NZ502473A - The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin - Google Patents

The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin

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Publication number
NZ502473A
NZ502473A NZ50247300A NZ50247300A NZ502473A NZ 502473 A NZ502473 A NZ 502473A NZ 50247300 A NZ50247300 A NZ 50247300A NZ 50247300 A NZ50247300 A NZ 50247300A NZ 502473 A NZ502473 A NZ 502473A
Authority
NZ
New Zealand
Prior art keywords
piglets
islet cells
nicotinamide
preparation
pancreas
Prior art date
Application number
NZ50247300A
Inventor
Robert Bartlet Elliott
Original Assignee
Diatranz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatranz Ltd filed Critical Diatranz Ltd
Priority to NZ50247300A priority Critical patent/NZ502473A/en
Priority to ES01942558T priority patent/ES2272482T3/en
Priority to EP01942558A priority patent/EP1248640B1/en
Priority to AU28930/01A priority patent/AU780366B2/en
Priority to US09/857,325 priority patent/US7122177B2/en
Priority to DK01942558T priority patent/DK1248640T3/en
Priority to AT01942558T priority patent/ATE341335T1/en
Priority to PCT/NZ2001/000006 priority patent/WO2001052871A1/en
Priority to DE60123574T priority patent/DE60123574T2/en
Publication of NZ502473A publication Critical patent/NZ502473A/en
Priority to US10/443,344 priority patent/US7323323B2/en
Priority to US11/932,538 priority patent/US8142769B2/en

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Xenotransplantable porcine islet preparations capable of producing porcine insulin in a suitable mammal are prepared from the pancreas of piglets at or near full term gestation. The method comprises harvesting the pancreas of piglets that are from -7 to +10 days full term gestation. A culture of the pancreatic b islet cells is prepared from the harvested pancreas in a supportive mammalian albumin, free of non-human microbiological agents. Simultaneously or after the preparation of the culture pancreatic b islet cells are extracted from the culture of the harvested pancreas. The extraction is performed using a collagenase selected from purified human collagenase or purified porcine collagenase. At some stage of the method the islets are treated with nicotinamide. Further more after extraction the islets can be encapsulated with a biocompatible xenotransplantable material that is glucose and insulin porous.
NZ50247300A 2000-01-20 2000-01-20 The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin NZ502473A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NZ50247300A NZ502473A (en) 2000-01-20 2000-01-20 The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin
DK01942558T DK1248640T3 (en) 2000-01-20 2001-01-19 Xenotransplantation of pig islets and their production
EP01942558A EP1248640B1 (en) 2000-01-20 2001-01-19 Preparation and xenotransplantation of porcine islets
AU28930/01A AU780366B2 (en) 2000-01-20 2001-01-19 Preparation and xenotransplantation of porcine islets
US09/857,325 US7122177B2 (en) 2000-01-20 2001-01-19 Preparation and xenotransplantation of porcine islets
ES01942558T ES2272482T3 (en) 2000-01-20 2001-01-19 PREPARATION AND XENOTRANSPLANT OF SWINE ISLOTS.
AT01942558T ATE341335T1 (en) 2000-01-20 2001-01-19 PREPARATION AND XENOTRANSPLANTATION OF ISLANDS FROM PIGS
PCT/NZ2001/000006 WO2001052871A1 (en) 2000-01-20 2001-01-19 Preparation and xenotransplantation of porcine islets
DE60123574T DE60123574T2 (en) 2000-01-20 2001-01-19 PREPARATION AND XENOTRANSPLANTATION OF PIG ISLANDS
US10/443,344 US7323323B2 (en) 2000-01-20 2003-05-22 Preparation and xenotransplantation of porcine islets
US11/932,538 US8142769B2 (en) 2000-01-20 2007-10-31 Preparation and xenotransplantation of porcine islets

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ50247300A NZ502473A (en) 2000-01-20 2000-01-20 The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin

Publications (1)

Publication Number Publication Date
NZ502473A true NZ502473A (en) 2002-09-27

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ID=19927718

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ50247300A NZ502473A (en) 2000-01-20 2000-01-20 The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin

Country Status (1)

Country Link
NZ (1) NZ502473A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122177B2 (en) 2000-01-20 2006-10-17 Diabcell Pty Ltd. Preparation and xenotransplantation of porcine islets

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122177B2 (en) 2000-01-20 2006-10-17 Diabcell Pty Ltd. Preparation and xenotransplantation of porcine islets
US7323323B2 (en) 2000-01-20 2008-01-29 Diabell Pty Ltd. Preparation and xenotransplantation of porcine islets

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Owner name: DIABCELL PTY LIMITED, AU

Free format text: OLD OWNER(S): DIATRANZ LIMITED

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Owner name: DIATRANZ OTSUKA LIMITED, NZ

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Free format text: PATENT RENEWED FOR 7 YEARS UNTIL 31 JAN 2021 BY AJ PARK

Effective date: 20140113

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