PE20050398A1 - Proceso y purificacion de las xantofilas de marigold - Google Patents
Proceso y purificacion de las xantofilas de marigoldInfo
- Publication number
- PE20050398A1 PE20050398A1 PE2003000966A PE2003000966A PE20050398A1 PE 20050398 A1 PE20050398 A1 PE 20050398A1 PE 2003000966 A PE2003000966 A PE 2003000966A PE 2003000966 A PE2003000966 A PE 2003000966A PE 20050398 A1 PE20050398 A1 PE 20050398A1
- Authority
- PE
- Peru
- Prior art keywords
- marigold
- aqueous solution
- extracts
- saponified
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- 239000000284 extract Substances 0.000 abstract 4
- 235000005881 Calendula officinalis Nutrition 0.000 abstract 3
- 241000736851 Tagetes Species 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000000049 pigment Substances 0.000 abstract 2
- 239000002798 polar solvent Substances 0.000 abstract 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 235000021466 carotenoid Nutrition 0.000 abstract 1
- 150000001747 carotenoids Chemical class 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical group 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 235000021588 free fatty acids Nutrition 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000001656 lutein Substances 0.000 abstract 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 abstract 1
- 229960005375 lutein Drugs 0.000 abstract 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 abstract 1
- 235000012680 lutein Nutrition 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 abstract 1
- JKQXZKUSFCKOGQ-QAYBQHTQSA-N zeaxanthin Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-QAYBQHTQSA-N 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
QUE COMPRENDE: a) ENSILAR DE 1 A 4 SEMANAS CON UNA SOLUCION ACUOSA DE 0,005 A 0,1% EN PESO DE ENZIMAS HIDROFILICAS RESPECTO DEL SILO, PRENSAR Y SECAR A TEMPERATURA AMBIENTE LOS PETALOS DE MARIGOLD PARA OBTENER UNA HARINA SECA DE MARIGOLD, LA CUAL ES EXTRAIDA CONVENCIONALMENTE CON UN SOLVENTE POLAR DEL TIPO DE HIDROCARBURO SATURADO DE CADENA CORTA C5-C8 PARA OBTENER EXTRACTOS SAPONIFICADOS DE MARIGOLD; b) DISOLVER LOS EXTRACTOS EN AGUA PARA OBTENER EMULSIONES QUE CONTIENEN DE 1 A 20 g DE CAROTENOIDES POR CADA Kg DE MEZCLA; c) AJUSTAR EL pH DE LA MEZCLA ENTRE 3 y 4, CON UNA SOLUCION ACUOSA DE UN HALOGENURO METALICO DEL TIPO DE CLORURO DE CALCIO, Mg, Zn o MEZCLA DE ELLOS, DONDE LOS ACIDOS GRASOS FORMAN LAS RESPECTIVAS SALES METALICAS PRECIPITANDO DE LA EMULSION; Y, d) FILTRAR LA MEZCLA ANTERIOR Y EL CAKE RESULTANTE LAVARLO CON UN SOLVENTE POLAR PARA RECUPERAR LOS PIGMENTOS DE INERTES. SE USAN SOLO LOS PETALOS DE MARIGOLD DE FLORES LIBRES DE CUALQUIER MANIPULACION GENETICA. LAS ENZIMAS EN (a) PUEDEN SER CELULASAS, PECTINASAS, LIPASAS, PROTEINAS SIMILARES O MEZCLAS DE ELLAS. LOS ACIDOS GRASOS LIBRES DEL EXTRACTO DE SAPONIFICADO Y DILUIDO SE HACEN REACCIONAR CON UNA SOLUCION ACUOSA DE UN HALOGENURO METALICO. LOS EXTRACTOS SAPONIFICADOS ESTAN LIBRES DE EPOXICAROTENOIDES. EL PRODUCTO FINAL OBTENIDO ES UN CONCENTRADO DE XANTOFILAS QUE CONTIENE 900 g DE PIGMENTOS POR CADA Kg DE LOS CUALES EL 95% ES LUTEINA Y EL 5% ES ZEAXANTINA
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2003000966A PE20050398A1 (es) | 2003-09-22 | 2003-09-22 | Proceso y purificacion de las xantofilas de marigold |
| US10/948,088 US7150890B2 (en) | 2003-09-22 | 2004-09-22 | Process for the purification of marigold xanthophylls |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2003000966A PE20050398A1 (es) | 2003-09-22 | 2003-09-22 | Proceso y purificacion de las xantofilas de marigold |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050398A1 true PE20050398A1 (es) | 2005-06-03 |
