PE20081360A1 - Compuestos analogos de lipoxina a4 para el tratamiento y prevencion de la fibrosis intestinal - Google Patents
Compuestos analogos de lipoxina a4 para el tratamiento y prevencion de la fibrosis intestinalInfo
- Publication number
- PE20081360A1 PE20081360A1 PE2007001139A PE2007001139A PE20081360A1 PE 20081360 A1 PE20081360 A1 PE 20081360A1 PE 2007001139 A PE2007001139 A PE 2007001139A PE 2007001139 A PE2007001139 A PE 2007001139A PE 20081360 A1 PE20081360 A1 PE 20081360A1
- Authority
- PE
- Peru
- Prior art keywords
- lipoxin
- prevention
- treatment
- analog compounds
- intestinal fibrosis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A COMPUESTOS ANALOGOS DE LIPOXINA A4 DE FORMULA (I) O (II), EN DONDE R1, R2 Y R3 SON INDEPENDIENTEMENTE HALO, -OR6, -SR6, S(O)tR7 (t ES 1 O 2) O -N(R7)R8; O R1 Y R2 JUNTO A LOS ATOMOS A LOS CUALES ESTAN UNIDOS FORMAN UN GRUPO DE FORMULA a), b), ENTRE OTROS; R4 ES -R9-R12, -R9-O-R10-R11, -R9-S(O)t-R10-R11, ENTRE OTROS, DONDE t ES DE 0 A 2; R5 ES ARILO O ARALQUILO OPCIONALMENTE SUSTITUIDOS CON ALQUILO, ALCOXILO, HALO, HALOALQUILO Y HALOALCOXILO; SIENDO PREFERIDO ACIDO 2-((2S,3R,4E,6E,10E,12S)-13-(4-FLUOROFENOXI)-2,3,12-TRIHIDROXITRIDECA-4,6,10-TRIEN-8-INILOXI)ACETICO, COMO ESTEREOISOMERO, MEZCLA RACEMICA O COMO CLATRATO DE CICLODEXTRINA, INDICADO PARA EL TRATAMIENTO Y/O PREVENCION DE LA FIBROSIS INTESTINAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83975506P | 2006-08-23 | 2006-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081360A1 true PE20081360A1 (es) | 2008-11-29 |
Family
ID=39107156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001139A PE20081360A1 (es) | 2006-08-23 | 2007-08-22 | Compuestos analogos de lipoxina a4 para el tratamiento y prevencion de la fibrosis intestinal |
Country Status (18)
Country | Link |
---|---|
US (1) | US20080119439A1 (es) |
EP (1) | EP2056816A2 (es) |
JP (1) | JP2010501506A (es) |
KR (1) | KR20090042982A (es) |
CN (1) | CN101528219A (es) |
AR (1) | AR062478A1 (es) |
AU (1) | AU2007287770A1 (es) |
BR (1) | BRPI0716576A2 (es) |
CA (1) | CA2660741A1 (es) |
CL (1) | CL2007002442A1 (es) |
IL (1) | IL196983A0 (es) |
MX (1) | MX2009001994A (es) |
PE (1) | PE20081360A1 (es) |
RU (1) | RU2009110244A (es) |
TW (1) | TW200816991A (es) |
UY (1) | UY30557A1 (es) |
WO (1) | WO2008022807A2 (es) |
ZA (1) | ZA200902005B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2288414A1 (en) * | 2008-05-22 | 2011-03-02 | Bayer Schering Pharma Aktiengesellschaft | Anhydrous and hydrate forms of crystalline 2- ( (2s, 3r, 4e, 6e, 1oe, 12s) -13- (4-fluorophenoxy) -2,3, 12- (trihydroxytrideca-4, 6, 10-trien-8-ynyl) oxy) acetic acid |
US20140323550A1 (en) | 2011-11-18 | 2014-10-30 | Nitto Denko Corporation | Intestinal fibrosis treatment agent |
CA3026264A1 (en) * | 2016-06-03 | 2017-12-07 | Thetis Pharmaceuticals Llc | Compositions and methods relating to salts of specialized pro-resolving mediators |
US20210401798A1 (en) * | 2018-10-23 | 2021-12-30 | The Brigham And Women's Hospital, Inc. | Lipoxin a4 analogs and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
US6006466A (en) * | 1998-08-20 | 1999-12-28 | Washecka; John | Concealed linear payout holder for fishing leader |
US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
-
2007
- 2007-08-16 TW TW096130343A patent/TW200816991A/zh unknown
- 2007-08-21 US US11/895,027 patent/US20080119439A1/en not_active Abandoned
- 2007-08-22 MX MX2009001994A patent/MX2009001994A/es not_active Application Discontinuation
- 2007-08-22 CN CNA2007800395466A patent/CN101528219A/zh active Pending
- 2007-08-22 AU AU2007287770A patent/AU2007287770A1/en not_active Abandoned
- 2007-08-22 EP EP07801988A patent/EP2056816A2/en not_active Withdrawn
- 2007-08-22 KR KR1020097005724A patent/KR20090042982A/ko not_active Application Discontinuation
- 2007-08-22 AR ARP070103723A patent/AR062478A1/es unknown
- 2007-08-22 BR BRPI0716576-5A2A patent/BRPI0716576A2/pt not_active Application Discontinuation
- 2007-08-22 WO PCT/EP2007/007567 patent/WO2008022807A2/en active Application Filing
- 2007-08-22 UY UY30557A patent/UY30557A1/es not_active Application Discontinuation
- 2007-08-22 RU RU2009110244/15A patent/RU2009110244A/ru not_active Application Discontinuation
- 2007-08-22 PE PE2007001139A patent/PE20081360A1/es not_active Application Discontinuation
- 2007-08-22 JP JP2009524965A patent/JP2010501506A/ja active Pending
- 2007-08-22 CL CL200702442A patent/CL2007002442A1/es unknown
- 2007-08-22 CA CA002660741A patent/CA2660741A1/en not_active Abandoned
-
2009
- 2009-02-09 IL IL196983A patent/IL196983A0/en unknown
- 2009-03-20 ZA ZA200902005A patent/ZA200902005B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008022807A2 (en) | 2008-02-28 |
JP2010501506A (ja) | 2010-01-21 |
WO2008022807A3 (en) | 2008-05-29 |
AR062478A1 (es) | 2008-11-12 |
CA2660741A1 (en) | 2008-02-28 |
BRPI0716576A2 (pt) | 2014-02-18 |
UY30557A1 (es) | 2008-03-31 |
TW200816991A (en) | 2008-04-16 |
MX2009001994A (es) | 2009-03-06 |
ZA200902005B (en) | 2010-05-26 |
IL196983A0 (en) | 2009-11-18 |
AU2007287770A1 (en) | 2008-02-28 |
KR20090042982A (ko) | 2009-05-04 |
EP2056816A2 (en) | 2009-05-13 |
RU2009110244A (ru) | 2010-09-27 |
US20080119439A1 (en) | 2008-05-22 |
CL2007002442A1 (es) | 2008-03-14 |
CN101528219A (zh) | 2009-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |