PE20040206A1 - BENZIMIDAZOLES USEFUL IN THE TREATMENT OF SEXUAL DYSFUNCTION - Google Patents

Abstract

SE REFIERE A COMPUESTOS BENZIMIDAZOLES DE FORMULA (I) DONDE A ES UN ANILLO HETEROCICLICO DE 5-6 MIEMBROS CON HETEROATOMOS DE N, S O X, Y POLISUSTITUIDO CON R1, R2, R3, R4 Y R5, SEGUN SEA EL CASO; X ES NH, O O S; R1, R2, R3, R4 Y R5 ES H, ALCOXI, ALQUENILO, ALQUILO, ALQUILSULFINILO, ALQUILSULFONILO, ALQUILCARBONILOXI, HIDROXI, MERCAPTO, CIANO, FORMILO, HALOGENO, -NZ1Z2,(NZ1Z2)CARBONILO, (NZ1Z2)SULFONILO, ENTRE OTROS; DONDE Z1 Y Z2 ES H, ALQUILO, ALQUILCARBONILO, ALQUILSULFONIO O FORMILO; L ES CH2, (CH2)n, Y n ES 2,3 Y 4; RA, RB, RC Y RD SON H, ALCOXI, ALQUENILO, ALQUILO, ALQUILSULFINILO, ALQUILSULFONILO, ALQUILTIO, ALQUILCARBONILOXI, -NZ1Z2, (NZ1Z2)CARBONILO, ENTRE OTROS; RE ES H, ALCOXICARBONILO, ALQUILO, CICLOALQUILCARBONILO, (NZ1Z2)CARBONILO, ENTRE OTROS; RF ES H O ALQUILO; Z ES N, C O CH ; --- ES UN ENLACE SI Z ES C ,O ESTA AUSENTE SI Z ES N O CH. SON COMPUESTOS PREFERIDOS: 2-{[4-(3-METILPIRIDIN-2-IL)PIPERAZIN-1-IL]METIL}-1H-BENCIMIDAZOL, 2-[(2-METIL-4-PIRIDIN-2-ILPIPERAZIN-1-IL)METIL]-1H-BENCIMIDAZOL, ENTRE OTROS.ESTOS COMPUESTOS SON AGONISTAS DE DOPAMINA Y PUEDEN UTILIZARSE EN EL TRATAMIENTO DE DISFUNCION SEXUALREFERS TO BENZIMIDAZOLES COMPOUNDS OF FORMULA (I) WHERE A IS A 5-6 MEMBER HETEROCYCLIC RING WITH N, S OR X HETEROATOMES, AND POLYSUSTITUTED WITH R1, R2, R3, R4 AND R5, WHICH MAY BE THE CASE; X IS NH, O O S; R1, R2, R3, R4 AND R5 IS H, ALCOXY, ALKENYL, ALKYL, ALKYLSULFINYL, ALKYLSULFONYL, ALKYLCARBONYLOXY, HYDROXY, MERCAPTO, CYANE, FORMYL, HALOGENO, -NZ1TONYL2, (NZULFONYL2) WHERE Z1 AND Z2 IS H, I RENT, ALKYLCARBONYL, ALKYLSULPHONIUM OR FORMYL; L IS CH2, (CH2) n, Y n IS 2,3 Y 4; RA, RB, RC AND RD ARE H, ALCOXY, ALKENYL, ALKYL, ALKYLSULFINYL, ALKYLSULFONYL, ALKYLTIO, ALKYLCARBONYLOXY, -NZ1Z2, (NZ1Z2) CARBONYL, AMONG OTHERS; RE IS H, ALCOXYCARBONYL, ALKYL, CYCLOALKYLCARBONYL, (NZ1Z2) CARBONYL, AMONG OTHERS; RF IS H OR RENT; Z IS N, C O CH; --- IT IS A LINK IF Z IS C, OR IS ABSENT IF Z IS N OR CH. PREFERRED COMPOUNDS ARE: 2 - {[4- (3-METHYLPYRIDIN-2-IL) PIPERAZIN-1-IL] METHYL} -1H-BENZIMIDAZOLE, 2 - [(2-METHYL-4-PYRIDIN-2-ILPIPERAZIN-1- IL) METHYL] -1H-BENZIMIDAZOLE, AMONG OTHERS.THESE COMPOUNDS ARE DOPAMINE AGONISTS AND MAY BE USED IN THE TREATMENT OF SEXUAL DYSFUNCTION