NZ793775A - Fungicidal combinations - Google Patents

Abstract

combination comprising a dithiocarbamate fungicide, a succinate dehydrogenase fungicide and at least one of ergosterol biosynthesis inhibitor fungicide or a quinone outside inhibitor fungicide.

Description

A combination comprising a dithiocarbamate fungicide, a succinate dehydrogenase fungicide and at least one of ergosterol thesis inhibitor fungicide or a quinone outside inhibitor fungicide.

NZ 793775 PCT00717 FUNGICIDAL COMBINATIONS Technical field: The present invention relates to a combination of fungicides. More specifically, the present invention relates to fungicidal combinations comprising succinate dehydrogenase inhibitor fungicides for controlling a broad um of fungal diseases.

Background of the invention: Fungicides are an integral and important tool yielded by farmers to control diseases, as well as to improve yields and quality of the crops. There are various fungicides that have been developed over the years with many desirable utes such as specificity, systemicity, curative and eradicant action and high activity at low use rates.

Succinate dehydrogenase inhibitor (SDHI) fungicides are known in the art to be broad spectrum and have a high potency. Pyrazolecarboxamides are a group of active compounds within the SDHI family of ides that are known to be more potent than most other SDHI fungicides. These molecules specifically bind to the ubiquinone-binding site (Q-site) of the mitochondrial x II, thereby inhibiting fungal respiration. These fungicides are known to control a broad spectrum of fungal diseases. s other classes of fungicides are also known in the art, such as Quinone outside inhibitors (QoIs), ergosterol-biosynthesis inhibitors, fungicides that act on le sites, fungicides that affect s etc. These fungicides have been mixed with SDHI fungicides to achieve a broad um of disease control.

PCT00717 WO2006037632 s combinations of SDHI fungicides with a second active compound. WO2013127818 teaches combinations of SDHI fungicides with s herbicides. WO2006037634 teaches methods of controlling fungi using a combination of SDHI fungicide with various ides. However, the prior art does not teach the use of ternary or higher combinations of SDHI fungicides.

Dithiocarbamate are known in the art as multi-site fungicides. These fungicides are used for broad-spectrum disease control in more than 70 crops. Mancozeb is ally important for controlling devastating and fast spreading diseases such as Phytophthora infestans, Venturia inaequalis etc.

Dithiocarbamate fungicides, especially mancozeb, are ularly useful for disease control because of their broad spectrum of activity, high tolerance by crop plants, and general usefulness for lling fungal plant diseases not controlled by active compounds that act on only a single target site in the fungus.

Mancozeb has been combined with various SDHI fungicides for e control. There is a need in the art to improve on the disease spectrum provided by these combinations.

There is therefore a need in the art for combinations of SDHIs with a specific fungicide that helps improve spectrum. With crop tolerances decreasing, lower use rates being imposed and resistance being increasingly observed, there is a need for a combination of actives that allows for broader disease control spectrum that es ve and preventive actives and has a lower dosage.

PCT00717 Therefore, ments of the present invention may ameliorate one or more of the above mentioned problems: Therefore, embodiments of the present invention may provide combinations of fungicides that possess an enhanced efficacy over the individual fungicides used in isolation. r object of the present invention is to provide a fungicidal combination that causes an enhanced greening of the crops to which it is administered.

Another object of the present ion is to provide a fungicidal combination that causes late senescence to the crop to which it is applied thereby resulting into an increasing yield of the crop.

Yet another object of the present invention is to provide a fungicidal combination that results into reduced fungal disease incidence in the crops to which it is applied.

Another object of the present invention is to provide a fungicidal combination that achieves sed yield in the crops to which it is applied.

Some or all these and other objects of the invention are can be achieved by way of the invention described hereinafter.

Summary of the invention: Thus, an aspect of the t invention can provide a fungicidal ation comprising at least one succinate ogenase inhibitor PCT00717 fungicide, at least one dithiocarbamate fungicide, and at least another fungicide.

Another aspect of the present ion can provide a fungicidal combination comprising at least one succinate ogenase inhibitor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

Another aspect of the present invention can e synergistic compositions comprising at least one succinate dehydrogenase inhibitor fungicide, at least one dithiocarbamate fungicide, and at least one other fungicide.

Another aspect of the t invention can provide synergistic itions comprising at least one succinate dehydrogenase inhibitor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

Detailed Description: The term ‘disease control’ as used herein denotes control and prevention of a disease. Controlling s include all ion from natural development, for example: killing, retardation, decrease of the fugal disease.

The term ‘plants’ refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage and fruits. The term "locus" of a plant as used herein is intended to embrace the place on which the plants are growing, where the plant ation materials of the plants are sown or where the plant propagation materials of the plants will be placed into the soil. The term "plant propagation material" is tood to denote generative parts of a plant, such as seeds, vegetative material such as cuttings or tubers, roots, fruits, tubers, bulbs, rhizomes and parts PCT00717 of plants, germinated plants and young plants which are to be transplanted after germination or after emergence from the soil. These young plants may be protected before lantation by a total or partial treatment by immersion. The term "agriculturally acceptable amount of active" refers to an amount of an active that kills or inhibits the plant disease for which control is desired, in an amount not icantly toxic to the plant being treated.

Succinate dehydrogenase inhibitor (SDHI) fungicides play an important role in plant protection against many phytopathogenic fungi. These molecules specifically bind to the ubiquinone-binding site (Q-site) of the mitochondrial complex II, thereby inhibiting fungal respiration. Dithiocarbamate are multisite contact fungicides. These molecules attack multiple sites within the fugal cells.

It has surprisingly been found that the addition of a dithiocarbamate fungicide to the combinations of succinate dehydrogenase inhibitors with at least r fungicide selected from an ergosterol biosynthesis inhibitors or Quinone outside inhibitors or a combination thereof, ed in surprising and unexpected advantages. It was surprising that the addition of a dithiocarbamate ide to the combination of a succinate dehydrogenase inhibitor with at least another fungicide selected from an ergosterol biosynthesis tors and/or Quinone outside inhibitors or a combination thereof resulted in an enhancement of the efficacy, and a surprising reduction in fungal disease incidence, seen only with the combination of succinate dehydrogenase inhibitors with at least another fungicide selected from an ergosterol thesis inhibitors or Quinone outside inhibitors or a ation thereof. It has further been found that the addition of a dithiocarbamate fungicide to these ations and application of these combinations during the flowering stage of the crop delayed the senescence in the crop to which they were applied, which led to better greening in the crop thereby increasing the level of photosynthesis occurring within the plant, thereby leading to a greater yield from the crop to which they were applied.

These sing advantages of the combinations of the invention were not observed when the dithiocarbamate fungicide was not present in the combination. Therefore, these unexpected ages of the combination of the t invention could be attributed to the inclusion of a dithiocarbamate fungicide to the combination of a succinate dehydrogenase inhibitor with at least another fungicide selected from an ergosterol biosynthesis inhibitors and/or Quinone outside inhibitors or a combination thereof.

Thus, in an aspect, the present invention provides a fungicidal combination comprising: (a) at least one dithiocarbamate fungicide; (b) at least one succinate dehydrogenase inhibitor ide; and (c) at least another fungicide selected from an ergosterol biosynthesis inhibitors and/or Quinone outside inhibitors.

In an embodiment, the dithiocarbamate fungicide is selected from the group consisting of amobam, asomate, azithiram, orph, cufraneb, am, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, , mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.

PCT00717 In an embodiment, the preferred dithiocarbamate ide is mancozeb.

In an embodiment, the succinate dehydrogenase tor is selected from pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicides.

However, it should be understood that the choice of succinate dehydrogenase inhibitors is not understood to be limited to these pyrazole carboxamide fungicides alone.

In an embodiment, the pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicide may be selected from benzovindiflupyr, bixafen, yroxad, furametpyr, azam, fen, penthiopyrad, and sedaxane.

