PA8624601A1 - Macrolidos y metodos para producir los mismos - Google Patents
Macrolidos y metodos para producir los mismosInfo
- Publication number
- PA8624601A1 PA8624601A1 PA20058624601A PA8624601A PA8624601A1 PA 8624601 A1 PA8624601 A1 PA 8624601A1 PA 20058624601 A PA20058624601 A PA 20058624601A PA 8624601 A PA8624601 A PA 8624601A PA 8624601 A1 PA8624601 A1 PA 8624601A1
- Authority
- PA
- Panama
- Prior art keywords
- produce
- macrolides
- methods
- same
- actinomycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
ESTA INVENCION SE REFIERE, EN PARTE, A COMPUESTOS MACROLIDOS, A CEPAS DE ACTINOMICETO PARA PRODUCIRLOS Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54948004P | 2004-03-02 | 2004-03-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8624601A1 true PA8624601A1 (es) | 2006-06-02 |
Family
ID=34919496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20058624601A PA8624601A1 (es) | 2004-03-02 | 2005-02-28 | Macrolidos y metodos para producir los mismos |
Country Status (21)
Country | Link |
---|---|
US (3) | US7247650B2 (es) |
EP (1) | EP1720886A1 (es) |
JP (2) | JP5032974B2 (es) |
KR (1) | KR20070009578A (es) |
CN (1) | CN1934117A (es) |
AR (1) | AR049681A1 (es) |
AU (1) | AU2005219822A1 (es) |
BR (1) | BRPI0508224A (es) |
CA (1) | CA2556622A1 (es) |
CR (1) | CR8568A (es) |
EC (1) | ECSP066822A (es) |
GT (1) | GT200500035A (es) |
IL (1) | IL177605A0 (es) |
NO (1) | NO20064034L (es) |
PA (1) | PA8624601A1 (es) |
PE (1) | PE20051143A1 (es) |
RU (1) | RU2006129647A (es) |
SG (1) | SG150518A1 (es) |
TW (1) | TW200602347A (es) |
WO (1) | WO2005085257A1 (es) |
ZA (1) | ZA200607347B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008501342A (ja) * | 2004-06-03 | 2008-01-24 | ワイス | 複合ポリケチドを生成するための生合成遺伝子クラスター |
US7595187B2 (en) * | 2004-11-12 | 2009-09-29 | Wyeth | Elaiophylin biosynthetic gene cluster |
TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
JP2009529049A (ja) * | 2006-03-07 | 2009-08-13 | ワイス | 神経障害の治療のためのメリダマイシン類似体 |
TW200808741A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts |
TW200808740A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof |
TW200811144A (en) * | 2006-06-09 | 2008-03-01 | Wyeth Corp | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline |
US7709593B2 (en) | 2006-07-28 | 2010-05-04 | Eastman Chemical Company | Multiple feeds of catalyst metals to a polyester production process |
CL2007003410A1 (es) * | 2006-11-28 | 2008-04-11 | Wyeth Corp | Compuestos derivados de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina; procedimiento de preparacion; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de trast |
CL2008000119A1 (es) * | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
MX2009008105A (es) * | 2007-01-29 | 2010-03-03 | Wyeth Corp | Ligando de inmunofilina ds y metodos para modular la inmunofilina y la actividad de canal de calcio. |
US20100022766A1 (en) * | 2008-07-25 | 2010-01-28 | Wyeth | Biosynthetic gene cluster for the production of a complex polyketide |
CN102174438B (zh) * | 2011-01-26 | 2012-07-25 | 南京大学 | 新大环内酯及其制备方法和应用 |
CN105456298A (zh) * | 2015-12-01 | 2016-04-06 | 中国人民解放军第二军医大学 | 草苔虫总内酯抗老年痴呆活性及其应用 |
CN110051680B (zh) * | 2018-01-19 | 2022-02-18 | 沈阳福洋医药科技有限公司 | 一种用于预防和/或治疗阿尔茨海默病的药物、组合产品及其应用 |
KR20200112898A (ko) | 2018-01-19 | 2020-10-05 | 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 | 캐리마이신 또는 이의 활성 성분의 용도 |
CN114591286B (zh) * | 2021-04-12 | 2023-05-23 | 南京大学 | 新型大环内酯化合物acautalides A-C及其制备方法和应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975372A (en) | 1989-01-13 | 1990-12-04 | Merck & Co., Inc. | Microbial transformation product of L-683,590 |
CA2071066A1 (en) * | 1991-06-19 | 1992-12-20 | Ali Shafiee | Fk-900520 enzymatic and/or microbial methylation products |
GB9302016D0 (en) * | 1993-02-02 | 1993-03-17 | Sandoz Ltd | Compounds |
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US6118521A (en) * | 1996-01-02 | 2000-09-12 | Lj Laboratories, L.L.C. | Apparatus and method for measuring optical characteristics of an object |
US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
JP3511361B2 (ja) * | 1997-08-04 | 2004-03-29 | セイコーインスツルメンツ株式会社 | 走査プローブ顕微鏡 |
US6111650A (en) * | 1997-08-14 | 2000-08-29 | Rawicz; Andrew | Method and apparatus for color matching of slightly colored translucent objects such as teeth and dental prosthesis, in particular |
US20050197356A1 (en) * | 2004-03-02 | 2005-09-08 | Wyeth | Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents |
US7273874B2 (en) * | 2004-12-20 | 2007-09-25 | Wyeth | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders |
DK1828202T3 (da) * | 2004-12-20 | 2012-05-07 | Wyeth Llc | Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser |
-
2005
- 2005-02-25 AU AU2005219822A patent/AU2005219822A1/en not_active Withdrawn
- 2005-02-25 WO PCT/US2005/005895 patent/WO2005085257A1/en active Application Filing
- 2005-02-25 BR BRPI0508224-2A patent/BRPI0508224A/pt not_active IP Right Cessation
- 2005-02-25 JP JP2007501836A patent/JP5032974B2/ja not_active Expired - Fee Related
- 2005-02-25 CN CNA2005800070291A patent/CN1934117A/zh not_active Withdrawn
- 2005-02-25 EP EP05723668A patent/EP1720886A1/en not_active Withdrawn
- 2005-02-25 RU RU2006129647/04A patent/RU2006129647A/ru not_active Application Discontinuation
- 2005-02-25 SG SG200901025-7A patent/SG150518A1/en unknown
- 2005-02-25 KR KR1020067017891A patent/KR20070009578A/ko not_active Application Discontinuation
- 2005-02-25 CA CA002556622A patent/CA2556622A1/en not_active Abandoned
- 2005-02-25 US US11/065,934 patent/US7247650B2/en not_active Expired - Fee Related
- 2005-02-25 GT GT200500035A patent/GT200500035A/es unknown
- 2005-02-28 PA PA20058624601A patent/PA8624601A1/es unknown
- 2005-03-01 PE PE2005000236A patent/PE20051143A1/es not_active Application Discontinuation
- 2005-03-01 TW TW094105998A patent/TW200602347A/zh unknown
- 2005-03-01 AR ARP050100770A patent/AR049681A1/es unknown
-
2006
- 2006-08-21 IL IL177605A patent/IL177605A0/en unknown
- 2006-08-24 CR CR8568A patent/CR8568A/es not_active Application Discontinuation
- 2006-09-01 ZA ZA200607347A patent/ZA200607347B/xx unknown
- 2006-09-04 EC EC2006006822A patent/ECSP066822A/es unknown
- 2006-09-07 NO NO20064034A patent/NO20064034L/no not_active Application Discontinuation
-
2007
- 2007-06-14 US US11/818,535 patent/US20070299019A1/en not_active Abandoned
-
2010
- 2010-12-15 US US12/968,728 patent/US20110144176A1/en not_active Abandoned
-
2012
- 2012-03-14 JP JP2012056599A patent/JP2012153699A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2007526307A (ja) | 2007-09-13 |
CR8568A (es) | 2007-02-05 |
AR049681A1 (es) | 2006-08-30 |
NO20064034L (no) | 2006-11-08 |
CA2556622A1 (en) | 2005-09-15 |
TW200602347A (en) | 2006-01-16 |
EP1720886A1 (en) | 2006-11-15 |
US20070299019A1 (en) | 2007-12-27 |
BRPI0508224A (pt) | 2007-07-17 |
US7247650B2 (en) | 2007-07-24 |
IL177605A0 (en) | 2006-12-10 |
RU2006129647A (ru) | 2008-04-10 |
PE20051143A1 (es) | 2006-02-06 |
ZA200607347B (en) | 2010-02-24 |
KR20070009578A (ko) | 2007-01-18 |
ECSP066822A (es) | 2006-11-24 |
US20050197379A1 (en) | 2005-09-08 |
GT200500035A (es) | 2005-10-24 |
AU2005219822A1 (en) | 2005-09-15 |
CN1934117A (zh) | 2007-03-21 |
JP5032974B2 (ja) | 2012-09-26 |
US20110144176A1 (en) | 2011-06-16 |
SG150518A1 (en) | 2009-03-30 |
JP2012153699A (ja) | 2012-08-16 |
WO2005085257A1 (en) | 2005-09-15 |
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