Family
ID=40121123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000966A PE20050398A1 (es) | 2003-09-22 | 2003-09-22 | Proceso y purificacion de las xantofilas de marigold |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US7150890B2 (es) |
| PE (1) | PE20050398A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE359266T1 (de) * | 2002-09-20 | 2007-05-15 | Riken Vitamin Co | Verfahren zur reinigung von marigold oleoresin |
| GB0515754D0 (en) | 2005-07-30 | 2005-09-07 | Dyson Technology Ltd | Drying apparatus |
| GB2428569B (en) | 2005-07-30 | 2009-04-29 | Dyson Technology Ltd | Dryer |
| GB0515744D0 (en) * | 2005-07-30 | 2005-09-07 | Dyson Technology Ltd | Dryer |
| GB0515749D0 (en) | 2005-07-30 | 2005-09-07 | Dyson Technology Ltd | Drying apparatus |
| GB0515750D0 (en) | 2005-07-30 | 2005-09-07 | Dyson Technology Ltd | Drying apparatus |
| US7629007B2 (en) * | 2005-12-19 | 2009-12-08 | Industrias Vepinsa, S.A. de C.V. | Process for purification of free xanthophylls |
| GB2434094A (en) | 2006-01-12 | 2007-07-18 | Dyson Technology Ltd | Drying apparatus with sound-absorbing material |
| ES2318992B1 (es) * | 2006-09-18 | 2009-12-28 | Carotenoid Technologies, S.A. | Procedimiento para la preparacion de luteina esencialmente pura a partir de extractos de marigold. |
| US20080107768A1 (en) * | 2006-09-29 | 2008-05-08 | Industrial Organica, S.A. De C.V. | Method for increasing the health condition of crustaceans in aquaculture |
| US8802422B2 (en) | 2007-06-01 | 2014-08-12 | Solazyme, Inc. | Renewable diesel and jet fuel from microbial sources |
| AU2009234176B2 (en) * | 2008-04-09 | 2014-08-07 | Corbion Biotech, Inc. | Direct chemical modification of microbial biomass and microbial oils |
| US20100297296A1 (en) * | 2008-10-14 | 2010-11-25 | Solazyme, Inc. | Healthier Baked Goods Containing Microalgae |
| US20100297323A1 (en) * | 2008-10-14 | 2010-11-25 | Solazyme, Inc. | Gluten-free Foods Containing Microalgae |
| JP5859311B2 (ja) | 2008-11-28 | 2016-02-10 | ソラザイム, インコーポレイテッドSolazyme Inc | 組み換え従属栄養微生物における、用途に応じた油の生産 |
| US8247615B2 (en) | 2010-05-14 | 2012-08-21 | Kalamazoo Holdings, Inc. | Process of converting esterified xanthophylls from Capsicum to non-esterified xanthophylls in high yields and purities |
| US8716533B2 (en) | 2009-05-29 | 2014-05-06 | Kalamazoo Holdings, Inc. | Methods of saponifying xanthophyll esters and isolating xanthophylls |
| CA3039432A1 (en) | 2010-05-28 | 2011-12-01 | Corbion Biotech, Inc. | Tailored oils produced from recombinant heterotrophic microorganisms |
| ES2583004T3 (es) | 2010-10-13 | 2016-09-16 | Vigenent Inc. | Olleya marilimosa y su uso en un método para la preparación de una composición que contiene zeaxantina |
| CA3024641A1 (en) | 2010-11-03 | 2012-05-10 | Corbion Biotech, Inc. | Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods |
| CA2825691C (en) | 2011-02-02 | 2020-08-25 | Solazyme, Inc. | Tailored oils produced from recombinant oleaginous microorganisms |
| WO2012154626A1 (en) | 2011-05-06 | 2012-11-15 | Solazyme, Inc. | Genetically engineered microorganisms that metabolize xylose |
| WO2013097056A1 (zh) | 2011-12-31 | 2013-07-04 | 晨光生物科技集团股份有限公司 | 一种制备叶黄素晶体的方法 |
| ES2744868T3 (es) | 2012-04-18 | 2020-02-26 | Corbion Biotech Inc | Aceites hechos a medida |
| MX361455B (es) | 2012-12-19 | 2018-12-06 | Novus Int Inc | Composiciones de xantofila y metodos de uso. |
| US10098371B2 (en) | 2013-01-28 | 2018-10-16 | Solazyme Roquette Nutritionals, LLC | Microalgal flour |
| FR3009619B1 (fr) | 2013-08-07 | 2017-12-29 | Roquette Freres | Compositions de biomasse de microalgues riches en proteines de qualite sensorielle optimisee |