Benzovindiflupyr has the chemical name N-[(1RS,4SR)(dichloromethylene)- 1,2,3,4-tetrahydro-1,4-methanonaphthalenyl](difluoromethyl) methylpyrazolecarboxamide and has the structure: Bixafen has the chemical name N-(3',4'-dichlorofluorobiphenylyl) (difluoromethyl)methylpyrazolecarboxamide and the structure: PCT00717 Fluxapyroxad has the chemical name 3-(difluoromethyl)methyl-N-(3',4',5'- trifluorobiphenylyl)pyrazolecarboxamide and has the structure: Furametpyr has the chemical name (RS)chloro-N-(1,3-dihydro-1,1,3- trimethylisobenzofuranyl)-1,3-dimethylpyrazolecarboxamide and has the structure: Isopyrazam is a mixture of 2 isomers 3-(difluoromethyl)methyl-N- [(1RS,4SR,9RS)-1,2,3,4-tetrahydroisopropyl-1,4-methanonaphthalen yl]pyrazolecarboxamide and 2 rs 3-(difluoromethyl)methyl-N- PCT00717 [(1RS,4SR,9SR)-1,2,3,4-tetrahydroisopropyl-1,4-methanonaphthalen yl]pyrazolecarboxamide and its tautomer’s have the structure: Penflufen has the chemical name N-[2-(1,3-dimethylbutyl)phenyl]fluoro- methyl-1H-pyrazolecarboxamide, and has the following structure: Penthiopyrad has the chemical name (RS)-N-[2-(1,3-dimethylbutyl)thienyl]- 1-methyl(trifluoromethyl)pyrazolecarboxamide, and has the following structure: PCT00717 Sedaxane is a mixture of 2 cis-isomers RS,2RS)-1,1'-bicyclopropyl]- 3-(difluoromethyl)methylpyrazolecarboxanilide and 2 trans-isomers 2'- 2SR)-1,1'-bicyclopropyl](difluoromethyl)methylpyrazole carboxanilide , and its tautomer’s have the structure: In an embodiment, the succinate dehydrogenase inhibitor fungicide may be selected from the group consisting of benodanil, flutolanil, mepronil, isofetamid, fluopyram, am, carboxin, oxycarboxin, thifluzamide, boscalid and IR9792.

In an ment, the third and/or fourth fungicides in the combinations of the t invention may be selected from ergosterol biosynthesis inhibitors, and/or e outside (Qo) inhibitors or es thereof.

Thus in an embodiment, the ergosterol biosynthesis inhibitors may be selected from the group consisting of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, myclobutanil, penconazole, Propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, PCT00717 oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox , pyrisoxazole, triforine and mixtures thereof.

In another ment, the ergosterol thesis inhibitors may be selected from oconazole, tebuconazole, hexaconazole, cyroconazole or epoxiconazole.

In an embodiment, the third fungicide may be a Quinone outside (Qo) inhibitor fungicide selected from azoxystrobin, coumoxystrobin, trobin, flufenoxystrobin, strobin, ystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb and mixtures thereof.

In an embodiment, the e outside (Qo) inhibitor fungicide may be selected from azoxystrobin, picoxystrobin, kresoxim-methyl, pyraclostrobin and trifloxystrobin.

In an ment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is isopyrazam.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 1 Mancozeb Isopyrazam Cyproconazole - 2 Mancozeb Isopyrazam Difenoconazole - PCT00717 3 Mancozeb Isopyrazam Epoxiconazole - 4 Mancozeb azam Hexaconazole - Mancozeb azam nazole - 6 Mancozeb Isopyrazam Tetraconazole - 7 Mancozeb Isopyrazam Prothioconazole - 8 Mancozeb Isopyrazam - Azoxystrobin 9 Mancozeb Isopyrazam - Picoxystrobin Mancozeb Isopyrazam - Pyraclostrobin 11 eb Isopyrazam - Kresoximmethyl 12 Mancozeb azam - Trifloxystrobin 13 Mancozeb Isopyrazam Cyproconazole Azoxystrobin 14 Mancozeb Isopyrazam Cyproconazole Picoxystrobin Mancozeb Isopyrazam Cyproconazole Pyraclostrobin 16 Mancozeb Isopyrazam onazole Kresoximmethyl 17 Mancozeb Isopyrazam Cyproconazole Trifloxystrobin 18 Mancozeb Isopyrazam Difenoconazole Azoxystrobin 19 Mancozeb Isopyrazam Difenoconazole Picoxystrobin Mancozeb Isopyrazam Difenoconazole Pyraclostrobin 21 Mancozeb Isopyrazam Difenoconazole Kresoximmethyl 22 Mancozeb Isopyrazam Difenoconazole Trifloxystrobin 23 Mancozeb Isopyrazam Epoxiconazole Azoxystrobin 24 Mancozeb azam onazole Picoxystrobin Mancozeb Isopyrazam Epoxiconazole Pyraclostrobin 26 Mancozeb Isopyrazam Epoxiconazole Kresoximmethyl 27 Mancozeb Isopyrazam onazole Trifloxystrobin 28 Mancozeb azam Hexaconazole Azoxystrobin 29 Mancozeb azam Hexaconazole Picoxystrobin Mancozeb Isopyrazam Hexaconazole Pyraclostrobin 31 Mancozeb Isopyrazam Hexaconazole Kresoximmethyl 32 Mancozeb azam Hexaconazole Trifloxystrobin 33 eb Isopyrazam Tebuconazole Azoxystrobin 34 Mancozeb Isopyrazam Tebuconazole Picoxystrobin Mancozeb Isopyrazam Tebuconazole Pyraclostrobin 36 Mancozeb Isopyrazam Tebuconazole Kresoximmethyl 37 Mancozeb Isopyrazam Tebuconazole Trifloxystrobin 38 Mancozeb Isopyrazam Tetraconazole Azoxystrobin 39 Mancozeb Isopyrazam Tetraconazole Picoxystrobin 40 Mancozeb Isopyrazam Tetraconazole Pyraclostrobin 41 Mancozeb Isopyrazam Tetraconazole Kresoximmethyl 42 Mancozeb Isopyrazam Tetraconazole Trifloxystrobin 43 Mancozeb Isopyrazam oconazole Azoxystrobin 44 Mancozeb Isopyrazam Prothioconazole Picoxystrobin 45 Mancozeb Isopyrazam Prothioconazole Pyraclostrobin 46 Mancozeb Isopyrazam oconazole Kresoximmethyl 47 Mancozeb Isopyrazam Prothioconazole Trifloxystrobin PCT00717 In an embodiment of the combinations of the present ion, the preferred succinate dehydrogenase inhibitor fungicide is Benzovindiflupyr.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 48 Mancozeb Benzovindiflupyr Cyproconazole - 49 Mancozeb Benzovindiflupyr Difenoconazole - 50 Mancozeb Benzovindiflupyr onazole - 51 Mancozeb Benzovindiflupyr Hexaconazole - 52 Mancozeb Benzovindiflupyr Tebuconazole - 53 Mancozeb Benzovindiflupyr Tetraconazole - 54 Mancozeb Benzovindiflupyr Prothioconazole - 55 Mancozeb Benzovindiflupyr - Azoxystrobin 56 Mancozeb Benzovindiflupyr - Picoxystrobin 57 Mancozeb indiflupyr - Pyraclostrobin 58 Mancozeb Benzovindiflupyr - Kresoximmethyl 59 Mancozeb Benzovindiflupyr - Trifloxystrobin 60 Mancozeb Benzovindiflupyr Cyproconazole Azoxystrobin 61 Mancozeb Benzovindiflupyr Cyproconazole Picoxystrobin 62 Mancozeb Benzovindiflupyr Cyproconazole ostrobin 63 Mancozeb Benzovindiflupyr Cyproconazole Kresoximmethyl 64 eb indiflupyr Cyproconazole Trifloxystrobin PCT00717 65 eb Benzovindiflupyr Difenoconazole trobin 66 Mancozeb Benzovindiflupyr Difenoconazole Picoxystrobin 67 Mancozeb indiflupyr Difenoconazole Pyraclostrobin 68 Mancozeb indiflupyr Difenoconazole Kresoximmethyl 69 Mancozeb Benzovindiflupyr Difenoconazole Trifloxystrobin 70 Mancozeb Benzovindiflupyr Epoxiconazole Azoxystrobin 71 Mancozeb indiflupyr Epoxiconazole Picoxystrobin 72 Mancozeb Benzovindiflupyr Epoxiconazole ostrobin 73 Mancozeb Benzovindiflupyr onazole Kresoximmethyl 74 Mancozeb Benzovindiflupyr Epoxiconazole Trifloxystrobin 75 Mancozeb Benzovindiflupyr Hexaconazole Azoxystrobin 76 Mancozeb Benzovindiflupyr Hexaconazole Picoxystrobin 77 Mancozeb Benzovindiflupyr nazole Pyraclostrobin 78 Mancozeb Benzovindiflupyr Hexaconazole Kresoximmethyl 79 Mancozeb Benzovindiflupyr Hexaconazole Trifloxystrobin 80 Mancozeb Benzovindiflupyr Tebuconazole Azoxystrobin 81 Mancozeb Benzovindiflupyr Tebuconazole Picoxystrobin 82 Mancozeb Benzovindiflupyr Tebuconazole Pyraclostrobin 83 Mancozeb Benzovindiflupyr nazole Kresoximmethyl 84 Mancozeb Benzovindiflupyr Tebuconazole Trifloxystrobin 85 Mancozeb Benzovindiflupyr Tetraconazole Azoxystrobin 86 Mancozeb Benzovindiflupyr Tetraconazole Picoxystrobin 87 Mancozeb Benzovindiflupyr Tetraconazole Pyraclostrobin PCT00717 88 Mancozeb indiflupyr Tetraconazole Kresoximmethyl 89 Mancozeb Benzovindiflupyr Tetraconazole Trifloxystrobin 90 Mancozeb Benzovindiflupyr Prothioconazole Azoxystrobin 91 Mancozeb Benzovindiflupyr Prothioconazole Picoxystrobin 92 Mancozeb Benzovindiflupyr Prothioconazole Pyraclostrobin 93 eb Benzovindiflupyr Prothioconazole Kresoximmethyl 94 Mancozeb Benzovindiflupyr Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the red succinate dehydrogenase inhibitor fungicide is Penthiopyrad.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 95 Mancozeb Penthiopyrad Cyproconazole - 96 Mancozeb Penthiopyrad conazole - 97 Mancozeb Penthiopyrad Epoxiconazole - 98 Mancozeb Penthiopyrad Hexaconazole - 99 Mancozeb Penthiopyrad Tebuconazole - 100 Mancozeb Penthiopyrad Tetraconazole - 101 Mancozeb opyrad Prothioconazole - 102 Mancozeb opyrad - Azoxystrobin 103 Mancozeb Penthiopyrad - strobin 104 Mancozeb Penthiopyrad - Pyraclostrobin PCT00717 105 Mancozeb Penthiopyrad - Kresoximmethyl 106 Mancozeb Penthiopyrad - Trifloxystrobin 107 Mancozeb Penthiopyrad Cyproconazole Azoxystrobin 108 Mancozeb Penthiopyrad Cyproconazole Picoxystrobin 109 eb Penthiopyrad Cyproconazole Pyraclostrobin 110 Mancozeb Penthiopyrad onazole Kresoximmethyl 111 Mancozeb Penthiopyrad Cyproconazole Trifloxystrobin 112 Mancozeb Penthiopyrad Difenoconazole Azoxystrobin 113 Mancozeb opyrad Difenoconazole Picoxystrobin 114 eb Penthiopyrad Difenoconazole Pyraclostrobin 115 Mancozeb Penthiopyrad Difenoconazole Kresoximmethyl 116 Mancozeb Penthiopyrad Difenoconazole Trifloxystrobin 117 Mancozeb Penthiopyrad Epoxiconazole Azoxystrobin 118 Mancozeb opyrad Epoxiconazole Picoxystrobin 119 Mancozeb Penthiopyrad Epoxiconazole Pyraclostrobin 120 eb Penthiopyrad onazole Kresoximmethyl 121 Mancozeb Penthiopyrad onazole Trifloxystrobin 122 Mancozeb Penthiopyrad Hexaconazole Azoxystrobin 123 Mancozeb Penthiopyrad Hexaconazole Picoxystrobin 124 Mancozeb Penthiopyrad Hexaconazole Pyraclostrobin 125 Mancozeb Penthiopyrad Hexaconazole Kresoximmethyl 126 Mancozeb Penthiopyrad Hexaconazole Trifloxystrobin PCT00717 127 Mancozeb Penthiopyrad Tebuconazole Azoxystrobin 128 Mancozeb Penthiopyrad Tebuconazole Picoxystrobin 129 Mancozeb opyrad Tebuconazole Pyraclostrobin 130 Mancozeb Penthiopyrad Tebuconazole immethyl 131 Mancozeb Penthiopyrad Tebuconazole Trifloxystrobin 132 Mancozeb opyrad Tetraconazole Azoxystrobin 133 Mancozeb Penthiopyrad Tetraconazole Picoxystrobin 134 Mancozeb Penthiopyrad Tetraconazole Pyraclostrobin 135 Mancozeb Penthiopyrad Tetraconazole Kresoximmethyl 136 Mancozeb Penthiopyrad Tetraconazole Trifloxystrobin 137 Mancozeb Penthiopyrad Prothioconazole Azoxystrobin 138 Mancozeb opyrad Prothioconazole strobin 139 Mancozeb Penthiopyrad Prothioconazole Pyraclostrobin 140 Mancozeb Penthiopyrad Prothioconazole Kresoximmethyl 141 Mancozeb Penthiopyrad oconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred ate dehydrogenase inhibitor fungicide is boscalid.

