NZ305626A - Reversible protease inhibitors - Google Patents
Reversible protease inhibitorsInfo
- Publication number
- NZ305626A NZ305626A NZ305626A NZ30562696A NZ305626A NZ 305626 A NZ305626 A NZ 305626A NZ 305626 A NZ305626 A NZ 305626A NZ 30562696 A NZ30562696 A NZ 30562696A NZ 305626 A NZ305626 A NZ 305626A
- Authority
- NZ
- New Zealand
- Prior art keywords
- protease inhibitors
- compounds
- optionally substituted
- reversible protease
- 2nhr14
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 230000002441 reversible effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101000790711 Chlamydomonas reinhardtii Uncharacterized membrane protein ycf78 Proteins 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
- -1 arylalkanoyl Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000005102 carbonylalkoxy group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- 239000002852 cysteine proteinase inhibitor Substances 0.000 abstract 1
- 125000004472 dialkylaminosulfonyl group Chemical group 0.000 abstract 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
rovided are compounds as depicted and their salts in which n is 0 to 13; A-B represents a linkage selected from -CONR3-, -CH2NR3- and -NR3CO-; Y is -CH(R5)- or -N(R5)-; Z is -(CH2)2-, -C(R6)(R7)- or -N(R7)-; Z1 is -(CH2)2-, -C(R6)(R8)- or -N(R8)-; R1 is H, alkoxycarbonylalkanoyl, carbonylalkoxy, an optionally substituted alkanoyl,cycloalkylcarbonyl, an optionally substituted heterocycloalkylcarbonyl, arylalkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, arylalkanoyl, aroyl, alkylsulfonyl, dialkylaminosulfonyl or heteroarylsulfonyl; X represents a bond, -CH2-, or -CH2CH(R4)-, wherein R4 is hydrogen, alkyl or arylalkyl; R9 is cyano, -COOR10, P(O)(OR10)2, -S(O)(NR10)R10, -C(O)R11, -S(O)R11, -CONR12R13, -S(O)2NR12R13, -CONHR14 OR -S(O)2NHR14; and the remaining symbols are defined in the specification. These compounds are reported to be cysteine protease inhibitors
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40999695A | 1995-03-24 | 1995-03-24 | |
| PCT/US1996/003844 WO1996030353A1 (en) | 1995-03-24 | 1996-03-21 | Reversible protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ305626A true NZ305626A (en) | 2000-01-28 |
Family
ID=23622800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ305626A NZ305626A (en) | 1995-03-24 | 1996-03-21 | Reversible protease inhibitors |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0817778A1 (en) |
| JP (1) | JPH11503417A (en) |
| KR (1) | KR19980703261A (en) |
| CN (1) | CN1071751C (en) |
| AU (1) | AU713492B2 (en) |
| CA (1) | CA2216151A1 (en) |
| CZ (1) | CZ298197A3 (en) |
| IL (1) | IL117638A0 (en) |
| MY (1) | MY113489A (en) |
| NO (1) | NO311573B1 (en) |
| NZ (1) | NZ305626A (en) |
| PL (1) | PL322409A1 (en) |
| TW (1) | TW470750B (en) |
| WO (1) | WO1996030353A1 (en) |
| ZA (1) | ZA962336B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ332390A (en) | 1996-04-22 | 2000-07-28 | Brigham & Womens Hospital | Suppression of immune response via inhibition of Cathepsin S by vinyl sulfone derivatives |
| NZ333713A (en) * | 1996-07-30 | 2000-12-22 | Axys Pharm Inc | Compounds for treating diseases associated with tryptase activity |
| DE19817461A1 (en) | 1998-04-20 | 1999-10-21 | Basf Ag | New benzamide derivatives useful as cysteine protease inhibitors for treating neurodegenerative diseases, neuronal damage, stroke, cranial trauma, Alzheimer's disease, etc. |
| EP1159273A1 (en) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| NZ518255A (en) * | 1999-09-13 | 2004-11-26 | Boehringer Ingelheim Pharma | Novel spiroheterocyclic compounds useful as reversible inhibitors of cysteine proteases |
| ATE364689T1 (en) | 1999-11-18 | 2007-07-15 | Dendreon Corp | NUCLEIC ACIDS WHICH CODE FOR ENDOTHELIASES, ENDOTHELIASES, AND THEIR USE |
| US7700341B2 (en) | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
| US6635633B2 (en) | 2000-08-14 | 2003-10-21 | Ortho-Pharmaceutical, Inc. | Substituted pyrazoles |
