PE20040324A1 - Formulaciones liquidas de baja dosis de entecavir y uso - Google Patents

Formulaciones liquidas de baja dosis de entecavir y uso

Info

Publication number
PE20040324A1
PE20040324A1 PE2003000351A PE2003000351A PE20040324A1 PE 20040324 A1 PE20040324 A1 PE 20040324A1 PE 2003000351 A PE2003000351 A PE 2003000351A PE 2003000351 A PE2003000351 A PE 2003000351A PE 20040324 A1 PE20040324 A1 PE 20040324A1
Authority
PE
Peru
Prior art keywords
entecavir
liquid
formulated
composition
compositions
Prior art date
Application number
PE2003000351A
Other languages
English (en)
Inventor
Divyakant Desai
Danping Danping
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20040324A1 publication Critical patent/PE20040324A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPOSICIONES FARMACEUTICAS LIQUIDAS QUE TIENEN UNA BAJA DOSIS DE ENTECAVIR PARA TRATAR INFECCIONES POR EL VIRUS DE HEPATITIS B COMO: a) UNA COMPOSICION LIQUIDA DE ENTECAVIR LISTA PARA USAR, FORMULADA PARA SER ESTABLE Y DE SABOR AGRADABLE, DONDE EL ENTECAVIR ESTA PRESENTE EN LA COMPOSICION EN UNA CANTIDAD DE ALREDEDOR DE 0.001% HASTA ALREDEDOR DE 20% P/V, b) UNA COMPOSICION LIQUIDA QUE ESTA FORMULADA A PARTIR DE UN POLVO PARA CONSTITUCION COMO UNA COMPOSICION LIQUIDA EN ELMOMENTO DE USO, QUE COMPRENDE ALREDEDOR DE 0.001% HASTA ALREDEDOR DE 20% PESO DE ENTECAVIR BASADO EN EL PESO TOTAL DE LA COMPOSICION EN POLVO.ESTAS COMPOSICIONES TIENEN POR LO MENOS UN COMPONENTE ADICIONAL SELECCIONADO DE UNO O MAS DE LOS SIGUIENTES: EDULCORANTE, CONSERVADOR, AGENTE SABORIZANTE, AGENTE DE SOLUCION AMORTIGUADORA AGENTE DE AJUSTE DE PH O COMBINACION DE ESTOS, TAMBIEN PUEDEN SER FORMULADAS EN COMBINACION CON OTROS AGENTES FARMACEUTICAMENTE ACTIVOS COMO DIDANOSINA, LAMIVUDINA, ABACAVIR, ADEFOVIR, ADEFOVIR DIPIVOXIL,FAMCICLOVIR, PROTEINAS INMUNOMODULADORAS DE HEPATITIS B ENTRE OTROS.TAMBIEN SE REFIERE A UN PROCESO PARA FORMULAR AMBAS COMPOSICIONES.
PE2003000351A 2002-04-08 2003-04-08 Formulaciones liquidas de baja dosis de entecavir y uso PE20040324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37067402P 2002-04-08 2002-04-08

Publications (1)

Publication Number Publication Date
PE20040324A1 true PE20040324A1 (es) 2004-05-29

Family

ID=29250568

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000351A PE20040324A1 (es) 2002-04-08 2003-04-08 Formulaciones liquidas de baja dosis de entecavir y uso

Country Status (22)