In an embodiment, the combinations of the t invention include the following preferred combinations: S No. I II III IV 142 Mancozeb Boscalid Cyproconazole - PCT00717 143 Mancozeb Boscalid Difenoconazole - 144 Mancozeb Boscalid Epoxiconazole - 145 Mancozeb Boscalid Hexaconazole - 146 Mancozeb Boscalid Tebuconazole - 147 Mancozeb Boscalid Tetraconazole - 148 Mancozeb Boscalid Prothioconazole - 149 Mancozeb Boscalid - Azoxystrobin 150 Mancozeb Boscalid - strobin 151 Mancozeb Boscalid - Pyraclostrobin 152 Mancozeb Boscalid - Kresoximmethyl 153 Mancozeb Boscalid - xystrobin 154 Mancozeb Boscalid Cyproconazole Azoxystrobin 155 Mancozeb Boscalid Cyproconazole Picoxystrobin 156 Mancozeb Boscalid Cyproconazole Pyraclostrobin 157 Mancozeb Boscalid Cyproconazole Kresoximmethyl 158 Mancozeb Boscalid Cyproconazole Trifloxystrobin 159 Mancozeb Boscalid Difenoconazole trobin 160 Mancozeb Boscalid conazole Picoxystrobin 161 Mancozeb Boscalid Difenoconazole Pyraclostrobin 162 Mancozeb Boscalid Difenoconazole Kresoximmethyl 163 Mancozeb id Difenoconazole xystrobin 164 Mancozeb id onazole Azoxystrobin 165 Mancozeb Boscalid Epoxiconazole Picoxystrobin 166 Mancozeb Boscalid Epoxiconazole Pyraclostrobin PCT00717 167 Mancozeb id Epoxiconazole Kresoximmethyl 168 Mancozeb id Epoxiconazole Trifloxystrobin 169 Mancozeb Boscalid Hexaconazole Azoxystrobin 170 Mancozeb Boscalid Hexaconazole Picoxystrobin 171 Mancozeb Boscalid Hexaconazole Pyraclostrobin 172 Mancozeb Boscalid nazole Kresoximmethyl 173 Mancozeb Boscalid Hexaconazole Trifloxystrobin 174 Mancozeb Boscalid Tebuconazole Azoxystrobin 175 Mancozeb Boscalid Tebuconazole Picoxystrobin 176 Mancozeb Boscalid Tebuconazole Pyraclostrobin 177 Mancozeb Boscalid Tebuconazole immethyl 178 Mancozeb Boscalid nazole Trifloxystrobin 179 Mancozeb id Tetraconazole Azoxystrobin 180 Mancozeb Boscalid Tetraconazole Picoxystrobin 181 Mancozeb Boscalid Tetraconazole Pyraclostrobin 182 Mancozeb Boscalid Tetraconazole Kresoximmethyl 183 Mancozeb Boscalid Tetraconazole Trifloxystrobin 184 Mancozeb Boscalid Prothioconazole Azoxystrobin 185 Mancozeb Boscalid Prothioconazole Picoxystrobin 186 eb Boscalid Prothioconazole Pyraclostrobin 187 Mancozeb Boscalid Prothioconazole Kresoximmethyl 188 Mancozeb id Prothioconazole Trifloxystrobin PCT00717 In an ment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is . IR9792 is a SDHI fungicide, developed by Isagro, with the proposed common name fluindapyr.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 189 Mancozeb IR9792 Cyproconazole - 190 Mancozeb IR9792 Difenoconazole - 191 Mancozeb IR9792 Epoxiconazole - 192 Mancozeb IR9792 Hexaconazole - 193 Mancozeb IR9792 Tebuconazole - 194 Mancozeb IR9792 Tetraconazole - 195 Mancozeb IR9792 Prothioconazole - 196 Mancozeb IR9792 - Azoxystrobin 197 Mancozeb IR9792 - strobin 198 Mancozeb IR9792 - ostrobin 199 Mancozeb IR9792 - Kresoximmethyl 200 Mancozeb IR9792 - Trifloxystrobin 201 Mancozeb IR9792 Cyproconazole Azoxystrobin 202 Mancozeb IR9792 Cyproconazole strobin 203 Mancozeb IR9792 Cyproconazole Pyraclostrobin PCT00717 204 Mancozeb IR9792 onazole Kresoximmethyl 205 Mancozeb IR9792 Cyproconazole Trifloxystrobin 206 Mancozeb IR9792 Difenoconazole Azoxystrobin 207 Mancozeb IR9792 Difenoconazole Picoxystrobin 208 Mancozeb IR9792 Difenoconazole Pyraclostrobin 209 eb IR9792 Difenoconazole Kresoximmethyl 210 Mancozeb IR9792 Difenoconazole xystrobin 211 Mancozeb IR9792 Epoxiconazole Azoxystrobin 212 Mancozeb IR9792 Epoxiconazole Picoxystrobin 213 Mancozeb IR9792 Epoxiconazole Pyraclostrobin 214 Mancozeb IR9792 Epoxiconazole Kresoximmethyl 215 Mancozeb IR9792 Epoxiconazole Trifloxystrobin 216 Mancozeb IR9792 Hexaconazole Azoxystrobin 217 Mancozeb IR9792 Hexaconazole Picoxystrobin 218 Mancozeb IR9792 Hexaconazole Pyraclostrobin 219 Mancozeb IR9792 Hexaconazole Kresoximmethyl 220 Mancozeb IR9792 nazole Trifloxystrobin 221 Mancozeb IR9792 Tebuconazole Azoxystrobin 222 Mancozeb IR9792 Tebuconazole Picoxystrobin 223 Mancozeb IR9792 Tebuconazole Pyraclostrobin 224 Mancozeb IR9792 Tebuconazole Kresoximmethyl 225 Mancozeb IR9792 Tebuconazole Trifloxystrobin PCT00717 226 Mancozeb IR9792 Tetraconazole Azoxystrobin 227 Mancozeb IR9792 Tetraconazole Picoxystrobin 228 Mancozeb IR9792 Tetraconazole Pyraclostrobin 229 Mancozeb IR9792 Tetraconazole Kresoximmethyl 230 Mancozeb IR9792 Tetraconazole Trifloxystrobin 231 Mancozeb IR9792 oconazole Azoxystrobin 232 eb IR9792 Prothioconazole Picoxystrobin 233 Mancozeb IR9792 Prothioconazole ostrobin 234 Mancozeb IR9792 Prothioconazole Kresoximmethyl 235 Mancozeb IR9792 oconazole xystrobin In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is n.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 236 Mancozeb Bixafen Cyproconazole - 237 Mancozeb Bixafen Difenoconazole - 238 Mancozeb Bixafen Epoxiconazole - 239 Mancozeb Bixafen Hexaconazole - 240 eb Bixafen Tebuconazole - 241 Mancozeb Bixafen Tetraconazole - 242 Mancozeb Bixafen Prothioconazole - PCT00717 243 Mancozeb Bixafen - Azoxystrobin 244 Mancozeb Bixafen - Picoxystrobin 245 Mancozeb Bixafen - ostrobin 246 Mancozeb Bixafen - Kresoximmethyl 247 Mancozeb Bixafen - xystrobin 248 Mancozeb Bixafen Cyproconazole Azoxystrobin 249 Mancozeb Bixafen onazole Picoxystrobin 250 Mancozeb Bixafen Cyproconazole Pyraclostrobin 251 Mancozeb Bixafen Cyproconazole Kresoximmethyl 252 Mancozeb Bixafen Cyproconazole Trifloxystrobin 253 Mancozeb n Difenoconazole Azoxystrobin 254 Mancozeb Bixafen Difenoconazole Picoxystrobin 255 Mancozeb Bixafen Difenoconazole Pyraclostrobin 256 Mancozeb Bixafen Difenoconazole Kresoximmethyl 257 Mancozeb Bixafen conazole Trifloxystrobin 258 Mancozeb Bixafen Epoxiconazole Azoxystrobin 259 Mancozeb Bixafen onazole Picoxystrobin 260 eb Bixafen Epoxiconazole Pyraclostrobin 261 Mancozeb Bixafen Epoxiconazole Kresoximmethyl 262 Mancozeb Bixafen Epoxiconazole Trifloxystrobin 263 Mancozeb Bixafen Hexaconazole Azoxystrobin 264 Mancozeb Bixafen nazole Picoxystrobin 265 Mancozeb Bixafen Hexaconazole Pyraclostrobin PCT00717 266 Mancozeb Bixafen Hexaconazole Kresoximmethyl 267 eb Bixafen Hexaconazole Trifloxystrobin 268 Mancozeb Bixafen Tebuconazole Azoxystrobin 269 Mancozeb Bixafen Tebuconazole Picoxystrobin 270 Mancozeb Bixafen Tebuconazole Pyraclostrobin 271 Mancozeb n Tebuconazole immethyl 272 eb Bixafen Tebuconazole Trifloxystrobin 273 Mancozeb Bixafen Tetraconazole Azoxystrobin 274 Mancozeb Bixafen Tetraconazole Picoxystrobin 275 Mancozeb Bixafen Tetraconazole Pyraclostrobin 276 Mancozeb Bixafen Tetraconazole Kresoximmethyl 277 Mancozeb Bixafen Tetraconazole Trifloxystrobin 278 Mancozeb Bixafen Prothioconazole Azoxystrobin 279 Mancozeb Bixafen Prothioconazole Picoxystrobin 280 Mancozeb Bixafen Prothioconazole Pyraclostrobin 281 Mancozeb Bixafen Prothioconazole Kresoximmethyl 282 Mancozeb n Prothioconazole Trifloxystrobin In an ment of the combinations of the present invention, the preferred ate dehydrogenase inhibitor fungicide is Fluxapyroxad.

