NZ331221A - Novel piperidines derived from 1-/(piperazin-1-yl)aryl-(oxo/amino)carbonyl/-4-aryl-piperidine as selective 5-ht 1dbeta receptor antagonists - Google Patents

Novel piperidines derived from 1-/(piperazin-1-yl)aryl-(oxo/amino)carbonyl/-4-aryl-piperidine as selective 5-ht 1dbeta receptor antagonists

Info

Publication number
NZ331221A
NZ331221A NZ331221A NZ33122197A NZ331221A NZ 331221 A NZ331221 A NZ 331221A NZ 331221 A NZ331221 A NZ 331221A NZ 33122197 A NZ33122197 A NZ 33122197A NZ 331221 A NZ331221 A NZ 331221A
Authority
NZ
New Zealand
Prior art keywords
aryl
linear
carbon atoms
branched alkyl
selective
Prior art date
Application number
NZ331221A
Inventor
Serge Halazy
Catherine Jorand-Lebrun
Peter Pauwels
Chantal Moret
Marc Marien
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of NZ331221A publication Critical patent/NZ331221A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

he present invention relates to piperidines derived from arylpiperazine used as selective 5-HT1D› antagonists. These have the formula 1 which: Ar1 is phenyl, or naphthyl which may be substituted from one of the groups: - linear or branched alkyl residue comprising 1-6 carbon atoms - trifluoromethyl - ether (OR'2), - thioether (SR'2) - halogen - amine - nitro - nitrile A-B represents CH-CH2 or C=CH, X is O, NO, Ch2O or CH2-NH Ar2 represents a phenyl or a naphthyl to which X and piperazine are attached to different carbons and which may itself be variously substituted with a linear or branched alkyl radical comprising 1-6 carbon atoms, an ether or halogen. R1, R2, R3 and R4 which are identical or different, represent a hydrogen, linear or branched alkyl chain comprising 1-6 carbon atoms, R'2 is linear or branched alkyl chain comprising 1-6 carbon atoms and their salts, hydrates, solvates and bioprecursors which are physiologically acceptable for therapeutic use. Also claimed is the process for making these compounds, and pharmaceutical composition comprising these compounds.
NZ331221A 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl-(oxo/amino)carbonyl/-4-aryl-piperidine as selective 5-ht 1dbeta receptor antagonists NZ331221A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9601275A FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS
PCT/FR1997/000195 WO1997028140A1 (en) 1996-02-02 1997-01-31 NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDINE AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
NZ331221A true NZ331221A (en) 2000-01-28

Family

ID=9488770

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ331221A NZ331221A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl-(oxo/amino)carbonyl/-4-aryl-piperidine as selective 5-ht 1dbeta receptor antagonists

Country Status (10)

Country Link
EP (1) EP0886636A1 (en)
JP (1) JP2000504004A (en)
CN (1) CN1212690A (en)
AU (1) AU1607097A (en)
BR (1) BR9707261A (en)
CA (1) CA2244940A1 (en)
FR (1) FR2744448B1 (en)
MX (1) MX9806246A (en)
NZ (1) NZ331221A (en)
WO (1) WO1997028140A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2758327B1 (en) * 1997-01-15 1999-04-02 Pf Medicament NEW ARYLPIPERAZINES DERIVED FROM PIPERIDINE
MXPA04005999A (en) * 2001-12-21 2005-07-13 Taisho Pharma Co Ltd Piperazine derivative.
UA77536C2 (en) 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
PT1648878E (en) * 2003-07-24 2009-07-23 Euro Celtique Sa Piperidine compounds and pharmaceutical compositions containing them
NZ544009A (en) 2003-07-24 2009-07-31 Euro Celtique Sa Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
EP1867644B1 (en) 2003-07-24 2009-05-20 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
JP5372913B2 (en) 2007-04-27 2013-12-18 パーデュー、ファーマ、リミテッド、パートナーシップ Effective treatment for pain
PE20090422A1 (en) 2007-04-27 2009-04-18 Purdue Pharma Lp DERIVATIVES OF PIPERIDINE, PIPERAZINE OR TETRAHYDROPYRIDYL AS ANTAGONISTS OF TRPV1
FR2932481B1 (en) * 2008-06-13 2010-10-08 Sanofi Aventis 4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2932482B1 (en) * 2008-06-13 2010-10-08 Sanofi Aventis NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS
US8759362B2 (en) 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
US8703962B2 (en) 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
FR2953839A1 (en) 2009-12-14 2011-06-17 Sanofi Aventis NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75
FR2953836B1 (en) 2009-12-14 2012-03-16 Sanofi Aventis NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75
WO2011162409A1 (en) 2010-06-22 2011-12-29 Shionogi & Co., Ltd. Compounds having trpv1 antagonistic activity and uses thereof
PE20141531A1 (en) 2011-06-22 2014-10-23 Purdue Pharma Lp TRPV1 ANTAGONISTS INCLUDING DIHYDROXI SUBSTITUTES AND THEIR USES
WO2013021276A1 (en) 2011-08-10 2013-02-14 Purdue Pharma L.P. Trpv1 antagonists including dihydroxy substituent and uses thereof
EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
US9221796B2 (en) 2014-01-09 2015-12-29 Bristol-Myers Squibb Company Selective NR2B antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022820D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
GB9221931D0 (en) * 1992-10-17 1992-12-02 Wyeth John & Brother Ltd Piperazine derivatives
FR2722788B1 (en) * 1994-07-20 1996-10-04 Pf Medicament NOVEL PIPERAZIDES DERIVED FROM ARYL PIPERAZINE, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

Also Published As

Publication number Publication date
FR2744448A1 (en) 1997-08-08
AU1607097A (en) 1997-08-22
EP0886636A1 (en) 1998-12-30
CA2244940A1 (en) 1997-08-07
WO1997028140A1 (en) 1997-08-07
FR2744448B1 (en) 1998-04-24
BR9707261A (en) 1999-07-20
CN1212690A (en) 1999-03-31
MX9806246A (en) 1998-11-29
JP2000504004A (en) 2000-04-04

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