PE20001486A1 - Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas - Google Patents

Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas

Info

Publication number
PE20001486A1
PE20001486A1 PE2000000128A PE0001282000A PE20001486A1 PE 20001486 A1 PE20001486 A1 PE 20001486A1 PE 2000000128 A PE2000000128 A PE 2000000128A PE 0001282000 A PE0001282000 A PE 0001282000A PE 20001486 A1 PE20001486 A1 PE 20001486A1
Authority
PE
Peru
Prior art keywords
alkyl
het
compounds
cycloalkyl
etereo
Prior art date
Application number
PE2000000128A
Other languages
English (en)
Inventor
Wells Marquis Robert
Frank Veber Daniel
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20001486A1 publication Critical patent/PE20001486A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/16—Eight-membered rings
    • C07D313/18—Eight-membered rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS ETER ANULAR DE 7-14 MIEMBROS DE FORMULA I, DONDE A ES CO, CH(OH); R1 ES R3-N(R`)-C(R2)-C(=O)-; R' ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R'' ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R''' ES H, ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R2 ES H, ALQUENILO C2-C6, ALQUINILO C2-C6, HET, Ar, ALQUILO C1-C6 CON OR6, R6NC(O)OR5, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6, R4C(O)-, R4R7NC(O)-, ENTRE OTROS; R4 ES ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R5 ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R6 Y R7 SON H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; M ES HC=CH, H2C-CH2, H(OR2)C-C(OR2)H, H(OR2)C-CH2, H(NR2H)C-C(NR2H)H, ENTRE OTROS; n ES 1-7; l ES 0-1. SON COMPUESTOS PREFERIDOS [(S)-3-METIL-1-(3-OXO-3,4,5,8-TETRAHIDRO-2H-OXOCIN-4-ILCARBAMOIL)-BUTIL]-AMIDA DE ACIDO NAFTILENO-2-CARBOXILICO; [(S)-3-METIL-1((S)-3-OXO-3,4,5,8-TETRAHIDRO-2H-OXOCIN-4-ILCARBAMOIL)-BUTIL]-AMIDA DE ACIDO BENZO[b]TIOFEN-2-CARBOXILICO, ENTRE OTROS. EL COMPUESTO DE FORMULA I ES UN INHIBIDOR DE CISTEINA Y SERINA PROTEASA Y PUEDE SER UTIL PARA EL TRATAMIENTO OSTEOPOROSIS, PERIODONTITIS, ARTRITIS, GINGIVITIS, OSTEOARTRITIS
PE2000000128A 1999-02-19 2000-02-18 Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas PE20001486A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12069999P 1999-02-19 1999-02-19

Publications (1)

Publication Number Publication Date
PE20001486A1 true PE20001486A1 (es) 2001-02-08

Family

ID=22392011

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000128A PE20001486A1 (es) 1999-02-19 2000-02-18 Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas

Country Status (8)

Country Link
EP (1) EP1153022A4 (es)
JP (1) JP2002537297A (es)
AU (1) AU3235100A (es)
CO (1) CO5271679A1 (es)
DZ (1) DZ3083A1 (es)
HK (1) HK1042695A1 (es)
PE (1) PE20001486A1 (es)
WO (1) WO2000049011A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7168084B1 (en) 1992-12-09 2007-01-23 Sedna Patent Services, Llc Method and apparatus for targeting virtual objects
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
EP1232154A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp PROTEASE INHIBITORS
US6534498B1 (en) 1999-11-10 2003-03-18 Smithkline Beecham Corporation Protease inhibitors
EP1232155A4 (en) 1999-11-10 2002-11-20 Smithkline Beecham Corp PROTEASE INHIBITORS
CN1416346A (zh) 2000-03-21 2003-05-07 史密丝克莱恩比彻姆公司 蛋白酶抑制剂
ES2261341T3 (es) * 2000-11-17 2006-11-16 Medivir Ab Inhibidor de cisteina proteasa.
WO2002040462A2 (en) * 2000-11-17 2002-05-23 Medivir Uk Limited Cysteine protease inhibitors
ATE338803T1 (de) * 2003-05-27 2006-09-15 Merck Patent Gmbh Pyranderivative mit exocyclischer doppelbindung
DE102004021338A1 (de) * 2003-05-27 2005-03-03 Merck Patent Gmbh Pyranderivate
EP1757284A1 (en) * 2005-08-25 2007-02-28 Santhera Pharmaceuticals (Schweiz) AG Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
CA2157412A1 (en) * 1993-03-03 1994-09-15 Julia Marie Heerding Balanoids
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
AR013079A1 (es) * 1997-05-06 2000-12-13 Smithkline Beecham Corp Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios

Also Published As

Publication number Publication date
WO2000049011A1 (en) 2000-08-24
DZ3083A1 (fr) 2004-06-02
EP1153022A1 (en) 2001-11-14
AU3235100A (en) 2000-09-04
JP2002537297A (ja) 2002-11-05
CO5271679A1 (es) 2003-04-30
HK1042695A1 (zh) 2002-08-23
EP1153022A4 (en) 2002-03-27

Similar Documents

Publication Publication Date Title
PE20001486A1 (es) Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas
PE20021005A1 (es) Quinazolinas como inhibidores de mmp-13
PE20001340A1 (es) 4-amino-azepan-3-ona como inhibidores de proteasas
PE20030199A1 (es) Derivados de n-[benzoil]-fenilsulfonamida
PE20021014A1 (es) Derivados de glutaramida sustituida con n-fenpropilciclopentilo como inhibidores de nep para fsad
AR029870A1 (es) Proceso para la preparacion de amidas de octanoilo sustituido
PE20011233A1 (es) Compuestos alquil aminoazepan-3-ona como inhibidores de proteasas
HK1097273A1 (en) Aminopyrones and their use as atm inhibitors
PE20010984A1 (es) Derivados de nitrilo como inhibidores de catepsina k
NZ522568A (en) Substituted bicyclic derivatives for the treatment of abnormal cell growth
PE20031012A1 (es) Compuesto inhibidor de la hepatitis c
NZ505523A (en) Aromatic amides, intermediates, and a process for their preparation; useful as antibiotics
PE20010962A1 (es) Derivados de heterociclo-alquilsulfonil-pirazol como agentes anti-inflamatorios/analgesicos
PE20011374A1 (es) 4-amino-azepan-3-ona como inhibidores de proteasas
PE20001237A1 (es) Inhibidores de proteasas
BR0308643A (pt) Composto do derivado do ácido piridobenzoxazina carboxìlico e agente antibacteriano contendo o mesmo
PE20001564A1 (es) 1,3-dioxepin-5-ona con un anillo de 7 miembros como inhibidores de proteasas
PE20001355A1 (es) 1,3-diamino-cetonas como inhibidores de proteasas
PE20001607A1 (es) 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS
DE60000500T2 (de) Substituierte n-(piperidin-4-yl)-4h-3,1-benzo(thia/oxa)zin-2-amine, ihre herstellung und therapeutische verwendung
ES2190781T3 (es) Derivados de 1-trifluorometil-4-hidroxi-7-piperidinil-aminometilcromano.
AR026244A1 (es) Compuestos
CO5580804A2 (es) Derivados de diazepanes utiles como inhibidores de lfa
GR3002958T3 (en) Thiophene derivatives
ES2034537T3 (es) Procedimiento para la obtencion de derivados del acido 5-(n-3,4,5,6-tetrahidroftalimido)-canimico.

Legal Events

Date Code Title Description
FD Application declared void or lapsed