NZ335977A - Pyridine derivatives which are knoevenagel condensation products - Google Patents
Pyridine derivatives which are knoevenagel condensation productsInfo
- Publication number
- NZ335977A NZ335977A NZ335977A NZ33597797A NZ335977A NZ 335977 A NZ335977 A NZ 335977A NZ 335977 A NZ335977 A NZ 335977A NZ 33597797 A NZ33597797 A NZ 33597797A NZ 335977 A NZ335977 A NZ 335977A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pyridine derivatives
- condensation products
- independently
- knoevenagel condensation
- diseases
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title abstract 2
- 238000006000 Knoevenagel condensation reaction Methods 0.000 title 1
- 239000007859 condensation product Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 2
- CKSZCFRCBFCTJW-UHFFFAOYSA-N 5-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Chemical compound CC1=NC=C(CO)C(C=C2C(NC(=S)S2)=O)=C1O CKSZCFRCBFCTJW-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229930003270 Vitamin B Natural products 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000019156 vitamin B Nutrition 0.000 abstract 1
- 239000011720 vitamin B Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
The pyridine derivatives, their salts, hydrates or stereoisomers have the formula I wherein: X1, X2 and X3 are independently -O-, -S- or -NR5-; Y is -O- or -S-; Z is -CR5 or =N-; R1 to R5 are independently a substituent such as hydrogen, halo, hydroxy, amino, aminoalkyl, alkoxy or a substituent containing a group negatively charged under physiological conditions; R6 is an optionally substituted hydrocarbon or -O- and n is 0 or 1; provided that the compound is not pyridoxylidenerhodanine. A pharmaceutical composition thereof is useful for treating infectious diseases, tumours, autoimmune diseases or diseases associated with defects of the vitamin B metabolism, immune system or enzymatic reactions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19645974A DE19645974C1 (en) | 1996-11-07 | 1996-11-07 | (Z) -5 - [[3-Hydroxy-2-methyl-5 - [(phosphonooxy) methyl] -4-pyridinyl] methylene] -2-thioxo-4-thiazolidinone, process for its preparation and use |
| PCT/EP1997/006184 WO1998020013A1 (en) | 1996-11-07 | 1997-11-07 | New knoevenagel condensation products, method for their production and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ335977A true NZ335977A (en) | 2000-12-22 |
Family
ID=7810958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ335977A NZ335977A (en) | 1996-11-07 | 1997-11-07 | Pyridine derivatives which are knoevenagel condensation products |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0937089A1 (en) |
| JP (1) | JP2001503752A (en) |
| KR (1) | KR20000053141A (en) |
| CN (1) | CN1236369A (en) |
| AU (1) | AU728345B2 (en) |
| BR (1) | BR9712930A (en) |
| CA (1) | CA2270973A1 (en) |
| CZ (1) | CZ160999A3 (en) |
| DE (1) | DE19645974C1 (en) |
| HU (1) | HUP9904289A3 (en) |
| IL (1) | IL129826A0 (en) |
| NO (1) | NO992209L (en) |
| NZ (1) | NZ335977A (en) |
| PL (1) | PL333128A1 (en) |
| SK (1) | SK61799A3 (en) |
| TR (1) | TR199901733T2 (en) |
| WO (1) | WO1998020013A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910207A (en) | 1998-05-04 | 2001-01-09 | Andreas Johannes Kesel | Monomeric, oligomeric and polymeric knoevenagel condensation products |
| AU743411B2 (en) * | 1998-08-21 | 2002-01-24 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
| CA2371653A1 (en) * | 1999-04-30 | 2000-11-09 | Walter Oberthur | Antioxidative vitamin b6 analogs |
| US6940497B2 (en) | 2001-10-16 | 2005-09-06 | Hewlett-Packard Development Company, L.P. | Portable electronic reading apparatus |
| US20030071780A1 (en) * | 2001-10-16 | 2003-04-17 | Vincent Kent D. | High resolution display |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103776D0 (en) * | 1991-12-19 | 1991-12-19 | Astra Ab | NEW COMPOUNDS |
| IT1266570B1 (en) * | 1993-07-30 | 1997-01-09 | Zambon Spa | DERIVATIVES OF PROPANAMIDE N-ETEROARYL SUBSTITUTES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES |
| FR2722790B1 (en) * | 1994-07-19 | 1996-10-04 | Roussel Uclaf | NOVEL CEPHALOSPORINS COMPRISING IN POSITION 7 A SUBSTITUTED RADICAL BENZYLOXYMINO, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
-
1996
- 1996-11-07 DE DE19645974A patent/DE19645974C1/en not_active Expired - Fee Related
-
1997
- 1997-11-07 NZ NZ335977A patent/NZ335977A/en unknown
- 1997-11-07 EP EP97951145A patent/EP0937089A1/en not_active Withdrawn
- 1997-11-07 CN CN97199496A patent/CN1236369A/en active Pending
- 1997-11-07 BR BRPI9712930-5A patent/BR9712930A/en not_active IP Right Cessation
- 1997-11-07 IL IL12982697A patent/IL129826A0/en unknown
- 1997-11-07 AU AU54798/98A patent/AU728345B2/en not_active Revoked
- 1997-11-07 PL PL97333128A patent/PL333128A1/en unknown
- 1997-11-07 TR TR1999/01733T patent/TR199901733T2/en unknown
- 1997-11-07 CA CA002270973A patent/CA2270973A1/en not_active Withdrawn
- 1997-11-07 KR KR1019990704073A patent/KR20000053141A/en not_active Application Discontinuation
- 1997-11-07 JP JP52107198A patent/JP2001503752A/en active Pending
- 1997-11-07 SK SK617-99A patent/SK61799A3/en unknown
- 1997-11-07 CZ CZ991609A patent/CZ160999A3/en unknown
- 1997-11-07 HU HU9904289A patent/HUP9904289A3/en unknown
- 1997-11-07 WO PCT/EP1997/006184 patent/WO1998020013A1/en not_active Application Discontinuation
-
1999
- 1999-05-06 NO NO992209A patent/NO992209L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL333128A1 (en) | 1999-11-22 |
| NO992209L (en) | 1999-07-01 |
| CZ160999A3 (en) | 1999-09-15 |
| CA2270973A1 (en) | 1998-05-14 |
| HUP9904289A2 (en) | 2001-04-28 |
| WO1998020013A1 (en) | 1998-05-14 |
| JP2001503752A (en) | 2001-03-21 |
| DE19645974C1 (en) | 1998-08-13 |
| BR9712930A (en) | 2006-04-18 |
| NO992209D0 (en) | 1999-05-06 |
| CN1236369A (en) | 1999-11-24 |
| KR20000053141A (en) | 2000-08-25 |
| SK61799A3 (en) | 2000-01-18 |
| IL129826A0 (en) | 2000-02-29 |
| HUP9904289A3 (en) | 2001-08-28 |
| AU5479898A (en) | 1998-05-29 |
| EP0937089A1 (en) | 1999-08-25 |
| AU728345B2 (en) | 2001-01-04 |
| TR199901733T2 (en) | 1999-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |