PE20040548A1 - Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2 - Google Patents

Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2

Info

Publication number
PE20040548A1
PE20040548A1 PE2003001177A PE2003001177A PE20040548A1 PE 20040548 A1 PE20040548 A1 PE 20040548A1 PE 2003001177 A PE2003001177 A PE 2003001177A PE 2003001177 A PE2003001177 A PE 2003001177A PE 20040548 A1 PE20040548 A1 PE 20040548A1
Authority
PE
Peru
Prior art keywords
adhesive
skin
active agent
layer
parecoxib
Prior art date
Application number
PE2003001177A
Other languages
English (en)
Inventor
Gary D Edwin
Brenda M Stoller
Guang Wei Lu
Kathry M Kienle
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PE20040548A1 publication Critical patent/PE20040548A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA, QUE COMPRENDE: 1)UNA LAMINA DE SOPORTE QUE SE ADAPTA FLEXIBLEMENTE A LA PIEL, LA CUAL TIENE SUPERFICIES OPUESTAS DISTALES Y PROXIMALES A LA PIEL CUANDO SE APLICA; 2)UN REVESTIMIENTO SOBRE LA SUPERFICIE PROXIMAL DE (1), QUE COMPRENDE a)DE 70% A 97% DE UN ADHESIVO, b)DE 1% A 10% DE UN AGENTE ACTIVO, SELECCIONADO DE VALDECOXIB, PARECOXIB Y PARECOXIB SODICO, O UNO DE SUS PROFARMACOS O UNA DE SUS SALES, QUE VA DISPERSO EN UNA MATRIZ, QUE COMPRENDE UNA CANTIDAD EFECTIVA QUE SOLUBILIZA AL AGENTE ACTIVO EN TOTAL DE UNO O MAS DISOLVENTES DIFERENTES DEL ADHESIVO, SIENDO R1 Y R2 INDEPENDIENTEMENTE HIDROGENO O UN GRUPO QUE ES METABOLICAMENTE REEMPLAZABLE POR HIDROGENO O UNA SAL FARMACEUTICAMENTE ESTABLE DE TAL COMPUESTO; c)UNA MEMBRANA ENTRE LA CAPA DE RESERVA Y LA CAPA DEL ADHESIVO, PERMITIENDO EL PASO DEL AGENTE ACTIVO; Y, d)DE 2% A 20% DE UNO O MAS POTENCIADORES DE PENETRACION A TRAVES DE LA PIEL, SELECCIONADO DE TERPENOS, TERPENOIDES, ALCOHOLES GRASOS, EUCALIPTOL, ESTERES DE SORBITAN, ENTRE OTROS; Y, 3)UN RECUBRIMIENTO DE LIBERACION QUE SE PUEDE DESPEGAR, QUE ANTES DE SU USO ES ADYACENTE A LA CAPA QUE CONTIENE EL ADHESIVO. TIENE APLICACION EN EL TRATAMIENTO LOCAL DE DOLOR Y/O INFLAMACION PROPORCIONANDO UN EFECTO TERAPEUTICO, LOCAL O SISTEMICO, PRESENTANDOSE EN LA FORMA DE PARCHES, EMPLASTOS, CATAPLASMAS Y SIMILARES
PE2003001177A 2002-11-21 2003-11-20 Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2 PE20040548A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42820802P 2002-11-21 2002-11-21

Publications (1)

Publication Number Publication Date
PE20040548A1 true PE20040548A1 (es) 2004-08-28

Family

ID=32393363

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001177A PE20040548A1 (es) 2002-11-21 2003-11-20 Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2

Country Status (15)

