PE20090142A1 - Derivados de furo[2,3-b] piridina sustituidos como moduladores del receptor canabinoide-1 - Google Patents

Derivados de furo[2,3-b] piridina sustituidos como moduladores del receptor canabinoide-1

Info

Publication number
PE20090142A1
PE20090142A1 PE2008000617A PE2008000617A PE20090142A1 PE 20090142 A1 PE20090142 A1 PE 20090142A1 PE 2008000617 A PE2008000617 A PE 2008000617A PE 2008000617 A PE2008000617 A PE 2008000617A PE 20090142 A1 PE20090142 A1 PE 20090142A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
furo
receptor
canabinoid
Prior art date
Application number
PE2008000617A
Other languages
English (en)
Inventor
Matthew J Clements
John S Debenham
Jeffrey J Hale
Christina B Madsen-Duggan
Thomas F Walsh
Andrey V Peresypkin
Roy Helmy
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20090142A1 publication Critical patent/PE20090142A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE FUROPIRIDINA DE FORMULA I, EN EL QUE R1 ES FENILO, HETEROARILO, -C(O)Ra, -C(O)NRbRc, ENTRE OTROS; Rb Y Rc SON ALQUILO(C1-C6), FENILO, H O JUNTO AL CARBONO AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE 4 A 10 MIEMBROS; Ra ES ALQUILO(C1-C6) Y CICLOALQUILO(C3-C7); R2 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C10), -C(O)N(Rb)2, -C(O)ALQUILO(C1-C10), ENTRE OTROS; R3 ES ALQUILO(C1-C10), -CN, -C(O)O-ALQUILO(C1-C4), -S-ALQUILO(C1-C4); R4 ES PIRAZOL, OXADIAZOL, ISOXAZOL, TIADIAZOL, ENTRE OTROS; R5 ES HALOGENO, -CF3, -O-ALQUILO(C1-C4), ENTRE OTROS. SON SELECCIONADOS N-[5-(4-CLOROFENIL)-6-[2-CLORO-4-(1H-PIRAZOL-4-IL)FENIL]-2-(2-HIDROXI-2-METILPROPANOIL)FURO[2,3-b]PIRIDIN-3-IL]ACETAMIDA, 2-(TERC-BUTILSULFONIL)-5-(4-CLOROFENIL)-6-[2-CLORO-4-(1H-PIRAZOL-4-IL)FENIL]-3-METILFURO[2,3-b]PIRIDINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR CB-1 UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, TALES COMO PSICOSIS, ALZHEIMER, SINDROME DE GUILLAIN-BARRE, EPILEPSIA, ABUSO DE SUSTANCIAS, ENCEFALITIS VIRICA, ENTRE OTROS
PE2008000617A 2007-04-11 2008-04-04 Derivados de furo[2,3-b] piridina sustituidos como moduladores del receptor canabinoide-1 PE20090142A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92285107P 2007-04-11 2007-04-11

Publications (1)

Publication Number Publication Date
PE20090142A1 true PE20090142A1 (es) 2009-02-19

Family

ID=39473766

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000617A PE20090142A1 (es) 2007-04-11 2008-04-04 Derivados de furo[2,3-b] piridina sustituidos como moduladores del receptor canabinoide-1

Country Status (12)

Country Link
US (1) US20080269279A1 (es)
EP (1) EP2146997B1 (es)
JP (1) JP2010523665A (es)
AR (1) AR065983A1 (es)
AT (1) ATE487723T1 (es)
AU (1) AU2008239755A1 (es)
CA (1) CA2683586A1 (es)
CL (1) CL2008001007A1 (es)
DE (1) DE602008003432D1 (es)
PE (1) PE20090142A1 (es)
TW (1) TW200906398A (es)
WO (1) WO2008127585A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
US8921394B2 (en) * 2010-04-27 2014-12-30 Merck Sharp & Dohme Corp. Prolylcarboxypeptidase inhibitors
DK3360860T3 (da) * 2015-10-09 2022-06-20 Mitsui Chemicals Agro Inc Pyridonforbindelse og landbrugs-/havebrugsbactericid indbefattende samme som aktiv bestanddel
CA3188730A1 (en) 2020-08-12 2022-02-17 Christopher Barnes Methods and compositions for treating polycystic ovary syndrome

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1454864A (en) * 1974-03-05 1976-11-03 Wyeth John & Brother Ltd Thioureas
US4973587A (en) * 1990-03-08 1990-11-27 Sterling Drug Inc. 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method
US5013837A (en) * 1990-03-08 1991-05-07 Sterling Drug Inc. 3-Arylcarbonyl-1H-indole-containing compounds
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
US5489685A (en) * 1994-05-12 1996-02-06 Merck & Co., Ltd. Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
US5596106A (en) * 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
US5703116A (en) * 1995-04-18 1997-12-30 Geron Corporation Telomerase Inhibitors
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
FR2741621B1 (fr) * 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
US7774473B2 (en) * 2002-07-31 2010-08-10 Oracle America, Inc. System and method for sticky routing of requests within a server farm
ES2294330T3 (es) * 2002-08-02 2008-04-01 MERCK & CO., INC. Derivados de furo(2,3-b)piridina sustituidos.
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US20040214856A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7141669B2 (en) * 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US7145012B2 (en) * 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7268133B2 (en) * 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
TW200602314A (en) * 2004-05-28 2006-01-16 Tanabe Seiyaku Co A novel pyrrolidine compound and a process for preparing the same
US7674907B2 (en) * 2004-07-23 2010-03-09 Amgen Inc. Furanopyridine derivatives and methods of use

Also Published As

Publication number Publication date
AR065983A1 (es) 2009-07-15
EP2146997A1 (en) 2010-01-27
TW200906398A (en) 2009-02-16
EP2146997B1 (en) 2010-11-10
AU2008239755A1 (en) 2008-10-23
JP2010523665A (ja) 2010-07-15
CA2683586A1 (en) 2008-10-23
AU2008239755A8 (en) 2009-11-12
CL2008001007A1 (es) 2008-10-17
WO2008127585A1 (en) 2008-10-23
ATE487723T1 (de) 2010-11-15
US20080269279A1 (en) 2008-10-30
DE602008003432D1 (de) 2010-12-23

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