE 2008001184A PE 20090447 A1 PE20090447 A1 PE 20090447A1
- Authority
- PE
- Peru
- Prior art keywords
- gamma secretase
- secretase inhibitors
- bencensulfonil
- thiochromane
- chromane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA 1, DONDE X ES -O-, -S-, -S(O2)-, ENTRE OTROS; ----ES ENLACE OPCIONAL; Y, Z SON CADA UNO N, C; Q ES ANILLO DE 5-8 MIEMBROS FUSIONADOS CON A1 Y Q1; Q1 ES ANILLO DE 5-7 MIEMBROS CON UN HETEROATOMO SLEECIONADO DE N, O, S(O) Y S(O2) FUSIONADO CON Q; L1 ES HALOGENO, ALQUILO, -CN, -CF3, -O-(ALQUILO C1-C6), ENTRE OTROS; Ar ES ARILO SUSTITUIDO O NO, HETEROARILO SUSTITUIDO O NO. UN COMPUESTO PREFERIDO ES (5aR,13aS)-11bR-[(4-CLOROFENIL)SULFONIL]-8,11-DIFLUORO-2,3,5a,6,11b,12,13,13a-OCTAHIDRO[1]BENZOPIRANO[4',3':5,6]PIRIDO[1,2-c]PIRIMIDIN-4(1H)-ONA. DICHOS COMPUESTOS SON INHIBIDORES DE GAMMA SECRETASA UTILES EN EL TRATAMIENTO DE ALZHEIMER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95016007P | 2007-07-17 | 2007-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090447A1 true PE20090447A1 (es) | 2009-04-18 |
Family
ID=39831616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001184A PE20090447A1 (es) | 2007-07-17 | 2008-07-15 | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores relacionados de la gamma secretasa |
Country Status (13)
Country | Link |
---|---|
US (1) | US8618123B2 (es) |
EP (1) | EP2178882B1 (es) |
JP (1) | JP5204227B2 (es) |
KR (1) | KR20100044840A (es) |
CN (1) | CN101970445A (es) |
AR (1) | AR067560A1 (es) |
AU (1) | AU2008276492A1 (es) |
CA (1) | CA2693216A1 (es) |
CL (1) | CL2008002084A1 (es) |
PE (1) | PE20090447A1 (es) |
TW (1) | TW200904447A (es) |
WO (1) | WO2009011851A1 (es) |
ZA (1) | ZA201000191B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
US9226927B2 (en) | 2011-09-09 | 2016-01-05 | Merck Sharp & Dohme Corp. | Gamma secretase inhibitors |
JP6134654B2 (ja) | 2012-02-08 | 2017-05-24 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
JP6553746B2 (ja) * | 2015-05-07 | 2019-07-31 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | RORγ調節因子としての三環式スルホン類 |
JP7182553B2 (ja) * | 2016-11-09 | 2022-12-02 | ブリストル-マイヤーズ スクイブ カンパニー | Rorガンマ調節剤としての三環スルホン類 |
EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
CN111004198B (zh) * | 2019-12-24 | 2023-03-28 | 瑞安宝源化工有限公司 | 一种苯并吡喃衍生物的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01008606A (es) | 1999-02-26 | 2003-05-05 | Merck & Co Inc | Compuestos de sulfonamida novedosos y uso de los mismos. |
HUP0600673A3 (en) | 2001-08-03 | 2011-08-29 | Schering Corp | Tetrahydroquinolin derivatives as gamma secretase inhibitors nad pharmaceutical compositions containing them |
GB0223039D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
EP1638951B1 (en) * | 2003-05-16 | 2008-02-13 | MERCK SHARP & DOHME LTD. | Cyclohexyl sulphones as gamma-secretase inhibitors |
MX2008009414A (es) * | 2006-01-20 | 2008-10-01 | Schering Corp | Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa. |
UY30377A1 (es) | 2006-06-02 | 2008-01-02 | Elan Pharm Inc | Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa |
US8664411B2 (en) | 2007-07-05 | 2014-03-04 | Merck Sharp & Dohme Corp. | Tetrahydropyranochromene gamma secretase inhibitors |
-
2008
- 2008-07-15 PE PE2008001184A patent/PE20090447A1/es not_active Application Discontinuation
- 2008-07-15 CA CA2693216A patent/CA2693216A1/en not_active Abandoned
- 2008-07-15 US US12/668,550 patent/US8618123B2/en active Active
- 2008-07-15 KR KR1020107003118A patent/KR20100044840A/ko not_active Application Discontinuation
- 2008-07-15 EP EP08794506.9A patent/EP2178882B1/en active Active
- 2008-07-15 CN CN2008801070409A patent/CN101970445A/zh active Pending
- 2008-07-15 AU AU2008276492A patent/AU2008276492A1/en not_active Abandoned
- 2008-07-15 CL CL2008002084A patent/CL2008002084A1/es unknown
- 2008-07-15 JP JP2010517007A patent/JP5204227B2/ja not_active Expired - Fee Related
- 2008-07-15 WO PCT/US2008/008646 patent/WO2009011851A1/en active Application Filing
- 2008-07-16 AR ARP080103050A patent/AR067560A1/es not_active Application Discontinuation
- 2008-07-16 TW TW097127012A patent/TW200904447A/zh unknown
-
2010
- 2010-01-11 ZA ZA2010/00191A patent/ZA201000191B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2178882B1 (en) | 2013-04-17 |
US8618123B2 (en) | 2013-12-31 |
AU2008276492A1 (en) | 2009-01-22 |
CL2008002084A1 (es) | 2009-01-23 |
US20110110948A1 (en) | 2011-05-12 |
AU2008276492A2 (en) | 2010-02-18 |
CN101970445A (zh) | 2011-02-09 |
JP5204227B2 (ja) | 2013-06-05 |
KR20100044840A (ko) | 2010-04-30 |
TW200904447A (en) | 2009-02-01 |
WO2009011851A1 (en) | 2009-01-22 |
EP2178882A1 (en) | 2010-04-28 |
ZA201000191B (en) | 2011-06-29 |
JP2010533713A (ja) | 2010-10-28 |
CA2693216A1 (en) | 2009-01-22 |
AR067560A1 (es) | 2009-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20090447A1 (es) | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores relacionados de la gamma secretasa | |
CY1118239T1 (el) | Πυραζολο[1,5-α]πυριμιδινες και -τριαζινες ως αντι-ιικοι παραγοντες | |
PE20121312A1 (es) | Metodo para preparar compuestos macrociclicos inhibidores de serina proteasas de hepatitis c | |
PE20130012A1 (es) | Derivados de pirazol como inhibidores de jak | |
PE20081612A1 (es) | Analogos de las pterinas | |
PE20071090A1 (es) | 5-pirazolpiperidinas-(sustituidas) | |
PE20081192A1 (es) | Tratamiento del dolor | |
PE20130346A1 (es) | Compuestos heterociclicos fusionados | |
PE20091085A1 (es) | NUEVOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA E IMIDAZO[1,2-b]-PIRIDAZINA | |
PE20140390A1 (es) | Derivados de imidazo[1,2-b]piridazina e imidazo[4,5-b]piridina como inhibidores de jak | |
PE20091039A1 (es) | IMIDAZO PIRAZINAS FUSIONADAS ARILO Y HETEROARILO [1,5-a] COMO INHIBIDORES DE LA FOSFODIESTERASA 10 | |
TW200740806A (en) | Bridged N-cyclic sulfonamido inhibitors of gamma secretase | |
PE20151249A1 (es) | Derivados de pirazolopirimidina como inhibidores de jak quinasas | |
TN2011000244A1 (en) | Organic compounds | |
PE20080893A1 (es) | Triazoles biciclicos como moduladores de la proteina cinasa | |
NZ594567A (en) | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators | |
MX2013006101A (es) | Compuestos heterociclicos nitrogenados sustituidos fusionados en posicion 6,6 y usos de los mismos. | |
EA201170770A1 (ru) | Органические соединения | |
PE20040832A1 (es) | Derivados de indolil pirazinona | |
PE20030922A1 (es) | Derivados de piridina y quinolina | |
PE20060455A1 (es) | Nucleosidos de 3-beta-d-ribofuranosiltiazolo[4,5-d]pirimidina | |
PE20080988A1 (es) | Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa | |
AR059937A1 (es) | Compuesto de pirido (2,3-d) pirimidin -7-ona o compuesto que contiene 3,4- dihidropirimido (4,5-d) pirimidin -2 (1h) -ona y proceso para su preparacion | |
PE20070010A1 (es) | Penemes triciclicos de 6-alquilideno como inhibidores de beta-lactasas clase d | |
PE20090049A1 (es) | Derivados de piridopirimidina como moduladores de la actividad de pde 4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |