PE20080010A1 - DIAZEPINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM - Google Patents

DIAZEPINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM

Info

Publication number
PE20080010A1
PE20080010A1 PE2007000320A PE2007000320A PE20080010A1 PE 20080010 A1 PE20080010 A1 PE 20080010A1 PE 2007000320 A PE2007000320 A PE 2007000320A PE 2007000320 A PE2007000320 A PE 2007000320A PE 20080010 A1 PE20080010 A1 PE 20080010A1
Authority
PE
Peru
Prior art keywords
diazepine
quinoline
depression
treatment
pharmaceutical compositions
Prior art date
Application number
PE2007000320A
Other languages
Spanish (es)
Inventor
Sharon Rosenzwig-Lipson
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080010A1 publication Critical patent/PE20080010A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

REFERIDA A UNA COMPOSICION QUE COMPRENDE: a) UNO O MAS FARMACOS ANTIDEPRESIVOS, b) UN PORTADOR O VEHICULO FARMACEUTICAMENTE ACEPTABLE Y c) UN DERIVADO DIAZEPINO DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O DOBLE; n ES 1 O 2; m ES 0 O 1; R1 Y R2 SON HALOGENO, CN, R, OR, ENTRE OTROS; R ES H O ALQUILO C1-C6; R3 Y R4 JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN LIGADOS, FORMAN UN ANILLO DE 4 A 8 MIEMBROS, SATURADO O INSATURADO Y QUE OPCIONALMENTE ESTA SUSTITUIDO CON HALOGENO, R U OR; R5 Y R6 SON R. SON COMPUESTOS DE FORMULA (I) FAVORITOS: 2-BROMO-4,5,6,7,9,9a,10,11,12,13,14,14a-DODECAHIDROCICLOHEPTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, 2-BROMO-4,5,6,7,9,,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, 2-CLORO-4,5,6,7,9,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, ENTRE OTROS. EL AGENTE ANTIDEPRESIVO ES ATIPAMEZOL, CITALOPRAM, FEMOXETINA, LITIO, FLUVOXAMINA, NORTRIPTILINA, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA DEPRESION U OTROS TRASTORNOS EMOCIONALESREFERRING TO A COMPOSITION THAT INCLUDES: a) ONE OR MORE ANTIDEPRESSIVE DRUGS, b) A PHARMACEUTICALLY ACCEPTABLE CARRIER OR VEHICLE AND c) A DIAZEPINE DERIVATIVE OF FORMULA (I), WHERE THE DOTTED LINE REPRESENTS A SIMPLE OR DOUBLE LINK; n IS 1 O 2; m IS 0 O 1; R1 AND R2 ARE HALOGEN, CN, R, OR, AMONG OTHERS; R IS H O C1-C6 ALKYL; R3 AND R4 TOGETHER WITH THE CARBON ATOMS TO WHICH THEY ARE LINKED, FORM A RING OF 4 TO 8 MEMBERS, SATURATED OR UNSATURATED AND WHICH IS OPTIONALLY REPLACED WITH HALOGEN, R OR OR; R5 AND R6 ARE R. THE FAVORITE COMPOUNDS OF FORMULA (I): 2-BROMO-4,5,6,7,9,9a, 10,11,12,13,14,14a-DODECAHYDROCYCLOHEPTA [c] [1, 4] DIAZEPINE [6,7,1-ij] QUINOLINE, 2-BROMO-4,5,6,7,9,, 9a, 10,11,12,12a-DECAHYDROCYCLOPENTA [c] [1,4] DIAZEPINE [ 6,7,1-ij] QUINOLINE, 2-CHLORINE-4,5,6,7,9,9a, 10,11,12,12a-DECAHYDROCYCLOPENTA [c] [1,4] DIAZEPINE [6,7,1 -ij] QUINOLINE, AMONG OTHERS. THE ANTIDEPRESSIVE AGENT IS ATIPAMEZOL, CITALOPRAM, FEMOXETINE, LITHIUM, FLUVOXAMINE, NORTRIPTILINA, AMONG OTHERS. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF DEPRESSION OR OTHER EMOTIONAL DISORDERS

PE2007000320A 2006-03-24 2007-03-23 DIAZEPINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM PE20080010A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78545406P 2006-03-24 2006-03-24

Publications (1)

Publication Number Publication Date
PE20080010A1 true PE20080010A1 (en) 2008-03-10

Family

ID=38466269

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000320A PE20080010A1 (en) 2006-03-24 2007-03-23 DIAZEPINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM

Country Status (19)

Country Link
US (1) US20070225279A1 (en)
EP (1) EP1998773A2 (en)
JP (1) JP2009531435A (en)
KR (1) KR20080105104A (en)
CN (1) CN101410112A (en)
AR (1) AR060087A1 (en)
AU (1) AU2007231011A1 (en)
BR (1) BRPI0709159A2 (en)
CA (1) CA2644662A1 (en)
CR (1) CR10245A (en)
EC (1) ECSP088763A (en)
IL (1) IL193747A0 (en)
MX (1) MX2008012094A (en)
NO (1) NO20083758L (en)
PA (1) PA8720801A1 (en)
PE (1) PE20080010A1 (en)
RU (1) RU2008135326A (en)
TW (1) TW200806300A (en)
WO (1) WO2007112014A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105036A1 (en) 2003-05-12 2006-05-18 Stephen Peroutka Threo-dops controlled release formulation
US8158149B2 (en) 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
GT200500317A (en) * 2004-11-05 2006-10-27 PROCESS TO PREPARE QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED FROM THEM
AR054849A1 (en) * 2005-07-26 2007-07-18 Wyeth Corp DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
CA2644656A1 (en) * 2006-03-24 2007-10-04 Wyeth Treatment of pain
AU2007229491A1 (en) * 2006-03-24 2007-10-04 Wyeth Methods for treating cognitive and other disorders
ES2500053T3 (en) 2007-03-09 2014-09-29 Chelsea Therapeutics, Inc. Pharmaceutical composition comprising droxidopa for the treatment of fibromyalgia
CA2686723A1 (en) * 2007-05-07 2008-11-13 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
CL2008002777A1 (en) * 2007-09-21 2010-01-22 Wyeth Corp Method of preparing chiral diazepinoquinoline compounds by recrystallization in a ternary solvent system.
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
JP5880913B2 (en) 2011-05-17 2016-03-09 三郎 佐古田 Treatment for trunk symptoms (postural reflex abnormalities) in Parkinson's disease
SG11201501894VA (en) * 2012-09-14 2015-04-29 Abbvie Inc Tricyclic quinoline and quinoxaline derivatives
US20140080813A1 (en) 2012-09-14 2014-03-20 AbbVie Deutschland GmbH & Co. KG Tricyclic quinoline and quinoxaline derivatives
CN102977053B (en) * 2012-11-30 2015-04-15 山东诚创医药技术开发有限公司 Preparation method of tianeptine sodium impurity D
MX2016008272A (en) * 2016-06-17 2017-12-18 S1 Biopharma Inc Methods of treating women for hypoactive sexual desire disorder (hsdd) with bupropion and trazodone combination treatment.
US11266633B2 (en) 2017-06-30 2022-03-08 Chase Therapeutics Corporation NK-1 antagonist compositions and methods for use in treating depression
CN113631157A (en) * 2019-02-17 2021-11-09 诺拉威尔治疗公司 Compositions and methods for treating depression and other disorders

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2554736A (en) * 1951-05-29 Tertiary aminoalkyl-iminodibenzyls
US3158619A (en) * 1962-06-14 1964-11-24 Searle & Co Certain sulfur-containing ortho-fused polycyclic pyrazole derivatives
US3235564A (en) * 1964-03-27 1966-02-15 Searle & Co Intermediates to certain sulfur-containing ortho-fused polycyclic pyrazole derivatives
US3296252A (en) * 1964-04-02 1967-01-03 Sandoz Ag Tetracyclic diazepinone compounds
US3335134A (en) * 1964-04-02 1967-08-08 Sandoz Ag Certain 3, 4-dihydrofluoreno[1, 9a, 9-e, f]1, 4-diazepin-3(2h)-ones
GB1120461A (en) * 1964-07-06 1968-07-17 Manuf Prod Pharma Derivatives of fluoreno-[1,9-ef]1,4-diazepine-1-oxide
US3329676A (en) * 1964-11-09 1967-07-04 American Home Prod Fused 1, 4-diazepine ring systems
US3417101A (en) * 1964-11-09 1968-12-17 American Home Prod Fused ring compounds
US3714149A (en) * 1969-11-03 1973-01-30 Upjohn Co Pyridobenzodiazepinones
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
US3914250A (en) * 1974-08-01 1975-10-21 American Home Prod 1,4-Diazepino{8 6,5,4-jk{9 carbazoles
NL7503310A (en) * 1975-03-20 1976-09-22 Philips Nv CONNECTIONS WITH ANTIDEPRESSIVE ACTION.
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4210754A (en) * 1977-02-01 1980-07-01 Hoffmann-La Roche Inc. Morpholino containing benzamides
IL56369A (en) * 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
FR2508035A1 (en) * 1981-06-23 1982-12-24 Fabre Sa Pierre ARYL-1-AMINOMETHYL-2 CYCLOPROPANES CARBOXAMIDE (Z) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH02180885A (en) * 1988-09-01 1990-07-13 Glaxo Group Ltd Lactam derivative
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
KR0166088B1 (en) * 1990-01-23 1999-01-15 . Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
DE4200259A1 (en) * 1992-01-08 1993-07-15 Asta Medica Ag NEW 1,2,4-TRIAMINOBENZOL DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US6005109A (en) * 1997-10-30 1999-12-21 Pflizer Inc. Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
PL176526B1 (en) * 1992-12-17 1999-06-30 Pfizer Pyrolopyrimidines as compounds acting as antagonists of corticotrophin releasing factor
EP0639374B1 (en) * 1993-06-28 2002-02-20 American Home Products Corporation New treatments using phenethyl derivatives
US5705646A (en) * 1993-09-30 1998-01-06 Pfizer Inc. Substituted pyrazoles as CRF antagonists
US5668145A (en) * 1993-11-12 1997-09-16 Pfizer Inc. Amino-substituted pyrazoles having CRF antagonistic activity
ES2199251T3 (en) * 1994-06-15 2004-02-16 Otsuka Pharmaceutical Company, Limited BENZOHETEROCICLIC DERIVATIVES USED AS VASOPRESIN OR OXITOCINE MODULATORS.
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
CA2195697A1 (en) * 1996-02-02 1997-08-03 Masahumi Kitano Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
US6274171B1 (en) * 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
GB9711643D0 (en) * 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6194407B1 (en) * 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6031098A (en) * 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
CO5210925A1 (en) * 1998-11-17 2002-10-30 Novartis Ag TETRASUSTITUID DIAMINUM NITROGUANIDINE DERIVATIVES
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
CA2324813A1 (en) * 1999-11-10 2001-05-10 Susan Beth Sobolov-Jaynes Combination treatment for depression and anxiety
US6593340B1 (en) * 2000-02-28 2003-07-15 Cv Technologies, Inc. Pharmaceutical compositions containing N-propargylphentermine and related analogs to treat neurodegeneration and/or depression
US7256191B2 (en) * 2000-04-24 2007-08-14 Aryx Therapeutics Materials and methods for the treatment of depression
AR031198A1 (en) * 2000-11-03 2003-09-10 Wyeth Corp PROCEDURE FOR THE PREPARATION OF CYCLOPENTA DERIVATIVES (B) DIAZEPINO (6,7,1) INDOL
AR031201A1 (en) * 2000-11-03 2003-09-10 Wyeth Corp / 1,4 / DIAZEPINO / 6,7,1-JK / CARBAZOLES AND DERIVATIVES
ES2230382T3 (en) * 2000-11-03 2005-05-01 Wyeth CYCLOPENTAL (B) (1,4) DIAZPINO (6,7,1-HI) INDOLES AS 5HT2C ANTAGONISTS.
AR031196A1 (en) * 2000-11-03 2003-09-10 Wyeth Corp PROCEDURE FOR THE PREPARATION OF CYCLOPENTA (B) (1,4) -DIAZEPINO (6,7,1-HI) INDOLES AND DERIVATIVES
AR031200A1 (en) * 2000-11-03 2003-09-10 Wyeth Corp CYCLOCATE [B] [1,4] DIAZEPINO [6,7,1-HI] INDOLES AND DERIVATIVES
AR031202A1 (en) * 2000-11-03 2003-09-10 Wyeth Corp CYCLOPENTA (B) (1,4) DIAZEPINO (6,7,1-HI) INDOLES AND DERIVATIVES
US6916922B2 (en) * 2000-11-03 2005-07-12 Wyeth Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives
AR031199A1 (en) * 2000-11-03 2003-09-10 Wyeth Corp CICLOHEPTA / B // 1,4 / DIACEPINO / 6,7,1-HI / INDOLES AND DERIVATIVES
US7141563B2 (en) * 2000-11-03 2006-11-28 Wyeth Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives
SE0004245D0 (en) * 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
US6849619B2 (en) * 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
KR20030070073A (en) * 2000-12-20 2003-08-27 브리스톨-마이어스스퀴브컴파니 Substituted Pyridoindoles As Serotonin Agonists and Antagonists
RU2003121306A (en) * 2000-12-20 2005-03-10 Бристол-Маерс Сквибб Компани (Us) Бристол-Маерс Сквибб Компани (Us) SUBSTITUTED Pyrroloquinolines and Pyridoquinolines as Agonists and Antagonists of Serotonin
US20020107244A1 (en) * 2001-02-02 2002-08-08 Howard Harry R. Combination treatment for depression
AR033095A1 (en) * 2001-04-04 2003-12-03 Wyeth Corp METHODS FOR THE TREATMENT OF HYPERACTIVE GASTRIC MOTILITY
BR0211559A (en) * 2001-08-06 2004-07-13 Upjohn Co Therapeutically useful compounds, tetracyclic binder compositions and their uses
CA2464412A1 (en) * 2001-10-18 2003-04-24 Pharmacia & Upjohn Company Tetracyclic azaindoles and -indolines having serotonin 5-ht2cactivity
TWI312781B (en) * 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) * 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TW200307682A (en) * 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
SE0201544D0 (en) * 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
US20030092770A1 (en) * 2002-10-23 2003-05-15 Phil Skolnick Combination therapy for treatment of depression
US20040235856A1 (en) * 2003-04-25 2004-11-25 Pfizer Inc Treatment of incontinence
US20050069936A1 (en) * 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
AR051946A1 (en) * 2004-11-05 2007-02-21 Wyeth Corp FORMULATIONS OF DERIVATIVES OF [1,4] DIAZEPINA [6,7,1-IJ] QUINOLINA
PE20060939A1 (en) * 2004-11-05 2006-11-10 Wyeth Corp METABOLITES DERIVED FROM [1,4] DIAZEPIN [6,7,1-IJ] QUINOLINE AND PREPARATION PROCEDURE
GT200500317A (en) * 2004-11-05 2006-10-27 PROCESS TO PREPARE QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED FROM THEM
AR054849A1 (en) * 2005-07-26 2007-07-18 Wyeth Corp DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM
AR056695A1 (en) * 2005-10-17 2007-10-17 Wyeth Corp TETRAHYDROQUINOLINS, ITS SYNTHESIS AND INTERMEDIARIES
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
CA2644656A1 (en) * 2006-03-24 2007-10-04 Wyeth Treatment of pain
BRPI0709129A2 (en) * 2006-03-24 2011-06-28 Wyeth Corp therapeutic combinations for the treatment or prevention of psychotic disorders
WO2007112073A2 (en) * 2006-03-24 2007-10-04 Wyeth Methods for modulating bladder function
AU2007229491A1 (en) * 2006-03-24 2007-10-04 Wyeth Methods for treating cognitive and other disorders
CL2008002777A1 (en) * 2007-09-21 2010-01-22 Wyeth Corp Method of preparing chiral diazepinoquinoline compounds by recrystallization in a ternary solvent system.

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EP1998773A2 (en) 2008-12-10
AU2007231011A1 (en) 2007-10-04
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MX2008012094A (en) 2008-10-03
CA2644662A1 (en) 2007-10-04
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CN101410112A (en) 2009-04-15
KR20080105104A (en) 2008-12-03
NO20083758L (en) 2008-10-21
JP2009531435A (en) 2009-09-03
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AR060087A1 (en) 2008-05-21

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