PA8653501A1 - NEW COMPOUNDS - Google Patents

NEW COMPOUNDS

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Publication number
PA8653501A1
PA8653501A1 PA20058653501A PA8653501A PA8653501A1 PA 8653501 A1 PA8653501 A1 PA 8653501A1 PA 20058653501 A PA20058653501 A PA 20058653501A PA 8653501 A PA8653501 A PA 8653501A PA 8653501 A1 PA8653501 A1 PA 8653501A1
Authority
PA
Panama
Prior art keywords
rent
alcoxi
het
members
heterocicle
Prior art date
Application number
PA20058653501A
Other languages
Spanish (es)
Inventor
Gavin Alistair Whitlock
Alan Stobie
Florian Wakenhut
Thomas Ryckmans
Paul Vincent Fish
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PA8653501A1 publication Critical patent/PA8653501A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Abstract

UN COMPUESTO DE FORMULA (l) Y SUS DERIVADOS FARMACEUTICA Y/O VETERINARIAMENTE ACEPTABLES, EN LA QUE R1, R2, R3 Y R20 SON CADA UNO INDEPENDIENTEMENTE H, CI, BR, F CF3, OCF3, ME O ET; R4 ES HET O CICLOALQUILO DE C3-7 OPCIONALMENTE SUBSTITUIDO CON ALQUILO DE C1-4, ALCOXI DE C1-4, ALCOXIALQUILO QUE CONTIENE DE 2 A 4 ATOMOS DE CARBONO, O S-(ALQUILO DE C1-4); A ES O O 1; Y HET ES UN HETEROCICLO NO AROMATICO DE 4, 5 O 6 MIEMBROS QUE CONTIENEN POR LO MENOS UN HETEROATOMO DE N, O ó S, OPCIONALMENTE CONDENSADO CON UN GRUPO CARBOCICLICO DE 5 O 6 MIEMBROS O UN SEGUNDO HETEROCICLO DE 4, 5 O 6 MIEMBROS QUE CONTIENE POR LO MENOS UN HETEROATOMO DE N O o S, EN EL QUE EL GRUPO HET ESTA OPCIONALMENTE SUBSTITUIDO POR LO MENOS CON UN SUBSTITUYENTE SELECCIONADO INDEPENDIENTEMENTE DE ALQUILO DE C1-8, ALCOXI DE C1-8, OH, HALO, CF3, OCF3, SCF3, HIDROXI-ALQUILO DE C1-6, ALCOXI DE C1-4-AQUILO DE C1-6 Y ALQUIL DE C1-4-S-ALQUILO DE C1-4; CON TAL DE QUE POR LO MENOS UNO DE R1,R2,Y R3 SEA DISTINTO DE H. LOS COMPUESTOS DE LA INVENCION EXHIBEN ACTIVIDAD COMO INHIBIDORES DE LA RECAPTACION TANTO DE SEROTONINA COMO DE NORADRENALINA Y POR LO TANTO TIENEN UTILIDAD EN VARIAS AREAS TERAPEUTICAS, POR EJEMPLO, INCONTINENCIA URINARIA.A COMPOSITE OF FORMULA (l) AND ITS PHARMACEUTICAL AND / OR VETERINARLY ACCEPTABLE DERIVATIVES, IN WHICH R1, R2, R3 AND R20 ARE EACH INDEPENDENTLY H, CI, BR, F CF3, OCF3, ME OR ET; R4 IS HET OR C3-7 CYCLALKYL OPTIONALLY SUBSTITUTED WITH C1-4 RENT, C1-4 ALCOXI, ALCOXIALQUIL CONTAINING FROM 2 TO 4 CARBON ATOMS, OR S- (C1-4 RENT); A ES O O 1; AND HET IS A NON-AROMATIC HETEROCICLE OF 4, 5 OR 6 MEMBERS CONTAINING AT LEAST ONE HETEROATOMY OF N, OR OR S, OPTIONALLY CONDENSED WITH A CARBOYCLIC GROUP OF 5 OR 6 MEMBERS OR A SECOND HETEROCICLE OF 4, 5 OR 6 MEMBERS THAT CONTAINS AT LEAST ONE HETEROATOMO OF NO or S, IN WHICH THE GROUP HET IS OPTIONALLY SUBSTITUTED AT LEAST WITH A SUBSTITUENTLY SELECTED FROM RENT OF C1-8, ALCOXI OF C1-8, OH, HALO, CF3, OCF3, SCF3, HYDROXI-RENT OF C1-6, ALCOXI OF C1-4-AQUILO OF C1-6 AND RENT OF C1-4-S-RENT OF C1-4; SO THAT AT LEAST ONE OF R1, R2, AND R3 IS DIFFERENT FROM H. THE COMPOUNDS OF THE INVENTION EXHIBIT ACTIVITY AS INHIBITORS OF THE RECAPTATION OF BOTH SEROTONIN AND NORADRENALINE AND THEREFORE THEY ARE USED IN VARIOUS THERAPEUTIC AREAS EXAMPLE, URINARY INCONTINENCE.