Country Link
US (1) US20030190334A1 (es)
EP (1) EP1492510A4 (es)
JP (1) JP2005528389A (es)
KR (1) KR20040099403A (es)
CN (1) CN1319517C (es)
AR (1) AR039388A1 (es)
AU (1) AU2003226259A1 (es)
BR (1) BR0309057A (es)
CA (1) CA2481092A1 (es)
EA (1) EA008102B1 (es)
EC (1) ECSP045349A (es)
HR (1) HRP20040893A2 (es)
MX (1) MXPA04009735A (es)
MY (1) MY131488A (es)
NO (1) NO20044451L (es)
NZ (1) NZ535535A (es)
PE (1) PE20040324A1 (es)
PL (1) PL372322A1 (es)
RS (1) RS88404A (es)
TW (1) TWI275392B (es)
WO (1) WO2003086367A1 (es)
ZA (1) ZA200407672B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7511139B2 (en) 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
CN1732944B (zh) * 2005-09-02 2013-05-08 海南中和药业有限公司 恩替卡韦分散片及其制备方法
US20070060599A1 (en) * 2005-09-09 2007-03-15 Dimarco John D Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
RU2381807C1 (ru) * 2008-07-18 2010-02-20 Алексей Глебович Одинец Противовирусное средство
CN101869569A (zh) * 2009-04-21 2010-10-27 李迪 即用型恩替卡韦组合物
EP2508172A1 (en) 2011-04-06 2012-10-10 Zentiva, a.s. Stable and uniform formulations of entecavir and preparation method thereof
PE20141328A1 (es) 2011-08-16 2014-10-04 Gilead Sciences Inc Tenofovir alafenamida hemifumarato
CN102908312B (zh) * 2011-11-10 2014-06-04 陈小花 抗乙肝病毒液体组合物
US8517850B1 (en) * 2012-12-11 2013-08-27 Cobra Golf Incorporated Golf club grip with device housing
KR101462018B1 (ko) * 2013-04-01 2014-11-19 썬시스템즈(주) 엔테카비르 함유 구강 붕해형 필름제제
CN103301071A (zh) * 2013-06-03 2013-09-18 北京阜康仁生物制药科技有限公司 一种稳定的恩替卡韦无糖型颗粒剂及其制备方法
CN105722503A (zh) * 2013-08-06 2016-06-29 东国制药株式会社 恩替卡韦微球及包含其的非口服给药用药学组合物
EP3158998A4 (en) * 2014-06-20 2018-02-14 CTC Bio, Inc. Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
CN104083374A (zh) * 2014-07-18 2014-10-08 石家庄创建医药科技有限公司 一种恩替卡韦口服液组合物
CN109984996B (zh) * 2018-01-02 2022-01-18 扬子江药业集团有限公司 恩替卡韦口服溶液及其制备方法
CN108434096A (zh) * 2018-06-20 2018-08-24 广州大光制药有限公司 一种恩替卡韦口服溶液及其制备方法
KR20210029787A (ko) * 2018-06-29 2021-03-16 학교법인 도시샤 엠리카산을 포함하는 제제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
TW536403B (en) * 1997-03-24 2003-06-11 Glaxo Group Ltd An ethanol and ethylenediaminetetraacetic acid free pharmaceutical composition comprising lamivudine and exhibiting antimicrobial preservative efficacy
US5997905A (en) * 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
JP2002534438A (ja) * 1999-01-12 2002-10-15 スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム 新規治療法
CZ303395B6 (cs) * 2000-02-29 2012-08-29 Bristol-Myers Squibb Co. Farmaceutický prostredek s nízkou dávkou entekaviru
CA2311734C (en) * 2000-04-12 2011-03-08 Bristol-Myers Squibb Company Flash-melt oral dosage formulation

Also Published As

Publication number Publication date
HRP20040893A2 (en) 2005-02-28
CA2481092A1 (en) 2003-10-23
JP2005528389A (ja) 2005-09-22
EP1492510A1 (en) 2005-01-05
CN1658844A (zh) 2005-08-24
EP1492510A4 (en) 2006-01-11
EA008102B1 (ru) 2007-04-27
TWI275392B (en) 2007-03-11
AU2003226259A1 (en) 2003-10-27
ECSP045349A (es) 2005-01-03
BR0309057A (pt) 2005-02-01
US20030190334A1 (en) 2003-10-09
WO2003086367A1 (en) 2003-10-23
KR20040099403A (ko) 2004-11-26
EA200401298A1 (ru) 2005-02-24
AR039388A1 (es) 2005-02-16
NO20044451L (no) 2004-11-04
TW200306840A (en) 2003-12-01
NZ535535A (en) 2006-09-29
MY131488A (en) 2007-08-30
MXPA04009735A (es) 2005-01-11
RS88404A (en) 2006-12-15
CN1319517C (zh) 2007-06-06
PL372322A1 (en) 2005-07-11
ZA200407672B (en) 2005-10-12

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