NZ744861A - New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors - Google Patents
New heterobicyclic derivatives and their use as autotaxin (atx) inhibitorsInfo
- Publication number
- NZ744861A NZ744861A NZ74486113A NZ74486113A NZ744861A NZ 744861 A NZ744861 A NZ 744861A NZ 74486113 A NZ74486113 A NZ 74486113A NZ 74486113 A NZ74486113 A NZ 74486113A NZ 744861 A NZ744861 A NZ 744861A
- Authority
- NZ
- New Zealand
- Prior art keywords
- conditions
- compounds
- atx
- autotaxin
- pharmaceutically acceptable
- Prior art date
Links
Abstract
The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds. More particularly, R2 is a saturated, partially saturated or unsaturated mono-, bi- or tricyclic heterocycle. The compounds or their pharmaceutically acceptable salts and esters inhibit autotaxin (ATX) activity and therefore inhibit lysophosphatidic acid (LPA) production and modulate LPA levels and associated signalling. The compounds and their pharmaceutically acceptable salts or esters may be useful in the treatment or prophylaxis of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12185941 | 2012-09-25 | ||
NZ70374813 | 2013-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ744861A true NZ744861A (en) | 2019-10-25 |
Family
ID=68318673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ74486113A NZ744861A (en) | 2012-09-25 | 2013-09-23 | New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ744861A (en) |
-
2013
- 2013-09-23 NZ NZ74486113A patent/NZ744861A/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 23 SEP 2021 BY THOMSON REUTERS Effective date: 20200820 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 23 SEP 2022 BY THOMSON REUTERS Effective date: 20210803 |
|
LAPS | Patent lapsed |