Country Link
US (1) US20040127531A1 (es)
EP (1) EP1565169A1 (es)
JP (1) JP2006509761A (es)
AR (1) AR042104A1 (es)
AU (1) AU2003287732A1 (es)
BR (1) BR0316275A (es)
CA (1) CA2501287A1 (es)
GT (1) GT200300247A (es)
MX (1) MXPA05005510A (es)
NL (1) NL1024816C2 (es)
PA (1) PA8589101A1 (es)
PE (1) PE20040548A1 (es)
TW (1) TW200427471A (es)
UY (1) UY28087A1 (es)
WO (1) WO2004047815A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4283507B2 (ja) * 2002-08-02 2009-06-24 久光製薬株式会社 経皮投与用貼付剤
EP1708700A1 (en) * 2003-12-24 2006-10-11 Pharmacia Corporation Metal salts of parecoxib as prodrugs of the cox-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
US20070258935A1 (en) * 2006-05-08 2007-11-08 Mcentire Edward Enns Water dispersible films for delivery of active agents to the epidermis
US20070259029A1 (en) * 2006-05-08 2007-11-08 Mcentire Edward Enns Water-dispersible patch containing an active agent for dermal delivery
US20080057090A1 (en) * 2006-09-01 2008-03-06 Mcentire Edward Enns Wrinkle masking film composition for skin
US7879942B2 (en) * 2006-10-05 2011-02-01 Eastman Chemical Company Switchable adhesive article for attachment to skin and method of using the same
US8445037B2 (en) * 2008-10-28 2013-05-21 A. M. Todd Company Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest
US8563031B2 (en) * 2010-05-27 2013-10-22 Absize, Inc. Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith
JP2012020991A (ja) * 2010-06-16 2012-02-02 Takasago Internatl Corp 経皮吸収促進剤、及びこれを含有する皮膚外用製剤
US11311423B2 (en) * 2012-12-19 2022-04-26 Nichiban Co., Ltd. Facial patch
US20160256407A1 (en) * 2013-10-11 2016-09-08 Xep, Inc. Energy patch
JP7431724B2 (ja) * 2017-09-27 2024-02-15 アクエスティブ セラピューティクス インコーポレイテッド 増強された透過を有する医薬組成物
KR102042456B1 (ko) * 2018-03-22 2019-11-08 크리스탈지노믹스(주) 경피흡수제제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892791B1 (en) * 1996-04-12 2003-03-05 G.D. Searle & Co. N-[[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL]PHENYL]SULFONYLPROPYLAMIDE and its SODIUMSALT AS PRODRUGS OF COX-2 INHIBITORS
CN1231592A (zh) * 1996-10-30 1999-10-13 瑟垃技术有限公司 作为渗透促进剂的羟乙酸及其盐的脂肪酸酯
CA2366852A1 (en) * 1999-03-01 2000-09-08 Alejandro Fabio Scasso Transdermal device comprising non-steroidal anti-inflammatory drugs incorporated in acrylic adhesive polymer matrix
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
IN191512B (es) * 2000-01-21 2003-12-06 Panacea Biotech
DE10032132A1 (de) * 2000-07-01 2002-01-17 Lohmann Therapie Syst Lts Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung
CA2448627A1 (en) * 2001-05-31 2002-12-05 Pharmacia Corporation Skin-permeable composition comprising a selective cyclooxygenase-2 inhibitor a monohydric alcohol
JP4283507B2 (ja) * 2002-08-02 2009-06-24 久光製薬株式会社 経皮投与用貼付剤

Also Published As

Publication number Publication date
AU2003287732A1 (en) 2004-06-18
NL1024816A1 (nl) 2004-05-26
PA8589101A1 (es) 2005-02-04
GT200300247A (es) 2004-07-12
TW200427471A (en) 2004-12-16
EP1565169A1 (en) 2005-08-24
CA2501287A1 (en) 2004-06-10
US20040127531A1 (en) 2004-07-01
AR042104A1 (es) 2005-06-08
NL1024816C2 (nl) 2006-03-06
UY28087A1 (es) 2004-06-30
JP2006509761A (ja) 2006-03-23
BR0316275A (pt) 2005-10-04
WO2004047815A1 (en) 2004-06-10
MXPA05005510A (es) 2005-07-25

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Legal Events

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FA Abandonment or withdrawal