NZ744861A - New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors - Google Patents

New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors

Info

Publication number
NZ744861A
NZ744861A NZ74486113A NZ74486113A NZ744861A NZ 744861 A NZ744861 A NZ 744861A NZ 74486113 A NZ74486113 A NZ 74486113A NZ 74486113 A NZ74486113 A NZ 74486113A NZ 744861 A NZ744861 A NZ 744861A
Authority
NZ
New Zealand
Prior art keywords
conditions
compounds
atx
autotaxin
pharmaceutically acceptable
Prior art date
Application number
NZ74486113A
Inventor
Lisha Wang
Daniel Hunziker
Patrizio Mattei
Harald Mauser
Jerome Hert
Guozhi Tang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NZ744861A publication Critical patent/NZ744861A/en

Links

Abstract

The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds. More particularly, R2 is a saturated, partially saturated or unsaturated mono-, bi- or tricyclic heterocycle. The compounds or their pharmaceutically acceptable salts and esters inhibit autotaxin (ATX) activity and therefore inhibit lysophosphatidic acid (LPA) production and modulate LPA levels and associated signalling. The compounds and their pharmaceutically acceptable salts or esters may be useful in the treatment or prophylaxis of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.
NZ74486113A 2012-09-25 2013-09-23 New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors NZ744861A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12185941 2012-09-25
NZ70374813 2013-09-23

Publications (1)

Publication Number Publication Date
NZ744861A true NZ744861A (en) 2019-10-25

Family

ID=68318673

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ74486113A NZ744861A (en) 2012-09-25 2013-09-23 New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors

Country Status (1)

Country Link
NZ (1) NZ744861A (en)

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NZ744861A (en) New heterobicyclic derivatives and their use as autotaxin (atx) inhibitors

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Effective date: 20200820

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Effective date: 20210803

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