In an embodiment, the combinations of the present ion include the following preferred combinations: S No. I II III IV 283 Mancozeb yroxad Cyproconazole - 284 Mancozeb Fluxapyroxad conazole - 285 Mancozeb Fluxapyroxad Epoxiconazole - 286 Mancozeb Fluxapyroxad Hexaconazole - 287 eb Fluxapyroxad Tebuconazole - 288 Mancozeb Fluxapyroxad Tetraconazole - 289 Mancozeb Fluxapyroxad Prothioconazole - 290 Mancozeb Fluxapyroxad - Azoxystrobin 291 Mancozeb Fluxapyroxad - Picoxystrobin 292 Mancozeb Fluxapyroxad - Pyraclostrobin 293 Mancozeb Fluxapyroxad - Kresoximmethyl 294 eb Fluxapyroxad - xystrobin 295 Mancozeb Fluxapyroxad Cyproconazole Azoxystrobin 296 Mancozeb Fluxapyroxad Cyproconazole Picoxystrobin 297 Mancozeb Fluxapyroxad Cyproconazole Pyraclostrobin 298 Mancozeb Fluxapyroxad Cyproconazole Kresoximmethyl 299 Mancozeb Fluxapyroxad Cyproconazole Trifloxystrobin 300 Mancozeb Fluxapyroxad Difenoconazole Azoxystrobin 301 Mancozeb Fluxapyroxad Difenoconazole Picoxystrobin 302 Mancozeb Fluxapyroxad Difenoconazole Pyraclostrobin 303 Mancozeb Fluxapyroxad conazole Kresoximmethyl 304 Mancozeb Fluxapyroxad Difenoconazole Trifloxystrobin PCT00717 305 Mancozeb Fluxapyroxad Epoxiconazole Azoxystrobin 306 Mancozeb Fluxapyroxad Epoxiconazole strobin 307 Mancozeb Fluxapyroxad Epoxiconazole ostrobin 308 eb Fluxapyroxad Epoxiconazole Kresoximmethyl 309 eb Fluxapyroxad Epoxiconazole Trifloxystrobin 310 Mancozeb Fluxapyroxad Hexaconazole Azoxystrobin 311 Mancozeb Fluxapyroxad Hexaconazole Picoxystrobin 312 Mancozeb Fluxapyroxad Hexaconazole Pyraclostrobin 313 Mancozeb Fluxapyroxad Hexaconazole Kresoximmethyl 314 Mancozeb Fluxapyroxad Hexaconazole Trifloxystrobin 315 Mancozeb Fluxapyroxad Tebuconazole Azoxystrobin 316 Mancozeb Fluxapyroxad Tebuconazole strobin 317 Mancozeb yroxad Tebuconazole Pyraclostrobin 318 Mancozeb Fluxapyroxad Tebuconazole Kresoximmethyl 319 Mancozeb Fluxapyroxad Tebuconazole Trifloxystrobin 320 Mancozeb Fluxapyroxad Tetraconazole Azoxystrobin 321 Mancozeb Fluxapyroxad Tetraconazole Picoxystrobin 322 Mancozeb yroxad Tetraconazole Pyraclostrobin 323 Mancozeb Fluxapyroxad Tetraconazole Kresoximmethyl 324 Mancozeb Fluxapyroxad Tetraconazole Trifloxystrobin 325 Mancozeb Fluxapyroxad Prothioconazole trobin 326 Mancozeb Fluxapyroxad Prothioconazole Picoxystrobin 327 Mancozeb Fluxapyroxad Prothioconazole Pyraclostrobin PCT00717 328 Mancozeb Fluxapyroxad Prothioconazole Kresoximmethyl 329 Mancozeb Fluxapyroxad Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor ide is tpyr.

In an embodiment, the combinations of the present invention include the following red combinations: S No. I II III IV 330 Mancozeb Furametpyr Cyproconazole - 331 Mancozeb Furametpyr Difenoconazole - 332 Mancozeb Furametpyr Epoxiconazole - 333 Mancozeb Furametpyr Hexaconazole - 334 Mancozeb Furametpyr Tebuconazole - 335 Mancozeb tpyr Tetraconazole - 336 Mancozeb Furametpyr Prothioconazole - 337 Mancozeb Furametpyr - Azoxystrobin 338 Mancozeb Furametpyr - Picoxystrobin 339 Mancozeb Furametpyr - Pyraclostrobin 340 Mancozeb Furametpyr - Kresoximmethyl 341 Mancozeb Furametpyr - Trifloxystrobin 342 Mancozeb Furametpyr Cyproconazole trobin 343 Mancozeb Furametpyr Cyproconazole Picoxystrobin 344 eb Furametpyr Cyproconazole Pyraclostrobin PCT00717 345 Mancozeb Furametpyr Cyproconazole Kresoximmethyl 346 Mancozeb Furametpyr Cyproconazole Trifloxystrobin 347 Mancozeb Furametpyr Difenoconazole Azoxystrobin 348 Mancozeb Furametpyr Difenoconazole Picoxystrobin 349 Mancozeb Furametpyr Difenoconazole Pyraclostrobin 350 Mancozeb Furametpyr Difenoconazole Kresoximmethyl 351 Mancozeb Furametpyr Difenoconazole Trifloxystrobin 352 Mancozeb Furametpyr Epoxiconazole trobin 353 Mancozeb Furametpyr Epoxiconazole Picoxystrobin 354 Mancozeb tpyr Epoxiconazole Pyraclostrobin 355 Mancozeb Furametpyr Epoxiconazole immethyl 356 Mancozeb Furametpyr Epoxiconazole Trifloxystrobin 357 Mancozeb Furametpyr Hexaconazole Azoxystrobin 358 Mancozeb Furametpyr nazole Picoxystrobin 359 Mancozeb Furametpyr Hexaconazole Pyraclostrobin 360 Mancozeb Furametpyr Hexaconazole Kresoximmethyl 361 Mancozeb Furametpyr Hexaconazole Trifloxystrobin 362 Mancozeb Furametpyr Tebuconazole Azoxystrobin 363 eb Furametpyr Tebuconazole Picoxystrobin 364 Mancozeb Furametpyr nazole ostrobin 365 Mancozeb Furametpyr nazole Kresoximmethyl 366 Mancozeb Furametpyr Tebuconazole Trifloxystrobin 367 Mancozeb Furametpyr Tetraconazole Azoxystrobin 368 Mancozeb Furametpyr Tetraconazole strobin 369 eb Furametpyr Tetraconazole Pyraclostrobin 370 Mancozeb Furametpyr Tetraconazole Kresoximmethyl 371 Mancozeb Furametpyr Tetraconazole Trifloxystrobin 372 Mancozeb Furametpyr oconazole trobin 273 Mancozeb Furametpyr Prothioconazole Picoxystrobin 374 Mancozeb Furametpyr Prothioconazole Pyraclostrobin 375 Mancozeb Furametpyr Prothioconazole Kresoximmethyl 376 Mancozeb Furametpyr Prothioconazole Trifloxystrobin In an embodiment of the combinations of the t invention, the preferred succinate dehydrogenase tor fungicide is Penflufen.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 377 Mancozeb Penflufen Cyproconazole - 378 Mancozeb Penflufen conazole - 379 Mancozeb Penflufen Epoxiconazole - 380 Mancozeb Penflufen Hexaconazole - 381 Mancozeb Penflufen Tebuconazole - 382 Mancozeb Penflufen Tetraconazole - 383 Mancozeb Penflufen Prothioconazole - PCT00717 384 Mancozeb Penflufen - Azoxystrobin 385 Mancozeb Penflufen - Picoxystrobin 386 Mancozeb fen - Pyraclostrobin 387 eb Penflufen - immethyl 388 Mancozeb Penflufen - Trifloxystrobin 389 Mancozeb Penflufen Cyproconazole Azoxystrobin 390 Mancozeb Penflufen Cyproconazole Picoxystrobin 391 Mancozeb Penflufen Cyproconazole Pyraclostrobin 392 Mancozeb Penflufen Cyproconazole Kresoximmethyl 393 Mancozeb Penflufen Cyproconazole Trifloxystrobin 394 Mancozeb Penflufen Difenoconazole Azoxystrobin 395 Mancozeb Penflufen Difenoconazole Picoxystrobin 396 Mancozeb Penflufen Difenoconazole Pyraclostrobin 397 Mancozeb Penflufen Difenoconazole Kresoximmethyl 398 eb Penflufen Difenoconazole Trifloxystrobin 399 Mancozeb fen Epoxiconazole Azoxystrobin 400 eb Penflufen Epoxiconazole Picoxystrobin 401 Mancozeb Penflufen Epoxiconazole Pyraclostrobin 402 Mancozeb Penflufen Epoxiconazole immethyl 403 Mancozeb Penflufen Epoxiconazole Trifloxystrobin 404 Mancozeb Penflufen Hexaconazole Azoxystrobin 405 Mancozeb Penflufen Hexaconazole Picoxystrobin 406 Mancozeb fen Hexaconazole Pyraclostrobin PCT00717 407 Mancozeb Penflufen nazole Kresoximmethyl 408 Mancozeb Penflufen Hexaconazole xystrobin 409 Mancozeb Penflufen Tebuconazole Azoxystrobin 410 Mancozeb Penflufen Tebuconazole Picoxystrobin 411 Mancozeb fen Tebuconazole Pyraclostrobin 412 Mancozeb Penflufen Tebuconazole Kresoximmethyl 413 Mancozeb Penflufen Tebuconazole Trifloxystrobin 414 Mancozeb Penflufen Tetraconazole Azoxystrobin 415 Mancozeb Penflufen Tetraconazole Picoxystrobin 416 Mancozeb Penflufen Tetraconazole Pyraclostrobin 417 Mancozeb Penflufen Tetraconazole Kresoximmethyl 418 Mancozeb Penflufen Tetraconazole Trifloxystrobin 419 Mancozeb Penflufen Prothioconazole Azoxystrobin 420 Mancozeb Penflufen Prothioconazole Picoxystrobin 421 Mancozeb fen Prothioconazole Pyraclostrobin 422 Mancozeb Penflufen Prothioconazole Kresoximmethyl 423 Mancozeb Penflufen Prothioconazole xystrobin In an embodiment of the ations of the t invention, the preferred succinate dehydrogenase inhibitor fungicide is Sedaxane.

