OA17769A - A subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negativestrand RNA virus as carriers of heterologous polypeptides - Google Patents
A subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negativestrand RNA virus as carriers of heterologous polypeptides Download PDFInfo
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- OA17769A OA17769A OA1201600185 OA17769A OA 17769 A OA17769 A OA 17769A OA 1201600185 OA1201600185 OA 1201600185 OA 17769 A OA17769 A OA 17769A
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Abstract
The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (RNPs) comprising nucleoproteins of a non-segmented negativestrand ribonucleic acid (RNA) virus as carriers of heterologous polypeptides. The present invention also relates to multimeric RNPs resulting from the assembly of at least 200 fusion proteins with a cellular RNA, or to recombinant yeasts or yeast lysates expressing these multimeric RNPs. It also concerns a process for the preparation of these multimeric RNPs or recombinant yeasts or yeast lysates. In particular, the present invention relates to their use as active ingredient for the in vitro production of an immunogenic composition or in eliciting a protective prophylactic or a therapeutic immune response against said heterologous polypeptide in a host in need thereof. Recombinant yeasts or yeast lysates of the invention can also be used as expression and vector systems for delivery to a host
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13306577.1 | 2013-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA17769A true OA17769A (fr) | 2017-11-30 |
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