NZ334809A - Assay for the detection of antibodies against p53 - Google Patents

Assay for the detection of antibodies against p53

Info

Publication number
NZ334809A
NZ334809A NZ334809A NZ33480997A NZ334809A NZ 334809 A NZ334809 A NZ 334809A NZ 334809 A NZ334809 A NZ 334809A NZ 33480997 A NZ33480997 A NZ 33480997A NZ 334809 A NZ334809 A NZ 334809A
Authority
NZ
New Zealand
Prior art keywords
serum sample
assay
detection
antibodies against
biosensor
Prior art date
Application number
NZ334809A
Inventor
Daniel T Mytych
Steven J Swanson
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NZ334809A publication Critical patent/NZ334809A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

Abstract

A method for detecting antibodies capable of binding to p53 protein comprises: A) immobilizing a peptide capable of specifically being bound to an anti-p53 antibody directly onto a flowcell of a sensor chip in a biosensor; B) obtaining a serum sample from a patient to be tested and diluting the serum sample in a suitable buffer; C) contacting the diluted serum sample with the immobilized peptide and D) measuring binding of antibodies to the immobilized peptide by means of the biosensor.
NZ334809A 1996-10-07 1997-10-01 Assay for the detection of antibodies against p53 NZ334809A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2853396P 1996-10-07 1996-10-07
PCT/US1997/016132 WO1998015834A1 (en) 1996-10-07 1997-10-01 ASSAY FOR THE DETECTION OF ANTIBODIES AGAINST p53

Publications (1)

Publication Number Publication Date
NZ334809A true NZ334809A (en) 2000-12-22

Family

ID=21843977

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ334809A NZ334809A (en) 1996-10-07 1997-10-01 Assay for the detection of antibodies against p53

Country Status (11)

Country Link
EP (1) EP0929811A1 (en)
JP (1) JP2001502419A (en)
KR (1) KR20000048833A (en)
CN (1) CN1240028A (en)
AU (1) AU4583397A (en)
BR (1) BR9712504A (en)
CA (1) CA2267200A1 (en)
HU (1) HUP9904222A3 (en)
IL (1) IL129323A0 (en)
NZ (1) NZ334809A (en)
WO (1) WO1998015834A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1090111A1 (en) * 1998-06-25 2001-04-11 Institut Pasteur Exhaustive analysis of viral protein interactions by two-hybrid screens and selection of correctly folded viral interacting polypeptides
AUPP932199A0 (en) * 1999-03-19 1999-04-15 St Vincent's Hospital Sydney Limited Anti-p53 antibodies
CN1217194C (en) * 2001-01-04 2005-08-31 上海数康生物科技有限公司 Protein chip and its preparing process and application
JP4562018B2 (en) * 2001-05-07 2010-10-13 株式会社ハイペップ研究所 Peptide-immobilized substrate and target protein measurement method using the same
KR20030092462A (en) * 2002-05-30 2003-12-06 박영미 Method and kit for diagnosis of progress stage of cancer
JP5160447B2 (en) * 2005-12-22 2013-03-13 アボット・ラボラトリーズ Methods and marker combinations for screening for propensity to lung cancer
DK2245464T3 (en) 2008-01-25 2017-02-20 Multivir Inc P53 BIOMARKETS
JP6119607B2 (en) * 2011-09-20 2017-04-26 コニカミノルタ株式会社 Sample dilution solution, kit using the same, and fluorescence measurement method
WO2013116455A1 (en) * 2012-01-31 2013-08-08 Bio-Rad Laboratories, Inc. Improved sensitivity and specificity for ovarian cancer
EP3201234B1 (en) * 2014-09-30 2018-11-07 Diadem S.r.l. Antibody binding a linear epitope of human p53 and diagnostic applications thereof
CN112964870B (en) * 2021-02-03 2024-01-26 军事科学院军事医学研究院军事兽医研究所 Influenza virus rapid detection method based on SPR biosensor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2698367B1 (en) * 1992-11-02 1995-02-17 Eurobio Lab Fragments of the p53 protein and their uses in the detection and monitoring of disease states.
IL108726A (en) * 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor

Also Published As

Publication number Publication date
KR20000048833A (en) 2000-07-25
AU4583397A (en) 1998-05-05
HUP9904222A3 (en) 2000-08-28
BR9712504A (en) 1999-10-19
EP0929811A1 (en) 1999-07-21
WO1998015834A1 (en) 1998-04-16
IL129323A0 (en) 2000-02-17
CN1240028A (en) 1999-12-29
CA2267200A1 (en) 1998-04-16
JP2001502419A (en) 2001-02-20
HUP9904222A2 (en) 2000-04-28

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