NZ525368A - Novel aggrecanase molecules - Google Patents

Novel aggrecanase molecules

Info

Publication number
NZ525368A
NZ525368A NZ525368A NZ52536801A NZ525368A NZ 525368 A NZ525368 A NZ 525368A NZ 525368 A NZ525368 A NZ 525368A NZ 52536801 A NZ52536801 A NZ 52536801A NZ 525368 A NZ525368 A NZ 525368A
Authority
NZ
New Zealand
Prior art keywords
aggrecanase
antibodies
enzymes
inhibitors
novel aggrecanase
Prior art date
Application number
NZ525368A
Inventor
Lisa Anne Racie
Natalie Constance Twine
Michael John Agostino
Edward R Lavallie
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Publication of NZ525368A publication Critical patent/NZ525368A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The identification of aggrecanase protein molecules capable of cleaving aggrecanase, the nucleotide sequences which encode aggrecanase enzymes and the processes for the production of aggrecanases are disclosed. The composition comprises the aggrecanase enzymes, the antibodies and methods for developing inhibitors of the aggrecanase. The inhibitors and antibodies may be used in the treatment of conditions characterised by degradation of articular cartilage.
NZ525368A 2000-10-20 2001-10-17 Novel aggrecanase molecules NZ525368A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24231700P 2000-10-20 2000-10-20
PCT/US2001/032596 WO2002034895A2 (en) 2000-10-20 2001-10-17 Novel aggrecanase molecules

Publications (1)

Publication Number Publication Date
NZ525368A true NZ525368A (en) 2006-03-31

Family

ID=22914296

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ525368A NZ525368A (en) 2000-10-20 2001-10-17 Novel aggrecanase molecules

Country Status (13)

Country Link
EP (1) EP1326967A2 (en)
JP (2) JP2004512043A (en)
AU (1) AU2002245758A1 (en)
BR (1) BR0114719A (en)
CA (1) CA2426463A1 (en)
CZ (1) CZ2003996A3 (en)
MX (1) MXPA03003425A (en)
NO (1) NO20031649L (en)
NZ (1) NZ525368A (en)
PL (1) PL362008A1 (en)
SK (1) SK4632003A3 (en)
WO (1) WO2002034895A2 (en)
ZA (1) ZA200303865B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018277343A1 (en) 2017-06-02 2020-01-02 Ablynx N.V. Adamts binding immunoglobulins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
AU7717800A (en) * 1999-09-27 2001-04-30 Curagen Corporation Novel polynucleotides encoding proteins containing thrombospondin type 1 repeats

Also Published As

Publication number Publication date
CZ2003996A3 (en) 2004-04-14
MXPA03003425A (en) 2004-05-04
BR0114719A (en) 2004-01-27
CA2426463A1 (en) 2002-05-02
WO2002034895A3 (en) 2002-10-10
PL362008A1 (en) 2004-10-18
SK4632003A3 (en) 2004-05-04
JP2008301813A (en) 2008-12-18
WO2002034895A2 (en) 2002-05-02
AU2002245758A1 (en) 2002-05-06
NO20031649L (en) 2003-06-11
NO20031649D0 (en) 2003-04-10
ZA200303865B (en) 2004-08-19
EP1326967A2 (en) 2003-07-16
JP2004512043A (en) 2004-04-22

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