NZ743488A - Controlled-release cnp agonists with low initial npr-b activity - Google Patents

Controlled-release cnp agonists with low initial npr-b activity

Info

Publication number
NZ743488A
NZ743488A NZ743488A NZ74348817A NZ743488A NZ 743488 A NZ743488 A NZ 743488A NZ 743488 A NZ743488 A NZ 743488A NZ 74348817 A NZ74348817 A NZ 74348817A NZ 743488 A NZ743488 A NZ 743488A
Authority
NZ
New Zealand
Prior art keywords
controlled
cnp agonist
release
npr
activity
Prior art date
Application number
NZ743488A
Inventor
Harald Rau
Kennett Sprogøe
Ulrich Hersel
Felix Cleemann
Caroline Elisabeth Rasmussen
Original Assignee
Ascendis Pharma Growth Disorders As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascendis Pharma Growth Disorders As filed Critical Ascendis Pharma Growth Disorders As
Publication of NZ743488A publication Critical patent/NZ743488A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a controlled-release CNP agonist from which CNP agonist is released with a release half-life of at least 6 hours under physiological conditions and which controlled-release CNP agonist has an EC50 that is at least 20-fold higher than the EC50 of the corresponding free CNP agonist and which released CNP agonist has an EC50 that is at most 3-fold higher than the EC50 of the corresponding free CNP agonist; to pharmaceutical compositions comprising said controlled-release CNP agonist; their use; and to methods of treatment. The controlled-release CNP agonist comprises a cyclic CNP peptide attached to a reversible linker at the ring position, where the reversible linker is further attached to a carrier comprising a branched PEG group.
NZ743488A 2016-01-08 2017-01-05 Controlled-release cnp agonists with low initial npr-b activity NZ743488A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP16150631 2016-01-08
EP16179291 2016-07-13
EP16191462 2016-09-29
PCT/EP2017/050217 WO2017118703A1 (en) 2016-01-08 2017-01-05 Controlled-release cnp agonists with low initial npr-b activity

Publications (1)

Publication Number Publication Date
NZ743488A true NZ743488A (en) 2023-02-24

Family

ID=57860818

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ743488A NZ743488A (en) 2016-01-08 2017-01-05 Controlled-release cnp agonists with low initial npr-b activity

Country Status (7)

Country Link
US (2) US11389510B2 (en)
EP (1) EP3400022A1 (en)
AU (2) AU2017205693B2 (en)
CA (1) CA3007982C (en)
IL (1) IL259827A (en)
NZ (1) NZ743488A (en)
WO (1) WO2017118703A1 (en)

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EP3400021A1 (en) 2016-01-08 2018-11-14 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with low npr-c binding
MX2018008061A (en) 2016-01-08 2018-08-23 Ascendis Pharma Growth Disorders As Cnp prodrugs with large carrier moieties.
AU2017205693B2 (en) 2016-01-08 2022-03-31 Ascendis Pharma Growth Disorders A/S Controlled-release CNP agonists with low initial NPR-B activity
CA3037448A1 (en) 2016-09-29 2018-04-05 Ascendis Pharma Growth Disorders A/S Combination therapy with controlled-release cnp agonists
US20220118053A1 (en) 2019-02-11 2022-04-21 Ascendis Pharma Growth Disorders A/S Dry Pharmaceutical Formulations of CNP Conjugates
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WO2023227505A1 (en) 2022-05-23 2023-11-30 Ascendis Pharma Growth Disorders A/S Liquid pharmaceutical formulations of cnp compounds

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Also Published As

Publication number Publication date
US11389510B2 (en) 2022-07-19
IL259827A (en) 2018-07-31
US20190328840A1 (en) 2019-10-31
US20230103820A1 (en) 2023-04-06
AU2017205693A1 (en) 2018-06-07
EP3400022A1 (en) 2018-11-14
CA3007982A1 (en) 2017-07-13
AU2022202280A1 (en) 2022-04-21
AU2017205693B2 (en) 2022-03-31
CA3007982C (en) 2023-12-19
AU2022202280B2 (en) 2023-11-02
WO2017118703A1 (en) 2017-07-13

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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 05 JAN 2025 BY PAVIS PAYMENTS GMBH

Effective date: 20231221