NZ501709A - Pharmaceutical compositions comprising a compound having affinity for FKB12, a neurotrophic factor and a pharmaceuticl carrier - Google Patents

Pharmaceutical compositions comprising a compound having affinity for FKB12, a neurotrophic factor and a pharmaceuticl carrier

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Publication number
NZ501709A
NZ501709A NZ501709A NZ50170996A NZ501709A NZ 501709 A NZ501709 A NZ 501709A NZ 501709 A NZ501709 A NZ 501709A NZ 50170996 A NZ50170996 A NZ 50170996A NZ 501709 A NZ501709 A NZ 501709A
Authority
NZ
New Zealand
Prior art keywords
compound
neurotrophic factor
compositions
pharmaceutical compositions
methods
Prior art date
Application number
NZ501709A
Inventor
David M Armistead
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Priority claimed from NZ310339A external-priority patent/NZ310339A/en
Publication of NZ501709A publication Critical patent/NZ501709A/en

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The application relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound of the formula below, where A is O, NH or Nalkyl; T is heteroaryl, aryl or substituted cyclohexyl, E is O, CH-U. J is H or alkyl, K is alkyl, benzyl or cyclohexylmethyl, or J and K together form a 7 membered heterocyclic ring and B, D and U are as defined in the specification. which binds to the FK-506 binding protein (FKBP) and a neurotrophic factor, such as nerve growth factor NGF. The methods comprise treating nerve cells with the above-described compositions or compositions comprising the FKBP binding compound without a neurotrophic factor. The methods can be used to promote repair of neuronal damage caused by disease or physical trauma.
NZ501709A 1995-06-08 1996-06-06 Pharmaceutical compositions comprising a compound having affinity for FKB12, a neurotrophic factor and a pharmaceuticl carrier NZ501709A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48600495A 1995-06-08 1995-06-08
NZ310339A NZ310339A (en) 1995-06-08 1996-06-06 Compositions for stimulating neurite growth comprising a neurotrophic amount of a compound with affinity for FKBP12 and a neurotrophic agent

Publications (1)

Publication Number Publication Date
NZ501709A true NZ501709A (en) 2000-10-27

Family

ID=26651728

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ501709A NZ501709A (en) 1995-06-08 1996-06-06 Pharmaceutical compositions comprising a compound having affinity for FKB12, a neurotrophic factor and a pharmaceuticl carrier

Country Status (1)

Country Link
NZ (1) NZ501709A (en)

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