PA8475901A1 - COMBINATION THERAPY FOR MUSCULOSKELETAL FRAGILITY - Google Patents
COMBINATION THERAPY FOR MUSCULOSKELETAL FRAGILITYInfo
- Publication number
- PA8475901A1 PA8475901A1 PA19998475901A PA8475901A PA8475901A1 PA 8475901 A1 PA8475901 A1 PA 8475901A1 PA 19998475901 A PA19998475901 A PA 19998475901A PA 8475901 A PA8475901 A PA 8475901A PA 8475901 A1 PA8475901 A1 PA 8475901A1
- Authority
- PA
- Panama
- Prior art keywords
- fragility
- compositions
- fenil
- oxo
- combination therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ESTA INVENCION SE REFIERE A COMPOSICIONES FARMACEUTICAS DE COMBINACION Y A PROCEDIMIENTOS QUE CONTIENEN (-)-CIS-6-FENIL-5-(4-(2-PIRROLIDIN-1-IL-ETOXI)-FENIL)-5,6,7,8-TETRAHIDRONAFTALEN-2-OL O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES Y 2-AMINO-N-(2-(3A(R)-BENCIL-2-METIL-3-OXO-2,3,3A,4,6,7-HEXAHIDRO-PIRAZOLO[4,3-C]PIRIDIN-5-IL)-1(R)-BENCILOXIMETIL-2-OXO-ETIL)-ISOBUTIRAMIDA O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, A PROCEDIMIENTOS PARA USAR TALES COMPOSICIONES Y A ESTUCHES QUE CONTIENEN COMPISICIONES. LAS COMPOSICIONES SON DE UTILIDAD PARA TRATAR FRAGILIDAD MUSCULOESQUELETICA, INCLUYENDO OSTEOPOROSIS, FRACTURA OSTEOPOROTICA, MASA OSEA REDUCIDA, FRAGILIDAD Y MASA MUSCULAR REDUCIDA.THIS INVENTION REFERS TO PHARMACEUTICAL COMBINATION COMPOSITIONS AND PROCEDURES CONTAINING (-) - CIS-6-FENIL-5- (4- (2-PIRROLIDIN-1-IL-ETOXI) -FENIL) -5,6,7,8 -TETRAHIDRONAFTALEN-2-OL OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND 2-AMINO-N- (2- (3A (R) -BENCIL-2-METHYL-3-OXO-2,3,3A, 4,6,7 -HEXAHIDRO-PIRAZOLO [4,3-C] PIRIDIN-5-IL) -1 (R) -BENCILOXIMETIL-2-OXO-ETIL) -ISOBUTIRAMIDA OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS, TO PROCEDURES FOR USING SUCH COMPOSITIONS AND CASES CONTAIN COMPISITIONS. THE COMPOSITIONS ARE USEFUL FOR TREATING MUSCULOSKELETAL FRAGILITY, INCLUDING OSTEOPOROSIS, OSTEOPOROTIC FRACTURE, REDUCED BONE MASS, FRAGILITY AND REDUCED MUSCLE MASS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8946998P | 1998-06-16 | 1998-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8475901A1 true PA8475901A1 (en) | 2000-05-24 |
Family
ID=22217825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA19998475901A PA8475901A1 (en) | 1998-06-16 | 1999-06-15 | COMBINATION THERAPY FOR MUSCULOSKELETAL FRAGILITY |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1087764A1 (en) |
| JP (1) | JP2002518326A (en) |
| KR (1) | KR20010052852A (en) |
| CN (1) | CN1301160A (en) |
| AP (1) | AP9901582A0 (en) |
| AR (1) | AR018869A1 (en) |
| AU (1) | AU4054799A (en) |
| BG (1) | BG105041A (en) |
| BR (1) | BR9911324A (en) |
| CA (1) | CA2335134A1 (en) |
| CO (1) | CO5070587A1 (en) |
| EA (1) | EA200001186A1 (en) |
| GT (1) | GT199900087A (en) |
| HN (1) | HN1999000097A (en) |
| HR (1) | HRP20000859A2 (en) |
| HU (1) | HUP0102505A3 (en) |
| ID (1) | ID27599A (en) |
| IL (1) | IL138630A0 (en) |
| IS (1) | IS5691A (en) |
| MA (1) | MA26652A1 (en) |
| NO (1) | NO20006312D0 (en) |
| OA (1) | OA11505A (en) |
| PA (1) | PA8475901A1 (en) |
| PE (1) | PE20000646A1 (en) |
| PL (1) | PL344981A1 (en) |
| SK (1) | SK18912000A3 (en) |
| TN (1) | TNSN99124A1 (en) |
| TR (1) | TR200003544T2 (en) |
| WO (1) | WO1999065486A1 (en) |
| ZA (1) | ZA993975B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2653300A (en) * | 1999-02-08 | 2000-08-29 | Mcgill University | Non-human transgenic animal whose germ cells and somatic cells contain a knockout mutation in dna encoding orphan nuclear receptor erralpha |
| EP1156120B1 (en) | 2000-05-08 | 2006-11-22 | Pfizer Products Inc. | Enzymatic resolution of selective estrogen receptor modulators |
| IL145106A0 (en) * | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
| EP1313473A2 (en) * | 2000-08-30 | 2003-05-28 | Pfizer Products Inc. | Sustained release formulations for growth hormone secretagogues |
| US7476653B2 (en) * | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| WO2006024931A2 (en) * | 2004-08-31 | 2006-03-09 | Pfizer Products Inc. | Therapeutic combinations comprising a selective estrogen receptor modulator and a selective androgen receptor modulator |
| CU23558A1 (en) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE |
| AU2008241532A1 (en) | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA51676C2 (en) * | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)cis-6(S)-phenyl-5(R)-[4-(2-pyrrolidin-I-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol D-tartrate, a method of its preparation, method of THE treatment OF diseases medicated by agonists of estrogen and a pharmaceutical composition |
| TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| HN1996000101A (en) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | COMBINED THERAPY FOR OSTEOPOROSIS |
-
1999
- 1999-06-15 ZA ZA9903975A patent/ZA993975B/en unknown
- 1999-06-15 HN HN1999000097A patent/HN1999000097A/en unknown
- 1999-06-15 AP APAP/P/1999/001582A patent/AP9901582A0/en unknown
- 1999-06-15 AR ARP990102848A patent/AR018869A1/en not_active Application Discontinuation
- 1999-06-15 PA PA19998475901A patent/PA8475901A1/en unknown
- 1999-06-15 PE PE1999000528A patent/PE20000646A1/en not_active Application Discontinuation
- 1999-06-16 KR KR1020007014186A patent/KR20010052852A/en not_active Application Discontinuation
- 1999-06-16 SK SK1891-2000A patent/SK18912000A3/en unknown
- 1999-06-16 IL IL13863099A patent/IL138630A0/en unknown
- 1999-06-16 BR BR9911324-4A patent/BR9911324A/en not_active Application Discontinuation
- 1999-06-16 CA CA002335134A patent/CA2335134A1/en not_active Abandoned
- 1999-06-16 WO PCT/IB1999/001117 patent/WO1999065486A1/en not_active Application Discontinuation
- 1999-06-16 TR TR2000/03544T patent/TR200003544T2/en unknown
- 1999-06-16 CN CN99806237A patent/CN1301160A/en active Pending
- 1999-06-16 EA EA200001186A patent/EA200001186A1/en unknown
- 1999-06-16 ID IDW20002627A patent/ID27599A/en unknown
- 1999-06-16 TN TNTNSN99124A patent/TNSN99124A1/en unknown
- 1999-06-16 HU HU0102505A patent/HUP0102505A3/en unknown
- 1999-06-16 CO CO99037622A patent/CO5070587A1/en unknown
- 1999-06-16 AU AU40547/99A patent/AU4054799A/en not_active Abandoned
- 1999-06-16 JP JP2000554366A patent/JP2002518326A/en active Pending
- 1999-06-16 PL PL99344981A patent/PL344981A1/en not_active Application Discontinuation
- 1999-06-16 EP EP99923802A patent/EP1087764A1/en not_active Withdrawn
- 1999-06-16 GT GT199900087A patent/GT199900087A/en unknown
- 1999-06-16 MA MA25628A patent/MA26652A1/en unknown
-
2000
- 2000-10-20 OA OA1200000290A patent/OA11505A/en unknown
- 2000-10-27 IS IS5691A patent/IS5691A/en unknown
- 2000-12-11 BG BG105041A patent/BG105041A/en unknown
- 2000-12-12 NO NO20006312A patent/NO20006312D0/en not_active Application Discontinuation
- 2000-12-14 HR HR20000859A patent/HRP20000859A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT199900087A (en) | 2000-12-07 |
| OA11505A (en) | 2004-05-07 |
| ZA993975B (en) | 2000-12-15 |
| CN1301160A (en) | 2001-06-27 |
| BR9911324A (en) | 2001-04-03 |
| AU4054799A (en) | 2000-01-05 |
| ID27599A (en) | 2001-04-12 |
| HRP20000859A2 (en) | 2001-04-30 |
| PE20000646A1 (en) | 2000-08-05 |
| TR200003544T2 (en) | 2001-04-20 |
| CA2335134A1 (en) | 1999-12-23 |
| CO5070587A1 (en) | 2001-08-28 |
| PL344981A1 (en) | 2001-11-19 |
| IS5691A (en) | 2000-10-27 |
| AR018869A1 (en) | 2001-12-12 |
| WO1999065486A1 (en) | 1999-12-23 |
| EP1087764A1 (en) | 2001-04-04 |
| NO20006312L (en) | 2000-12-12 |
| NO20006312D0 (en) | 2000-12-12 |
| HN1999000097A (en) | 1999-11-03 |
| HUP0102505A3 (en) | 2002-12-28 |
| TNSN99124A1 (en) | 2005-11-10 |
| HUP0102505A2 (en) | 2001-11-28 |
| IL138630A0 (en) | 2001-10-31 |
| SK18912000A3 (en) | 2001-10-08 |
| MA26652A1 (en) | 2004-12-20 |
| JP2002518326A (en) | 2002-06-25 |
| AP9901582A0 (en) | 1999-06-30 |
| BG105041A (en) | 2001-08-31 |
| EA200001186A1 (en) | 2001-06-25 |
| KR20010052852A (en) | 2001-06-25 |
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