PE20080141A1 - Sistemas estables de nanocapsulas para la administracion de moleculas activas - Google Patents
Sistemas estables de nanocapsulas para la administracion de moleculas activasInfo
- Publication number
- PE20080141A1 PE20080141A1 PE2007000261A PE2007000261A PE20080141A1 PE 20080141 A1 PE20080141 A1 PE 20080141A1 PE 2007000261 A PE2007000261 A PE 2007000261A PE 2007000261 A PE2007000261 A PE 2007000261A PE 20080141 A1 PE20080141 A1 PE 20080141A1
- Authority
- PE
- Peru
- Prior art keywords
- molecula
- active
- lipofilica
- refers
- oil
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN SISTEMA DE NANOCAPSULAS CON UN TAMANO INFERIOR 1 UM DISPERSAS EN UN MEDIO ACUOSO, DONDE LA NANOCAPSULA COMPRENDE A) UNA FASE LIPOFILICA QUE COMPRENDE: i) AL MENOS UN COMPONENTE FOSFOLIPIDICO TAL COMO LECITINA DE SOJA; ii) UN ACEITE QUE COMPRENDE UNO O MAS ACIDOS GRASOS DE CADENA (C12-C24) SATURADOS Y/O INSATURADOS TAL COMO ACEITE DE RICINO; Y B) UNA FASE HIDROFILICA QUE COMPRENDE: i) QUITOSANO O UN DERIVADO; Y ii) UN COMPUESTO POLIOXIALQUILENADO TAL COMO POLIOXIETILENO O UN COPOLIMERO DE OXIDO DE ETILENO-OXIDO DE PROPILENO; ADEMAS COMPRENDE UNA MOLECULA LIPOFILICA ACTIVA EN LA FASE LIPOFILA SELECCIONADO DE CICLOSPORINA, HODROCORTISONA, PREDNISONA, ENTRE OTRAS; O UNA M0LECULA ACTIVA DE CARACTER HIDROLIFICO ADSORBIDA SOBRE LA SUPERFICIE DE LA NANOPCAPSULA SELECCIONADO DE PEPTIDOS PROTEINAS, HORMONAS, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA O COSMETICA CUANDO COMPRENDE UNA MOLECULA LIPOFILICA COSMETICA TAL COMO EMOLIENTE, CONSERVANTE, ENTRE OTRAS. ESTE SISTEMA PRESENTA UNA ELEVADA ESTABILIDAD DURANTE LARGOS PERIODOS Y CAPACIDAD PARA SER SOMETIDOS A ALTAS TEMPERATURAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06380048A EP1834635B1 (en) | 2006-03-13 | 2006-03-13 | Stable nanocapsule systems for the administration of active molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080141A1 true PE20080141A1 (es) | 2008-03-04 |
Family
ID=36743270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000261A PE20080141A1 (es) | 2006-03-13 | 2007-03-09 | Sistemas estables de nanocapsulas para la administracion de moleculas activas |
Country Status (17)
Country | Link |
---|---|
US (1) | US20090074824A1 (es) |
EP (1) | EP1834635B1 (es) |
JP (1) | JP5222739B2 (es) |
KR (1) | KR20080102303A (es) |
CN (1) | CN101426479B (es) |
AR (1) | AR059829A1 (es) |
AT (1) | ATE515260T1 (es) |
AU (1) | AU2007224471B2 (es) |
BR (1) | BRPI0709594A2 (es) |
CA (1) | CA2646338A1 (es) |
DK (1) | DK1834635T3 (es) |
ES (1) | ES2369244T3 (es) |
IL (1) | IL194005A0 (es) |
PE (1) | PE20080141A1 (es) |
PL (1) | PL1834635T3 (es) |
PT (1) | PT1834635E (es) |
WO (1) | WO2007104732A2 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8119780B2 (en) | 2006-06-02 | 2012-02-21 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
US20080248508A1 (en) * | 2006-08-17 | 2008-10-09 | Shenda Baker | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials |
KR20100062990A (ko) * | 2007-06-12 | 2010-06-10 | 크리스틴 알렌 | 국소적 약물전달을 위한 주사용 고분자-지질 배합물 |
EP2042166A1 (en) * | 2007-09-25 | 2009-04-01 | The Jordanian Pharmaceutical Manufacturing Co. | Nanocapsules for oral delivery of proteins |
SI2200588T1 (sl) * | 2007-09-25 | 2019-08-30 | Solubest Ltd. | Sestavki, ki obsegajo lipofilne aktivne spojine, in postopek za njihovo pripravo |
KR101199580B1 (ko) * | 2008-08-06 | 2013-11-27 | (주)에델프라우 | 국소 투여용 나노에멀젼 |
BRPI0805854A2 (pt) | 2008-10-10 | 2010-08-24 | Biolab Sanus Farmaceutica Ltda | sistema nanoparticulado, processo de preparaÇço do mesmo, uso do mesmo, composiÇço fotoproterora, processo de preparaÇço da mesma, mÉtodo de prevenÇço de doenÇas e distérbios da pele |
TWI328565B (en) * | 2008-12-19 | 2010-08-11 | Taiwan Textile Res Inst | Dispersions of conductive carbon materials and methods for preparing the same |
EP2405934B1 (en) | 2009-03-12 | 2014-03-26 | Nordic Bioscience A/S | Treatment of diabetes and metabolic syndrome |
ES2347119B2 (es) * | 2009-04-22 | 2011-04-28 | Universidad De Santiago De Compostela | Nanocapsulas de poliarginina. |
EP2266546A1 (en) * | 2009-06-08 | 2010-12-29 | Advancell Advanced in Vitro Cell Technologies,S.A. | Process for the preparation of colloidal systems for the delivery of active compounds |
EP2364600A1 (en) * | 2010-02-18 | 2011-09-14 | Nestec S.A. | Liquid-filled chitosan-anionic liposoluble capsule dispsersions |
BRPI1002601E2 (pt) * | 2010-06-01 | 2020-06-30 | Embrapa Pesquisa Agropecuaria | composição nanoestruturada de uso veterinário para administração de fármacos |
JP6189749B2 (ja) * | 2010-06-23 | 2017-08-30 | ブライトサイド イノベーションズ,インコーポレイティド | レシチン担体小胞とその作製方法 |
EP2642985A4 (en) * | 2010-11-26 | 2014-05-07 | Univ Witwatersrand Jhb | POLYMER MATRIX OF POLYMER-LIPID NANOPARTICLES AS DOSED PHARMACEUTICAL FORM |
US9801829B2 (en) * | 2011-04-29 | 2017-10-31 | University Of Florida Research Foundation, Inc. | Methods and systems of making nanostructures |
DE102011076149A1 (de) * | 2011-05-19 | 2012-11-22 | Rovi Cosmetics International Gmbh | Ladungsgeber für ein vesikuläres Trägersystem eines UV-Schutzmittels für die Haut oder die Haare |
ES2366255B2 (es) * | 2011-06-27 | 2012-08-08 | Universidade De Santiago De Compostela | Nanocomposiciones sacarídicas para la liberación de vacunas. |
JP6170933B2 (ja) | 2011-11-02 | 2017-07-26 | キーバイオサイエンス・アクチエンゲゼルシャフト | ペプチドの使用 |
HUE039105T2 (hu) | 2011-11-02 | 2018-12-28 | Keybioscience Ag | Kalcitonin mimetikumok betegségek és rendellenességek kezelésére |
US20130123194A1 (en) * | 2011-11-15 | 2013-05-16 | Allergan, Inc. | Autoclavable suspensions of cyclosporin a form 2 |
US8968790B2 (en) | 2011-12-09 | 2015-03-03 | Shaker A. Mousa | Nanoformulation of vitamin D derivatives and/or vitamin D metabolites |
EP2625966A1 (en) | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof |
WO2014096165A2 (en) * | 2012-12-21 | 2014-06-26 | Bracco Suisse Sa | Gas-filled microvesicles |
CA3002989C (en) | 2013-10-14 | 2021-03-16 | Nanosphere Health Sciences, Llc | Nanoparticle compositions and methods as carriers of nutraceutical factors across cell membranes and biological barriers |
DK3068796T3 (en) | 2013-11-14 | 2018-03-05 | Keybioscience Ag | CALCITONIN MIMETICS FOR THE TREATMENT OF DISEASES AND DISORDERS |
CN104117066B (zh) | 2014-07-16 | 2016-03-02 | 陈凌 | 外敷用抗甲状腺软膏的制备方法 |
CA3050535C (en) | 2014-12-15 | 2021-11-09 | Richard Clark Kaufman | Methods of treating inflammatory disorders and global inflammation with compositions comprising phospholipid nanoparticle encapsulations of anti-inflammatory nutraceuticals |
GB201500263D0 (en) | 2015-01-08 | 2015-02-25 | Keybioscience Ag | Calcitonin analogues for treating diseases and disorders |
CA2979184C (en) | 2015-03-10 | 2020-09-08 | Nanosphere Health Sciences, Llc | Lipid nanoparticle compositions and methods as carriers of cannabinoids in standardized precision-metered dosage forms |
PL229276B1 (pl) * | 2015-07-17 | 2018-06-29 | Univ Jagiellonski | Nanokapsuła do przenoszenia związku lipofilowego i sposób jej wytwarzania |
TWI709410B (zh) * | 2015-08-11 | 2020-11-11 | 荷蘭商艾西優藥物股份有限公司 | 具有生物活性親脂性化合物之聚乙二醇化脂質奈米粒子 |
JP2019513359A (ja) * | 2016-03-25 | 2019-05-30 | アディッソ・フランス・エス.エー.エス.Adisseo France S.A.S. | 脂溶性の有効成分のナノカプセル並びにその製造方法及び使用方法 |
GB201704429D0 (en) | 2017-03-21 | 2017-05-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
GB201707955D0 (en) | 2017-05-18 | 2017-07-05 | Keybioscience Ag | Dual amylin and calcitonin receptor agonists for treating diseases and disorders |
US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
GB201813677D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
GB201813678D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
CN109316602A (zh) * | 2018-11-13 | 2019-02-12 | 西安力邦医药科技有限责任公司 | 一种长效镇痛并促进伤口愈合的复方缓释递药***的组方与应用 |
EP4272731A3 (en) | 2018-12-11 | 2024-02-14 | Disruption Labs Inc. | Compositions for the delivery of therapeutic agents and methods of use and making thereof |
KR102384808B1 (ko) * | 2018-12-20 | 2022-04-08 | 주식회사 스킨메드 | 키토산으로 코팅된 나노 캡슐 및 이의 용도 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
DE59310166D1 (de) * | 1992-05-18 | 2001-05-31 | Ciclomulsion Ag | Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur intravenösen Applikation sowie Verfahren zu ihrer Herstellung |
US20030224022A1 (en) * | 1993-01-19 | 2003-12-04 | Amos Nussinovitch | Hydrocolloid cellular solid matrices |
US5744155A (en) * | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
ES2093562B1 (es) * | 1995-05-26 | 1997-07-01 | Univ Santiago Compostela | Estabilizacion de sistemas coloidales mediante formacion de complejos ionicos lipido-polisacarido. |
US6649192B2 (en) * | 1996-07-29 | 2003-11-18 | Universidade De Santiago De Compostela | Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms |
JP3441665B2 (ja) * | 1999-02-04 | 2003-09-02 | 株式会社資生堂 | (2−置換オキシフェニル)アルカンアミド誘導体及び養毛剤、皮膚外用剤 |
EP1190702A1 (en) * | 2000-09-22 | 2002-03-27 | Ciba SC Holding AG | Chitosan emulsion formulation |
EP1243323B1 (de) * | 2001-03-22 | 2005-01-05 | Cognis Iberia, S.L. | Nanokapseln |
JP2005513097A (ja) * | 2001-11-01 | 2005-05-12 | イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム | ドライアイ治療方法および組成物 |
-
2006
- 2006-03-13 DK DK06380048.6T patent/DK1834635T3/da active
- 2006-03-13 PT PT06380048T patent/PT1834635E/pt unknown
- 2006-03-13 PL PL06380048T patent/PL1834635T3/pl unknown
- 2006-03-13 AT AT06380048T patent/ATE515260T1/de active
- 2006-03-13 EP EP06380048A patent/EP1834635B1/en active Active
- 2006-03-13 ES ES06380048T patent/ES2369244T3/es active Active
-
2007
- 2007-03-09 PE PE2007000261A patent/PE20080141A1/es not_active Application Discontinuation
- 2007-03-12 US US12/282,366 patent/US20090074824A1/en not_active Abandoned
- 2007-03-12 JP JP2008558798A patent/JP5222739B2/ja not_active Expired - Fee Related
- 2007-03-12 CA CA002646338A patent/CA2646338A1/en not_active Abandoned
- 2007-03-12 CN CN2007800139239A patent/CN101426479B/zh not_active Expired - Fee Related
- 2007-03-12 AU AU2007224471A patent/AU2007224471B2/en not_active Ceased
- 2007-03-12 WO PCT/EP2007/052276 patent/WO2007104732A2/en active Application Filing
- 2007-03-12 BR BRPI0709594-5A patent/BRPI0709594A2/pt not_active IP Right Cessation
- 2007-03-12 KR KR1020087024897A patent/KR20080102303A/ko active IP Right Grant
- 2007-03-13 AR ARP070101016A patent/AR059829A1/es unknown
-
2008
- 2008-09-09 IL IL194005A patent/IL194005A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT1834635E (pt) | 2011-10-13 |
AU2007224471B2 (en) | 2013-05-02 |
JP5222739B2 (ja) | 2013-06-26 |
CN101426479B (zh) | 2012-10-10 |
AR059829A1 (es) | 2008-04-30 |
AU2007224471A1 (en) | 2007-09-20 |
PL1834635T3 (pl) | 2012-01-31 |
EP1834635A1 (en) | 2007-09-19 |
ES2369244T3 (es) | 2011-11-28 |
WO2007104732A3 (en) | 2007-11-08 |
CN101426479A (zh) | 2009-05-06 |
EP1834635B1 (en) | 2011-07-06 |
DK1834635T3 (da) | 2011-10-24 |
JP2009530241A (ja) | 2009-08-27 |
ATE515260T1 (de) | 2011-07-15 |
WO2007104732A2 (en) | 2007-09-20 |
BRPI0709594A2 (pt) | 2011-07-19 |
US20090074824A1 (en) | 2009-03-19 |
CA2646338A1 (en) | 2007-09-20 |
IL194005A0 (en) | 2011-08-01 |
KR20080102303A (ko) | 2008-11-24 |
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