| EP3052636A2 (en) | 2013-10-04 | 2016-08-10 | Solazyme, Inc. | Tailored oils |
| WO2016007862A2 (en) | 2014-07-10 | 2016-01-14 | Solazyme, Inc. | Novel ketoacyl acp synthase genes and uses thereof |
| CN109232345B (zh) * | 2018-07-10 | 2021-03-09 | 浙江医药股份有限公司新昌制药厂 | 一种从含叶黄素二酯的植物油树脂中提取分离叶黄素晶体的方法 |
| CN114957073A (zh) * | 2021-02-25 | 2022-08-30 | 内蒙古昶辉生物科技股份有限公司 | 利用万寿菊油膏制备叶黄素酯的方法与叶黄素酯 |
| CN115028613B (zh) * | 2022-06-27 | 2024-03-22 | 山东天音生物科技有限公司 | 一种提取万寿菊花中叶黄素酯和槲皮万寿菊素的方法 |
| CN115633779B (zh) * | 2022-09-23 | 2024-05-14 | 宁夏灏瀚生物科技产业有限公司 | 一种提高植物类胡萝卜素生物利用率的加工方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523138A (en) * | 1965-03-01 | 1970-08-04 | Eastman Kodak Co | Treatment of marigold petal meal to obtain a xanthophyll product |
| US4048203A (en) | 1976-12-06 | 1977-09-13 | Thomas Philip | Purification of lutein-fatty acid esters from plant materials |
| WO1991003571A1 (en) * | 1989-08-30 | 1991-03-21 | Applied Food Biotechnology, Inc. | Production of zeaxanthin and zeaxanthin-containing compositions |
| US5382714A (en) | 1994-03-17 | 1995-01-17 | The Catholic University Of America | Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof |
| HUT75371A (en) | 1995-10-09 | 1997-05-28 | Motiv Magyar Nemet Kereskedelm | Natural carotene-concentrate of vegetable material and process for producing of that |
| US5648564A (en) | 1995-12-21 | 1997-07-15 | Kemin Industries, Inc. | Process for the formation, isolation and purification of comestible xanthophyll crystals from plants |
| WO1998045241A2 (en) | 1997-04-04 | 1998-10-15 | Henkel Corporation | Lutein esters having high bioavailability |
| US6221417B1 (en) | 1997-05-14 | 2001-04-24 | Kemin Industries, Inc. | Conversion of xanthophylls in plant material for use as a food colorant |
| US5876782A (en) | 1997-05-14 | 1999-03-02 | Kemin Industries, Inc. | Method for the conversion of xanthophylls in plant material |
| US6191293B1 (en) | 1998-04-20 | 2001-02-20 | Inexa, Industria Extractora C.A. | Trans-xanthophyll ester concentrates of enhanced purity and methods of making same |
| US6262284B1 (en) | 1998-10-21 | 2001-07-17 | University Of Maryland | Process for extraction and purification of lutein, zeaxanthin and rare carotenoids from marigold flowers and plants |
| US6504067B1 (en) | 1999-11-24 | 2003-01-07 | Industrial Organica S.A. De C.V. | Process to obtain xanthophyll concentrates of high purity |
| US6329557B1 (en) | 2000-06-09 | 2001-12-11 | Prodemex, S.A. De C.V. | Purification of xanthophylls from marigold extracts that contain high levels of chlorophylls |
| ES2240496T3 (es) * | 2000-07-27 | 2005-10-16 | University Of Maryland, College Park | Metodo de produccion de carotenoides poco comunes a partir de luteina disponible comercialmente. |
| US6380442B1 (en) | 2001-10-10 | 2002-04-30 | Bioactives, Llc | Process for the isolation of mixed carotenoids from plants |
| US6811801B2 (en) * | 2001-12-12 | 2004-11-02 | Abbott Laboratories | Methods and compositions for brightening the color of thermally processed nutritionals |
| DE60324116D1 (de) * | 2002-03-26 | 2008-11-27 | Dsm Ip Assets Bv | Esterifizierung von xanthophyllen |
| US6743953B2 (en) | 2002-08-26 | 2004-06-01 | Kancor Flavours & Extracts Ltd. | Process for the preparation of xanthophyll crystals |
-
2003
- 2003-09-22 PE PE2003000966A patent/PE20050398A1/es not_active Application Discontinuation
-
2004
- 2004-09-22 US US10/948,088 patent/US7150890B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050153002A1 (en) | 2005-07-14 |
| US7150890B2 (en) | 2006-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |