PE20090143A1 - Inhibidores no nucleosidos de transcriptasa inversa - Google Patents

Inhibidores no nucleosidos de transcriptasa inversa

Info

Publication number
PE20090143A1
PE20090143A1 PE2008000622A PE2008000622A PE20090143A1 PE 20090143 A1 PE20090143 A1 PE 20090143A1 PE 2008000622 A PE2008000622 A PE 2008000622A PE 2008000622 A PE2008000622 A PE 2008000622A PE 20090143 A1 PE20090143 A1 PE 20090143A1
Authority
PE
Peru
Prior art keywords
alkyl
nucleosid
fluor
inhibitors
chloro
Prior art date
Application number
PE2008000622A
Other languages
English (en)
Inventor
Roland Joseph Billedeau
Wylie Solang Palmer
Zachary Kevin Sweeney
Jeffrey Wu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090143A1 publication Critical patent/PE20090143A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS NO NUCLEOSIDOS DE FORMULA I, DONDE X ES CH2 O NH; Y ES CH2 U O; X1 ES N O CH; R1 ES C(=O)Ar, OAr, FLUOR O H; R2 ES OAr, HIDROGENO, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6) O CICLOALQUILO(C3-C5); R3 Y R4 SON H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6) O CICLOALQUILO(C3-C5); Ra ES H, CH2OH, CH2OC(=O)(CH2)nC(=O)OH, ENTRE OTROS; n ES DE 2 A 5; Rb ES FENILO O ALQUILO INFERIOR(C1-C6); Ar ES FENILO SUSTITUIDO POR 1-3 HALOGENO, CIANO, HALOALQUILO(C1-C6) O ALQUILO(C1-C6). SON SELECCIONADOS 3-CLORO-5-[6-CLORO-2-FLUOR-3-(1H-PIRAZOLO[3,4-b]PIRIDIN-3-ILMETOXI)-FENOXI]-BENZONITRILO, 3-[3-BROMO-2-FLUOR-6-(1H-PIRAZOLO[3,4-c]PIRIDAZIN-3-IL-METOXI)-FENOXI]-5-CLORO-BENZONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TRASCRIPTASA INVERSA DEL VIH Y ENCUENTRAN SU UTILIDAD EN EL TRATAMIENTO O PREVENCION DE INFECCION POR VIH-1, SIDA O ARC
PE2008000622A 2007-04-09 2008-04-07 Inhibidores no nucleosidos de transcriptasa inversa PE20090143A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92244907P 2007-04-09 2007-04-09
US96134607P 2007-07-20 2007-07-20

Publications (1)

Publication Number Publication Date
PE20090143A1 true PE20090143A1 (es) 2009-02-26

Family

ID=39798124

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000622A PE20090143A1 (es) 2007-04-09 2008-04-07 Inhibidores no nucleosidos de transcriptasa inversa

Country Status (15)

Country Link
US (1) US20080293664A1 (es)
EP (1) EP2134711A2 (es)
JP (1) JP2010523613A (es)
KR (1) KR20100015435A (es)
CN (1) CN101679414A (es)
AR (1) AR066404A1 (es)
AU (1) AU2008235549A1 (es)
BR (1) BRPI0810496A2 (es)
CA (1) CA2683046A1 (es)
CL (1) CL2008000996A1 (es)
IL (1) IL200886A0 (es)
MX (1) MX2009010932A (es)
PE (1) PE20090143A1 (es)
TW (1) TW200906410A (es)
WO (1) WO2008122534A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080132510A1 (en) * 2005-01-21 2008-06-05 Bingsong Han Imidazolylmethyl and Pyrazolylmethyl Heteroaryl Derivatives
ES2463720T3 (es) * 2007-11-16 2014-05-29 Gilead Sciences, Inc. Inhibidores de la replicación del virus de inmunodeficiencia humana
KR101610415B1 (ko) * 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
CN103025696B (zh) 2010-07-15 2015-08-12 阿尔比马尔公司 用于制备4-溴代-2-甲氧基苯甲醛的方法
US9497234B2 (en) * 2012-12-27 2016-11-15 Facebook, Inc. Implicit social graph connections
WO2016004305A2 (en) * 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128287D0 (en) * 2001-11-26 2002-01-16 Smithkline Beecham Plc Novel method and compounds
GB0206723D0 (en) * 2002-03-21 2002-05-01 Glaxo Group Ltd Novel compounds
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
JP4485520B2 (ja) * 2003-03-24 2010-06-23 エフ．ホフマン−ラ ロシュ アーゲー 逆転写酵素阻害剤としてのベンジル−ピリダジノン類
JP4627315B2 (ja) * 2004-03-23 2011-02-09 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤としてのベンジルピリダジノン誘導体
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
BRPI0513858B8 (pt) * 2004-07-27 2021-05-25 Hoffmann La Roche compostos de benziltriazolona como inibidores não-nucleosídeos da transcriptase reversa, seu processo de preparação, seu uso e composição farmacêutica que os compreende
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
CN101501002B (zh) * 2006-08-16 2012-06-27 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂

Also Published As

Publication number Publication date
JP2010523613A (ja) 2010-07-15
KR20100015435A (ko) 2010-02-12
US20080293664A1 (en) 2008-11-27
AU2008235549A1 (en) 2008-10-16
CL2008000996A1 (es) 2008-10-10
WO2008122534A3 (en) 2009-02-05
EP2134711A2 (en) 2009-12-23
AR066404A1 (es) 2009-08-19
CA2683046A1 (en) 2008-10-16
WO2008122534A2 (en) 2008-10-16
CN101679414A (zh) 2010-03-24
BRPI0810496A2 (pt) 2018-11-06
IL200886A0 (en) 2010-05-17
TW200906410A (en) 2009-02-16
MX2009010932A (es) 2009-10-29

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Legal Events

Date Code Title Description
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