In an embodiment, the combinations of the present ion include the following preferred combinations: PCT00717 S No. I II III IV 424 Mancozeb Sedaxane Cyproconazole - 425 Mancozeb Sedaxane Difenoconazole - 426 Mancozeb ne Epoxiconazole - 427 Mancozeb Sedaxane Hexaconazole - 428 Mancozeb Sedaxane Tebuconazole - 429 eb Sedaxane Tetraconazole - 430 Mancozeb ne Prothioconazole - 431 Mancozeb Sedaxane - Azoxystrobin 432 Mancozeb Sedaxane - Picoxystrobin 433 Mancozeb Sedaxane - Pyraclostrobin 434 Mancozeb Sedaxane - Kresoximmethyl 435 Mancozeb Sedaxane - xystrobin 436 Mancozeb Sedaxane Cyproconazole trobin 437 Mancozeb Sedaxane Cyproconazole Picoxystrobin 438 Mancozeb Sedaxane Cyproconazole Pyraclostrobin 439 Mancozeb Sedaxane Cyproconazole Kresoximmethyl 440 Mancozeb Sedaxane Cyproconazole Trifloxystrobin 441 Mancozeb Sedaxane Difenoconazole Azoxystrobin 442 Mancozeb Sedaxane Difenoconazole Picoxystrobin 443 Mancozeb Sedaxane Difenoconazole Pyraclostrobin 444 eb Sedaxane Difenoconazole Kresoximmethyl 445 Mancozeb Sedaxane Difenoconazole Trifloxystrobin PCT00717 446 Mancozeb Sedaxane Epoxiconazole Azoxystrobin 447 eb Sedaxane Epoxiconazole Picoxystrobin 448 eb Sedaxane Epoxiconazole Pyraclostrobin 449 eb Sedaxane onazole Kresoximmethyl 450 Mancozeb Sedaxane Epoxiconazole Trifloxystrobin 451 Mancozeb ne Hexaconazole Azoxystrobin 452 eb Sedaxane Hexaconazole Picoxystrobin 453 Mancozeb Sedaxane Hexaconazole Pyraclostrobin 454 Mancozeb Sedaxane Hexaconazole Kresoximmethyl 455 Mancozeb Sedaxane Hexaconazole Trifloxystrobin 456 Mancozeb Sedaxane Tebuconazole Azoxystrobin 457 Mancozeb Sedaxane Tebuconazole Picoxystrobin 458 Mancozeb Sedaxane Tebuconazole Pyraclostrobin 459 Mancozeb Sedaxane Tebuconazole Kresoximmethyl 460 Mancozeb Sedaxane Tebuconazole xystrobin 461 Mancozeb Sedaxane Tetraconazole trobin 462 Mancozeb Sedaxane Tetraconazole Picoxystrobin 463 Mancozeb Sedaxane Tetraconazole Pyraclostrobin 464 Mancozeb Sedaxane Tetraconazole Kresoximmethyl 465 Mancozeb Sedaxane Tetraconazole Trifloxystrobin 466 Mancozeb Sedaxane Prothioconazole Azoxystrobin 467 eb Sedaxane Prothioconazole Picoxystrobin 468 Mancozeb Sedaxane Prothioconazole Pyraclostrobin PCT00717 469 Mancozeb Sedaxane Prothioconazole Kresoximmethyl 470 Mancozeb Sedaxane Prothioconazole Trifloxystrobin The combinations of the present invention may be formulated in the form of a composition.

In an ment, the t invention may provide a composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one carbamate fungicide; (c) at least one quinone outside inhibitor; and (d) at least one agrochemically acceptable excipient.

In an embodiment, the present invention may provide a composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one ergostrol biosynthesis inhibitor; and (d) at least one agrochemically acceptable excipient.

In an embodiment, the present invention may provide a composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one a quinone e tor; (d) at least one rol thesis inhibitor; and (e) at least one agrochemically acceptable excipient.

PCT00717 The amount of a composition according to the invention to be applied, will depend on various factors, such as the subject of the treatment, such as, for example plants, soil or seeds; the type of treatment, such as, for e spraying, dusting or seed dressing; the purpose of the treatment, such as, for example prophylactic or therapeutic disease control; in case of e l the type of fungi to be controlled or the application time. This amount of the combinations of the present invention to be applied can be readily deduced by a skilled agronomist.

Thus in an embodiment, the t invention may provide compositions comprising: (a) at least one pyrazaole carboxamide selected from benzovindiflupyr, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, and sedaxane; (b) at least one quinone outside inhibitor, and/or at least one ergostrol biosynthesis inhibitor; and (c) at last one dithiocarbamate fungicide; said fungicides being combined in agrochemically able amounts.

In an embodiment, the total amount of ate dehydrogenase inhibitor in the composition may typically be in the range of 0.1 to 99% by weight, preferably 0.2 to 90% by weight. The total amount of dithiocarbamate fungicide in the composition may be in the range of 0.1 to 99% by weight.

The total amount of ergostrol biosynthesis inhibitor in the composition may be in the range of 0.1 to 99% by weight. The total amount of Quinone outside tor in the composition may be in the range of 0.1 to 99% by weight.

PCT00717 In an ment, the constituent fungicides of the combination of the present invention may be admixed in ratio of (1-80): (1-80): (1-80) of the dithiocarbamate fungicide, succinate dehydrogenase inhibitor fungicide and the third fungicide respectively.

In an embodiment, the constituents of the composition of the present invention may be tank mixed and sprayed at the locus of the infection, or may be alternatively be mixed with surfactants and then sprayed.

In an ment, the constituents of the ition of the present ion may be used for foliar application, ground or applications to plant propagation materials.

In an embodiment, the compositions of the present invention may typically be produce by mixing the s in the composition with an inert carrier, and adding tants and other adjuvants and carriers as needed and formulated into solid, or liquid formulations, including but not limited to wettable s, granules, dusts, Soluble (liquid) concentrates, suspension concentrates, oil in water on, water in oil emulsion, emulsifiable concentrates, capsule suspensions, ZC formulations, oil dispersions or other known formulation types. The composition may also be used for treatment of a plant propagation material such as seeds etc.

Examples of the solid r used in formulation include fine powders or granules such as minerals such as kaolin clay, attapulgite clay, bentonite, montmorillonite, acid white clay, pyrophyllite, talc, diatomaceous earth and calcite; natural organic materials such as corn rachis powder and walnut PCT00717 husk ; synthetic organic materials such as urea; salts such as calcium carbonate and ammonium sulfate; synthetic inorganic materials such as tic hydrated silicon oxide; and as a liquid carrier, aromatic hydrocarbons such as xylene, alkylbenzene and methylnaphthalene; alcohols such as 2-propanol, ethyleneglycol, propylene glycol, and ethylene glycol monoethyl ether; ketones such as acetone, cyclohexanone and isophorone; vegetable oil such as soybean oil and cotton seed oil; petroleum tic hydrocarbons, , dimethylsulfoxide, acetonitrile and water.

Examples of the surfactant include anionic surfactants such as alkyl sulfate ester salts, alkylaryl sulfonate salts, dialkyl sulfosuccinate salts, polyoxyethylene alkylaryl ether phosphate ester salts, lignosulfonate salts and naphthalene ate formaldehyde polycondensates; and nonionic surfactants such as polyoxyethylene alkyl aryl ethers, polyoxyethylene alkylpolyoxypropylene block copolymers and sorbitan fatty acid esters and cationic surfactants such as alkyltrimethylammonium salts. es of the other formulation auxiliary agents include water-soluble polymers such as polyvinyl l and polyvinylpyrrolidone, polysaccharides such as Arabic gum, alginic acid and the salt thereof, CMC (carboxymethylcellulose ) , Xanthan gum, nic materials such as aluminum magnesium silicate and alumina sol, preservatives, coloring agents and stabilization agents such as PAP (acid ate isopropyl) and BHT.

The compositions ing to the present invention is effective for the following plant diseases: PCT00717 Disease in rice: Blast (Magnaporthe grisea), Helminthosporium leaf spot (Cochliobolus anus), sheath blight (Rhizoctonia solani) , and bakanae disease (Gibberella roi).

Diseases in wheat: powdery mildew (Erysiphe graminis) , Fusariuin head blight (Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale) , rust (Puccinia striiformis, P. is, P. recondita) , pink snow mold (Micronectriella nivale), Typhula snow blight la sp . ) , loose smut (Ustilago tritici) , bunt (Tilletia caries) , eyespot (Pseudocercosporella richoides) , leaf blotch (Mycosphaerella graminicola) , glume blotch (Stagonospora nodorum) , septoria, and yellow spot (Pyrenophora triticirepentis Diseases of barley: powdery mildew (Erysiphe graminis), Fusarium head blight (Fusarium earum, F. avenacerum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. ) , loose smut ago nuda) , scald (Rhynchosporium secalis) , net blotch (Pyrenophora teres), spot blotch (Cochliobolus sativus), leaf stripe (Pyrenophora graminea) , and Rhizoctonia damping-off (Rhizoctonia solani) .

Diseases in corn: smut (Ustilago maydis), brown spot (Cochliobolus heterostrophus), copper spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), gray leaf spot (Cercospora zeae-maydis), white spot (Phaeosphaeria mydis and/or Pantoea ananatis) and tonia damping- off (Rhizoctonia solani).

PCT00717 Diseases of citrus: melanose (Diaporthe citri), scab (Elsinoe fawcetti), penicillium rot (Penicillium digitatum, P.italicum), and brown rot (Phytophthora parasitica, Phytophthora citrophthora) . es of apple: blossom blight (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), Alternaria leaf spot (Alternaria alternata apple pathotype) , scab (Venturia inaequalis) , y mildew, bitter rot (Colletotrichum acutatum), crown rot (Phytophtora cactorum) , blotch (Diplocarpon mali) , and ring rot (Botryosphaeria berengeriana) .

Diseases of pear: scab (Venturia nashicola, V. pirina) , powdery mildew, black spot (Alternaria alternata se pear pathotype) , rust (Gymnosporangium haraeanum) , and phytophthora fruit rot (Phytophtora um).

Diseases of peach: brown rot (Monilinia fructicola), powdery mildew, scab sporium carpophilum), and phomopsis rot psis sp.).

