PA8467601A1 - Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 - Google Patents
Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1Info
- Publication number
- PA8467601A1 PA8467601A1 PA19998467601A PA8467601A PA8467601A1 PA 8467601 A1 PA8467601 A1 PA 8467601A1 PA 19998467601 A PA19998467601 A PA 19998467601A PA 8467601 A PA8467601 A PA 8467601A PA 8467601 A1 PA8467601 A1 PA 8467601A1
- Authority
- PA
- Panama
- Prior art keywords
- avermectin
- directs
- relation
- streptomyces avermitilis
- gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Abstract
LA PRESENTE INVENCION SE REFIERE A MOLECULAS POLINUCLEOTIDICAS QUE COMPRENDEN SECUENCIAS DE NUCLEOTIDOS QUE CODIFICAN UN PRODUCTO GENICO AVEC, MOLECULAS POLINUCLEOTIDICAS QUE PUEDEN USARSE PARA ALTERAR LA RELACION O CANTIDAD DE AVERMECTINAS DE CLASES 2:1 PRODUCIDAS EN CULTIVOS DE FERMENTACION DE S. AVERMITILIS. LA PRESENTE INVENCION SE REFIERE ADEMAS A VECTORES, CELULAS HOSPEDADORAS Y CEPAS MUTANTES DE S. AVERMITILIS EN LAS QUE EL GEN AVEC SE HA INACTIVADO O MUTADO PARA CAMBIAR LA RELACION O CANTIDAD DE AVERMECTINAS DE CLASES 2:1 PRODUCIDAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8467601A1 true PA8467601A1 (es) | 2000-09-29 |
Family
ID=22120706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA19998467601A PA8467601A1 (es) | 1998-02-13 | 1999-01-26 | Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (es) |
| JP (2) | JP2002503473A (es) |
| KR (3) | KR20040053390A (es) |
| CN (2) | CN1297485A (es) |
| AP (1) | AP9901463A0 (es) |
| AR (1) | AR018085A1 (es) |
| AU (1) | AU752343C (es) |
| BG (1) | BG64911B1 (es) |
| BR (1) | BR9907893A (es) |
| CA (2) | CA2320031A1 (es) |
| CO (1) | CO5070698A1 (es) |
| DZ (1) | DZ2720A1 (es) |
| EA (1) | EA003905B1 (es) |
| GT (1) | GT199900014A (es) |
| HN (1) | HN1999000008A (es) |
| HR (1) | HRP20000539A2 (es) |
| HU (1) | HUP0100784A3 (es) |
| IL (2) | IL137610A0 (es) |
| IS (1) | IS5567A (es) |
| MA (1) | MA24760A1 (es) |
| NO (1) | NO20004044L (es) |
| NZ (2) | NZ518657A (es) |
| OA (1) | OA11449A (es) |
| PA (1) | PA8467601A1 (es) |
| PE (1) | PE20000352A1 (es) |
| PL (1) | PL194270B1 (es) |
| SK (1) | SK11722000A3 (es) |
| TN (1) | TNSN99017A1 (es) |
| TW (1) | TW585910B (es) |
| WO (1) | WO1999041389A1 (es) |
| YU (1) | YU50900A (es) |
| ZA (1) | ZA991138B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| BR9907893A (pt) * | 1998-02-13 | 2000-11-14 | Pfizer Prod Inc | Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
| EP1200606B1 (en) | 1999-08-12 | 2006-10-04 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| WO2003068955A2 (en) | 2002-02-12 | 2003-08-21 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| CN107338210B (zh) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | 一种阿维链霉菌合成培养基及其发酵液的制备方法 |
| CN111269296B (zh) * | 2020-03-06 | 2021-11-05 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (es) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| EP0313297B1 (en) * | 1987-10-23 | 1993-05-19 | Pfizer Inc. | Process for production of avermectin aglycones and cultures therefor |
| JPH0747171B2 (ja) * | 1988-09-20 | 1995-05-24 | 株式会社東芝 | 圧延機の設定方法および装置 |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| NZ233116A (en) * | 1989-03-31 | 1994-09-27 | Merck & Co Inc | Cloning genes from steptomyces avermitilis for avermectin biosynthesis |
| JP2888586B2 (ja) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法 |
| FI942725A (fi) * | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| BR9907893A (pt) * | 1998-02-13 | 2000-11-14 | Pfizer Prod Inc | Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
-
1999
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/pt not_active Application Discontinuation
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/hu not_active Application Discontinuation
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/ko active Search and Examination
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Application Discontinuation
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/sk unknown
- 1999-01-25 EA EA200000758A patent/EA003905B1/ru not_active IP Right Cessation
- 1999-01-25 CN CN99805027A patent/CN1297485A/zh active Pending
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 IL IL13761099A patent/IL137610A0/xx unknown
- 1999-01-25 PL PL99342468A patent/PL194270B1/pl not_active IP Right Cessation
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/ko not_active IP Right Cessation
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/ja active Pending
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/ko active Search and Examination
- 1999-01-25 YU YU50900A patent/YU50900A/sh unknown
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-25 NZ NZ505676A patent/NZ505676A/xx unknown
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/zh active Pending
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/es unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/es unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/es unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/es not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/zh active
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/xx active
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/fr unknown
- 1999-02-10 MA MA25460A patent/MA24760A1/fr unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-11 AR ARP990100571A patent/AR018085A1/es unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/xx unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/es unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/is unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 HR HR20000539A patent/HRP20000539A2/hr not_active Application Discontinuation
- 2000-08-11 NO NO20004044A patent/NO20004044L/no not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/bg unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
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