PA20058653501A 2004-11-23 2005-11-23 NEW COMPOUNDS PA8653501A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0425766.3A GB0425766D0 (en) 2004-11-23 2004-11-23 Novel compounds

Publications (1)

Publication Number Publication Date
PA8653501A1 true PA8653501A1 (en) 2006-06-02

Family

ID=33548739

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058653501A PA8653501A1 (en) 2004-11-23 2005-11-23 NEW COMPOUNDS

Country Status (26)

Country Link
EP (1) EP1817281A1 (en)
JP (1) JP4233596B2 (en)
KR (1) KR100886294B1 (en)
CN (1) CN101065355A (en)
AP (1) AP2007004003A0 (en)
AR (1) AR052243A1 (en)
AU (1) AU2005308534A1 (en)
BR (1) BRPI0518486A2 (en)
CA (1) CA2589258A1 (en)
CR (1) CR9171A (en)
EA (1) EA011217B1 (en)
GB (1) GB0425766D0 (en)
GT (1) GT200500337A (en)
IL (1) IL183191A0 (en)
MA (1) MA29038B1 (en)
MX (1) MX2007006138A (en)
NL (2) NL1030485C2 (en)
NO (1) NO20072486L (en)
PA (1) PA8653501A1 (en)
PE (1) PE20061056A1 (en)
SV (1) SV2006002311A (en)
TN (1) TNSN07201A1 (en)
TW (1) TWI300776B (en)
UY (1) UY29224A1 (en)
WO (1) WO2006056884A1 (en)
ZA (1) ZA200703910B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628885A5 (en) * 1978-01-01 1982-03-31 Anphar Sa Piperidine derivative
GB0314054D0 (en) * 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
CA2530159C (en) * 2003-06-17 2010-02-02 Pfizer Inc. N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors

Also Published As

Publication number Publication date
EA200700920A1 (en) 2007-12-28
PE20061056A1 (en) 2006-11-08
JP2008520646A (en) 2008-06-19
EA011217B1 (en) 2009-02-27
GB0425766D0 (en) 2004-12-22
KR100886294B1 (en) 2009-03-04
WO2006056884A1 (en) 2006-06-01
CN101065355A (en) 2007-10-31
ZA200703910B (en) 2008-09-25
CA2589258A1 (en) 2006-06-01
UY29224A1 (en) 2006-06-30
AR052243A1 (en) 2007-03-07
NL1030485A1 (en) 2006-05-24
NL1030485C2 (en) 2006-11-07
NL1032760C2 (en) 2007-04-17
EP1817281A1 (en) 2007-08-15
AU2005308534A1 (en) 2006-06-01
KR20070086599A (en) 2007-08-27
MA29038B1 (en) 2007-11-01
TWI300776B (en) 2008-09-11
NL1032760A1 (en) 2006-12-13
TW200626543A (en) 2006-08-01
AP2007004003A0 (en) 2007-06-30
NO20072486L (en) 2007-06-20
GT200500337A (en) 2006-06-13
JP4233596B2 (en) 2009-03-04
BRPI0518486A2 (en) 2008-11-18
CR9171A (en) 2007-07-04
IL183191A0 (en) 2007-08-19
MX2007006138A (en) 2007-07-19
TNSN07201A1 (en) 2008-11-21
SV2006002311A (en) 2006-09-14

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