Diseases of grape: anthracnose (Elsinoe ampelina) , ripe rot rella cingulata), powdery mildew (Uncinula necator) , rust (Phakopsora ampelopsidis) , black rot (Guignardia bidwellii) , botrytis, and downy mildew (Plasmopara viticola) .

Diseases of Japanese persimmon: anthracnose sporium kaki) , and leaf spot (Cercospora kaki, Mycosphaerella nawae) .

PCT00717 Diseases of gourd: anthracnose (Colletotrichum lagenarium) , powdery mildew (Sphaerotheca fuliginea) , gummy stem blight (Mycosphaerella s) , Fusarium wilt (Fusarium oxysporum) , downy mildew (Pseudoperonospora cubensis) , Phytophthora rot (Phytophthora sp.) , and damping-off (Pythium sp . ).

Diseases of : early blight (Alternaria solani) , leaf mold (Cladosporium fulvum) , and late blight phthora infestans) . es of eggplant: brown spot (Phomopsis vexans) , and powdery mildew (Erysiphe cichoracearum) Diseases of cruciferous vegetables: Alternaria leaf spot (Alternaria japonica) , white spot (Cercosporella brassicae) , clubroot (Plasmodiophora brassicae) , and downy mildew (Peronospora parasitica) .

Diseases of onion: rust (Puccinia allii) , and downy mildew (Peronospora destructor).

Diseases of soybean: purple seed stain (Cercospora kikuchii) , sphaceloma scad oe glycines) , pod and stem blight (Diaporthe phaseolorum var. sojae) , septoria brown spot (Septoria glycines), frogeye leaf spot (Cercospora sojina), rust (Phakopsora pachyrhizi) , Yellow rust, brown stem rot phthora sojae), and tonia damping-off (Rhizoctonia solani) .

Diseases of kidney bean: anthracnose (Colletotrichum lindemthianum) .

Diseases of peanut: leaf spot (Cercospora personata), brown leaf spot (Cercospora arachidicola) and southern blight (Sclerotium rolfsii).

PCT00717 es of garden pea: powdery mildew (Erysiphe pisi) , and root rot (Fusarium solani f. sp. pisi) .

Diseases of potato: early blight naria solani), late blight (Phytophthora infestans), pink rot (Phytophthora erythroseptica), and powdery scab (Spongospora subterranean f. sp. subterranea).

Diseases of strawberry: powdery mildew (Sphaerotheca humuli), and anthracnose (Glomerella ata).

Diseases of tea: net blister blight (Exobasidium latum), white scab (Elsinoe pila) , gray blight (Pestalotiopsis sp.), and anthracnose (Colletotrichum theae- sinensis) .

Diseases of tobacco: brown spot (Alternaria longipes) , powdery mildew (Erysiphe acearum), anthracnose (Colletotrichum tabacum), downy mildew (Peronospora tabacina) , and black shank (Phytophthora nicotianae).

Diseases of rapeseed: sclerotinia rot (Sclerotinia sclerotiorum) , and Rhizoctonia g-off (Rhizoctonia solani) . Diseases of cotton: Rhizoctonia damping-off (Rhizoctonia solani) .

Diseases of sugar beat: Cercospora leaf spot (Cercospora beticola) , leaf blight (Thanatephorus cucumeris), Root rot (Thanatephorus cucumeris), and myces root rot (Aphanomyces cochlioides) .

Diseases of rose: black spot (Diplocarpon rosae) , powdery mildew (Sphaerotheca pannosa) , and downy mildew (Peronospora sparsa) .

PCT00717 Diseases of chrysanthemum and asteraceous plants: downy mildew (Bremia lactucae), leaf blight (Septoria chrysanthemi-indici) , and white rust (Puccinia horiana).

Diseases of various groups: diseases caused by Pythium spp. um aphanidermatum, Pythium debarianum, Pythium graminicola, Pythium irregulare, Pythium m), gray mold. (Botrytis a), and Sclerotinia rot (Sclerotinia sclerotiorum).

Disease of Japanese radish: Alternaria leaf spot (Alternaria brassicicola).

Diseases of turfgrass: dollar spot (Sclerotinia homeocarpa), and brown patch and large patch (Rhizoctonia solani).

Disease of banana: Black sigatoka (Mycosphaerella fijiensis), Yellow sigatoka (Mycosphaerella musicola).

Disease of sunflower: downy mildew (Plasmopara halstedii) .

Seed diseases or diseases in the early stages of the growth of various plants caused by Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., viopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., tonia spp. and Diplodia spp.

Viral diseases of s plants mediated by Polymixa spp. or Olpidium spp. and so on.

PCT00717 The compositions of the present ion can be used in agricultural lands such as fields, paddy , lawns and orchards or in non-agricultural lands.

The present invention may be used to control diseases in ltural lands for cultivating the plants without any phytotoxicity to the plant.

Examples of the crops on which the present compositions may be used include but are not limited to corn, rice, wheat, barley, rye, oat, sorghum, , soybean, , buckwheat, beet, ed, sunflower, sugar cane, tobacco, etc.; vegetables: solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous bles such as radish, white turnip, horseradish, kohlrabi, e cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, ruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc. , trees other than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, ptus, Ginkgo biloba, lilac, maple, Quercus, , Judas tree, Liquidambar PCT00717 formosana, plane tree, a, Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.

In an embodiment, the constituent fungicides of the combination of the t invention may be admixed in ratio of (1-80): (1-80): (1-80): (1:80) In an aspect, the present invention may provide methods of controlling fungal es comprising applying a combination sing: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one quinone outside inhibitor and/or at least one rol biosynthesis inhibitor; and (c) at least one dithiocarbamate fungicide.

In an ment, the succinate dehydrogenase inhibitor fungicide, the quinone outside inhibitor fungicide, the ergosterol biosynthesis inhibitor fungicide, and the dithiocarbamate fungicide may be selected according to any of the preferred embodiments of the combinations described above.

The combinations of the present invention may be sold as a pre-mix composition or a kit of parts such that individual actives may be mixed before ng. Alternatively, the kit of parts may contain succinate dehydrogenase inhibitor fungicide and the dithiocarbamate fungicide premixed and the third active may be admixed with an nt such that the two components may be tank mixed before spraying.

The composition of the present invention maybe applied simultaneously as a tank mix or a formulation or may be applied sequentially. The application PCT00717 may be made to the soil before emergence of the plants, either pre-planting or post-planting. The ation may be made as a foliar spray at different s during crop development, with either one or two applications early or late post-emergence.

The compositions according to the invention can be applied before or after infection of the useful plants or the propagation material thereof by the fungi.

As will be trated in the examples, the addition of a carbamate fungicide to a combination of succinate dehydrogenase inhibitors which are combined with Quinone outside inhibitors and/or ergosterol biosynthesis inhibitors, y improved the disease control as well as improved yield and demonstrated a synergistic effect. The lower the mixture performance in the disease control, the greater the additional benefit of the mancozeb when added to the compositions of the present ion.

Examples: Studies were conducted to study the addition of dithiocarbamate fungicides to succinate dehydrogenase inhibitor fungicides and at least one other ide and the contribution of the dithiocarbamate to the efficacy of these mixtures. Experiments were conducted over a period of two years to study the effect of the on of dithiocarbamates on the efficacy of succinate dehydrogenase inhibitors alone and when combined with a cofungicide such as a Quinone outside inhibitors and/or ergosterol biosynthesis inhibitor fungicide. Doses tested were at rates of 1500 g/ha for Mancozeb, 150 ml/ha for the ergosterol biosynthesis inhibitor, 200 g/ha for the Quinone outside inhibitor, 1000 g/ha and 200 g/ha for succinate ogenase inhibitor fungicides. The combinatios were tested for PCT00717 efficacy of disease l in soybean for the control of Asian soybean rust. The trials were carried out at various locations in India.

The test were conducted on soybean cultivar Monsoy 9144 RR. The commercially available individual active ingredients were used at the indicated s.

Table 1: Table 1 shows the efficacy of mancozeb when added to combinations containing succinate dehydrogenase inhibitor fungicides and ergosterol thesis inhibitor. ent Dose rates Mean percent disease (ml/g/ha) control 2015/16 2016/17 Prothioconazole + Benzovindiflupyr 150+200 88.04 71.04 Prothioconazole + 95.07 95.07 150+200+1500 Benzovindiflupyr+ Mancozeb Prothioconazole + Isopyrazam 150+1000 87.14 70.23 Prothioconazole + Isopyrazam+ 150+1000+150 93.4 93.07 Mancozeb 0 Prothioconazole + Penthoipyrad 150+1000 83.33 68.15 Prothioconazole + Penthiopyrad + 150+1000+150 93.07 92.18 Mancozeb 0 Table 1 clearly demonstrates the increase in l when eb is added to the combination of ergosterol biosynthesis inhibitors and succinate ogenase inhibitor fungicides.

