NZ505951A - A method for enhancing the complexation efficiency of a heterocyclic drug with cyclodextrin, by subjecting the heterocycloc drug to chemically reversible ring-opening - Google Patents
A method for enhancing the complexation efficiency of a heterocyclic drug with cyclodextrin, by subjecting the heterocycloc drug to chemically reversible ring-openingInfo
- Publication number
- NZ505951A NZ505951A NZ505951A NZ50595199A NZ505951A NZ 505951 A NZ505951 A NZ 505951A NZ 505951 A NZ505951 A NZ 505951A NZ 50595199 A NZ50595199 A NZ 50595199A NZ 505951 A NZ505951 A NZ 505951A
- Authority
- NZ
- New Zealand
- Prior art keywords
- drug
- cyclodextrin
- enhancing
- opening
- heterocycloc
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A method for enhancing the complexation efficiency of a benzodiazepine with cyclodextrin comprising: complexing benzodiazepine with cyclodextrin in an aqueous medium at a pH level below 5 and allowing the resultant complexation medium to equilibrate for sufficient time to effect chemically reversible ring-opening of at least 1% by weight of benzodiazepine, an d further comprising detecting the presence of the ring-opened form of benzodiazepine.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7554498P | 1998-02-23 | 1998-02-23 | |
PCT/IS1999/000003 WO1999042111A1 (en) | 1998-02-23 | 1999-02-16 | High-energy cyclodextrin complexes |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ505951A true NZ505951A (en) | 2003-02-28 |
Family
ID=22126450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ505951A NZ505951A (en) | 1998-02-23 | 1999-02-16 | A method for enhancing the complexation efficiency of a heterocyclic drug with cyclodextrin, by subjecting the heterocycloc drug to chemically reversible ring-opening |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1067942A1 (en) |
JP (1) | JP2003522207A (en) |
AU (1) | AU759280C (en) |
CA (1) | CA2320772A1 (en) |
IS (1) | IS5572A (en) |
NZ (1) | NZ505951A (en) |
WO (1) | WO1999042111A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7937500A (en) * | 1999-10-27 | 2001-05-08 | Farmarc Nederland Bv | Pharmaceutical composition containing midazolam |
DE60115217T2 (en) * | 2000-03-28 | 2006-07-20 | Farmarc Nederland B.V. | ALPRAZOLAM INCLUSION COMPLEXES AND ITS PHARMACEUTICAL COMPOSITIONS |
PT1406633E (en) | 2001-06-18 | 2012-01-12 | Noven Pharma | Enhanced drug delivery in transdermal systems |
US6805878B2 (en) | 2001-09-13 | 2004-10-19 | Noven Pharmaceuticals, Inc. | Transdermal administration of ACE inhibitors |
WO2003022270A1 (en) * | 2001-09-13 | 2003-03-20 | Noven Pharmaceuticals, Inc. | Transdermal administration of an enalapril ester |
ATE386532T1 (en) * | 2002-06-13 | 2008-03-15 | Novartis Pharma Gmbh | QUATERNIZED AMMONIUM CYCLODEXTRIN COMPOUNDS |
US7888328B2 (en) | 2003-03-28 | 2011-02-15 | Ares Trading S.A. | Oral formulations of cladribine |
AU2004311478A1 (en) | 2003-12-31 | 2005-07-21 | Cydex Pharmaceuticals, Inc. | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
GB0400804D0 (en) * | 2004-01-14 | 2004-02-18 | Innoscience Technology Bv | Pharmaceutical compositions |
MXPA06012240A (en) | 2004-04-23 | 2007-01-31 | Cydex Inc | Dpi formulation containing sulfoalkyl ether cyclodextrin. |
PT2583668E (en) | 2005-10-26 | 2015-01-05 | Cydex Pharmaceuticals Inc | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
BRPI0717460A2 (en) * | 2006-10-20 | 2013-12-24 | Icos Corp | CHK1 INHIBITOR COMPOSITIONS |
US20100056500A1 (en) * | 2006-11-21 | 2010-03-04 | Thitiwan Buranachokaisan | Stable Parenteral Formulation |
DK2152078T3 (en) | 2007-04-27 | 2021-02-08 | Cydex Pharmaceuticals Inc | FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYLETHERCYCLODEXTRINE AND USE PROCEDURES |
EP2106786A1 (en) * | 2008-04-04 | 2009-10-07 | Roewer, Norbert, Univ.-Prof. Dr. med. | Pharmaceutical preparation comprising permethylated cyclodextrin |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
US20110318474A1 (en) | 2008-12-29 | 2011-12-29 | Mark John Berry | Food products enriched with methylxanthines |
CN102625658B (en) | 2009-05-13 | 2015-01-28 | 锡德克斯药物公司 | Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same |
EP2571502B1 (en) | 2010-05-19 | 2016-04-27 | Unilever N.V. | Theobromine for increasing hdl-cholesterol |
EP2678320B1 (en) | 2011-02-23 | 2018-09-19 | Coeruleus Ltd. | Flumazenil complexes, compositions comprising same and uses thereof |
DK2814849T3 (en) | 2012-02-15 | 2020-03-09 | Cydex Pharmaceuticals Inc | Process for Preparation of Cyclodextrin Derivatives |
CN110066351B (en) | 2012-02-28 | 2022-06-14 | 锡德克斯药物公司 | Alkylated cyclodextrin compositions and methods of making and using the same |
NZ707323A (en) | 2012-10-22 | 2018-11-30 | Cydex Pharmaceuticals Inc | Alkylated cyclodextrin compositions and processes for preparing and using the same |
CN104870001B (en) | 2012-11-15 | 2019-01-18 | 赛博尔泰克股份公司 | Delphinidin complex compound as anti-inflammatory or immunosupress effective component |
EP2931287B1 (en) | 2012-12-11 | 2017-10-04 | Sapiotec GmbH | Delphinidin for combating melanoma cells |
PT3183295T (en) | 2014-08-22 | 2023-11-03 | Cydex Pharmaceuticals Inc | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0166088B1 (en) * | 1990-01-23 | 1999-01-15 | . | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
-
1999
- 1999-02-16 CA CA002320772A patent/CA2320772A1/en not_active Abandoned
- 1999-02-16 AU AU26385/99A patent/AU759280C/en not_active Ceased
- 1999-02-16 EP EP99906440A patent/EP1067942A1/en not_active Withdrawn
- 1999-02-16 JP JP2000532126A patent/JP2003522207A/en not_active Withdrawn
- 1999-02-16 NZ NZ505951A patent/NZ505951A/en unknown
- 1999-02-16 WO PCT/IS1999/000003 patent/WO1999042111A1/en not_active Application Discontinuation
-
2000
- 2000-07-25 IS IS5572A patent/IS5572A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO1999042111A1 (en) | 1999-08-26 |
AU759280B2 (en) | 2003-04-10 |
AU2638599A (en) | 1999-09-06 |
EP1067942A1 (en) | 2001-01-17 |
CA2320772A1 (en) | 1999-08-26 |
AU759280C (en) | 2004-01-22 |
IS5572A (en) | 2000-08-16 |
JP2003522207A (en) | 2003-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RENW | Renewal (renewal fees accepted) | ||
S38A | Application for proceedings under section 38 (amendment of specification with leave of commissioner) |
Free format text: BY WAY OF DISCLAIMER |
|
PSEA | Patent sealed | ||
S38C | Proceedings under section 38 (amendment of specification with leave of commissioner): specification amended |