PE14696A1 - PHENETHANOLAMINE DERIVATIVE - Google Patents

PHENETHANOLAMINE DERIVATIVE

Info

Publication number
PE14696A1
PE14696A1 PE1995270670A PE27067095A PE14696A1 PE 14696 A1 PE14696 A1 PE 14696A1 PE 1995270670 A PE1995270670 A PE 1995270670A PE 27067095 A PE27067095 A PE 27067095A PE 14696 A1 PE14696 A1 PE 14696A1
Authority
PE
Peru
Prior art keywords
carbon atoms
alkyl
compounds
preferred
replaced
Prior art date
Application number
PE1995270670A
Other languages
Spanish (es)
Inventor
Michael Walter Foxton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9411589A external-priority patent/GB9411589D0/en
Priority claimed from GBGB9504169.5A external-priority patent/GB9504169D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE14696A1 publication Critical patent/PE14696A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I DONDE: R1 REPRESENTA UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO POR UNO O MAS SUSTITUYENTES, SELECCIONADO DE HALO, HIDROXI, ALCOXI DE 1 A 6 ATOMOS DE CARBONO, ENTRE OTROS; DE PREFERENCIA ES UN GRUPO FENILO SUSTITUIDO POR UN ATOMO DE CLORO EN POSICION META; R2 REPRESENTA H o ALQUILO DE 1 A 6 ATOMOS DE CARBONO, DE PREFERENCIA ES METILO o H; R3 ES UN GRUPO FENILO O HETEROARILO SUSTITUIDO CON R6 Y R7; R4 y R5 CADA UNO REPRESENTA INDEPENDIENTEMENTE H o ALQUILO DE 1 A 6 ATOMOS DE CARBONO O R4 Y R5 CONJUNTAMENTE FORMAN UN GRUPO CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO; X ES (CH2)n DONDE n ES 1 o 2, DE PREFERENCIA 2. ESTOS COMPUESTOS SE CARACTERIZAN POR ACTUAR COMO AGONISTAS EN LOS BETA-ADRENORECEPTORES ATIPICOS , SIENDO UTILES EN EL TRATAMIENTO DE DESORDENES GASTROINTESTINALES EN PARTICULAR LOS ASOCIADOS CON LA INFLAMACION Y ULCERACIONIT REFERS TO FORMULA I COMPOUNDS WHERE: R1 REPRESENTS AN ARILO GROUP OPTIONALLY REPLACED BY ONE OR MORE SUBSTITUTES, SELECTED FROM HALO, HIDROXI, ALCOXI FROM 1 TO 6 CARBON ATOMS, AMONG OTHERS; OF PREFERENCE IS A PHENYLUS GROUP REPLACED BY A CHLORINE ATOME IN GOAL POSITION; R2 REPRESENTS H or ALKYL FROM 1 TO 6 CARBON ATOMS, PREFERRED IS METHYL or H; R3 IS A PHENYL OR HETEROARYL GROUP REPLACED WITH R6 AND R7; R4 and R5 EACH ONE INDEPENDENTLY REPRESENTS H or ALKYL FROM 1 TO 6 CARBON ATOMS OR R4 AND R5 TOGETHER FORM A CYCLOALKYL GROUP OF 3 TO 6 CARBON ATOMS; X IS (CH2) n WHERE n IS 1 or 2, PREFERRED 2. THESE COMPOUNDS ARE CHARACTERIZED BY ACTING AS AGONISTS IN THE BETA-ADRENORECEPTORS ATYPICAL, BEING USEFUL IN THE TREATMENT OF GASTROINTESTINAL DISORDERS AND ASSOCIATED WITH ULCH

PE1995270670A 1994-06-09 1995-06-07 PHENETHANOLAMINE DERIVATIVE PE14696A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9411589A GB9411589D0 (en) 1994-06-09 1994-06-09 Chemical compounds
GBGB9504169.5A GB9504169D0 (en) 1995-03-02 1995-03-02 Chemical compounds

Publications (1)

Publication Number Publication Date
PE14696A1 true PE14696A1 (en) 1996-05-13

Family

ID=26305035

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995270670A PE14696A1 (en) 1994-06-09 1995-06-07 PHENETHANOLAMINE DERIVATIVE

Country Status (5)

Country Link
AU (1) AU2737295A (en)
CO (1) CO4410319A1 (en)
IL (1) IL114059A0 (en)
PE (1) PE14696A1 (en)
WO (1) WO1995033724A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9525121D0 (en) * 1995-12-08 1996-02-07 Glaxo Group Ltd Chemical compounds
GB9525177D0 (en) * 1995-12-08 1996-02-07 Glaxo Group Ltd Chemical compounds
US5914339A (en) * 1996-05-14 1999-06-22 American Home Products Corporation Substituted 1,3-benzodioxoles
FR2751646B1 (en) * 1996-07-23 1999-01-22 Sanofi Sa PHENOXYPROPANOLAMINE WITH ANTAGONIST BETA3-ADRENERGIC ACTION
GB9706707D0 (en) * 1997-04-02 1997-05-21 Glaxo Group Ltd Chemical compounds
GB9812709D0 (en) * 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
GB9929118D0 (en) * 1999-12-10 2000-02-02 Glaxo Group Ltd Chemical compounds
US7034053B2 (en) 2001-01-31 2006-04-25 Smithkline Beecham Corporation Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors
GB0102408D0 (en) * 2001-01-31 2001-03-14 Glaxo Group Ltd Chemical compounds
US7709677B2 (en) 2001-01-31 2010-05-04 Glaxosmithkline Llc Process of preparing arylethanoldiamines
GB0102407D0 (en) 2001-01-31 2001-03-14 Glaxo Group Ltd Process
NZ540698A (en) 2002-12-24 2008-05-30 Astrazeneca Ab Phosphonooxy quinazoline derivatives and their pharmaceutical use
EP1595873A1 (en) * 2004-05-13 2005-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Substituted cycloalkyl derivatives for the treatment of respiratory diseases
US7423035B2 (en) 2004-05-13 2008-09-09 Boehringer Ingelheim International Gmbh Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament
DK2484680T3 (en) 2005-12-07 2013-09-08 Basilea Pharmaceutica Ag Useful combinations of monolactam antibiotics with beta-lactamase inhibitors
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
KR20170086659A (en) 2014-12-03 2017-07-26 벨리셉트 테라퓨틱스, 인크. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
FI3365321T3 (en) 2015-10-23 2024-01-02 B3Ar Therapeutics Inc Solabegron zwitterion and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154761A (en) * 1976-02-09 1979-05-15 Allen & Hanburys Limited Pharmacologically active compounds
DK31578A (en) * 1977-02-03 1978-08-04 Allen & Hanburys Ltd PROCEDURE FOR THE PRODUCTION OF BENZENE DERIVATIVES
US5061727A (en) * 1990-05-04 1991-10-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
NO179246C (en) * 1991-11-20 1996-09-04 Sankyo Co Aromatic amino-alcohol derivatives and intermediates for their preparation
GB9207964D0 (en) * 1992-04-10 1992-05-27 Ici Plc Chemical compounds

Also Published As

Publication number Publication date
WO1995033724A1 (en) 1995-12-14
AU2737295A (en) 1996-01-04
IL114059A0 (en) 1995-10-31
CO4410319A1 (en) 1997-01-09

Similar Documents

Publication Publication Date Title
PE14696A1 (en) PHENETHANOLAMINE DERIVATIVE
AR055878A1 (en) CYCLOPROPANOCARBOXAMIDE DERIVATIVES
CO4700576A1 (en) NEW TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
ECSP066405A (en) ARIL OR HETEROARIL AMIDA COMPOUNDS
ES2059069T3 (en) NEW DERIVATIVES OF 1-ALCOXI- (2-ACILAMINO-ETIL) -NAPHTHALENS AND ITS PREPARATION PROCEDURE.
PE10897A1 (en) FUSED BENZO COMPOUNDS
CO4650117A1 (en) BENCILSULFIDE DERIVATIVES AND PROCESS FOR ITS PRODUCTION.
JPS5278900A (en) Improvement in organic compound
SE8002345L (en) THERAPEUTIC AGENTS
SE7602144L (en) QUATER IMIDAZOLIUM ASSOCIATIONS
PE20050160A1 (en) 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE
ES2055867T3 (en) DIBENZOTIAZEPINE DERIVATIVES USEFUL AS ANTIESPASMODIC AGENTS.
ES2145067T3 (en) PHARMACEUTICAL COMPOSITIONS BASED ON ARGATROBAN ANALOGS.
ES2106015T3 (en) DERIVATIVES OF INDOL.
FR2378077A1 (en) STABILIZED HEAT EXCHANGE MEDIA BASED ON FLUORINE HYDROCARBON, ABSORBENT AND A STABILIZING FORM OF PHOSPHITE
EA200001184A1 (en) PHENYL SULPHONAMIDPHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS
PE47296A1 (en) NEW USE OF INDOL DERIVATIVE
SE9001269D0 (en) 2-SUBSTITUTED N, N-DITRIMETHOXYBENZOYL PIPERAZINES, AND PREPARATION PROCESS OF THE SAME AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
HUT50777A (en) Process for producing 2-/3-pyridyl/-3-phenoxy-propionitril derivatives and intermediates and fungicide compositions containing the former ones as active components
PE62099A1 (en) N-LINKED SULPHONAMIDES OF HETERO CYCLIC THIOESTERS
FI853685A0 (en) NYA N-ALK (EN) YL-N- (O, O-DISUBSTITUTE-THIOPHOSPHORYL) -N'N'-DISUBSTITUTE-GLYCINAMIDER
ES466363A1 (en) N-9,10-dihydrolysergyl-m-aminobenzoic acid amide derivative
FI962768A (en) N- (2-phthalimidoethyl) substituted trans-piperidine-2,5-dicarboxylates
DE69700338T2 (en) Fluoropropene compound, insecticide containing them, and intermediate for their preparation
ATE33980T1 (en) BENZALDOXIME CARBAMATE DERIVATIVES.

Legal Events

Date Code Title Description
FX Voluntary withdrawal