| RU2317988C2 (en) | 2000-08-14 | 2008-02-27 | Орто-Макнейл Фармасьютикал, Инк. | Substituted pyrazoles, pharmaceutical composition based on thereof, using pharmaceutical composition and method for inhibition of cathepsin s activity |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| AU2001281255B2 (en) | 2000-08-14 | 2006-07-20 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
| WO2002020002A2 (en) | 2000-09-06 | 2002-03-14 | Ortho Mcneil Pharmaceutical, Inc. | A method for treating allergies |
| WO2002048097A1 (en) * | 2000-12-12 | 2002-06-20 | Corvas International, Inc. | Compounds, compositions and methods for treatment of parasitic infections |
| JP2004523506A (en) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | Novel compounds and compositions as cathepsin inhibitors |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| WO2003024923A1 (en) * | 2001-09-14 | 2003-03-27 | Axys Pharmaceuticals, Inc. | Sulfonamide compounds as protease inhibitors |
| MXPA04002282A (en) * | 2001-09-14 | 2005-03-07 | Axis Pharmaceutical Inc | Novel compounds and compositions as cathepsin inhibitors. |
| RU2004117877A (en) | 2001-11-14 | 2006-01-10 | Авентис Фармасьютикалз Инк. (Us) | OLIGOPEPTIDES AND COMPOSITIONS CONTAINING THEM, AS CATATEPSIN S INHIBITORS |
| GB0311406D0 (en) * | 2003-05-17 | 2003-06-25 | Queen Mary & Westfield College | Substituted phosphonate fluorescent sensors,and use thereof |
| JP2011524340A (en) * | 2008-05-21 | 2011-09-01 | ニュー・ワールド・ラボラトリーズ・インコーポレイテッド | Selective caspase inhibitors and uses thereof |
| WO2010133000A1 (en) | 2009-05-21 | 2010-11-25 | New World Laboratories Inc. | Selective caspase inhibitors and uses thereof |
| WO2011069149A2 (en) | 2009-12-04 | 2011-06-09 | Dcb-Usa Llc | Cathepsin s inhibitors |
| US9944674B2 (en) | 2011-04-15 | 2018-04-17 | Genesis Technologies Limited | Selective cysteine protease inhibitors and uses thereof |
| KR101309578B1 (en) * | 2011-05-06 | 2013-09-17 | 연세대학교 산학협력단 | Dityrosine compounds having selectivity for cysteine proteases and method for monitoring cysteine proteases using the same |
| KR101385855B1 (en) * | 2012-10-16 | 2014-04-22 | 이동익 | Diaromatic amino acid-based substrate for detecting cathepsins |
| WO2019142890A1 (en) * | 2018-01-19 | 2019-07-25 | 株式会社大阪ソーダ | Organosilicon compound and rubber composition including same |
| EP3553521A1 (en) * | 2018-04-12 | 2019-10-16 | Koninklijke Philips N.V. | Gingivitis diagnostic methods, uses and kits |
-
1996
- 1996-03-21 PL PL96322409A patent/PL322409A1/en unknown
- 1996-03-21 CA CA002216151A patent/CA2216151A1/en not_active Abandoned
- 1996-03-21 JP JP8529509A patent/JPH11503417A/en active Pending
- 1996-03-21 EP EP96910499A patent/EP0817778A1/en not_active Withdrawn
- 1996-03-21 CZ CZ972981A patent/CZ298197A3/en unknown
- 1996-03-21 CN CN96193951A patent/CN1071751C/en not_active Expired - Fee Related
- 1996-03-21 NZ NZ305626A patent/NZ305626A/en unknown
- 1996-03-21 KR KR1019970706665A patent/KR19980703261A/en not_active Application Discontinuation
- 1996-03-21 WO PCT/US1996/003844 patent/WO1996030353A1/en not_active Application Discontinuation
- 1996-03-21 AU AU53674/96A patent/AU713492B2/en not_active Ceased
- 1996-03-22 ZA ZA962336A patent/ZA962336B/en unknown
- 1996-03-22 MY MYPI96001076A patent/MY113489A/en unknown
- 1996-03-24 IL IL11763896A patent/IL117638A0/en unknown
- 1996-04-12 TW TW085104392A patent/TW470750B/en active
-
1997
- 1997-09-23 NO NO19974403A patent/NO311573B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ298197A3 (en) | 1998-03-18 |
| AU713492B2 (en) | 1999-12-02 |
| CN1071751C (en) | 2001-09-26 |
| CN1184472A (en) | 1998-06-10 |
| MY113489A (en) | 2002-03-30 |
| IL117638A0 (en) | 1996-07-23 |
| WO1996030353A1 (en) | 1996-10-03 |
| ZA962336B (en) | 1996-07-31 |
| JPH11503417A (en) | 1999-03-26 |
| EP0817778A1 (en) | 1998-01-14 |
| TW470750B (en) | 2002-01-01 |
| NO974403D0 (en) | 1997-09-23 |
| PL322409A1 (en) | 1998-01-19 |
| KR19980703261A (en) | 1998-10-15 |
| AU5367496A (en) | 1996-10-16 |
| NO974403L (en) | 1997-11-17 |
| NO311573B1 (en) | 2001-12-10 |
| CA2216151A1 (en) | 1996-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |