OA08941A - Process for the synthesis of alpha amino acids, N alkyls and their esters. Application to the synthesis of carboxyalkyl dipeptides. - Google Patents
Process for the synthesis of alpha amino acids, N alkyls and their esters. Application to the synthesis of carboxyalkyl dipeptides.Info
- Publication number
- OA08941A OA08941A OA59436A OA59436A OA08941A OA 08941 A OA08941 A OA 08941A OA 59436 A OA59436 A OA 59436A OA 59436 A OA59436 A OA 59436A OA 08941 A OA08941 A OA 08941A
- Authority
- OA
- OAPI
- Prior art keywords
- synthesis
- application
- alkyls
- esters
- amino acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Process for industrial synthesis of the derivative of formula (I): <IMAGE> and their addition salts with an inorganic or organic acid or base, in which: R1 is linear or branched lower alkyl (of 1 to 6 carbon atoms), R2 is hydrogen or a linear or branched lower alkyl group (of 1 to 4 carbon atoms). Application to the industrial synthesis of carboxyalkyl dipeptides.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8712902A FR2620700B1 (en) | 1987-09-17 | 1987-09-17 | PROCESS FOR THE SYNTHESIS OF ALPHA AMINO ACIDS N ALKYLS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES |
Publications (1)
Publication Number | Publication Date |
---|---|
OA08941A true OA08941A (en) | 1989-10-31 |
Family
ID=9354994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA59436A OA08941A (en) | 1987-09-17 | 1988-09-16 | Process for the synthesis of alpha amino acids, N alkyls and their esters. Application to the synthesis of carboxyalkyl dipeptides. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0309324B1 (en) |
JP (2) | JPH0725723B2 (en) |
AT (1) | ATE61567T1 (en) |
AU (1) | AU607260B2 (en) |
CA (1) | CA1341380C (en) |
DE (1) | DE3862006D1 (en) |
DK (1) | DK173730B1 (en) |
ES (1) | ES2034324T3 (en) |
FR (1) | FR2620700B1 (en) |
GR (1) | GR3001874T3 (en) |
HK (1) | HK55196A (en) |
IE (1) | IE60995B1 (en) |
NZ (1) | NZ226222A (en) |
OA (1) | OA08941A (en) |
PT (1) | PT88530B (en) |
ZA (1) | ZA886933B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2620699B1 (en) * | 1987-09-17 | 1990-06-01 | Adir | PROCESS FOR THE SYNTHESIS OF ALPHA AMINO N ALKYL ACIDS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES |
DE19804100C1 (en) | 1998-02-03 | 1999-05-12 | Daimler Chrysler Ag | Automobile seat with incorporated ventilation |
JP3892963B2 (en) * | 1998-03-17 | 2007-03-14 | 住友化学株式会社 | Method for producing L-valine benzyl ester p-toluenesulfonate |
US6706916B1 (en) | 1999-02-23 | 2004-03-16 | Toray Fine Chemicals Co., Ltd. | Optically active amino acid derivatives and processes for the preparation of the same |
JP2000247934A (en) * | 1999-02-23 | 2000-09-12 | Toray Ind Inc | Production of amino acid benzyl ester having high optical purity |
FR2807431B1 (en) * | 2000-04-06 | 2002-07-19 | Adir | NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
FR2807430B1 (en) * | 2000-04-11 | 2002-05-17 | Adir | NOVEL PROCESS FOR THE SYNTHESIS OF N - [(S) -1- CARBOXYBUTYL] - (S) -ALANINE ESTERS AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL |
AR036187A1 (en) * | 2001-07-24 | 2004-08-18 | Adir | A PROCESS FOR THE PREPARATION OF PERINDOPRIL, ANALOG COMPOUNDS AND ITS SALTS, INTERMEDIARY COMPOUND 2,5-DIOXO-OXAZOLIDINE AND PROCESS TO PREPARE A INTERMEDIARY |