PCT00717 Table 2: Table 2 demonstrates effiacacy when eb is added to combinations of succinate dehydrogenase inhibitor fungicides and quinone outside inhibitor fungicides and ergosterol biosynthesis inhibitors. ent Dose rates Mean percent disease (ml/g/ha) control 2015/16 2016/17 Prothioconazole + Benzovindiflupyr 150+200+500 + Azoxystrobin 93.07 91.07 Prothioconazole + Benzovindiflupyr 150+200+500+1500 + Azoxystrobin + Mancozeb 96.36 95.03 Table 2 clearly demonstrates the importance of adding mancozeb to the combination. The addition of mancozeb improved disease control.

It was thus found that the incorporation of mancozeb greatly increased efficacy and e control of the succinate dehydrogenase inhibitor fungicide treatments when mixed with ergosterol biosynthesis inhibitors or quinone e inhibitors. It was thus concluded that the addition of mancozeb ed the efficacy of the ation and surpsingly gave a synergistic effect. The addition of a dithiocarbamate increased disease l and improved yield of plants. The instant invention is more specifically explained by above examples. r, it should be understood that the scope of the present ion is not limited by the examples in any manner. It will be appreciated by any person skilled in this art that the present ion includes aforesaid examples and further can be modified and altered within the technical scope of the present invention.

PCT00717 While the foregoing written description of the invention enables one of ordinary skill to make and use what is ered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the ic embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all ments and methods within the scope and spirit of the invention.

EMBODIMENTS OF THE DISCLOSURE The following numbered paragraphs define some particular embodiments of the present disclosure: 1. A fungicidal combination comprising at least one ate dehydrogenase inhibitor ide, at least one dithiocarbamate fungicide, and at least another ide. 2. The combination of paragraph 1, wherein the dithiocarbamate fungicide is selected from amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, per, mancozeb, maneb, metiram, polycarbamate, propineb and zineb. 3. The ation of paragraph 2, wherein the dithiocarbamate fungicide is mancozeb.

PCT00717 4. The combination of paragraph 1, wherein the succinate dehydrogenase inhibitor is selected from pyrazole carboxamide class of ate dehydrogenase inhibitor fungicides. 5. The combination of paragraph 4, n the pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicide is ed from benzovindiflupyr, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, and sedaxane. 6. The combination of paragraph 1, wherein atleast another fungicide is selected from an atleast one of ergosterol biosynthesis inhibitor fungicide, and quinone outside inhibitor ide. 7. The combination of aph 6, wherein the ergosterol biosynthesis inhibitors is selected azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, zole, metconazole, myclobutanil, penconazole, Propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, ol, pyrifenox , pyrisoxazole, triforine and mixtures f. 8. The combination of paragraph 6, wherein the Quinone outside (Qo) inhibitor fungicide is selected from azoxystrobin, ystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, ostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb and mixtures thereof. 9. A fungicidal combination comprising at least one succinate ogenase tor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

. The combination of aph 1 sing: (a) Mancozeb; and (b) Isopyrazam, benzovindiflupyr, penthiopyrad, boscalid, fluindapyr, bixafen, fluxapyroxad, furametpyr, penflufen, or sedaxane; and (c) onazole, difenoconazole, epoxiconazole, hexaconazole, hexaconazole, tebuconazole, tetraconazole, prothioconazole, azoxystrobin, picoxystrobin, pyraclostrobin, kresoxim-methyl, trifloxystrobin, or combinations thereof. 11. The combination of paragraph 1 sing: (a) Mancozeb; and (b) Benzovindiflupyr, isopyrazam, or penthipyrad; and (c) Prothioconazole and/or azoxystrobin. 12. A composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one ergostrol biosynthesis inhibitor and/or at least one a quinone outside inhibitor; and (d) at least one agrochemically acceptable excipient. 13. The composition of aph 12, n the composition is formulated into wettable powders, granules, dusts, Soluble (liquid) concentrates, sion concentrates, oil in water emulsion, water in oil emulsion, emulsifiable concentrates, capsule suspensions, ZC formulations, oil sions. 14. The combination of any one of the preceding paragraphs, wherein the constituent fungicides of the combination are admixed in ratio of (1- 80): (1-80): (1-80): (1:80).

. The combination of any one of the preceding paragraphs, wherein the total amount of succinate dehydrogenase inhibitor in the composition is in the range of 0.1 to 99% by weight, the total amount of dithiocarbamate ide in the composition is in the range of 0.1 to 99% by weight; the total amount of ergostrol biosynthesis inhibitor in the composition is in the range of 0.1 to 99% by weight; and the total amount of Quinone outside inhibitor in the composition is in the range of 0.1 to 99% by weight. 16. The composition of any one of the preceding paragraphs, wherein the composition is used for foliar application, or applications to plant ation materials. 17. A method of controlling fungal diseases comprising applying to the locus of the plant a combination comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one quinone outside tor and/or at least one ergostrol biosynthesis inhibitor; and (c) at least one dithiocarbamate fungicide.

PCT00717

Claims (17)

1. A fungicidal combination comprising at least one succinate dehydrogenase inhibitor fungicide, at least one carbamate 5 fungicide, and at least another fungicide

2. The ation of claim 1, wherein the dithiocarbamate fungicide is selected from amobam, e, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, 10 urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.

3. The combination of claim 2, wherein the dithiocarbamate fungicide is mancozeb.

4. The combination of claim 1, n the succinate ogenase inhibitor is from a pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicides.. 20

5. The combination as claimed in claim 4, n the pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicide is selected from bixafen, fluindapyr, fluxapyroxad, furametpyr, isopyrazam, penflufen, opyrad, and sedaxane. 25 6. The combination as d in claim 1, wherein at least another fungicide is selected from an ergosterol biosynthesis inhibitor fungicide, and quinone outside inhibitor fungicide

6. PCT00717

7. The combination as claimed in claim 6, wherein the ergosterol biosynthesis inhibitor is selected from azole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, 5 flusilazole, flutriafol, hexaconazole, conazole, Ipconazole, metconazole, myclobutanil, azole, Propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox , pyrisoxazole, triforine and 10 mixtures thereof.

8. The combination as claimed in claim 6, wherein the e outside (Qo) inhibitor fungicide is selected from azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, 15 mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, nostrobin, xystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb, and mixtures thereof. 20

9. A idal combination comprising at least one ate dehydrogenase inhibitor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

10. The combination as claimed in claim 1 comprising: 25 (a) mancozeb; and (b) azam, penthiopyrad, boscalid, fluindapyr, n, fluxapyroxad, furametpyr, penflufen, or sedaxane as the succinate dehydrogenase inhibitor; and PCT00717 (c) cyproconazole, conazole, epoxiconazole, hexaconazole, tebuconazole, tetraconazole, prothioconazole, trobin, picoxystrobin, pyraclostrobin, kresoxim-methyl, trifloxystrobin, or combinations thereof as the atleast another fungicide.

11. The combination as claimed in claim 1 comprising: (a) Mancozeb and (b) isopyrazam, or penthiopyrad as the ate dehydrogenase inhibitor; and 10 (c) oconazole and/or azoxystrobin as the atleast another fungicide.

12. A composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; 15 (b) at least one dithiocarbamate fungicide; (c) at least one ergosterol biosynthesis inhibitor and/or at least one a quinone outside inhibitor; and (d) at least one agrochemically acceptable excipient. 20

13. The composition as claimed in claim 12, n the composition is formulated into wettable powders, granules, dusts, soluble (liquid) concentrates, suspension trates, oil in water emulsion, water in oil emulsion, emulsifiable concentrates, capsule suspensions, ZC formulations or oil dispersions.

14. The combination as claimed in any one of the preceding claims, wherein the constituent fungicides of the combination are admixed in ratio of : (1-80): : (1-80). PCT00717

15. The composition as claimed in claim 12, wherein the total amount of succinate dehydrogenase inhibitor in the composition is in the range of 0.1 to 99% by weight, the total amount of dithiocarbamate 5 fungicide in the composition is in the range of 0.1 to 99% by weight; the total amount of ergosterol biosynthesis inhibitor in the composition is in the range of 0.1 to 99% by weight; and the total amount of e outside inhibitor in the composition is in the range of 0.1 to 99% by .

16. The composition as claimed in claim 12, wherein the composition is used for foliar application, or applications to plant propagation materials. 15

17. A method of controlling fungal diseases comprising applying to the locus of the plant a combination sing: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one quinone e inhibitor and/or at least one ergosterol biosynthesis inhibitor; and 20 (c) at least one dithiocarbamate fungicide.