NZ510359A - Amelioration of apomorphine adverse effects for sexual dysfunction in males and females - Google Patents

Amelioration of apomorphine adverse effects for sexual dysfunction in males and females

Info

Publication number
NZ510359A
NZ510359A NZ510359A NZ51035999A NZ510359A NZ 510359 A NZ510359 A NZ 510359A NZ 510359 A NZ510359 A NZ 510359A NZ 51035999 A NZ51035999 A NZ 51035999A NZ 510359 A NZ510359 A NZ 510359A
Authority
NZ
New Zealand
Prior art keywords
apomorphine
patient
dose
adverse effects
sexual dysfunction
Prior art date
Application number
NZ510359A
Inventor
Ragab El-Rashidy
Bruce Ronsen
Original Assignee
Pentech Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentech Pharmaceuticals Inc filed Critical Pentech Pharmaceuticals Inc
Publication of NZ510359A publication Critical patent/NZ510359A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Adverse effects of apomorphine can be minimized by administering to a patient a threshold dose of apomorphine followed by administering a series of increasing periodic doses of apomorphine greater than the threshold dose until a final apomorphine dose in excess of a therapeutic dose has been received by the patient and then administering to the patient a therapeutic dose of apomorphine. The therapeutic dose of apomorphine to be administered is an amount sufficient to induce a penile erection sufficient for vaginal penetration in a male patient and an amount sufficient to ameliorate sexual dysfunction in a female patient by inducing clitoral erectogenesis and vaginal engorgement on stimulation of the female.
NZ510359A 1998-08-24 1999-07-01 Amelioration of apomorphine adverse effects for sexual dysfunction in males and females NZ510359A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/138,982 US5994363A (en) 1998-08-24 1998-08-24 Amelioration of apomorphine adverse effects
PCT/US1999/014965 WO2000010567A1 (en) 1998-08-24 1999-07-01 Amelioration of apomorphine adverse effects

Publications (1)

Publication Number Publication Date
NZ510359A true NZ510359A (en) 2003-06-30

Family

ID=22484576

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ510359A NZ510359A (en) 1998-08-24 1999-07-01 Amelioration of apomorphine adverse effects for sexual dysfunction in males and females

Country Status (14)

Country Link
US (1) US5994363A (en)
EP (1) EP1105129A4 (en)
JP (1) JP2002523370A (en)
CN (1) CN1212841C (en)
AU (1) AU764068B2 (en)
BR (1) BR9913235A (en)
CA (1) CA2341673A1 (en)
CZ (1) CZ2001610A3 (en)
HU (1) HUP0201212A3 (en)
IL (1) IL141512A0 (en)
NO (1) NO20010899L (en)
NZ (1) NZ510359A (en)
PL (1) PL346273A1 (en)
WO (1) WO2000010567A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
BR0005797A (en) * 2000-03-20 2001-10-16 Abbott Lab Methods for the treatment of sexual dysfunction with apomorphine at specified plasma concentration levels
CZ20023637A3 (en) 2000-04-07 2003-02-12 Tap Pharmaceutical Products, Inc. Apomorphine derivatives and methods of their use
CA2408399A1 (en) * 2000-05-09 2001-11-15 Nitromed, Inc. Infrared thermography and methods of use
DE10053397A1 (en) 2000-10-20 2002-05-02 Schering Ag Use of a dopaminergic active ingredient for the treatment of dopaminerg treatable diseases
DE10043321B4 (en) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Use of a transdermal therapeutic system for the treatment of Parkinson's disease, for the treatment and prevention of premenstrual syndrome and for lactation inhibition
WO2002062315A1 (en) * 2001-02-08 2002-08-15 Pharmacia Corporation Rapid-onset medicament for the treatment of sexual dysfunction
ES2180446B1 (en) * 2001-07-02 2004-01-16 Esteve Labor Dr EMPLOYMENT OF 2,5-DIHYDROXIBENCENOSULPHONIC ACID DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT TO POWER THE EFFECT OF OTHER PHARMACOS IN THE TREATMENT OF ERECTILE DYSFUNCTION.
CN100346832C (en) * 2002-02-07 2007-11-07 法玛西雅公司 Pharmaceutical dosage form for mucosal delivery
AU2003223304A1 (en) * 2002-03-19 2003-10-08 Michael Holick Glycoside and orthoester glycoside derivatives of apomorphine, analogs, and uses thereof
PT2561860T (en) * 2002-05-31 2018-05-08 Titan Pharmaceuticals Inc Implantable polymeric device for sustained release of buprenorphine
AU2003284005B2 (en) * 2002-10-03 2009-12-17 Forest Laboratories Holdings Limited Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
EP1610791B1 (en) * 2003-03-31 2011-02-23 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of dopamine agonist
BRPI0409380A (en) * 2003-04-14 2006-04-18 Vectura Ltd pharmaceutical compositions
US20040204439A1 (en) * 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
CA2562465A1 (en) * 2004-04-13 2005-10-27 The Mclean Hospital Corporation R(-)-11-hydroxyaporphine derivatives and uses thereof
US20060083724A1 (en) * 2004-10-01 2006-04-20 Hilst Todd W Compositions for the treatment of femal sexual dysfunction
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
GB2463833B (en) * 2007-06-26 2012-02-08 Parkinson S Inst Compositions that prevent or reverse alpha-synuclein fibrillation for use in the treatment of neurological disorders
WO2009009083A1 (en) * 2007-07-12 2009-01-15 The Mclean Hospital Corporation R(-)-2-methoxy-11-hydroxyaporphine and derivatives thereof
GB0721394D0 (en) * 2007-10-31 2007-12-12 Vectura Group Plc Compositions for trating parkinson's disease
EP2442650B1 (en) 2009-06-12 2015-08-26 Cynapsus Therapeutics Inc. Sublingual apomorphine
AU2011343429B2 (en) 2010-12-16 2016-10-20 Sunovion Pharmaceuticals Inc. Sublingual films
EP2545905A1 (en) * 2011-07-11 2013-01-16 Britannia Pharmaceuticals Limited A new therapeutical composition containing apomorphine as active ingredient
WO2016172095A1 (en) 2015-04-21 2016-10-27 Cynapsus Therapeutics, Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
IT202100009857A1 (en) 2021-04-19 2022-10-19 Univ Degli Studi Di Torino PROLONGED AND CONTROLLED RELEASE FORMULATION OF APOMORPHINE

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2818855A (en) * 1954-02-11 1958-01-07 Anthony P Miller Surgical device
US3976780A (en) * 1968-07-29 1976-08-24 Societe D'etudes Scientifiques Et Industrielles L'ile-De-France Methods of protection against emesis in mammals by administration of a 3-alkoxy-thianaphthene-2-carboxamide
US4127118B1 (en) * 1977-03-16 1995-12-19 Alvaro Latorre Method of effecting and enhancing an erection
US4543256A (en) * 1982-03-17 1985-09-24 Northeastern University (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers
AU1508183A (en) * 1982-06-04 1983-12-08 Beecham Group Plc Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane
US4687773A (en) * 1983-03-28 1987-08-18 Mclean Hospital (+)-N-N-propylnorapomorphine and selective limbic activity
US4521421A (en) * 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
US4749700A (en) * 1984-10-23 1988-06-07 Nastech Pharmaceutical Co, Inc. Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same
US4624965A (en) * 1984-11-15 1986-11-25 Nastech Pharmaceutical Co., Inc. Novel method of administering anti-nausea and anti-emetic pharmaceutical agents and novel dosage forms containing same
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US4749686A (en) * 1986-12-04 1988-06-07 New York Medical College Combinations of renal vasodilators and α1 -adrenergic or ganglionic blocking agents and methods for treating diseases
US4801587A (en) * 1987-03-02 1989-01-31 Gene Voss Impotence ointment
US5102887A (en) * 1989-02-17 1992-04-07 Arch Development Corporation Method for reducing emesis and nausea induced by the administration of an emesis causing agent
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
US5166145A (en) * 1990-09-10 1992-11-24 Alza Corporation Antiemetic therapy
DE69514794T2 (en) * 1994-04-22 2000-07-27 Pentech Pharmaceuticals Inc SUBLINGUAL DOSAGE FORMS CONTAINING APOMORPHIN FOR USE IN THE TREATMENT OF ERECTILE DYSFUNCTION
US5562917A (en) * 1994-12-23 1996-10-08 Pentech Pharmaceuticals, Inc. Transdermal administration of apomorphine

Also Published As

Publication number Publication date
CN1324238A (en) 2001-11-28
US5994363A (en) 1999-11-30
AU4965199A (en) 2000-03-14
EP1105129A4 (en) 2003-11-12
CN1212841C (en) 2005-08-03
NO20010899L (en) 2001-04-24
JP2002523370A (en) 2002-07-30
WO2000010567A1 (en) 2000-03-02
CA2341673A1 (en) 2000-03-02
PL346273A1 (en) 2002-01-28
HUP0201212A3 (en) 2004-12-28
HUP0201212A2 (en) 2002-08-28
IL141512A0 (en) 2002-03-10
BR9913235A (en) 2001-12-04
EP1105129A1 (en) 2001-06-13
AU764068B2 (en) 2003-08-07
NO20010899D0 (en) 2001-02-22
CZ2001610A3 (en) 2002-03-13

Similar Documents

Publication Publication Date Title
NZ510359A (en) Amelioration of apomorphine adverse effects for sexual dysfunction in males and females
JO2085B1 (en) Treatment of female sexual dysfunction
US5891915A (en) Method for enhancing female sexual response and an ointment therefor
KR970702041A (en) Dosage forms and method for ameliorating male erectile dysfunction
EA200001042A2 (en) CONNECTIONS FOR THE TREATMENT OF FEMALE SEXUAL DYSFUNCTION
AU6848098A (en) Use of misoprostol or/and misoprostol acid for preparing drug in order to cu re erectile dysfunction
HK1081425A1 (en) Condom
HUP9902094A2 (en) Pge-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction
Steinberger The treatment of dysmenorrhea by acupuncture
AR019694A1 (en) METHOD FOR THE TREATMENT OR REDUCTION OF FEMALE SEXUAL DYSFUNCTION.
PT1251850E (en) USE OF A PREPARATION OF COMBINATION IN CANCER THERAPY
顾月华 TREATMENT OF ACUTE ABDOMEN BY ELECTRO-ACUPUNCTURE——A Report of 245 Cases
CN2229257Y (en) Physical therapeutical ball
CN201384597Y (en) Time-delay liner
RU2266095C2 (en) Method for treating male patients for sexual disorders
CN102743487B (en) Traditional Chinese medicine for treating wet cold invasion type rheumatic aching muscles
CN201175401Y (en) Physics time lagged type safety guard
CN2139442Y (en) Massage device for curing sexual desire cheerless of woman
KR20220109191A (en) Penis assistance device
KR20130119704A (en) Panty
Fishman et al. Case report, lontophoretic delivery of steroids in the treatment of Peyronie's disease: Case reports of three successful outcomes
CN1116888C (en) Medicine composition for treating woman's sexual function disease
Hongzhao et al. Acupuncture treatment for insomnia
Sarrel Sexual physiology and sexual functioning
Zhi-cheng et al. Clinical study on treatment of simple obesity with acupuncture

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)