NZ513356A - Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate - Google Patents

Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate

Info

Publication number
NZ513356A
NZ513356A NZ513356A NZ51335600A NZ513356A NZ 513356 A NZ513356 A NZ 513356A NZ 513356 A NZ513356 A NZ 513356A NZ 51335600 A NZ51335600 A NZ 51335600A NZ 513356 A NZ513356 A NZ 513356A
Authority
NZ
New Zealand
Prior art keywords
transcription factor
modulating
involved
jasmonate
response
Prior art date
Application number
NZ513356A
Inventor
Johan Memelink
Der Fits Cornelia Theodora Van
Frank Callus Leonardus H Menke
Jan Willem Kijne
Original Assignee
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leiden filed Critical Univ Leiden
Publication of NZ513356A publication Critical patent/NZ513356A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

A method for modulating in a cell the expression of one or more genes involved in the biosynthesis of a metabolite or a precursor for this metabolite by inserting into a cell a nucleotide sequence coding for a transcription factor comprising an AP2 DNA-binding domain, and/or by modifying the expression of a nucleotide sequence coding for such a transcription factor already present in the cell is provided. The method is useful for enhancing the biosynthesis of secondary metabolites in plants such as alkaloids including terpenoid indole alkaloids. Also provided is a method for enhancing stress tolerance in plants by the use of such transcription factors.
NZ513356A 1999-02-05 2000-02-07 Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate NZ513356A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900158 1999-02-05
US11938899P 1999-02-10 1999-02-10
PCT/NL2000/000075 WO2000046383A2 (en) 1999-02-05 2000-02-07 Method of modulating metabolite biosynthesis in recombinant cells

Publications (1)

Publication Number Publication Date
NZ513356A true NZ513356A (en) 2004-01-30

Family

ID=26063424

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ513356A NZ513356A (en) 1999-02-05 2000-02-07 Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate

Country Status (6)

Country Link
EP (1) EP1157119A1 (en)
JP (1) JP2002535993A (en)
AU (1) AU779162B2 (en)
CA (1) CA2361678A1 (en)
NZ (1) NZ513356A (en)
WO (1) WO2000046383A2 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7663025B2 (en) 1999-03-23 2010-02-16 Mendel Biotechnology, Inc. Plant Transcriptional Regulators
US7858848B2 (en) 1999-11-17 2010-12-28 Mendel Biotechnology Inc. Transcription factors for increasing yield
US7888558B2 (en) 1999-11-17 2011-02-15 Mendel Biotechnology, Inc. Conferring biotic and abiotic stress tolerance in plants
US8912394B2 (en) 2001-04-18 2014-12-16 Mendel Biotechnology Inc. Transcriptional regulation of plant disease tolerance
US8030546B2 (en) 1998-09-22 2011-10-04 Mendel Biotechnology, Inc. Biotic and abiotic stress tolerance in plants
US6835540B2 (en) * 2001-03-16 2004-12-28 Mendel Biotechnology, Inc. Biosynthetic pathway transcription factors
WO2000070059A2 (en) * 1999-05-14 2000-11-23 Pioneer Hi-Bred International, Inc. Signal transduction genes and methods of use
AU2001286617A1 (en) * 2000-08-22 2002-03-04 Luc Adam Genes for modifying plant traits iv
JP2004529645A (en) 2001-04-18 2004-09-30 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー Use of a gene encoding a membrane transporter pump to promote production of secondary metabolites in biological cells
EP1293572A1 (en) * 2001-09-17 2003-03-19 Syngenta Participations AG Method of altering plant secondary metobolite biosynthesis in plant cells
US7176027B2 (en) 2001-12-20 2007-02-13 Pioneer Hi-Bred International, Inc. Genes and regulatory DNA sequences associated with stress-related gene expression in plants and methods of using the same
WO2003059928A1 (en) * 2002-01-15 2003-07-24 Avestha Gengraine Technologies Pvt. Ltd. Polynucleotide encoding an ap-2 domain transcription factor
PT2368553E (en) 2003-04-08 2015-03-03 Progenics Pharm Inc Pharmaceutical formulations containing methylnaltrexone
JP2008528010A (en) 2005-01-31 2008-07-31 アブリンクス ナームローゼ フェンノートシャップ Methods for creating variable domain sequences of heavy chain antibodies
WO2006115575A1 (en) 2005-04-20 2006-11-02 Ceres Inc. Regulatory regions from papaveraceae
DK1888640T3 (en) 2005-05-18 2012-06-18 Ablynx Nv Enhanced nanobodies against tumor necrosis factor-alpha
RU2433139C2 (en) 2005-05-20 2011-11-10 Аблинкс Н.В. Nanobodiec tm for treatment of aggregation-mediated diseases
WO2008074839A2 (en) 2006-12-19 2008-06-26 Ablynx N.V. Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
EP2514767A1 (en) 2006-12-19 2012-10-24 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
MX351611B (en) 2007-03-29 2017-10-20 Wyeth Llc Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof.
KR20100097716A (en) 2007-11-27 2010-09-03 아블린쓰 엔.브이. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
KR101581480B1 (en) 2008-02-06 2015-12-30 프로제닉스 파머슈티컬스, 인코포레이티드 Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
WO2009109635A2 (en) 2008-03-05 2009-09-11 Ablynx Nv Novel antigen binding dimer-complexes, methods of making and uses thereof
JP2011516520A (en) 2008-04-07 2011-05-26 アブリンクス エン．ヴェー． Amino acid sequence having directivity in Notch pathway and use thereof
CA2721202A1 (en) 2008-04-17 2009-10-22 Hilde Adi Pierrette Revets Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
AU2009255796B2 (en) * 2008-06-06 2014-09-25 Grasslanz Technology Limited Novel genes involved in biosynthesis
EP2403873A1 (en) 2009-03-05 2012-01-11 Ablynx N.V. Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
EP2417163B1 (en) 2009-04-10 2019-02-27 Ablynx N.V. Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
HUE035773T2 (en) 2009-06-05 2018-05-28 Ablynx Nv Trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections
WO2011040978A2 (en) 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd. Immunodominant mhc dr52b restricted ny-eso-1 epitopes, mhc class ii monomers and multimers, and uses thereof
EP2507262A1 (en) 2009-11-30 2012-10-10 Ablynx N.V. Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
CA2788993A1 (en) 2010-02-05 2011-08-11 Ablynx N.V. Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
MX343085B (en) 2010-11-08 2016-10-24 Novartis Ag Cxcr2 binding polypeptides.
WO2012169893A1 (en) * 2011-06-10 2012-12-13 Stichting Technologisch Topinstituut Groene Genetica (Foundation Technological Top Institute Green Genetics) Transcription factor modulating terpene biosynthesis
WO2012175740A1 (en) 2011-06-23 2012-12-27 Ablynx Nv Immunoglobulin single variable domains directed against ige
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
NL1040254C2 (en) 2013-05-17 2014-11-24 Ablynx Nv Stable formulations of immunoglobulin single variable domains and uses thereof.
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US10501541B2 (en) 2015-01-27 2019-12-10 Lava Therapeutics B.V. Single domain antibodies targeting CD1d
WO2017089618A1 (en) 2015-11-27 2017-06-01 Ablynx Nv Polypeptides inhibiting cd40l
US11098113B2 (en) 2016-09-15 2021-08-24 Vib Vzw Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
WO2018091606A1 (en) 2016-11-16 2018-05-24 Ablynx Nv T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
TWI802576B (en) 2017-06-02 2023-05-21 德商馬克專利公司 Adamts binding immunoglobulins
TWI811220B (en) 2017-06-02 2023-08-11 比利時商艾伯林克斯公司 Aggrecan binding immunoglobulins
TWI826376B (en) 2017-06-02 2023-12-21 德商麥克專利有限公司 Polypeptides binding adamts5, mmp13 and aggrecan
EP3630178A1 (en) 2017-06-02 2020-04-08 Merck Patent GmbH Mmp13 binding immunoglobulins
MX2020008294A (en) 2018-02-06 2020-11-18 Ablynx Nv Methods of treating initial episode of ttp with immunoglobulin single variable domains.
WO2020185069A1 (en) 2019-03-08 2020-09-17 Linxis B.V. Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation
WO2020245663A1 (en) 2019-06-01 2020-12-10 Institut Pasteur Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection
WO2021026119A1 (en) * 2019-08-05 2021-02-11 University Of Virginia Patent Foundation TRANSCRIPTION FACTOR NtERF221 AND METHODS OF USING THE SAME
CN110526961B (en) * 2019-09-09 2021-02-19 四川大学 Application of transcription factor participating in regulation and control of synthesis of tomato steroid alkaloid
CN113265388B (en) * 2020-02-14 2023-02-03 中国科学院分子植物科学卓越创新中心 Tobacco system for producing ajmaline
CA3171472A1 (en) * 2020-03-04 2021-09-10 Pioneer Hi-Bred International, Inc. Cis-acting regulatory elements
CN111690661A (en) * 2020-06-01 2020-09-22 云南省烟草农业科学研究院 Tobacco NtbHLH13 gene mutant and molecular identification method and application
EP4214235A1 (en) 2020-09-16 2023-07-26 LinXis B.V. Internalizing binding molecules
EP4019548A1 (en) 2020-12-23 2022-06-29 Vrije Universiteit Brussel Anti lag3 vhhs and their use
CN115433733A (en) 2021-06-04 2022-12-06 生物岛实验室 Cyclic RNA (ribonucleic acid) Circ-ACE2 translated polypeptide and application thereof
CA3236038A1 (en) 2021-10-20 2023-04-27 Takeda Pharmaceutical Company Limited Compositions targeting bcma and methods of use thereof
WO2024023271A1 (en) 2022-07-27 2024-02-01 Ablynx Nv Polypeptides binding to a specific epitope of the neonatal fc receptor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09224672A (en) * 1996-02-21 1997-09-02 Mitsui Gyosai Shokubutsu Bio Kenkyusho:Kk Dna coding new dna-connected protein
US6846669B1 (en) * 1996-08-20 2005-01-25 The Regents Of The University Of California Methods for improving seeds
US6417428B1 (en) * 1996-09-04 2002-07-09 Michael F. Thomashow Plant having altered environmental stress tolerance
US5892009A (en) * 1996-09-04 1999-04-06 Michigan State University DNA and encoded protein which regulates cold and dehydration regulated genes
GB9801598D0 (en) * 1998-01-26 1998-03-25 Unilever Plc Methods and compositions for modulating flavonoid content
JP2000050877A (en) * 1998-08-11 2000-02-22 Natl Inst Of Agrobiological Resources Transcription factor which regulates expression of ethylene-inducing gene cluster
JP3183458B2 (en) * 1998-08-12 2001-07-09 農林水産省国際農林水産業研究センター所長 Genes encoding plant transcription factors
JP3178672B2 (en) * 1998-10-14 2001-06-25 農林水産省国際農林水産業研究センター所長 Environmental stress tolerant plant

Also Published As

Publication number Publication date
AU2580600A (en) 2000-08-25
WO2000046383A3 (en) 2001-09-07
AU779162B2 (en) 2005-01-06
WO2000046383A8 (en) 2001-11-01
WO2000046383A2 (en) 2000-08-10
EP1157119A1 (en) 2001-11-28
CA2361678A1 (en) 2000-08-10
JP2002535993A (en) 2002-10-29

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