PE20030120A1 - Sal amina de un antagonista de receptor de integrin - Google Patents

Sal amina de un antagonista de receptor de integrin

Info

Publication number
PE20030120A1
PE20030120A1 PE2002000515A PE2002000515A PE20030120A1 PE 20030120 A1 PE20030120 A1 PE 20030120A1 PE 2002000515 A PE2002000515 A PE 2002000515A PE 2002000515 A PE2002000515 A PE 2002000515A PE 20030120 A1 PE20030120 A1 PE 20030120A1
Authority
PE
Peru
Prior art keywords
salt
refers
hydroximethyl
naphthyridin
aminomethane
Prior art date
Application number
PE2002000515A
Other languages
English (en)
Inventor
Wei Xu
Guy R Humphrey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20030120A1 publication Critical patent/PE20030120A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

SE REFIERE A UNA SAL AMINA DEL ACIDO 3-(PIRIMIDIN-5-IL)-9-(5,6,7,8-TETRAHIDRO-[1,8]-NAFTIRIDIN-2-IL)-NONANOICO O UN SOLVATO FARMACEUTICAMENTE ACEPTABLE CON INCLUSION DE HIDRATO DE FORMULA I QUE SE CARACTERIZA POR SU PATRON DE DIFRACCION DE RAYOS X QUE EXHIBE PICOS DE DIFRACCION CORRESPONDIENTE A ESPACIAMIENTOS d QUE VARIAN ENTRE 16,38A° Y 3,23A°, CURVA CALORIMETRICA DE EXPLORACION DIFERENCIAL, ESPECTRO DE RESONANCIA MAGNETICA NUCLEAR DE AMGPC EN ESTADO SOLIDO CARBONO 13 QUE MUESTRA SENALES ENTRE 179,0 Y 20,4, ESPECTRO INFRARROJO CON TF QUE MUESTRA BANDAS DE ABSORCION SIGNIFICATIVA ENTRE 3347 Y 659 cm(-1). TAMBIEN SE REFIERE A UNA SAL QUE COMPRENDE IONES DEL ANION ACIDO 3-(PIRIMIDIN-5-IL)-9-(5,6,7,8,-TETRAHIDRO-[1,8]-NAFTIRIDIN-2-IL)-NONANOICO Y EL CATION PROTONADO TRIS(HIDROXIMETIL)AMINOMETANO.TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE LA SAL QUE COMPRENDE PONER EN CONTACTO UN EQUIVALENTE MOLAR DEL COMPUESTO EN UN DISOLVENTE ORGANICO (METANOL, ETANOL, ENTRE OTROS) CON UN EQUIVALENTE MOLAR DE TRIS(HIDROXIMETIL)AMINOMETANO A UNA TEMPERATURA ENTRE LOS LIMITES DE 0°C A 100°C. LA SAL PUEDE SER UTL PARA EL TRATAMIENTO DE OSTEOPOROSIS, ENFERMEDAD O AFECCION CAUSADA POR UN EXCESO DE ANGIOGENESIS, DEGENERACION DE MACULA, RECURRENCIA DE ESTENOSIS VASCULAR, RETINOPATIA DIABETICA, ATEROSCLEROSIS, ARTRITIS INFLAMATORIA, CANCER, CRECIMIENTO TUMORAL METASTASICO
PE2002000515A 2001-06-19 2002-06-14 Sal amina de un antagonista de receptor de integrin PE20030120A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29934401P 2001-06-19 2001-06-19

Publications (1)

Publication Number Publication Date
PE20030120A1 true PE20030120A1 (es) 2003-02-12

Family

ID=23154380

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000515A PE20030120A1 (es) 2001-06-19 2002-06-14 Sal amina de un antagonista de receptor de integrin

Country Status (4)

Country Link
US (1) US6750220B2 (es)
DO (1) DOP2002000420A (es)
PE (1) PE20030120A1 (es)
WO (1) WO2002102374A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) * 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2230232A1 (en) * 2009-03-13 2010-09-22 Almirall, S.A. Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
EP2314577A1 (en) 2009-10-16 2011-04-27 Almirall, S.A. Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
HUE063437T2 (hu) 2013-09-24 2024-01-28 Fujifilm Corp Nitrogént tartalmazó vegyületet vagy sóját vagy fémkomplexét tartalmazó gyógyászati készítmény

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048861A (en) 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
KR20010033248A (ko) * 1997-12-17 2001-04-25 폴락 돈나 엘. 인테그린 수용체 길항제
US6444680B1 (en) * 2000-11-30 2002-09-03 Merck & Co., Inc. Amine salts of an integrin receptor antagonist

Also Published As

Publication number Publication date
DOP2002000420A (es) 2002-12-30
US6750220B2 (en) 2004-06-15
WO2002102374A1 (en) 2002-12-27
US20030004171A1 (en) 2003-01-02

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Legal Events

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FA Abandonment or withdrawal