NZ542425A - A method and device for distribution of a fluid - Google Patents

A method and device for distribution of a fluid

Info

Publication number
NZ542425A
NZ542425A NZ542425A NZ54242504A NZ542425A NZ 542425 A NZ542425 A NZ 542425A NZ 542425 A NZ542425 A NZ 542425A NZ 54242504 A NZ54242504 A NZ 54242504A NZ 542425 A NZ542425 A NZ 542425A
Authority
NZ
New Zealand
Prior art keywords
liquid
pipe
distributed
valve
inlet pipe
Prior art date
Application number
NZ542425A
Inventor
Christian Neumann
Original Assignee
Stedim Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stedim Sa filed Critical Stedim Sa
Publication of NZ542425A publication Critical patent/NZ542425A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
    • G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2931—Diverse fluid containing pressure systems
    • Y10T137/3115—Gas pressure storage over or displacement of liquid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Hydrology & Water Resources (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A method and device for distributing a fluid are disclosed. A valve (1) has multiple inlets and outlets and is equipped with a check valve. Connected to the valve are: a fluid sampling and injecting device, such as a syringe (2); a gas (e.g. air) supply conduit; a supply conduit for the liquid to be distributed; and a discharge conduit (6). The method consists of drawing in the liquid to be distributed in order to transfer it to the sampling and injecting device (2), injecting the liquid into the discharge conduit (6), drawing off the gas in order to transfer it into the sampling and injecting device (2), and injecting the gas into the discharge conduit (6) in order to push the remaining liquid into the discharge conduit (6).

Description

542425 1 A METHOD AND DEVICE FOR DISTRIBUTION OF A FLUID The present invention relates to a method and disposable device for sampling and apportionment of liquid, in particular under sterile conditions.
In the fields in particular of food, medicine, pharmaceuticals or biotechnology, there is the problem of the repeated transfer of fluids in particular in a sterile manner, and apportionment of a reproducible, precisely measured volume.
Today, this type of operation is carried out by separate, successive actions which multiply the connection/disconnection operations. The multiplication of these connections/disconnections leads to a high risk of contamination, either by exposure to the air, or because of incorrect handling by the operator.
A standard application is, for example in parenteral nutrition, the preparation of batches of nutritive mixtures to be administered subsequently to the patient, from a certain number of stock solutions such as: a solution of amino acids, a glucose solution, a lipid emulsion, to which are added small volumes of complementary substrates such as trace elements, mineral salts and vitamins.
In paediatrics and neonatology in particular, the composition of these mixtures is varied from day to day as a function of the nutritive state of the patient and the need to ensure that he has a suitable calorie intake.
The need to vary this mixture from day to day does not allow the use of standard mixtures supplied by the pharmaceuticals industry, the composition of which does not vary by definition.
These mixtures must therefore be prepared in the hospital, under perfectly aseptic conditions. This operation is generally carried out on a laboratory table under a laminar air flow.
A standard application is, for example in biotechnology, the repeated taking of samples from a solution in cell culture, throughout this same culture which extends over several days. This repeated sampling makes it Intellectual property office of n.2. 2 8 NOV 2006 RECEIVED Office of nz."""' 2 6 OCT 200S 2 -RECEIVED possible to ensure counting of the cells in a given volume and thus to follow their growth curve, and even to carry out sterility tests on the samples taken in order to ensure the absence of any contamination.
According to the method stage, this operation is generally carried out either on a laboratory table, or under a laminar air flow, or in controlled production zone.
In cell therapy, cells potentialized by genetic engineering have to be apportioned and then cultured in multiple reproducible individual doses, for subsequent administration to the patient (autologous vaccine).
This apportionment requires the reproducibility of each of the doses and the transfer of the latter in sterile mode. This operation is generally carried out on a laboratory table, under a laminar air flow.
It would therefore be desirable to have a simple method which is easy to implement, for distribution and apportionment of a fluid, in particular under sterile conditions.
It is the object of the present invention to overcome or ameliorate one or more of the disadvantages of the prior art, or at least to provide a useful alternative.
In a first aspect, the present invention provides a method for distribution of a fluid, comprising the steps of: a) simultaneously connecting to a multiple inlet and outlet valve equipped with a non-return valve: - a fluid sampling and injection device such as a syringe - an inlet pipe for gas - an inlet pipe for liquid to be distributed, and - an outlet pipe, b) drawing of the liquid to be distributed in order to be transferred into the sampling and injection device, c) injecting the drawn off liquid into the outlet pipe, d) drawing off gas in order to be transferred into the sampling and injection device, e) injecting the drawn off gas into the outlet pipe in order to push the liquid remaining in the outlet pipe. the outlet pipe.
The multiple inlet and outlet valve equipped with a non-return valve is preferably arranged in order to let in the liquid to be distributed, to let it out towards the sampling and injection device, to let it in from the sampling and injection device without the [R:\L1BLL] 19124.doc:lzv 3 possibility of apportionment by the entry of the liquid to be distributed (effect of the nonreturn valve), to let it out towards the outlet pipe. Such non- return valves are well known. For example the valves marketed by the company Filtertek Inc (USA) under the name 3-way check valve can be mentioned.
The inlet pipe of liquid to be distributed is preferably connected to a container containing said liquid to be distributed. This container can be for example a bottle or a pouch. This liquid inlet pipe is preferably equipped with a valve allowing or not allowing communication between the container and said inlet.
The inlet pipe for liquid to be distributed is preferably connected to several 10 containers containing several liquids to be distributed and preferably to a container containing a rinsing liquid.
To this end, said liquid inlet pipe can be supplied by several supply tubes, each preferably being equipped with a valve.
The gas inlet pipe can preferably open directly into the multiple inlet and outlet valve.
The gas preferably originates from a branch pipe provided on the liquid inlet pipe. This branch pipe is itself also preferably equipped with a valve allowing or not allowing communication between the air intake and the liquid inlet pipe.
A filter, preferably a sterilising filter, is preferably provided on the gas inlet pipe. 20 The gas, for example the nitrogen or air coming from this pipe, is therefore sterile.
The fluid sampling and injection device can, for example, be a pump in particular a dosing pump, but is preferably a syringe.
The outlet pipe preferably opens into a collecting container such as flexible pouch and preferably to several collecting containers. To this end, said outlet pipe can 25 preferably be separated into several tubes, each being preferably equipped with a valve.
The collecting container is preferably pre-connected, i.e. the container preferably comprises connections allowing the direct mounting of said collecting container onto the outlet pipes(s).
A fraction of a single liquid to be distributed or a mixture of several fractions of 30 different liquids can preferably be collected.
This outlet pipe is preferably equipped with a branch leading to a waste container, equipped with a valve. In particular a rinsing fluid can thus preferably be eliminated.
The multiple inlet and outlet valve is preferably equipped with a pipe for a 35 rinsing liquid.
[R:\LIBLLJl9124.doc: Izv intellectual property office of n.2. 2 6 OCT 2006 Pimril#r-rN 4 However, the rinsing liquid can preferably be contained in one of the containers of liquid to be distributed. This avoids use of an additional inlet on the multiple inlet and outlet valve.
The multiple inlet valve is preferably connected by a pipe to a rinsing liquid, a 5 rinsing liquid is drawn off in order to be transferred into the sampling and injection device, and it is preferably injected into the outlet pipe in order to be transferred towards a waste-recovery container.
The inlet pipe for liquid to be distributed is preferably supplied for example by one or two, preferably three, and more preferably four or more, containers of liquid to 10 distributed.
The outlet pipe opens, for example, into one or two, preferably three, and more preferably four or more, collecting containers of the liquid or liquids distributed.
Apart from the multiple inlet and outlet valve, the other valves the function of which is to direct the flows of liquid and gas during the implementation of the method 15 can, for example, be taps or preferably reversible clamps.
The above liquid sampling and apportionment method is preferably implemented under sterile conditions, and more preferably, using disposable components.
In a second aspect, the present invention provides a device which can be used in a method as defined above, comprising a multiple inlet and outlet valve equipped with a 20 non-return valve, said multiple inlet and outlet valve being provided with: - an adapter for receiving the fluid sampling and injection device such as a syringe, - an inlet pipe for gas, - with an inlet pipe for liquid to be distributed, and 25 - an outlet pipe.
The above inlet pipe for liquid to be distributed preferably includes an adaptation system for cooperating, with a container containing a liquid to be distributed. This adaptation system can preferably be perforating, self-perforating, be screw or bayonet fitting, have aseptic connections etc.
The gas inlet pipe is preferably a branch from the inlet pipe for liquid to be distributed.
The inlet pipe for liquid to be distributed preferably comprises a shared section on the side of the multiple inlet and outlet valve and more preferably, a set of tubes for several containers containing a liquid to distributed. intellectual property office of n.z. 2 6 OCT 2006 [R:\LIFJLI-] 19124. doc: Izv IRECEIVEDI The gas inlet pipe is preferably connected onto the shared section of the inlet pipe for liquid to be distributed.
The outlet pipe preferably comprises a section on the side of the multiple inlet and outlet valve and moreover a set of tubes for several containers having to contain a liquid to be distributed.
The pipe towards the waste container is preferably connected onto the shared section of the outlet pipe.
In the case of a single stock solution, the inlet pipe is also preferably the supply tube, advantageously in a single piece.
The method for distributing a fluid, which is the subject of the present invention has very useful qualities. In a preferred form made from plastic, which is sterile and disposable: it minimizes the number of connections under aseptic conditions and therefore reduces the risk of contamination by contact with the operator; it implements the concept of the closed system, independent of the ambient air and therefore reduces the risk of bacterial contamination; it is disposable, thus eliminating any risk of cross-contamination, batch by batch; it allows the precise measurement of the volume sampled or transferred; it allows the reproducibility of the volume transferred.
These qualities justify the use of the method for distributing a fluid described above in the applications referred above.
The preferred embodiments for implementing the methods described above also apply to the other aspects of the invention referred to above, in particular to the devices for implementation of the methods.
The invention will be better understood with reference to the attached drawing (Figure 1) which is a diagrammatic representation of an example of an assembly of the invention with multiple inlets and outlets.
In Figure 1 it is possible to discern the central element of the method and device according to the invention, a valve 1 with multiple inlets and outlets equipped with a nonreturn valve. This non-return valve allows the introduction of the liquid drawn off into the rigid body of a syringe 2 and its transfer, without returning downstream, towards the apportionment line.
[R:\LlBLLJ19124.doc: lzv intellectual property office of n.2. 2 6 OCT 2006 6 It is then possible to discern from upstream to downstream in the circulation of the liquids: 1) Upstream, an inlet line with multiple tubes 3 provided for connecting to flasks, one or more pouches, a reactor or a tank, containing the stock solution or solutions to be filled (not represented). They join together into an inlet pipe 4 in the valve 1 with multiple inlets and outlets, and constitute a shared section. 2) The valve 1 with multiple inlets and outlets. 3) The syringe 2 - which may or may not be pre-connected - with a capacity for [R:\LIBLL] 19124.doc: !zv intellectual property office of n.z. 2 6 OCT 2006 .received example of 10 ml to 500 ml allowing the precise measurement (with a tolerance close to the measurement on the syringe body) of the volume drawn off. 4) Downstream, a distribution line with multiple tubes 5 allows the transfer and 5 apportionment of the fluid drawn off towards the collecting pouches. They join together into an outlet pipe 6 of the valve 1 with multiple inlets and outlets, which constitutes a shared section.
) One or more collecting pouches 7 pre-connected or not pre-connected to the distribution line, allowing the collection of the volumes of stock solutions transferred. 6) On the inlet line, upstream, a sterilizing hydrophobic filter 8 is pre-connected in a branch. Its function is to allow the introduction of filtered air into the device and to evacuate all of the dead volume of liquid which could remain there. The dead volume of this closed system being constant, purging it makes it possible to reproduce the drawing-off and transfer operation as many times as desired, in reproducible manner. 7) On the distribution line, downstream, a waste pouch 9 pre-connected to a branch, with a volume for example of 1 to 5 litres, makes it possible to collect either air, or part of the liquid transferred serving as rinsing liquid between each transfer, if necessary. 8) Reversible sealing clamps. On all the branches of the device, a reversible sealing clamp 10 is installed wherever necessary in order to direct the flow of liquid or air during use (10S means that the clamp is installed on an outlet tube, 10E that the clamp is installed on an inlet tube, 10F that the clamp is installed on the filter tube and 10R that the clamp is installed on the waste pouch tube).
The above device can be used according to the following method: 1) The clamp on the desired inlet line is opened, the desired volume of stock solution is drawn off by aspiration into the syringe 2, measuring this volume on the body of the syringe. 2) The clamp 10E on the inlet line is closed, the clamp 10S on the apportionment line is opened, the measured volume of stock solution is transferred into the 8 apportionment line as far as the collection pouch 7. 3) The clamp 10E on the inlet line is closed, the clamp 10F downstream of the hydrophobic filter 8 is opened, air is drawn through the filter 8, using the syringe 2. 4) The stock solution trapped in the dead volume is pushed by means of the filtered air introduced up to the apportionment line is emptied into the collection pouch 7.
) The clamp 10E on the inlet line is opened, a volume of stock solution is drawn into the syringe 2. 6) The clamp on the distribution line is closed, the clamp 10R of the waste pouch is opened, the volume of stock solution is transferred into the waste pouch 9, in order to rinse the pipes.
The above sequence is recommenced as many times as necessary in order to ensure the repeated and reproducible transfer of the 15 measured volume of stock solution.
As may be understood by a person skilled in the art, a device such as that above can be produced in modules from separate optionally multipurpose elements. In addition to the valve 1 with multiple inlets and outlets, pipes can be found which are equally suitable for the inlet and the outlet, 20 branched or not branched. For example the same type of branched pipes is equally suitable for mounting the filter and the waste pouch. Moreover a pipe suitable for the inlet and the outlet can be mounted on a piece provided with a set of channels allowing the same number of tubes to be mounted.
This is why a subject of the present Application is a fluid 25 distribution unit characterized in that it comprises a multiple inlet and outlet valve equipped with a non-return valve, said valve being equipped with a fluid sampling and injection device such as a syringe or an adapter such as a cone for attaching a syringe, and two pipes, one being equipped with a branch (Y-shaped pipe), or four 30 pipes and a branch end piece (3 pipes connected onto a branch end piece corresponding to a pipe equipped with a branch).

Claims (19)

9 WE CLAIM:
1. A method for distribution of a fluid, comprising the steps of: a) simultaneously connecting to a multiple inlet and outlet valve equipped with a non-return valve: 5 - a fluid sampling and injection device, - a gas inlet pipe, - a liquid inlet pipe for liquid to be distributed, and - an outlet pipe, b) drawing off the liquid to be distributed in order to be transferred into the 10 sampling and injection device, c) injecting the drawn off liquid into the outlet pipe, d) drawing off gas in order to be transferred into the sampling and injection device, e) injecting the drawn off gas into the outlet pipe in order to push the 15 liquid remaining in the outlet pipe.
2. A method according to claim 1, wherein the liquid inlet pipe is connected to several containers containing several liquids to be distributed. 20
3. A method according to claim 1 or 2, wherein the liquid inlet pipe is connected to a container containing a rinsing liquid.
4. A method according to one of claims 1 to 3, wherein the liquid inlet pipe is supplied by several supply tubes, each being equipped with a valve. 25
5. A method according to one of claims 1 to 4, wherein the gas originates from a branch pipe provided on the liquid inlet pipe.
6. A method according to one of claims 1 to 5, wherein a filter is provided 30 on the gas inlet pipe.
7. A method according to one of claims 1 to 6, wherein the fluid sampling and injection device is a dosing pump or a syringe. [R:\LIBLL] 19124.doc:lzv intellectual property office of n.2. 2 6 OCT 2006 RECEIVED 10
8. A method according to one of claims 1 to 7, wherein the outlet pipe opens into one or more collecting containers.
9. A method according to one of claims 1 to 8, wherein the outlet pipe 5 separates into several tubes, each being equipped with a valve.
10. A method according to claim 8, wherein the collecting container(s) is pre-connected.
11. A method according to one of claims 1 to 10, wherein a mixture of several fractions of different liquids is collected.
12. A method according to one of claims 1 to 11, wherein the outlet pipe is equipped with a branch towards a waste container, equipped with a valve.
13. A method according to one of claims 1 to 12, wherein the multiple inlet valve is connected by a pipe to a rinsing liquid, a rinsing liquid is drawn off in order to be transferred into the sampling and injection device, and the drawn off rinsing liquid is injected into the outlet pipe in order to be transferred towards a waste-recovery container.
14. A method according to one of claims 1 to 8, wherein the inlet pipe for liquid to be distributed is supplied by at least three containers for liquid to be distributed.
15. A method according to one of claims 1 to 14, wherein the outlet pipe opens into at least three collecting containers of the liquid(s) distributed.
16. A method according to one of claims 1 to 15, implemented under sterile conditions. 30 17. A device which can be used in a method as defined in one of claims 1 to 16, comprising a multiple inlet and outlet valve equipped with a non-return valve, said multiple inlet and outlet valve being provided with: - an adapter for receiving the fluid sampling and injection device, - a gas inlet pipe, 35 - a liquid inlet pipe for liquid to be distributed, and
[R:\LIB LL] 19124.doc :lzv 15 20 intellectual property office of n.z. 2 6 OCT 2006 RECEIVFn - an outlet pipe. 11
18. A device according to claim 17, wherein the outlet pipe is equipped with a branch towards a waste container. pipe comprises an adaptation system for cooperating with a container containing a liquid to be distributed. 20. A device according to one of claims 17 to 19, wherein the liquid inlet pipe comprises a shared section on the side of the multiple inlet and outlet valve and a set of tubes for several containers containing a liquid to be distributed. 21. A device according to claim 20, wherein the gas inlet pipe is connected onto the shared section of the liquid inlet pipe. 22. A device according to one of claims 17 to 21, wherein the outlet pipe comprises a shared section on the side of the multiple inlet and outlet valve and a set of tubes for several containers having to contain the liquid distributed. 23. A method for distribution of a fluid, said method substantially as hereinbefore described with reference to the accompanying drawing. 24. A device which can be used in a method for distribution of a fluid, said device substantially as hereinbefore described with reference to the accompanying drawing.
19. A device according to one of claims 17 and 18, wherein the liquid inlet Stedim S.A. By the Attorneys for the Applicant SPRUSON & FERGUSON intellectual property office of n.z. 2 6 OCT 2006 RECEIVED
NZ542425A 2003-03-11 2004-03-05 A method and device for distribution of a fluid NZ542425A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303016A FR2852259B1 (en) 2003-03-11 2003-03-11 METHOD AND DEVICE FOR SINGLE USE OF SAMPLING AND DISTRIBUTION OF LIQUID, IN PARTICULAR IN STERILE CONDITIONS
PCT/FR2004/000533 WO2004082829A2 (en) 2003-03-11 2004-03-05 Method and disposable device for sampling and distributing a liquid, for example, in sterile conditions

Publications (1)

Publication Number Publication Date
NZ542425A true NZ542425A (en) 2007-03-30

Family

ID=32893218

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ542425A NZ542425A (en) 2003-03-11 2004-03-05 A method and device for distribution of a fluid

Country Status (13)

Country Link
US (1) US20060231139A1 (en)
EP (1) EP1608465A2 (en)
JP (1) JP2006524126A (en)
KR (1) KR20050107507A (en)
CN (1) CN1756523A (en)
AU (1) AU2004222541A1 (en)
BR (1) BRPI0408122A (en)
CA (1) CA2517898A1 (en)
FR (1) FR2852259B1 (en)
MX (1) MXPA05009672A (en)
NO (1) NO20053652L (en)
NZ (1) NZ542425A (en)
WO (1) WO2004082829A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2606280A1 (en) * 2005-05-09 2006-11-16 Saxonia Biotec Gmbh Apparatus for providing media to cell culture modules
EP2089506A2 (en) * 2006-11-07 2009-08-19 Saxonia Bio Tec GmbH Supply system for cell culture module
GB0802216D0 (en) * 2008-02-07 2008-03-12 Hammersmith Imanet Ltd GMP dispenser for non-controlled environments
DE102009015188B4 (en) 2009-03-31 2011-12-15 Avl Emission Test Systems Gmbh Plant for taking exhaust gas samples from internal combustion engines and their use
GB0906836D0 (en) * 2009-04-21 2009-06-03 Cymtox Ltd Consumable component kit
CN104873389B (en) * 2009-07-29 2017-12-05 Icu医学有限公司 Fluid conveying device and application method
KR101040085B1 (en) * 2009-09-29 2011-06-09 아메스산업(주) Reagent synthetic apparatus with syringe pump unit for premixing
ES1076535Y (en) * 2011-12-12 2012-06-18 Gonzalez Antonio Gonzalez CLOSED DEVICE FOR FILLING THE DRIP CHAMBER OF SAFETY EQUIPMENT DURING THE ADMINISTRATION OF CYSTOSTATICS WITH PUMP CONNECTION
KR101655814B1 (en) 2015-02-10 2016-09-08 엘지전자 주식회사 Front Camera Module unified Rear View Mirror of Vehicles
CN105616160A (en) * 2016-03-15 2016-06-01 王彦军 Injector assistance control device
US11185472B2 (en) * 2017-03-24 2021-11-30 Carefusion 303, Inc. Rotary valve pump for automatic drug compounder
LU100486B1 (en) * 2017-10-20 2019-04-25 Luxembourg Inst Science & Tech List Automatic water sampler apparatus

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4084606A (en) * 1974-04-23 1978-04-18 Baxter Travenol Laboratories, Inc. Fluid transfer device
US4340153A (en) * 1980-11-28 1982-07-20 Spivey David L Method and apparatus for medication dispensing
US4433974A (en) * 1981-06-17 1984-02-28 Baxter Travenol Laboratories, Inc. Mixing system for parenteral liquids
DE3503320A1 (en) * 1985-01-31 1986-08-07 Baxter Travenol Laboratories, Inc., Deerfield, Ill. Multi-way valve
DE3520044A1 (en) * 1985-06-04 1986-12-04 Baxter Travenol Laboratories, Inc., Deerfield, Ill. ARRANGEMENT FOR THE ADMINISTRATION AND / OR PRODUCTION OF MEDICINE AND / OR NUTRITIONAL SOLUTIONS, IN PARTICULAR PARENTERAL NUTRITIONAL SOLUTIONS
DE3738162A1 (en) * 1987-11-10 1989-05-24 Baxter Travenol Lab SYSTEM FOR THE STORAGE, PREPARATION AND APPLICATION OF INFUSION SOLUTIONS FOR PARENTERAL NUTRITION
US4915688A (en) * 1987-12-03 1990-04-10 Baxter International Inc. Apparatus for administering solution to a patient
US5037390A (en) * 1989-12-28 1991-08-06 Kenneth Raines System and method for mixing parenteral nutrition solutions
US5762769A (en) * 1995-03-29 1998-06-09 Toa Electronics Ltd. Method of measuring concentration of nonelectrolyte in electrolyte solution, method of preparing mixed solution containing electrolytes and nonelectrolytes and apparatus for preparing the solution
IT1308253B1 (en) * 1999-03-16 2001-12-10 Molteni L E C Dei Flii Alitti PRECISION DISPENSER FOR LIQUIDS.
US6240952B1 (en) * 1999-08-12 2001-06-05 Lancer Partnership, Ltd. Aseptic product dispensing system
US6450215B1 (en) * 2000-09-29 2002-09-17 Charter Medical, Ltd. Apparatus and method for filling bags
US20020107501A1 (en) * 2001-02-02 2002-08-08 Smith James E. Weight dependent, automatic filling dosage system and method of using same

Also Published As

Publication number Publication date
FR2852259B1 (en) 2005-04-22
NO20053652D0 (en) 2005-07-27
CN1756523A (en) 2006-04-05
US20060231139A1 (en) 2006-10-19
WO2004082829A2 (en) 2004-09-30
NO20053652L (en) 2005-09-27
AU2004222541A1 (en) 2004-09-30
BRPI0408122A (en) 2006-03-01
EP1608465A2 (en) 2005-12-28
JP2006524126A (en) 2006-10-26
FR2852259A1 (en) 2004-09-17
MXPA05009672A (en) 2006-01-27
KR20050107507A (en) 2005-11-11
WO2004082829A3 (en) 2004-10-28
CA2517898A1 (en) 2004-09-30

Similar Documents

Publication Publication Date Title
US5334170A (en) Dye management system including an administration set with an in-line burette
US9433556B2 (en) Multi-vial dispensing
JP3051994B2 (en) Apparatus and method for periodic aseptic collection of liquid samples from a sterile liquid source
US20060231139A1 (en) Method and disposable device for sampling and distributing a liquid, for example, in sterile conditions
EP1789323B1 (en) By-pass line connector for compounding system
US20100236340A1 (en) Automatable aseptic sample withdrawal system
US4433974A (en) Mixing system for parenteral liquids
JP2013513406A (en) Disposable fluid pathway system and method for treating complex biological material
EP0267266A1 (en) System for metering nutrient media to cell culture containers and method
US7144727B2 (en) Interlinked culture chamber for biologicals
US5614412A (en) Apparatus for carrying flexible containers and method of transferring fluids to containers
KR20210006911A (en) Combination drug delivery device
US20220106550A1 (en) Cell processing unit, cell processing system and methods of use thereof
BR112019014291B1 (en) APPARATUS FOR PREPARING, MIXING AND DISCHARGE A STERILE MEDIUM FOR USE WITH A PIPE DEVICE AND METHOD FOR PREPARING, MIXING AND DISCHARGE A STERILE MEDIUM BY USE OF SAID APPARATUS
WO1994027645A1 (en) System for packaging and delivering of a sterile powder medium
JP2007325765A (en) Liquid transfer tool
WO1994028944A1 (en) System for packaging and delivering of a sterile powder medium
CN213239578U (en) Quantitative sampling device of disposable system
CN115326484A (en) Sampler and sampling method
CN117801927A (en) Device for treating tissues and cells
JPH0414029B2 (en)

Legal Events

Date Code Title Description
PSEA Patent sealed