ATE395913T1 (en) | 2003-02-28 | 2008-06-15 | Servier S A Lab | METHOD FOR PRODUCING PERINDOPRIL |
SI21800A (en) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New procedure of synthesis of perindopril |
EP1792896A1 (en) | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
JP4929938B2 (en) | 2006-09-12 | 2012-05-09 | 住友化学株式会社 | Process for producing optically active α-amino acid benzyl esters |
JP5785045B2 (en) * | 2011-10-06 | 2015-09-24 | エヌ・イーケムキャット株式会社 | Selective debenzylation method and selective hydrogenation catalyst used therefor |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (en) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4296110A (en) * | 1980-10-28 | 1981-10-20 | E. I. Du Pont De Nemours And Company | Antihypertensive I-substituted cyclic lactam-2-carboxylic acids |
JPS6058233B2 (en) * | 1982-05-24 | 1985-12-19 | 田辺製薬株式会社 | 2-oxoimidazolidine derivative and its production method |
FR2620709B1 (en) * | 1987-09-17 | 1990-09-07 | Adir | PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERINDOPRIL AND ITS MAIN INTERMEDIATE SYNTHESIS |
-
1987
- 1987-09-17 FR FR8712902A patent/FR2620700B1/en not_active Expired - Lifetime
-
1988
- 1988-09-07 CA CA000577079A patent/CA1341380C/en not_active Expired - Fee Related
- 1988-09-15 DK DK198805152A patent/DK173730B1/en active IP Right Grant
- 1988-09-16 EP EP19880402340 patent/EP0309324B1/en not_active Expired - Lifetime
- 1988-09-16 JP JP63232122A patent/JPH0725723B2/en not_active Expired - Lifetime
- 1988-09-16 NZ NZ226222A patent/NZ226222A/en unknown
- 1988-09-16 AT AT88402340T patent/ATE61567T1/en not_active IP Right Cessation
- 1988-09-16 PT PT88530A patent/PT88530B/en not_active IP Right Cessation
- 1988-09-16 OA OA59436A patent/OA08941A/en unknown
- 1988-09-16 AU AU22356/88A patent/AU607260B2/en not_active Expired
- 1988-09-16 ZA ZA886933A patent/ZA886933B/en unknown
- 1988-09-16 ES ES198888402340T patent/ES2034324T3/en not_active Expired - Lifetime
- 1988-09-16 IE IE280788A patent/IE60995B1/en not_active IP Right Cessation
- 1988-09-16 DE DE8888402340T patent/DE3862006D1/en not_active Expired - Lifetime
-
1991
- 1991-04-29 GR GR91400546T patent/GR3001874T3/en unknown
-
1994
- 1994-10-05 JP JP6241178A patent/JP2524489B2/en not_active Expired - Lifetime
-
1996
- 1996-03-28 HK HK55196A patent/HK55196A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2620700B1 (en) | 1990-06-01 |
DK173730B1 (en) | 2001-08-06 |
HK55196A (en) | 1996-04-03 |
NZ226222A (en) | 1990-06-26 |
JPH01110651A (en) | 1989-04-27 |
ATE61567T1 (en) | 1991-03-15 |
IE60995B1 (en) | 1994-09-07 |
FR2620700A1 (en) | 1989-03-24 |
EP0309324A1 (en) | 1989-03-29 |
CA1341380C (en) | 2002-08-06 |
PT88530A (en) | 1988-10-01 |
JPH0725723B2 (en) | 1995-03-22 |
EP0309324B1 (en) | 1991-03-13 |
ZA886933B (en) | 1989-05-30 |
GR3001874T3 (en) | 1992-11-23 |
PT88530B (en) | 1992-11-30 |
IE882807L (en) | 1989-03-17 |
DK515288A (en) | 1989-03-18 |
AU607260B2 (en) | 1991-02-28 |
JPH07206792A (en) | 1995-08-08 |
DE3862006D1 (en) | 1991-04-18 |
ES2034324T3 (en) | 1993-04-01 |
JP2524489B2 (en) | 1996-08-14 |
AU2235688A (en) | 1989-03-23 |
DK515288D0 (en) | 1988-09-15 |
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